Inhibition of histone deactylase

ABSTRACT

The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.

RELATED APPLICATIONS

[0001] This application claims priority from U.S. provisionalapplication serial No. 60/132,287, filed on May 3, 1999, which is herebyincorporated by reference in its entirety.

BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] This invention relates to the inhibition of histone deacetylaseexpression and enzymatic activity.

[0004] 2. Summary of the Related Art

[0005] Deacetylation of the core histones H1-H4 is mediated by a tworelated families of enzymes called the histone deacetylases. One familyof histone deacetylases includes HDAC-1, HDAC-2, and HDAC-3. A secondfamily of histone deacetylases includes HDAC-4 (formerly HDAC-A), HDAC-5(formerly HDAC-B), HDAC-C, HDAC-D, and HDAC-E. Histone deacetylaseactivity is thought to modulate the accessibility of transcriptionfactors to enhancer and promoter elements. Indeed, an enrichment ofunderacetylated histone H4 has been found in transcriptionally silentregions of the genome (Taunton et al., Science 272: 408-411, 1996).

[0006] Functional histone deacetylases have been implicated as arequirement in cell cycle progression in both normal and neoplasticcells. Trichostatin A (TCA), an antibiotic isolated from Streptomyces,has been shown to inhibit histone deacetylase activity and arrest cellcycle progression in cells in the G1 and G2 phases (Yoshida et al., J.Biol. Chem. 265: 17174-17179, 1990; Yoshida et al., Exp. Cell Res. 177:122-131, 1988). Other inhibitors of histone deacetylase activity,including trichostatin C, trapoxin, depudecin, suberoylanilidehydroxamic acid (SAHA), FR901228 (Fujisawa Pharmaceuticals), andbutyrate, have been found to similarly inhibit cell cycle progression incells (Taunton et al., Science 272: 408-411, 1996; Kijima et al., J.Biol. Chem. 268(30):22429-22435, 1993; Kwon et al., Proc. Natl. Acad.Sci. USA 95(7):3356-61, 1998).

[0007] The known inhibitors of histone deacetylase are all naturalproduct and are all small molecules that inhibit histone deacetylaseactivity at the protein level. Moreover, all of the known histonedeacetylase inhibitors are non-specific for a particular histonedeacetylase enzyme, and more or less inhibit all members of both thehistone deacetylase families equally.

[0008] Therefore, there remains a need to develop reagents forinhibiting histone deacetylases at a genetic level, as well as forinhibiting expression of a specific histone deacetylase. There is also aneed for the development of methods for using these reagents to identifyand inhibit a specific histone deacetylase involved in tumorigenesis.

BRIEF SUMMARY OF THE INVENTION

[0009] The invention provides methods and reagents for inhibitinghistone deacetylases at a nucleic acid level, as well as for inhibitingexpression of a specific histone by inhibiting expression at the nucleicacid level. The invention allows the identification of and specificinhibition of a specific histone deacetylase involved in tumorigenesis.

[0010] Accordingly, in a first aspect, the invention provides anantisense oligonucleotide that inhibits the expression of a histonedeacetylase. In certain embodiments of this aspect of the invention, thehistone deacetylase is HDAC-1, HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C,HDAC-D, or HDAC-E. In certain other embodiments, the oligonucleotideinhibits more than one histone deacetylase, or the oligonucleotideinhibits all histone deacetylases. Preferably, the oligonucleotide is achimeric oligonucleotide or a hybrid oligonucleotide.

[0011] In certain preferred embodiments of the first aspect of theinvention, the oligonucleotide inhibits transcription of a nucleic acidmolecule encoding the histone deacetylase. The nucleic acid molecule maybe genomic DNA (e.g., a gene), cDNA, or RNA. In other embodiments, theoligonucleotide inhibits translation of the histone deacetylase.

[0012] In various embodiments of the first aspect of the invention, theantisense oligonucleotide has at least one internucleotide linkageselected from the group consisting of phosphorothioate,phosphorodithioate, alkylphosphonate, alkylphosphonothioate,phosphotriester, phosphoramidate, siloxane, carbonate,carboxymethylester, acetamidate, carbamate, thioether, bridgedphosphoramidate, bridged methylene phosphonate, bridged phosphorothioateand sulfone internucleotide linkages. In certain embodiments, theoligonucleotide comprises a ribonucleotide or 2′-O-substitutedribonucleotide region and a deoxyribonucleotide region.

[0013] In a second aspect, the invention provides a method forinhibiting a histone deacetylase in a cell comprising contacting thecell with the antisense oligonucleotide of the first aspect of theinvention. In certain preferred embodiments of the second aspect of theinvention, cell proliferation is inhibited in the contacted cell. Inpreferred embodiments, the cell is a neoplastic cell which may be in ananimal, including a human, and which may be in a neoplastic growth. Incertain preferred embodiments, the method of the second aspect of theinvention further comprises contacting the cell with a histonedeacetylase protein inhibitor that interacts with and reduces theenzymatic activity of the histone deacetylase. Preferably, the histonedeacetylase protein inhibitor is operably associated with the antisenseoligonucleotide.

[0014] In a third aspect, the invention provides a method for inhibitingneoplastic cell growth in an animal comprising administering to ananimal having at least one neoplastic cell present in its body atherapeutically effective amount of the antisense oligonucleotide of thefirst aspect of the invention with a pharmaceutically acceptable carrierfor a therapeutically effective period of time.

[0015] In certain preferred embodiments of the third aspect of theinvention, the method further comprises administering to the animal atherapeutically effective amount of a histone deacetylase proteininhibitor that interacts with and reduces the enzymatic activity of thehistone deacetylase with a pharmaceutically acceptable carrier for atherapeutically effective period of time. Preferably, the histonedeacetylase protein inhibitor is operably associated with the antisenseoligonucleotide.

[0016] In a fourth aspect, the invention provides a method foridentifying a histone deacetylase that is involved in induction of cellproliferation comprising contacting a cell with an antisenseoligonucleotide that inhibits the expression of a histone deacetylase,wherein inhibition of cell proliferation in the contacted cellidentifies the histone deacetylase as a histone deacetylase that isinvolved in induction of cell proliferation. In certain preferredembodiments, the cell is a neoplastic cell, and the induction of cellproliferation is tumorigenesis. In preferred embodiments, the histonedeacetylase is HDAC-1, HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D,or HDAC-E.

[0017] In a fifth aspect, the invention provides a method foridentifying a histone deacetylase protein inhibitor that inhibits ahistone deacetylase that is involved in induction of cell proliferationcomprising contacting a histone deacetylase identified by the method ofthe fourth aspect of the invention with a candidate compound andmeasuring the enzymatic activity of the contacted histone deacetylase,wherein a reduction in the enzymatic activity of the contacted histonedeacetylase identifies the candidate compound as a histone deacetylaseprotein inhibitor that inhibits a histone deacetylase that is involvedin induction of cell proliferation. In certain preferred embodiments,the histone deacetylase protein inhibitor interacts with and reduces theenzymatic activity of fewer than all histone deacetylases.

[0018] In a sixth aspect, the invention provides a method foridentifying a histone deacetylase that is involved in induction of celldifferentiation comprising contacting a cell with an antisenseoligonucleotide that inhibits the expression of a histone deacetylase,wherein induction of differentiation in the contacted cell identifiesthe histone deacetylase as a histone deacetylase that is involved ininduction of cell differentiation. In certain preferred embodiments, thecell is a neoplastic cell. In preferred embodiments, the histonedeacetylase is HDAC-1, HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D,or HDAC-E.

[0019] In a seventh aspect, the invention provides a method foridentifying a histone deacetylase protein inhibitor that inhibits ahistone deacetylase that is involved in induction of celldifferentiation comprising contacting a histone deacetylase identifiedby the method of the sixth aspect of the invention with a candidatecompound and measuring the enzymatic activity of the contacted histonedeacetylase, wherein a reduction in the enzymatic activity of thecontacted histone deacetylase identifies the candidate compound as ahistone deacetylase protein inhibitor that inhibits a histonedeacetylase that is involved in induction of cell differentiation. Incertain preferred embodiments, the histone deacetylase protein inhibitorinteracts with and reduces the enzymatic activity of fewer than allhistone deacetylases.

[0020] In an eighth aspect, the invention provides a histone deacetylaseprotein inhibitor identified by the method of the fifth or the seventhaspects of the invention. Preferably, the histone deacetylase proteininhibitor is substantially pure.

[0021] In a ninth aspect, the invention provides a method for inhibitingcell proliferation in a cell comprising contacting a cell with at leasttwo of the reagents selected from the group consisting of an antisenseoligonucleotide that inhibits a histone deacetylase, a histonedeacetylase protein inhibitor, an antisense oligonucleotide thatinhibits a DNA methyltransferase, and a DNA methyltransferase proteininhibitor. In one embodiment, the inhibition of cell growth of thecontacted cell is greater than the inhibition of cell growth of a cellcontacted with only one of the reagents. In certain embodiments, each ofthe reagents selected from the group is substantially pure. In preferredembodiments, the cell is a neoplastic cell. In yet additional preferredembodiments, the reagents selected from the group are operablyassociated.

[0022] According to the invention, reagents found to specificallyinhibit a histone deacetylase involved in neoplasia may be used astherapeutic agents to inhibit neoplastic cell growth in patientssuffering from neoplasia. For example, an antisense oligonucleotide thatinhibits the expression of a histone deacetylase may be administeredwith a pharmaceutically-acceptable carrier (e.g., physiological sterilesaline solution) via any route of administration to a patient sufferingfrom neoplasia or hyperplasia in an attempt to alleviate any resultingdisease symptom (e.g., death). Likewise, an antisense oligonucleotidethat inhibits the expression of a histone deacetylase may beincorporated into a gene therapy expression vector (e.g., areplication-deficient adenoviral vector), and phage particles carryingsuch vectors may be delivered with a pharmaceutically-acceptable carrierdirectly to the cells of the neoplastic or hyperplastic growth.Pharmaceutically-acceptable carriers and their formulations arewell-known and generally described in, for example, Remington'sPharmaceutical Sciences (18th Edition, ed. A. Gennaro, Mack PublishingCo., Easton, Pa., 1990).

BRIEF DESCRIPTION OF THE DRAWINGS

[0023]FIG. 1 is a graphic representation of a Northern blotting analysisshowing the dose-dependent abilities of representative, nonlimiting,synthetic oligonucleotides according to the invention that specificallybind to either HDAC-1-encoding nucleic acid or both HDAC-1- andHDAC-2-encoding nucleic acids to inhibit expression of HDAC-1 mRNA orboth HDAC-1 MRNA and HDAC-2 mRNA, respectively.

[0024]FIG. 2 is a graphic representation of a Northern blotting analysisshowing the dose-dependent abilities of representative, nonlimiting,synthetic oligonucleotides according to the invention that specificallybind to HDAC-2-encoding nucleic acid to inhibit expression of HDAC-2MRNA.

[0025]FIG. 3 is a graphic representation of a Western blotting analysisshowing the abilities of representative, nonlimiting, syntheticoligonucleotides according to the invention that specifically bind toHDAC-2-encoding nucleic acid to specifically inhibit expression ofHDAC-2 protein.

[0026]FIG. 4 is a graphic representation of a Western blotting analysisshowing the abilities of representative, nonlimiting, syntheticoligonucleotides according to the invention that specifically bind toeither HDAC-1-encoding nucleic acid or both HDAC-1- and HDAC-2-encodingnucleic acid to inhibit expression of HDAC-1 protein or both HDAC-1protein and HDAC-2 protein, respectively. Mismatched syntheticoligonucleotides were used as negative controls. Equal loading of alllanes is evidenced by the equivalent expression of actin.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0027] The invention provides methods and reagents for inhibiting ahistone deacetylase at a nucleic acid level, as well as for inhibiting aspecific histone deacetylase at the nucleic acid level. The reagentsdescribed herein that inhibit histone deacetylase at the nucleic acidlevel (i.e., inhibiting transcription and translation) allows theidentification of a specific histone deacetylase which is involved inneoplasia. Moreover, therapeutical compositions for treating and/oralleviating the symptoms of neoplasia may be developed using thereagents of the invention that specifically inhibit a particular histonedeacetylase involved in neoplasia.

[0028] The reagents according to the invention are useful as analyticaltools and as therapeutic tools, including as gene therapy tools. Theinvention also provides methods and compositions which may bemanipulated and fine-tuned to fit the condition(s) to be treated whileproducing fewer side effects. The patent and scientific literaturereferred to herein establishes knowledge that is available to those withskill in the art. The issued patents, applications, and references,including GenBank database sequences, that are cited herein are herebyincorporated by reference to the same extent as if each was specificallyand individually indicated to be incorporated by reference.

[0029] In a first aspect, the invention provides an antisenseoligonucleotide that inhibits the expression of a histone deacetylase.In certain embodiments of this aspect of the invention, the histonedeacetylase is HDAC-1, HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D,or HDAC-E. In certain embodiments, the oligonucleotide inhibits morethan one histone deacetylase, or the oligonucleotide inhibits allhistone deacetylases.

[0030] The antisense oligonucleotides according to the invention arecomplementary to a region of RNA or double-stranded DNA that encodes ahistone deacetylase. For purposes of the invention, the term“oligonucleotide” includes polymers of two or more deoxyribonucleosides,ribonucleosides, or 2′-O-substituted ribonucleoside residues, or anycombination thereof. Preferably, such oligonucleotides have from about 8to about 50 nucleoside residues, and most preferably from about 12 toabout 30 nucleoside residues. The nucleoside residues may be coupled toeach other by any of the numerous known internucleoside linkages. Suchinternucleoside linkages include without limitation phosphorothioate,phosphorodithioate, alkylphosphonate, alkylphosphonothioate,phosphotriester, phosphoramidate, siloxane, carbonate,carboxymethylester, acetamidate, carbamate, thioether, bridgedphosphoramidate, bridged methylene phosphonate, bridgedphosphorothioate, and sulfone internucleotide linkages. In certainpreferred embodiments, these internucleoside linkages may bephosphodiester, phosphotriester, phosphorothioate, or phosphoramidatelinkages, or combinations thereof. The term oligonucleotide alsoencompasses such polymers having chemically modified bases or sugarsand/or having additional substituents, including without limitationlipophilic groups, intercalating agents, diamines, and adamantane. Forpurposes of the invention the term “2′-O-substituted” means substitutionof the 2′ position of the pentose moiety with an -O-lower alkyl groupcontaining 1-6 saturated or unsaturated carbon atoms, or with an -O-arylor allyl group having 2-6 carbon atoms, wherein such alkyl, aryl, orallyl group may be unsubstituted or may be substituted, e.g., with halo,hydroxy, trifluoromethyl, cyano, nitro, acyl, acyloxy, alkoxy, carboxyl,carbalkoxyl, or amino groups; or such 2′ substitution may be with ahydroxy group (to produce a ribonucleoside), an amino or a halo group,but not with a 2′-H group.

[0031] For purposes of the invention, the term “complementary” meanshaving the ability to hybridize to a genomic region, a gene, or an RNAtranscript thereof under physiological conditions. Such hybridization isordinarily the result of base-specific hydrogen bonding betweencomplementary strands, preferably to form Watson-Crick or Hoogsteen basepairs, although other modes of hydrogen bonding, as well as basestacking can lead to hybridization. As a practical matter, suchhybridization can be inferred from the observation of specific geneexpression inhibition, which may be at the level of transcription ortranslation (or both).

[0032] Particularly preferred antisense oligonucleotides utilized inthis aspect of the invention include chimeric oligonucleotides andhybrid oligonucleotides.

[0033] For purposes of the invention, a “chimeric oligonucleotide”refers to an oligonucleotide having more than one type ofinternucleoside linkage. One preferred embodiment of such a chimericoligonucleotide is a chimeric oligonucleotide comprising aphosphorothioate, phosphodiester or phosphorodithioate region,preferably comprising from about 2 to about 12 nucleotides, and analkylphosphonate or alkylphosphonothioate region (see e.g., Pederson etal. U.S. Pat. Nos. 5,635,377 and 5,366,878). Preferably, such chimericoligonucleotides contain at least three consecutive internucleosidelinkages selected from phosphodiester and phosphorothioate linkages, orcombinations thereof.

[0034] For purposes of the invention, a “hybrid oligonucleotide” refersto an oligonucleotide having more than one type of nucleoside. Onepreferred embodiment of such a hybrid oligonucleotide comprises aribonucleotide or 2′-O-substituted ribonucleotide region, preferablycomprising from about 2 to about 12 2′-O-substituted nucleotides, and adeoxyribonucleotide region. Preferably, such a hybrid oligonucleotidewill contain at least three consecutive deoxyribonucleosides and willalso contain ribonucleosides, 2′-O-substituted ribonucleosides, orcombinations thereof (see e.g., Metelev and Agrawal, U.S. Pat. No.5,652,355).

[0035] The exact nucleotide sequence and chemical structure of anantisense oligonucleotide utilized in the invention can be varied, solong as the oligonucleotide retains its ability to inhibit expression ofa histone deacetylase. This is readily determined by testing whether theparticular antisense oligonucleotide is active by quantitating theamount of mRNA encoding a histone deacetylase, quantitating the amountof histone deacetylase protein, quantitating the histone deacetylaseenzymatic activity, or quantitating the ability of histone deacetylaseto inhibit cell growth in a an in vitro or in vivo cell growth assay,all of which are described in detail in this specification.

[0036] Antisense oligonucleotides utilized in the invention mayconveniently be synthesized on a suitable solid support using well-knownchemical approaches, including H-phosphonate chemistry, phosphoramiditechemistry, or a combination of H-phosphonate chemistry andphosphoramidite chemistry (i.e., H-phosphonate chemistry for some cyclesand phosphoramidite chemistry for other cycles). Suitable solid supportsinclude any of the standard solid supports used for solid phaseoligonucleotide synthesis, such as controlled-pore glass (CPG) (see,e.g., Pon, R. T., Methods in Molec. Biol. 20: 465-496, 1993).

[0037] Antisense oligonucleotides according to the invention are usefulfor a variety of purposes. For example, they can be used as “probes” ofthe physiological function of histone deacetylase by being used toinhibit the activity of histone deacetylase in an experimental cellculture or animal system and to evaluate the effect of inhibiting suchhistone deacetylase activity. This is accomplished by administering to acell or an animal an antisense oligonucleotide that inhibits histonedeacetylase expression according to the invention and observing anyphenotypic effects. In this use, the antisense oligonucleotidesaccording to the invention is preferable to traditional “gene knockout”approaches because it is easier to use, and can be used to inhibithistone deacetylase activity at selected stages of development ordifferentiation. Thus, the method according to the invention can serveas a probe to test the role of histone deacetylation in various stagesof development.

[0038] Preferred antisense oligonucleotides of the invention inhibiteither the transcription of a nucleic acid molecule encoding the histonedeacetylase, or the translation of a nucleic acid molecule encoding thehistone deacetylase. Histone deacetylase-encoding nucleic acids may beRNA or double stranded DNA regions and include, without limitation,intronic sequences, untranslated 5′ and 3′ regions, intron-exonboundaries as well as coding sequences from a histone deacetylase familymember gene. For human sequences, see e.g., Yang et al., Proc. Natl.Acad. Sci. USA 93(23): 12845-12850, 1996; Furukawa et al., Cytogenet.Cell Genet. 73(1-2): 130-133, 1996; Yang et al., J. Biol. Chem. 272(44):28001-28007, 1997; Betz et al., Genomics 52(2): 245-246, 1998; Tauntonet al., Science 272(5260): 408-411, 1996; and Dangond et al., Biochem.Biophys. Res. Commun. 242(3): 648-652, 1998).

[0039] Particularly preferred non-limiting examples of antisenseoligonucleotides of the invention are complementary to regions of RNA ordouble-stranded DNA encoding a histone deacetylase (e.g., HDAC-1,HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D, or HDAC-E). Theantisense olignouncleotides according to the invention are complementaryto regions of RNA or double-stranded DNA that encode HDAC-1, HDAC-2,HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D, and/or HDAC-E. The sequence ofhuman HDAC-1 can be found in GenBank Accession No. U50079 (amino acidsequence in SEQ ID NO:24; nucleic acid sequence in SEQ ID NO:25. Thesequence of human HDAC-2 can be found in GenBank Accession No. U31814(amino acid sequence in SEQ ID NO: 26; nucleic acid sequence in SEQ IDNO: 27). The sequence of human HDAC-3 can be found in GenBank AccessionNo. U75697 (amino acid sequence in SEQ ID NO: 28; nucleic acid sequencein SEQ ID NO: 29). The sequence of human HDAC-4 (formerly human HDAC-A)in GenBank Accession No. AB006626 (amino acid sequence in SEQ ID NO: 30;nucleic acid sequence in SEQ ID NO: 31). The sequence of human HDAC-5(formerly human HDAC-B) can be found in GenBank Accession No. AB011172(amino acid sequence in SEQ ID NO: 32; nucleic acid sequence in SEQ IDNO: 33). The sequence of human HDAC-C can be found in GenBank AccessionNo. AC004994 (amino acid sequence in SEQ ID NO: 34; nucleic acidsequence in SEQ ID NO: 35). The sequence of human HDAC-D can be found inGenBank Accession No. AC004466 (nucleic acid sequence in SEQ ID NO: 36).

[0040] The sequences encoding histone deacetylases from many non-humananimal species are also known (see, for example, GenBank AccessionNumbers AF006603, AF006602,and AF074882 for murine histonedeacetylases). Accordingly, the antisense oligonucleotides of theinvention may also be complementary to regions of RNA or double-strandedDNA that encode histone deacetylases from non-human animals.Particularly, preferred oligonucleotides have nucleotide sequences offrom about 13 to about 35 nucleotides which include the nucleotidesequences shown below as SEQ ID NOs: 1-18. Yet additional particularlypreferred oligonucleotides have nucleotide sequences of from about 15 toabout 26 nucleotides of the nucleotide sequences shown below. Mostpreferably, the oligonucleotides shown below have phosphorothioatebackbones, are 20-26 nucleotides in length, and are modified such thatthe terminal four nucleotides at the 5′ end of the oligonucleotide andthe terminal four nucleotides at the 3′ end of the oligonucleotide eachhave 2′-O-methyl groups attached to their sugar residues.

[0041] Antisense oligonucleotide specific for human HDAC-1 (MG2608):

[0042] 5′-GAA ACG TGA GGG ACT CAG CA-3′ (SEQ ID NO: 1).

[0043] Antisense oligonucleotide specific for both human HDAC-1 andhuman HDAC-2 (MG2610) is a 25/25/25/25 mixture of four oligonucleotides:(SEQ ID NO:2) 5′-CAG CAA ATT ATG GGT CAT GCG GAT TC-3′; (SEQ ID NO:3)5′-CAG CAA GTT ATG AGT CAT GCG GAT TC-3′; (SEQ ID NO:4) 5′-CAG CAA ATTATG AGT CAT GCG GAT TC-3′; and (SEQ ID NO:5) 5′-CAG CAA GTT ATG GGT CATGCG GAT TC-3′.

[0044] Antisense oligonucleotide specific for human HDAC-2: (MG2628; SEQID NO:6) 5′-TGC TGC TGC TGC TGC TGC CG-3′; (MG2633; SEQ ID NO:7) 5′-CCTCCT GCT GCT GCT GCT GC-3′; (MG2635; SEQ ID NO:8) 5′-GGT TCC TTT GGT ATCTGT TT-3′; and (MG2636; SEQ ID NO:9) 5′-CTC CTT GAC TGT ACG CCA TG-3′.

[0045] The antisense oligonucleotides according to the invention mayoptionally be formulated with any of the well known pharmaceuticallyacceptable carriers or diluents (see preparation of pharmaceuticallyacceptable formulations in, e.g., Remington's Pharmaceutical Sciences,18th Edition, ed. A. Gennaro, Mack Publishing Co., Easton, Pa., 1990).

[0046] In a second aspect, the invention provides a method forinhibiting a histone deacetylase in a cell comprising contacting thecell with the antisense oligonucleotide that inhibits the expression ofa histone deacetylase. Preferably, cell proliferation is inhibited inthe contacted cell. Thus, the antisense oligonucleotides according tothe invention are useful in therapeutic approaches to human diseasesincluding benign and malignant neoplasms by inhibiting cellproliferation in cells contacted with the antisense oligonucleotides.The phrase “inhibiting cell proliferation” is used to denote an abilityof a histone deacetylase antisense oligonucleotide or a histonedeacetylase protein inhibitor (or combination thereof) to retard thegrowth of cells contacted with the oligonucleotide or protein inhibitor,as compared to cells not contacted. Such an assessment of cellproliferation can be made by counting contacted and non-contacted cellsusing a Coulter Cell Counter (Coulter, Miami, Fla.) or a hemacytometer.Where the cells are in a solid growth (e.g., a solid tumor or organ),such an assessment of cell proliferation can be made by measuring thegrowth with calipers, and comparing the size of the growth of contactedcells with non-contacted cells. Preferably, the term includes aretardation of cell proliferation that is at least 50% of non-contactedcells. More preferably, the term includes a retardation of cellproliferation that is 100% of non-contacted cells (i.e., the contactedcells do not increase in number or size). Most preferably, the termincludes a reduction in the number or size of contacted cells, ascompared to non-contacted cells. Thus, a histone deacetylase antisenseoligonucleotide or a histone deacetylase protein inhibitor that inhibitscell proliferation in a contacted cell may induce the contacted cell toundergo growth retardation, to undergo growth arrest, to undergoprogrammed cell death (i.e., to apoptose), or to undergo necrotic celldeath.

[0047] Conversely, the phrase “inducing cell proliferation” is used todenote the requirement of the presence or enzymatic activity of ahistone deacetylase for cell proliferation in a normal (i.e.,non-neoplastic) cell. Hence, over-expression of a histone deacetylasethat induces cell proliferation may or may not lead to increased cellproliferation; however, inhibition of a histone deacetylase that inducescell proliferation will lead to inhibition of cell proliferation.

[0048] The phrase “inducing cell differentiation” is used to denote theability of a histone deacetylase antisense oligonucleotide or histonedeacetylase protein inhibitor (or combination thereof) to inducedifferentiation in a contacted cell as compared to a cell that is notcontacted. Thus, a neoplastic cell, when contacted with a histonedeacetylase antisense oligonucleotide or histone deacetylase proteininhibitor (or both) of the invention, may be induced to differentiate,resulting in the production of a daughter cell that is phylogeneticallymore advanced than the contacted cell.

[0049] The cell proliferation inhibiting ability of the antisenseoligonucleotides according to the invention allows the synchronizationof a population of a-synchronously growing cells. For example, theantisense oligonucleotides of the invention may be used to arrest apopulation of non-neoplastic cells grown in vitro in the G1 or G2 phaseof the cell cycle. Such synchronization allows, for example, theidentification of gene and/or gene products expressed during the G1 orG2 phase of the cell cycle. Such a synchronization of cultured cells mayalso be useful for testing the efficacy of a new transfection protocol,where transfection efficiency varies and is dependent upon theparticular cell cycle phase of the cell to be transfected. Use of theantisense oligonucleotides of the invention allows the synchronizationof a population of cells, thereby aiding detection of enhancedtransfection efficiency.

[0050] The anti-neoplstic utility of the antisense oligonucleotidesaccording to the invention is described in detail elsewhere in thisspecification.

[0051] In yet other preferred embodiments, the cell contacted with ahistone deacetylase antisense oligonucleotide is also contacted with ahistone deacetylase protein inhibitor.

[0052] As used herein, the term “histone deacetylase protein inhibitor”denotes an active moiety capable of interacting with a histonedeacetylase at the protein level and reducing the activity of thathistone deacetylase. Histone deacetylase protein inhibitors include,without limitation, trichostatin A, trichostatin B, trichostatin C,depudecin, trapoxin, butyrate, suberoylanilide hydroxamic acid (SAHA),FR901228 (Fujisawa Pharmaceuticals), and acetyldinaline (el-Beltagi etal., Cancer Res. 53(13):3008-3014, 1993). A histone deacetylase proteininhibitor is a molecule that reduces the activity of a histonedeacetylase to a greater extent than it reduces the activity of anyunrelated protein. In a preferred embodiment, such reduction of theactivity of a histone deacetylase is at least 5-fold, more preferably atleast 10-fold, most preferably at least 50-fold. In another embodiment,the activity of a histone deacetylase is reduced 100-fold. Preferably, ahistone deacetylase protein inhibitor interacts with and reduces theactivity of fewer than all histone deacetylases. By “all histonedeacetylases” is meant all of the members of both of the histonedeacetylase families of proteins from a particular species of animal andincludes, without limitation, HDAC-1, HDAC-2, HDAC-3, HDAC-4, HDAC-5,HDAC-C, HDAC-D, or HDAC-E, all of which are considered “relatedproteins,” as used herein. For example, a preferred histone deacetylaseprotein inhibitor interacts with and inhibits HDAC-1 and HDAC-2, butdoes not interact with and inhibit HDAC-3. Most preferably, a histonedeacetylase protein inhibitor interacts with and reduces the activity ofone histone deacetylase (e.g., HDAC-2), but does not interact with orreduce the activities of the other histone deacetylases (e.g., HDAC-1and HDAC-3). As discussed below, a preferred histone deacetylase proteininhibitor is one that interacts with and reduces the enzymatic activityof a histone deacetylase that is involved in tumorigenesis.

[0053] Preferably, the histone deacetylase protein inhibitor is operablyassociated with the antisense oligonucleotide. As mentioned above, theantisense oligonucleotides according to the invention may optionally beformulated well known pharmaceutically acceptable carriers or diluents.This formulation may further contain one or more one or more additionalhistone deacetylase antisense oligonucleotide(s), and/or one or morehistone deacetylase protein inhibitor(s), or it may contain any otherpharmacologically active agent.

[0054] In a particularly preferred embodiment of the invention, theantisense oligonucleotide is in operable association with a histonedeacetylase protein inhibitor. The term “operable association” includesany association between the antisense oligonucleotide and the histonedeacetylase protein inhibitor which allows an antisense oligonucleotideto inhibit histone deacetylase-encoding nucleic acid expression andallows the histone deacetylase protein inhibitor to inhibit histonedeacetylase enzymic activity. One or more antisense oligonucleotide ofthe invention may be operably associated with one or more histonedeacetylase protein inhibitor. Preferably, an antisense oligonucleotideof the invention that targets one particular histone deacetylase (e.g.,HDAC-2) is operably associated with a histone deacetylase proteininhibitor which targets the same histone deacetylase. A preferredoperable association is a hydrolyzable. Preferably, the hydrolyzableassociation is a covalent linkage between the antisense oligonucleotideand the histone deacetylase protein inhibitor. Preferably, such covalentlinkage is hydrolyzable by esterases and/or amidases. Examples of suchhydrolyzable associations are well known in the art. Phosphate estersare particularly preferred.

[0055] In certain preferred embodiments, the covalent linkage may bedirectly between the antisense oligonucleotide and the histonedeacetylase protein inhibitor so as to integrate the histone deacetylaseprotein inhibitor into the backbone. Alternatively, the covalent linkagemay be through an extended structure and may be formed by covalentlylinking the antisense oligonucleotide to the histone deacetylase proteininhibitor through coupling of both the antisense oligonucleotide and thehistone deacetylase protein inhibitor to a carrier molecule such as acarbohydrate, a peptide or a lipid or a glycolipid. Other preferredoperable associations include lipophilic association, such as formationof a liposome containing an antisense oligonucleotide and the histonedeacetylase protein inhibitor covalently linked to a lipophilic moleculeand thus associated with the liposome. Such lipophilic molecules includewithout limitation phosphotidylcholine, cholesterol,phosphatidylethanolamine, and synthetic neoglycolipids, such assyalyllacNAc-HDPE. In certain preferred embodiments, the operableassociation may not be a physical association, but simply a simultaneousexistence in the body, for example, when the antisense oligonucleotideis associated with one liposome and the protein effector is associatedwith another liposome.

[0056] In a third aspect, the invention provides a method for inhibitingneoplastic cell proliferation in an animal comprising administering toan animal having at least one neoplastic cell present in its body atherapeutically effective amount of the antisense oligonucleotide of thefirst aspect of the invention with a pharmaceutically acceptable carrierfor a therapeutically effective period of time. Preferably, the animalis a mammal, particularly a domesticated mammal. Most preferably, theanimal is a human.

[0057] The term “neoplastic cell” is used to denote a cell that showsaberrant cell growth. Preferably, the aberrant cell growth of aneoplastic cell is increased cell growth. A neoplastic cell may be ahyperplastic cell, a cell that shows a lack of contact inhibition ofgrowth in vitro, a benign tumor cell that is incapable of metastasis invivo, or a cancer cell that is capable of metastases in vivo and thatmay recur after attempted removal. The term “tumorigenesis” is used todenote the induction of cell proliferation that leads to the developmentof a neoplastic growth.

[0058] The terms “therapeutically effective amount” and “therapeuticallyeffective period of time” are used to denote known treatments at dosagesand for periods of time effective to reduce neoplastic cell growth.Preferably, such administration should be parenteral, oral, sublingual,transdermal, topical, intranasal, or intrarectal. When administeredsystemically the therapeutic composition is preferably administered at asufficient dosage to attain a blood level of antisense oligonucleotidefrom about 0.1 μM to about 10 μM. For localized administration, muchlower concentrations than this may be effective, and much higherconcentrations may be tolerated. One of skill in the art will appreciatethat such therapeutic effect resulting in a lower effectiveconcentration of the histone deacetylase inhibitor may vary considerablydepending on the tissue, organ, or the particular animal or patient tobe treated according to the invention.

[0059] In a preferred embodiment, the therapeutic composition of theinvention is administered systemically at a sufficient dosage to attaina blood level of antisense oligonucleotide from about 0.01 μM to about20 μM. In a particularly preferred embodiment, the therapeuticcomposition is administered at a sufficient dosage to attain a bloodlevel of antisense oligonucleotide from about 0.05 μM to about 15 μM. Ina more preferred embodiment, the blood level of antisenseoligonucleotide is from about 0.1 μM to about 10 μM.

[0060] For localized administration, much lower concentrations than thismay be therapeutically effective. Preferably, a total dosage ofantisense oligonucleotide will range from about 0.1 mg to about 200 mgoligonucleotide per kg body weight per day. In a more preferredembodiment, a total dosage of antisense oligonucleotide will range fromabout 1 mg to about 20 mg oligonucleotide per kg body weight per day. Ina most preferred embodiment, a total dosage of antisense oligonucleotidewill range from about 2 mg to about 10 mg oligonucleotide per kg bodyweight per day. In a particularly preferred embodiment, thetherapeutically effective amount of a histone deacetylase antisenseoligonucleotide is about 0.5 mg oligonucleotide per kg body weight perday.

[0061] In certain preferred embodiments of the third aspect of theinvention, the method further comprises administering to the animal atherapeutically effective amount of a histone deacetylase proteininhibitor with a pharmaceutically acceptable carrier for atherapeutically effective period of time. Preferably, the histonedeacetylase protein inhibitor is operably associated with the antisenseoligonucleotide. Methods for the operable association of a histonedeacetylase protein inhibitor with a histone deacetylase antisenseoligonucleotide are described above.

[0062] The histone deacetylase protein inhibitor-containing therapeuticcomposition of the invention is administered systemically at asufficient dosage to attain a blood level histone deacetylase proteininhibitor from about 0.01 μM to about 10 μM. In a particularly preferredembodiment, the therapeutic composition is administered at a sufficientdosage to attain a blood level of histone deacetylase protein inhibitorfrom about 0.05 μM to about 10 μM. In a more preferred embodiment, theblood level of histone deacetylase protein inhibitor is from about 0.1μM to about 7 μM. For localized administration, much lowerconcentrations than this may be effective. Preferably, a total dosage ofhistone deacetylase protein inhibitor will range from about 0.01 mg toabout 5 mg protein effector per kg body weight per day. In a morepreferred embodiment, a total dosage of histone deacetylase proteininhibitor will range from about 0.1 mg to about 4 mg protein effectorper kg body weight per day. In a most preferred embodiment, a totaldosage of histone deacetylase protein inhibitor will range from about0.1 mg to about 1 mg protein effector per kg body weight per day. In aparticularly preferred embodiment, the therapeutically effectivesynergistic amount of histone deacetylase protein inhibitor (whenadministered with an antisense oligonucleotide) is 0.1 mg per kg bodyweight per day.

[0063] This aspect of the invention results in an improved inhibitoryeffect, thereby reducing the therapeutically effective concentrations ofeither or both of the nucleic acid level inhibitor (i.e., antisenseoligonucleotide) and the protein level inhibitor (i.e., histonedeacetylase protein inhibitor) required to obtain a given inhibitoryeffect as compared to those necessary when either is used individually.

[0064] Furthermore, one of skill will appreciate that thetherapeutically effective synergistic amount of either the antisenseoligonucleotide or the histone deacetylase inhibitor may be lowered orincreased by fine tuning and altering the amount of the other component.The invention therefore provides a method to tailor theadministration/treatment to the particular exigencies specific to agiven animal species or particular patient. Therapeutically effectiveranges may be easily determined for example empirically by starting atrelatively low amounts and by step-wise increments with concurrentevaluation of inhibition.

[0065] In a fourth aspect, the invention provides a method forinvestigating the role of a particular histone deacetylase in cellularproliferation, including the proliferation of neoplastic cells. In thismethod, the cell type of interest is contacted with an amount of anantisense oligonucleotide that inhibits the expression of a histonedeacetylase, as described for the first aspect according to theinvention, resulting in inhibition of expression of the histonedeacetylase in the cell. If the contacted cell with inhibited expressionof the histone deacetylase also shows an inhibition in cellproliferation, then the histone deacetylase is involved in the inductionof cell proliferation. In this scenario, if the contacted cell is aneoplastic cell, and the contacted neoplastic cell shows an inhibitionof cell proliferation, then the histone deacetylase whose expression wasinhibited is a histone deacetylase that is involved in tumorigenesis.Preferably, the histone deacetylase is HDAC-1, HDAC-2, HDAC-3, HDAC-4,HDAC-5, HDAC-C, HDAC-D, or HDAC-E.

[0066] Thus, by identifying a particular histone deacetylase that isinvolved in the induction of cell proliferation, only that particularhistone deacetylase need be targeted with an antisense oligonucleotideto inhibit cell proliferation or induce differentiation. Consequently, alower therapeutically effective dose of antisense oligonucleotide may beable to effectively inhibit cell proliferation. Moreover, undesirableside effects of inhibiting all histone deacetylases may be avoided byspecifically inhibiting the one (or more) histone deacetylase(s)involved in inducing cell proliferation.

[0067] Once such a histone deacetylase involved in inducing cellproliferation is identified using the antisense oligonucleotides of thefirst aspect of the invention, then histone deacetylase proteininhibitors may be generated that specifically inhibit the histonedeacetylase involved in inducing cell proliferation, while notinhibiting other histone deacetylases not involved in inducing cellproliferation. Accordingly, in a fifth aspect, the invention provides amethod for identifying a histone deacetylase protein inhibitor thatinhibits a histone deacetylase that is involved in the induction of cellproliferation. This method comprises contacting a histone deacetylaseidentified as being involved in inducing cell proliferation with acandidate compound and measuring the enzymatic activity of the contactedhistone deacetylase. A reduction in the enzymatic activity of thecontacted histone deacetylase identifies the candidate compound as ahistone deacetylase protein inhibitor that inhibits a histonedeacetylase that is involved in induction of cell proliferation.

[0068] Measurement of the enzymatic activity of a histone deacetylasecan be achieved using known methodologies. For example, Yoshida et al.(J. Biol. Chem. 265:17174-17179, 1990) describe the assessment ofhistone deacetylase enzymatic activity by the detection of acetylatedhistones in trichostatin A treated cells. Taunton et al. (Science 272:408-411, 1996) similarly describes methods to measure histonedeacetylase enzymatic activity using endogenous and recombinant HDAC-1.Both Yoshida et al. (J. Biol. Chem. 265:17174-17179, 1990) and Tauntonet al. (Science 272: 408-411, 1996) are hereby incorporated byreference.

[0069] Preferably, the histone deacetylase protein inhibitor thatinhibits a histone deacetylase that is involved in induction of cellproliferation is a histone deacetylase protein inhibitor that interactswith and reduces the enzymatic activity of fewer than all histonedeacetylases.

[0070] In a sixth aspect, the invention provides a method foridentifying a histone deacetylase that is involved in induction of celldifferentiation comprising contacting a cell with an antisenseoligonucleotide that inhibits the expression of a histone deacetylase,wherein induction of differentiation in the contacted cell identifiesthe histone deacetylase as a histone deacetylase that is involved ininduction of cell differentiation. Preferably, the cell is a neoplasticcell. In preferred embodiments, the histone deacetylase is HDAC-1,HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D, or HDAC-E.

[0071] In a seventh aspect, the invention provides a method foridentifying a histone deacetylase protein inhibitor that inhibits ahistone deacetylase that is involved in induction of celldifferentiation comprising contacting a histone deacetylase identifiedby the method of the sixth aspect of the invention with a candidatecompound and measuring the enzymatic activity of the contacted histonedeacetylase, wherein a reduction in the enzymatic activity of thecontacted histone deacetylase identifies the candidate compound as ahistone deacetylase protein inhibitor that inhibits a histonedeacetylase that is involved in induction of cell differentiation. Incertain preferred embodiments, the histone deacetylase protein inhibitorinteracts with and reduces the enzymatic activity of fewer than allhistone deacetylases.

[0072] In an eighth aspect, the invention provides a histone deacetylaseprotein inhibitor identified by the method of the fifth or the seventhaspects of the invention. Preferably, the histone deacetylase proteininhibitor is substantially pure.

[0073] Substantially purified proteins can be achieve by any standardmethod including, without limitation, expression of recombinant protein,affinity chromatography, antibody-based affinity purification, and highperformance liquid chromatography (HPLC; see, e.g., Fisher (1980)Laboratory Techniques in Biochemistry and Molecular Biology, Work andBurdon (eds.), Elsevier). Preferably, a substantially purified proteinis at least 80%, by weight, pure in that it is free from other proteinsor naturally-occurring organic molecules. More preferably, asubstantially purified protein is at least 90% pure, by weight. Mostpreferably, a substantially purified protein is at least 95% pure, byweight.

[0074] In a ninth aspect, the invention provides a method for inhibitingcell proliferation in a cell comprising contacting a cell with at leasttwo of the reagents selected from the group consisting of an antisenseoligonucleotide that inhibits a histone deacetylase, a histonedeacetylase protein inhibitor, an antisense oligonucleotide thatinhibits a DNA methyltransferase, and a DNA methyltransferase proteininhibitor. In one embodiment, the inhibition of cell growth of thecontacted cell is greater than the inhibition of cell growth of a cellcontacted with only one of the reagents. In certain preferredembodiments, each of the reagents selected from the group issubstantially pure. In preferred embodiments, the cell is a neoplasticcell. In yet additional preferred embodiments, the reagents selectedfrom the group are operably associated.

[0075] Antisense oligonucleotides that inhibit DNA methyltransferase aredescribed in Szyf and von Hofe, U.S. Pat. No. 5,578,716, the entirecontents of which are incorporated by reference. DNA methyltransferaseprotein inhibitors include, without limitation, 5-aza-2′-deoxycytidine(5-aza-dC), 5-fluoro-2′-deoxycytidine, 5-aza-cytidine (5-aza-C), or5,6-dihydro-5-aza-cytidine.

[0076] The following examples are intended to further illustrate certainpreferred embodiments of the invention and are not limiting in nature.Those skilled in the art will recognize, or be able to ascertain, usingno more than routine experimentation, numerous equivalents to thespecific substances and procedures described herein. Such equivalentsare considered to be within the scope of this invention, and are coveredby the appended claims.

EXAMPLE 1 Screening of Antisense Oligonucleotides

[0077] To identify which antisense oligonucleotides were most effectiveat inhibiting a specific histone deacetylase, a number ofoligonucleotides were generated based on the sequences provided inGenBank Accession Number U50079 for HDAC-1 and GenBank Accession NumberU31814 for HDAC-2. Some of the oligonucleotides screened were describedin Table 2 and Table 3 of Besterman et al., U.S. patent applicationserial No. 60/104,804, filed Oct. 19, 1998, the entire disclosure ofwhich is hereby incorporated by reference.

[0078] In addition, oligonucleotides were generated which werecomplementary to both HDAC-1 and HDAC-2.

[0079] To screen these oligonucleotides for an ability to inhibit thetargeted histone deacetylase, a Northern blotting analysis was firstperformed. To do this, T24 human bladder carcinoma cells (commerciallyavailable from the American Type Culture Collection (ATCC), Manassas,Va.) were grown under suggested conditions. Before addition ofoligonucleotides, cells were washed with PBS (phosphate bufferedsaline). Next, lipofectin transfection reagent (Gibco-BRL Mississauga,Ontario), at a concentration of 6.25 μg/ml, was added to serum freeOPTIMEM medium (GIBCO/BRL), which was then added to the cells.Oligonucleotides to be screened were then added to different wells ofcells (i.e., one oligonucleotide per well of cells). The sameconcentration of oligonucleotide (e.g., 50 nM) was used per well ofcells. The cells were allowed to incubate with lipofectin andoligonucleotide for 4 hours at 37° C. in a cell culture incubator. Thecells were then washed with PBS and returned to full serum-containingmedium. Twenty-four hours later, the cells were harvested fordetermination of HDAC mRNA levels by Northern blotting analysis.

[0080] For determination of mRNA levels by Northern blot, total RNA wasprepared from cells by the guanidinium isothiocyanate standard procedure(see, e.g., Ausubel et al., Current Protocols in Molecular Biology, JohnWiley & Sons, New York, N.Y., 1994), with the exception of an additionalprecipitation step in 2 M LiCl overnight at 4° C. to purify RNA fromcellular DNA contamination. Northern blotting analysis was performedaccording to standard protocols. Probes for HDAC-1 and HDAC-2 were fulllength cDNA clones generated by PCR amplification from the knownsequences for each (e.g., GenBank Accession Nos. U50079 and U31814,respectively). These probes were radiolabelled with ³²P-ATP. Northernblots were scanned and quantified using Alpha Imager (Alpha Innovotech).

[0081] The oligonucleotides which showed an ability to reduce the mRNAexpression of a targeted histone deacetylase (i.e., were able to inhibittranscription of the histone deacetylase mRNA) were next screened for anability to inhibit expression of the targeted histone deacetylaseprotein. To do this, T24 cells were transfected with oligonucleotideusing lipofectin as described above. Twenty-four hours later, the cellswere lysed according to standard procedures. The whole cell extracts (50μg) were resolved on 7-15% gradient SDS/PAGE, transferred to PVDFmembrane (Amersham, Arlington Heights, Ill.), and subjected to Westernblotting analysis with rabbit polyclonal HDAC1- and HDAC-2 specificantibodies (1:500, Santa Cruz Biotech., Santa Cruz, Calif.) were used.Detection was accomplished with a secondary anti-rabbit IgG-HRperoxidase antibody and an enhanced chemiluminescence detection kit(Amersham) accordingly to manufacturer's instructions.

[0082] Based on our results, the following antisense oligonucleotideswere identified as being most effective at inhibiting the expression oftargeted histone deacetylase as determined by both mRNA and proteinexpression blotting analysis. These oliognucleotides are as follows:

[0083] For inhibition of HDAC-1, Oligonucleotide No. MG2608 having thesequence:

[0084] 5′-GAA ACG TGA GGG ACT CAG CA-3′ (SEQ ID NO: 10).

[0085] For inhibition of both HDAC-1 and HDAC-2, Oligonucleotide No.MG2610 is a 25/25/25/25 mixture of four oligonucleotides having thesequences: (SEQ ID NO:11) 5′-CAG CAA ATT ATG GGT CAT GCG GAU UC-3′; (SEQID NO:12) 5′-CAG CAA GTT ATG AGT CAT GCG GAU UC-3′; (SEQ ID NO:13)5′-CAG CAA ATT ATG AGT CAT GCG GAU UC-3′; (SEQ ID NO:14) 5′-CAG CAA GTTATG GGT CAT GCG GAU UC-3′;

[0086] For inhibition of HDAC-2, Table I shows the antisenseoligonucleotides found to be most effective: TABLE I Oligonucleotide No.Sequence SEQ ID NO Target MG2628 5′-UGC UGC TGC TGC TGC TGC CG-3′ 15121-141 MG2633 5′-CCU CCT GCT GCT GCT GCU GC-3′ 16 132-152 MG26355′-GGU UCC TTT GGT ATC TGU UU-3′ 17 1605-1625 MG2636 5′-CUC CTT GAC TGTACG CCA UG-3′ 18  1-20

[0087] To evaluate the specificity of the second generation histonedeacetylase antisense oligonucleotides, mismatch controloligonucleotides of HDAC-1 (MG2608) and HDAC-1/2 (MG2610) weregenerated. These mismatch control oligonucleotides were generated bysubstituting bases, primarily in the four 5′ and 3′ nucleotides, wherethe highest affinity with the targeted histone deacetylase-encodingnucleic acid occurs.

[0088] HDAC-1 MISMATCH CONTROL (MG2609), has the sequence:

[0089] 5′-CAA UCG TCA GAG ACT CCG AA-3′ (SEQ ID NO: 19).

[0090] HDAC-1/2 MISMATCH CONTROL (MG2637), has a 225/25/25/25 mixture offour oligonucleotides having the sequences: (SEQ ID NO:20) 5′-AAG GAAGTC ATG AAT GAT GCC CAU UG-3′; (SEQ ID NO:21) 5′-AAG GAA ATC ATG GAT GATGCC CAU UG-3′; (SEQ ID NO:22) 5′-AAG GAA GTC ATG GAT GAT GCC CAU UG-3′;(SEQ ID NO:23) 5′-AAG GAA ATC ATG AAT GAT GCC CAU UG-3′.

[0091] These oligonucleotides (i.e., having SEQ ID NOs: 10-23) weresecond generation oligonucleotides (i.e., 4×4 hybrids). That is,oligonucleotides having SEQ ID NOs: 10-23 were chemically modified asfollows: A equals 2′-deoxyriboadenosine; C equals 2′-deoxyribocytidine;G equals 2′-deoxyriboguanosine; T equals 2′-deoxyribothymidine; A equalsriboadenosine; U equals uridine; C equals ribocytidine; and G equalsriboguanosine. The underlined bases were 2′-methoxyribose substitutednucleotides. Non-underhned bases indicate deoxyribose nucleosides. Thebackbone of each oligonucleotide consisted of a phosphorothioate linkagebetween adjoining nucleotides.

[0092] A number of oligonucleotides are next generated which arecomplementary to HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D, and HDAC-E.These oligonucleotides are based on the known nucleic acid sequences ofthese histone deacetylases (see, e.g., GenBank Accession No. U75697 forHDAC-3). Antisense oligonucleotides specific for one of these histonedeacetylases are screened for efficacy at inhibiting expression of mRNAand protein as described above for HDAC-1, HDAC-1/2, and HDAC-2. Inaddition, antisense oligonucleotides that inhibit more than one histonedeacetylase (e.g., HDAC-1/3/C-specific) are also generated by mixingantisense oligonucleotides specific for each histone deacetylase andscreened for efficacy.

EXAMPLE 2 Inhibition of Histone Deacetylase mRNA Expression WithAntisense Oligonucleotides

[0093] To determine the specificity and dose requirements of theantisense oligonucleotides specific for histone deacetylase-encodingnucleic acid, the dose dependent inhibition of these oligonucleotides onhistone deacetylase mRNA expression was examined.

[0094] To do this, T24 cells were transfected using lipofectin (asdescribed in Example 1) using 10, 25, 50, or 100 nM oligonucleotide. Thecells were harvested twenty-four hours following transfection, RNAprepared, and Northern blotting analysis performed as described inExample 1 using radiolabelled HDAC-1 and HDAC-2 cDNA as probe.

[0095]FIG. 1 shows the dose dependent inhibition of HDAC-1 mRNAexpression by both HDAC-1 and HDAC-1/2 antisense oligonucleotides at50-100 nM. Conversely, HDAC-2 mRNA expression was inhibited by only theHDAC-1/2 antisense oligonucleotide (MG2610) at 50-100 nM, while theHDAC-1 antisense oligonucleotide (MG2608) had no effect. Theoligonucleotides used in the experiment, the results of which are shownin FIG. 1, were first generation oligonucleotides (i.e., were notchemically modified). The oligonucleotides used to obtain the resultsshown in FIG. 1 had sequences of SEQ ID NOs: 1-5.

[0096]FIG. 2 shows the dose-dependent inhibition of HDAC-2 mRNA byHDAC-2 antisense oligonucleotide. All four HDAC-2 antisenseoligonucleotide (MG2628, MG2633, MG2635, and MG2636) were able to reducethe level of HDAC-2 mRNA expression at 50-100 nM. MG2628 appearedparticularly efficacious at reducing HDAC-2 mRNA expression in thisexperiment.

[0097] These data demonstrated that by targeting histone deacetylase atthe nucleic acid level with antisense oligonucleotide, a reduction inmRNA expression could be achieved 24 hours following exposure to theoligonucleotide.

EXAMPLE 3 Inhibition of Histone Deacetylase Protein Expression WithSecond Generation Antisense Oligonucleotides

[0098] To determine the ability of histone deacetylase antisenseoligonucleotides to inhibit protein expression, second generationversions of the HDAC-1, HDAC-1/2, and HDAC-2 antisense oligonucleotideswere generated. Each of these second generation antisenseoligonucleotides had a backbone consisting of a phosphorothioate linkagebetween each adjoining nucleotide. Moreover, the four terminalnucleotide residues at both the 5′ and 3′ ends of the olgonucleotide hadsugar residues comprising a 2′-O-methyl group. This modification to theterminal nucleotide residues served to increase binding affinity of theoligonucleotide to the targeted nucleic acid, and to increase thestability of the oligonucleotide by inhibiting nuclease susceptibility.

[0099]FIG. 3 shows the ability of second generation HDAC-2 antisenseoligonucleotides to inhibit HDAC-2 protein expression. T24 cells weretransfected with 0, 25, or 50 nM MG2628 or MG2636 using lipofectin, asdescribed in Example 1. Twenty-four hours later, the cells weretransfected a second time with the same amount of the sameoligonucleotide. Twenty-four hours after this (i.e., 48 hours after thefirst transfection), cellular proteins were prepared, resolved on 7-15%gradient SDS-PAGE, and subjected to Western blotting analysis asdescribed in Example 1 with rabbit polyclonal HDAC2 specific antibody(1:500, Santa Cruz Biotech). Following blotting with the secondaryanti-rabbit IgG-HR peroxidase antibody and visualization with theenhanced chemiluminescence detection kit (Amersham), the blot wasstripped and re-probed with an antibody specific to actin to verifyequal loading of all wells (data not shown).

[0100] As can be seen in FIG. 3, 50 μM of second generation MG2628 orMG2836 was able to inhibit HDAC-2 protein expression.

[0101]FIG. 4 shows the specific ability of the HDAC-1/2 and HDAC-1antisense oligonucleotides to inhibit protein expression of both HDAC-1and HDAC-2 or HDAC-1, respectively, when compared to the mismatchcontrols. T24 cells were transfected twice as described above with 50 nMoligonucleotide. Cell lysates were prepared twenty-four hours followingthe second transfection, resolved on 7-15% gradient SDS-PAGE, andtransferred to PVDF membrane. The PVDF membrane blot was first blottedwith anti-HDAC-1 antibody. Following detection with horseradishperoxidase-labelled secondary antibody and enhanced chemiluminescence,the blot was stripped, and re-probed with anti-HDAC-2 antibody.Following detection, the blot was stripped for a second time andre-probed with an actin-specific antibody to verify equal proteinloading in the lanes.

[0102] As can be seen in FIG. 4, both HDAC-1 and HDAC-1/2 mismatchcontrol oligonucleotides failed to inhibit HDAC-1 or HDAC-1 and HDAC-2protein expression, respectively. Conversely, HDAC-1 antisenseoligonucleotide effectively reduced expression of HDAC-1 protein, andHDAC-1/2 antisense oligonucleotide reduced protein expression of bothHDAC-1 and HDAC-2.

EXAMPLE 4 Identification of A Histone Deacetylase Involved in Inductionof Cell Proliferation

[0103] Antisense oligonucleotides that inhibit expression of differenthistone deacetylases, according to the invention, are screened toidentify a histone deacetylase that induces cell proliferation incultured cells.

[0104] To identify a histone deacetylase that induces normal (i.e.,non-neoplastic) cell division, cultured normal human fibroblast cellsare transfected with an antisense oligonucleotide that inhibits theexpression of a histone deacetylase. While any standard transfectionprotocol may be employed, including, without limitation, CaPO₄precipitation, electroporation, DEAE-dextran), transfection using thelipofectin transfection reagent (Gibco-BRL) is preferred. Followingtransfection with lipofectin and a histone deacetylase antisenseoligonucleotide, cells are harvested by trypsinization at various timepoints, and counted using a hemacytometer or a Coulter Cell Counter.Mock transfected control cells (i.e., treated with lipofectin plus acontrol, non-specific oligonucleotide) are also harvested and counted.Both the antisense oligonucleotide- and mock-transfected cells are alsovisually inspected under a microscope for any phenotypic changes (e.g.,induction of apoptosis). An antisense oligonucleotide that inhibits theexpression of a histone deacetylase that is found to inhibit cellproliferation when transfected into a normal cell identifies a histonedeacetylase that is involved in induction of cell proliferation innormal cells.

[0105] To identify a histone deacetylase that induces neoplastic cellproliferation, T24 bladder carcinoma cells are transfected with histonedeacetylase antisense oligonucleotides according to the invention andtheir growth pattern is observed and compared to that of untransfectedcontrol cells. For this purpose, one day before transfection, T24 cells(ATCC No. HTB-4) are plated onto 10 cm plates at 4×10⁵ cells/dish. Atthe time of transfection, cells are washed with phosphate bufferedsaline (PBS) and 5 ml of Opti-MEM media (Gibco-BRL, Mississauga,Ontario) containing 6.25 μg/ml lipofectin transfection reagent is added.The antisense oligonucleotides to be tested are diluted to the desiredconcentration from a 0.1 mM stock solution in the transfection media.After a four-hour incubation at 37° C. in a 5% CO₂ incubator, the platesare washed with PBS and 10 ml of fresh cell culture media is added. T24cells are transfected for a total of three days and split every otherday to ensure optimal transfection conditions. At various time points,cells are harvested by trypsinization and pelleted by centrifugation at1100 rpm and 4° C. for five minutes. The cells are resuspended in PBSand counted on a Coulter Particle Counter to determine the total cellnumber. Mock-transfected T24 cells (transfected with lipofectin and acontrol oligonucleotide) are similarly grown, harvested, and counted. Anantisense oligonucleotide that inhibits the expression of a histonedeacetylase that is found to inhibit cell proliferation when transfectedinto a neoplastic cell identifies a histone deacetylase that is involvedin induction of cell proliferation in neoplastic cells.

[0106] By screening a number of different histone deacetylase antisenseoligonucleotides in normal and neoplastic cells, a histone deacetylasethat is involved in induction of cell proliferation may be readilyidentified. Most preferably, a histone deacetylase antisenseoligonucleotide of the invention is one that inhibits cell proliferationof neoplastic cells, but does not inhibit cell proliferation in normalcells.

EXAMPLE 5 A Histone Deacetylase Protein Inhibitor that Interacts Withand Reduces the Enzymatic Activity of A Histone Deacetylase Involved inthe Induction of Cell Proliferation

[0107] A histone deacetylase that is identified as being involved in theinduction of cell proliferation (identified, for example, in the methodsof Example 4), is used as a target for candidate compounds designed tointeract with and inhibit its enzymatic activity. As a positive control,FR901228 (available from Fujisawa Pharmaceuticals), is used.

[0108] Candidate compounds can be derived from any source and may benaturally-occurring or synthetic, or may have naturally-occurring andsynthetic components. Candidate compounds may also be designed tochemically resemble any of the known histone deacetylase proteininhibitors, including, without limitation, trichostatin A, trichostatinC, trapoxin, depudecin, suberoylanilide hydroxamic acid (SAHA),FR901228, and butyrate.

[0109] Once candidate compounds are identified, a pool of such compoundsmay be added to a histone deacetylase. Such a histone deacetylase ispreferably one that is identified using the antisense oligonucleotidesof the invention as a histone deacetylase involved in induction of cellproliferation. The histone deacetylase may be purified, for example, byusing antibodies specific to that particular histone deacetylase (e.g.,anti-HDAC-1 antibody commercially available from Santa Cruz Biotech.) orby recombinant production of the histone deacetylase in prokaryotic oreukaryotic cells. The histone deacetylase may also be present in a cellwhich normally expresses the histone deacetylase.

[0110] Pools of candidate compounds are added to the histonedeacetylase, and the enzymatic activity of the histone deacetylase ismeasured. A pool of candidate compounds showing such a histonedeacetylase inhibiting activity is sub-divided, and the subdivisionstested until one candidate compound is isolated having a histonedeacetylase inhibiting activity. It will be understood that once a poolof candidate compounds is identified as having an ability to inhibithistone deacetylase enzymatic activity, the pool may be screened viavarious methods to ascertain the presence within the pool or one or morehistone deacetylase protein inhibitor compounds. For example, if thepool is initially screened in a cell having a histone deacetylase, thepool may be subsequently screened on purified histone deacetylase.

[0111] Preferably, the candidate compound(s) found to be a histonedeacetylase protein inhibitor inhibits the activity of fewer than allhistone deacetylases. More preferably, such a candidate compoundinhibits only those histone deacetylases that are involved in theinduction of cell proliferation. Even more preferably, the candidatecompound that is identified as a histone deacetylase protein inhibitoris one that inhibits only one histone deacetylase, where that onehistone deacetylase is involved in the induction of cell proliferation.Most preferably, the candidate compound that is identified as a histonedeacetylase protein inhibitor is one that inhibits only one histonedeacetylase, where that one histone deacetylase is involved in theinduction of cell proliferation in neoplastic cells, but is not involvedin the induction of cell proliferation in normal cells.

[0112] In another method to identify a candidate compound that is ahistone deacetylase protein inhibitor, purified histone deacetylase isallowed to adhere to the bottom of wells in a 96-well microtiter plate.Candidate compounds (or pools thereof) are then added to the plate,where each candidate compound has been modified with the covalentattachment of a detectable marker (e.g., a biotin label). Binding of thecandidate compound to the plate-bound histone deacetylase is detectedvia addition of a secondary reagent that binds to the detectable marker(e.g., a streptavidin-labelled fluorophore), and subsequent analysis ofthe plate on a micro-titer plate reader. Candidate compounds thusidentified which interact with purified histone deacetylase are thenscreened for an ability to inhibit the enzymatic activity of the histonedeacetylase.

EXAMPLE 6 Anti-Neoplastic Effect of Histone Deacetylase AntisenseOligonucleotide on Tumor Cells in Vivo

[0113] The purpose of this example is to illustrate the ability of thehistone deacetylase antisense oligonucleotide of the invention to treatdiseases responsive to histone deacetylase inhibition in animals,particularly mammals. This example further provides evidence of theability of the methods and compositions of the invention to inhibittumor growth in domesticated mammal. Eight to ten week old female BALB/cnude mice (Taconic Labs, Great Barrington, N.Y.) are injectedsubcutaneously in the flank area with 2×10⁶ preconditioned A549 humanlung carcinoma cells. Preconditioning of these cells is done by aminimum of three consecutive tumor transplantations in the same strainof nude mice. Subsequently, tumor fragments of approximately 30 mgs areexcised and implanted subcutaneously in mice, in the left flank areaunder Forene anesthesia (Abbott Labs., Geneva, Switzerland). When thetumors reaches a mean volume of 100 mm³, the mice are treatedintravenously, by daily bolous infusion into the tail vein, witholigonucleotide saline preparations containing 0.1-6 mg/kg of antisenseoligonucleotide (Sigma, St. Louis, Mo.). The optimal final concentrationof the oligonucleotide is established by dose response experimentsaccording to standard protocols. Tumor volume is calculated according tostandard methods every second day post infusion (e.g., Meyer et al.,Int. J. Cancer 43:851-856 (1989)). Treatment with the oligonucleotidesaccording to the invention causes a significant reduction in tumorweight and volume relative to controls treated with saline only (i.e.,no oligonucleotide) or controls treated with saline plus a control,non-specific oligonucleotide. In addition, the activity of histonedeacetylase when measured is expected to be significantly reducedrelative to saline treated controls.

EXAMPLE 7 Synergistic Anti-Neoplastic Effect of Histone DeacetylaseAntisense Oligonucleotide and Histone Deacetylase Protein Inhibitor onTumor Cells in Vivo

[0114] The purpose of this example is to illustrate the ability of thehistone deacetylase antisense oligonucleotide and the histonedeacetylase protein inhibitor of the invention to inhibit tumor growthin a mammal. As described in Example 6, mice bearing implanted A549tumors (mean volume 100 mm³) are treated daily with saline preparationscontaining from about 0.1 mg to about 30 mg per kg body weight ofhistone deacetylase antisense oligonucleotide. A second group of mice istreated daily with pharmaceutically acceptable preparations containingfrom about 0.01 mg to about 5 mg per kg body weight of histonedeacetylase protein inhibitor. Some mice receive both the antisenseoligonucleotide and the histone deacetylase protein inhibitor. Of thesemice, one group may receive the antisense oligonucleotide and thehistone deacetylase protein inhibitor simultaneously intravenously viathe tail vein. Another group may receive the antisense oligonucleotidevia the tail vein, and the histone deacetylase protein inhibitorsubcutaneously. Yet another group may receive both the antisenseoligonucleotide and the histone deacetylase protein inhibitorsimultaneously via a subcutaneous injection. Control groups of mice aresimilarly established which receive no treatment (e.g., saline only), amismatch antisense oligonucleotide only, a control compound that doesnot inhibit histone deacetylase activity, and mismatch antisenseoligonucleotide with control compound.

[0115] Tumor volume is measured with calipers. Treatment with theantisense oligonucleotide plus the histone deacetylase protein inhibitoraccording to the invention causes a significant reduction in tumorweight and volume relative to controls. Preferably, the antisenseoligonucleotide and the histone deacetylase protein inhibitor inhibitthe expression and activity of the same histone deacetylase.

1 36 1 20 DNA Artificial Sequence Description of Artificial Sequencesynthetic oligonucleotide 1 gaaacgtgag ggactcagca 20 2 26 DNA ArtificialSequence Description of Artificial Sequence synthetic oligonucleotide 2cagcaaatta tgggtcatgc ggattc 26 3 26 DNA Artificial Sequence Descriptionof Artificial Sequence synthetic oligonucleotide 3 cagcaagtta tgagtcatgcggattc 26 4 26 DNA Artificial Sequence Description of ArtificialSequence synthetic oligonucleotide 4 cagcaaatta tgagtcatgc ggattc 26 526 DNA Artificial Sequence Description of Artificial Sequence syntheticoligonucleotide 5 cagcaagtta tgggtcatgc ggattc 26 6 20 DNA ArtificialSequence Description of Artificial Sequence synthetic oligonucleotide 6tgctgctgct gctgctgccg 20 7 20 DNA Artificial Sequence Description ofArtificial Sequence synthetic oligonucleotide 7 cctcctgctg ctgctgctgc 208 20 DNA Artificial Sequence Description of Artificial Sequencesynthetic oligonucleotide 8 ggttcctttg gtatctgttt 20 9 20 DNA ArtificialSequence Description of Artificial Sequence synthetic oligonucleotide 9ctccttgact gtacgccatg 20 10 20 DNA Artificial Sequence modified_base 1-4and 17-20 are modified Positions 1-4 and 17-20 are 2′-methoxyribosesubstituted nucleotides; positions 5-16 are deoxyribonucleotides 10gaaacgtgag ggactcagca 20 11 26 DNA Artificial Sequence modified_base 1-4and 23-26 are modified Positions 1-4 and 23-26 are 2′-methoxyribosesubstituted nucleotides; positions 5-22 are deoxyribonucleotides 11cagcaaatta tgggtcatgc ggauuc 26 12 26 DNA Homo sapiens modified_base 1-4and 23-26 are modified Positions 1-4 and 23-26 are 2′-methoxyribosesubstituted nucleotides; positions 5-22 are deoxyribonucleotides 12cagcaagtta tgagtcatgc ggauuc 26 13 26 DNA Artificial Sequencemodified_base 1-4 and 23-26 are modified Positions 1-4 and 23-26 are2′-methoxyribose substituted nucleotides; positions 5-22 aredeoxyribonucleotides 13 cagcaaatta tgagtcatgc ggauuc 26 14 26 DNAArtificial Sequence modified_base 1-4 and 23-26 are modified Positions1-4 and 23-26 are 2′-methoxyribose substituted nucleotides; positions5-22 are deoxyribonucleotides 14 cagcaagtta tgggtcatgc ggauuc 26 15 20DNA Artificial Sequence modified_base 1-4 and 17-20 are modifiedPositions 1-4 and 17-20 are 2′-methoxyribose substituted nucleotides;positions 5-16 are deoxyribonucleotides 15 ugcugctgct gctgctgccg 20 1620 DNA Artificial Sequence modified_base 1-4 and 17-20 are modifiedPositions 1-4 and 17-20 are 2′-methoxyribose substituted nucleotides;positions 5-16 are deoxyribonucleotides 16 ccucctgctg ctgctgcugc 20 1720 DNA Artificial Sequence modified_base 1-4 and 17-20 are modifiedPositions 1-4 and 17-20 are 2′-methoxyribose substituted nucleotides;positions 5-16 are deoxyribonucleotides 17 gguucctttg gtatctguuu 20 1820 DNA Artificial Sequence modified_base 1-4 and 17-20 are modifiedPositions 1-4 and 17-20 are 2′-methoxyribose substituted nucleotides;positions 5-16 are deoxyribonucleotides 18 cuccttgact gtacgccaug 20 1920 DNA Artificial Sequence modified_base 1-4 and 17-20 are modifiedPositions 1-4 and 17-20 are 2′-methoxyribose substituted nucleotides;positions 5-16 are deoxyribonucleotides 19 caaucgtcag agactccgaa 20 2026 DNA Artificial Sequence modified_base 1-4 and 23-26 are modifiedPositions 1-4 and 23-26 are 2′-methoxyribose substituted nucleotides;positions 5-22 are deoxyribonucleotides 20 aaggaagtca tgaatgatgc ccauug26 21 26 DNA Artificial Sequence modified_base 1-4 and 23-26 aremodified Positions 1-4 and 23-26 are 2′-methoxyribose substitutednucleotides; positions 5-22 are deoxyribonucleotides 21 aaggaaatcatggatgatgc ccauug 26 22 26 DNA Artificial Sequence modified_base 1-4 and23-26 are modified Positions 1-4 and 23-26 are 2′-methoxyribosesubstituted nucleotides; positions 5-22 are deoxyribonucleotides 22aaggaagtca tggatgatgc ccattg 26 23 26 DNA Artificial Sequencemodified_base 1-4 and 23-26 are modified Positions 1-4 and 23-26 are2′-methoxyribose substituted nucleotides; positions 5-22 aredeoxyribonucleotides 23 aaggaaatca tgaatgatgc ccattg 26 24 482 PRT Homosapiens 24 Met Ala Gln Thr Gln Gly Thr Arg Arg Lys Val Cys Tyr Tyr TyrAsp 1 5 10 15 Gly Asp Val Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro MetLys Pro 20 25 30 His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr GlyLeu Tyr 35 40 45 Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Asn Ala GluGlu Met 50 55 60 Thr Lys Tyr His Ser Asp Asp Tyr Ile Lys Phe Leu Arg SerIle Arg 65 70 75 80 Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln ArgPhe Asn Val 85 90 95 Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu PheCys Gln Leu 100 105 110 Ser Thr Gly Gly Ser Val Ala Ser Ala Val Lys LeuAsn Lys Gln Gln 115 120 125 Thr Asp Ile Ala Val Asn Trp Ala Gly Gly LeuHis His Ala Lys Lys 130 135 140 Ser Glu Ala Ser Gly Phe Cys Tyr Val AsnAsp Ile Val Leu Ala Ile 145 150 155 160 Leu Glu Leu Leu Lys Tyr His GlnArg Val Leu Tyr Ile Asp Ile Asp 165 170 175 Ile His His Gly Asp Gly ValGlu Glu Ala Phe Tyr Thr Thr Asp Arg 180 185 190 Val Met Thr Val Ser PheHis Lys Tyr Gly Glu Tyr Phe Pro Gly Thr 195 200 205 Gly Asp Leu Arg AspIle Gly Ala Gly Lys Gly Lys Tyr Tyr Ala Val 210 215 220 Asn Tyr Pro LeuArg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala Ile 225 230 235 240 Phe LysPro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser Ala 245 250 255 ValVal Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu Gly 260 265 270Cys Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe Val 275 280285 Lys Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr Thr 290295 300 Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala Leu305 310 315 320 Asp Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr PheGlu Tyr 325 330 335 Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser AsnMet Thr Asn 340 345 350 Gln Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys GlnArg Leu Phe Glu 355 360 365 Asn Leu Arg Met Leu Pro His Ala Pro Gly ValGln Met Gln Ala Ile 370 375 380 Pro Glu Asp Ala Ile Pro Glu Glu Ser GlyAsp Glu Asp Glu Asp Asp 385 390 395 400 Pro Asp Lys Arg Ile Ser Ile CysSer Ser Asp Lys Arg Ile Ala Cys 405 410 415 Glu Glu Glu Phe Ser Asp SerGlu Glu Glu Gly Glu Gly Gly Arg Lys 420 425 430 Asn Ser Ser Asn Phe LysLys Ala Lys Arg Val Lys Thr Glu Asp Glu 435 440 445 Lys Glu Lys Asp ProGlu Glu Lys Lys Glu Val Thr Glu Glu Glu Lys 450 455 460 Thr Lys Glu GluLys Pro Glu Ala Lys Gly Val Lys Glu Glu Val Lys 465 470 475 480 Leu Ala25 1611 DNA Homo sapiens 25 atgtctgggg tctctgcccg ctggtgctgc tgtctcccactcggtcatcc tgagaacaca 60 gcctgagcgt ctctgtcact cggggtagac cacgcggggaggcgagcaag atggcgcaga 120 cgcagggcac ccggaggaaa gtctgttact actacgacggggatgttgga aattactatt 180 atggacaagg ccacccaatg aagcctcacc gaatccgcatgactcataat ttgctgctca 240 actatggtct ctaccgaaaa atggaaatct atcgccctcacaaagccaat gctgaggaga 300 tgaccaagta ccacagcgat gactacatta aattcttgcgctccatccgt ccagataaca 360 tgtcggagta cagcaagcag atgcagagat tcaacgttggtgaggactgt ccagtattcg 420 atggcctgtt tgagttctgt cagttgtcta ctggtggttctgtggcaagt gctgtgaaac 480 ttaataagca gcagacggac atcgctgtga attgggctgggggcctgcac catgcaaaga 540 agtccgaggc atctggcttc tgttacgtca atgatatcgtcttggccatc ctggaactgc 600 taaagtatca ccagagggtg ctgtacattg acattgatattcaccatggt gacggcgtgg 660 aagaggcctt ctacaccacg gaccgggtca tgactgtgtcctttcataag tatggagagt 720 acttcccagg aactggggac ctacgggata tcggggctggcaaaggcaag tattatgctg 780 ttaactaccc gctccgagac gggattgatg acgagtcctatgaggccatt ttcaagccgg 840 tcatgtccaa agtaatggag atgttccagc ctagtgcggtggtcttacag tgtggctcag 900 actccctatc tggggatcgg ttaggttgct tcaatctaactatcaaagga cacgccaagt 960 gtgtggaatt tgtcaagagc tttaacctgc ctatgctgatgctgggaggc ggtggttaca 1020 ccattcgtaa cgttgcccgg tgctggacat atgagacagctgtggccctg gatacggaga 1080 tccctaatga gcttccatac aatgactact ttgaatactttggaccagat ttcaagctcc 1140 acatcagtcc ttccaatatg actaaccaga acacgaatgagtacctggag aagatcaaac 1200 agcgactgtt tgagaacctt agaatgctgc cgcacgcacctggggtccaa atgcaggcga 1260 ttcctgagga cgccatccct gaggagagtg gcgatgaggacgaagacgac cctgacaagc 1320 gcatctcgat ctgctcctct gacaaacgaa ttgcctgtgaggaagagttc tccgattctg 1380 aagaggaggg agaggggggc cgcaagaact cttccaacttcaaaaaagcc aagagagtca 1440 aaacagagga tgaaaaagag aaagacccag aggagaagaaagaagtcacc gaagaggaga 1500 aaaccaagga ggagaagcca gaagccaaag gggtcaaggaggaggtcaag ttggcctgaa 1560 tggacctctc cagctctggc ttcctgctga gtccctcacgtttctttccc c 1611 26 488 PRT Homo sapiens 26 Met Ala Tyr Ser Gln Gly GlyGly Lys Lys Lys Val Cys Tyr Tyr Tyr 1 5 10 15 Asp Gly Asp Ile Gly AsnTyr Tyr Tyr Gly Gln Gly His Pro Met Lys 20 25 30 Pro His Arg Ile Arg MetThr His Asn Leu Leu Leu Asn Tyr Gly Leu 35 40 45 Tyr Arg Lys Met Glu IleTyr Arg Pro His Lys Ala Thr Ala Glu Glu 50 55 60 Met Thr Lys Tyr His SerAsp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 65 70 75 80 Arg Pro Asp Asn MetSer Glu Tyr Ser Lys Gln Met His Ile Phe Asn 85 90 95 Val Gly Glu Asp CysPro Ala Phe Asp Gly Leu Phe Glu Phe Cys Gln 100 105 110 Leu Ser Thr GlyGly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 115 120 125 Gln Thr AspMet Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 130 135 140 Lys TyrGlu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 145 150 155 160Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 165 170175 Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 180185 190 Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly195 200 205 Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr TyrAla 210 215 220 Val Asn Phe Pro Met Cys Asp Gly Ile Asp Asp Glu Ser TyrGly Gln 225 230 235 240 Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu MetTyr Gln Pro Ser 245 250 255 Ala Val Val Leu Gln Cys Gly Ala Asp Ser LeuSer Gly Asp Arg Leu 260 265 270 Gly Cys Phe Asn Leu Thr Val Lys Gly HisAla Lys Cys Val Glu Val 275 280 285 Val Lys Thr Phe Asn Leu Pro Leu LeuMet Leu Gly Gly Gly Gly Tyr 290 295 300 Thr Ile Arg Asn Val Ala Arg CysTrp Thr Tyr Glu Thr Ala Val Ala 305 310 315 320 Leu Asp Cys Glu Ile ProAsn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 325 330 335 Tyr Phe Gly Pro AspPhe Lys Leu His Ile Ser Pro Ser Asn Met Thr 340 345 350 Asn Gln Asn ThrPro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 355 360 365 Glu Asn LeuArg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 370 375 380 Ile ProGlu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 385 390 395 400Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 405 410415 Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 420425 430 Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu435 440 445 Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys GluGlu 450 455 460 Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr LysGly Thr 465 470 475 480 Lys Ser Glu Gln Leu Ser Asn Pro 485 27 1985 DNAHomo sapiens 27 cgccgagctt tcggcacctc tgccgggtgg taccgagcct tcccggcgccccctcctctc 60 ctcccaccgg cctgcccttc cccgcgggac tatcgccccc acgtttccctcagccctttt 120 ctctcccggc cgagccgcgg cggcagcagc agcagcagca gcagcaggaggaggagcccg 180 gtggcggcgg tggccgggga gcccatggcg tacagtcaag gaggcggcaaaaaaaaagtc 240 tgctactact acgacggtga tattggaaat tattattatg gacagggtcatcccatgaag 300 cctcatagaa tccgcatgac ccataacttg ctgttaaatt atggcttatacagaaaaatg 360 gaaatatata ggccccataa agccactgcc gaagaaatga caaaatatcacagtgatgag 420 tatatcaaat ttctacggtc aataagacca gataacatgt ctgagtatagtaagcagatg 480 catatattta atgttggaga agattgtcca gcgtttgatg gactctttgagttttgtcag 540 ctctcaactg gcggttcagt tgctggagct gtgaagttaa accgacaacagactgatatg 600 gctgttaatt gggctggagg attacatcat gctaagaaat acgaagcatcaggattctgt 660 tacgttaatg atattgtgct tgccatcctt gaattactaa agtatcatcagagagtctta 720 tatattgata tagatattca tcatggtgat ggtgttgaag aagctttttatacaacagat 780 cgtgtaatga cggtatcatt ccataaatat ggggaatact ttcctggcacaggagacttg 840 agggatattg gtgctggaaa aggcaaatac tatgctgtca attttccaatgtgtgatggt 900 atagatgatg agtcatatgg gcagatattt aagcctatta tctcaaaggtgatggagatg 960 tatcaaccta gtgctgtggt attacagtgt ggtgcagact cattatctggtgatagactg 1020 ggttgtttca atctaacagt caaaggtcat gctaaatgtg tagaagttgtaaaaactttt 1080 aacttaccat tactgatgct tggaggaggt ggctacacaa tccgtaatgttgctcgatgt 1140 tggacatatg agactgcagt tgcccttgat tgtgagattc ccaatgagttgccatataat 1200 gattactttg agtattttgg accagacttc aaactgcata ttagtccttcaaacatgaca 1260 aaccagaaca ctccagaata tatggaaaag ataaaacagc gtttgtttgaaaatttgcgc 1320 atgttacctc atgcacctgg tgtccagatg caagctattc cagaagatgctgttcatgaa 1380 gacagtggag atgaagatgg agaagatcca gacaagagaa tttctattcgagcatcagac 1440 aagcggatag cttgtgatga agaattctca gattctgagg atgaaggagaaggaggtcga 1500 agaaatgtgg ctgatcataa gaaaggagca aagaaagcta gaattgaagaagataagaaa 1560 gaaacagagg acaaaaaaac agacgttaag gaagaagata aatccaaggacaacagtggt 1620 gaaaaaacag ataccaaagg aaccaaatca gaacagctca gcaacccctgaatttgacag 1680 tctcaccaat ttcagaaaat cattaaaaag aaaatattga aaggaaaatgttttcttttt 1740 gaagacttct ggcttcattt tatactactt tggcatggac tgtatttattttcaaatggg 1800 actttttcgt ttttgttttt ctgggcaagt tttattgtga gattttctaattatgaagca 1860 aaatttcttt tctccaccat gctttatgtg atagtattta aaattgatgtgagttattat 1920 gtcaaaaaaa ctgatctatt aaagaagtaa ttggcctttc tgagctgaaaaaaaaaaaaa 1980 aaaag 1985 28 428 PRT Homo sapiens 28 Met Ala Lys ThrVal Ala Tyr Phe Tyr Asp Pro Asp Val Gly Asn Phe 1 5 10 15 His Tyr GlyAla Gly His Pro Met Lys Pro His Arg Leu Ala Leu Thr 20 25 30 His Ser LeuVal Leu His Tyr Gly Leu Tyr Lys Lys Met Ile Val Phe 35 40 45 Lys Pro TyrGln Ala Ser Gln His Asp Met Cys Arg Phe His Ser Glu 50 55 60 Asp Tyr IleAsp Phe Leu Gln Arg Val Ser Pro Thr Asn Met Gln Gly 65 70 75 80 Phe ThrLys Ser Leu Asn Ala Phe Asn Val Gly Asp Asp Cys Pro Val 85 90 95 Phe ProGly Leu Phe Glu Phe Cys Ser Arg Tyr Thr Gly Ala Ser Leu 100 105 110 GlnGly Ala Thr Gln Leu Asn Asn Lys Ile Cys Asp Ile Ala Ile Asn 115 120 125Trp Ala Gly Gly Leu His His Ala Lys Lys Phe Glu Ala Ser Gly Phe 130 135140 Cys Tyr Val Asn Asp Ile Val Ile Gly Ile Leu Glu Leu Leu Lys Tyr 145150 155 160 His Pro Arg Val Leu Tyr Ile Asp Ile Asp Ile His His Gly AspGly 165 170 175 Val Gln Glu Ala Phe Tyr Leu Thr Asp Arg Val Met Thr ValSer Phe 180 185 190 His Lys Tyr Gly Asn Tyr Phe Phe Pro Gly Thr Gly AspMet Tyr Glu 195 200 205 Val Gly Ala Glu Ser Gly Arg Tyr Tyr Cys Leu AsnVal Pro Leu Arg 210 215 220 Asp Gly Ile Asp Asp Gln Ser Tyr Lys His LeuPhe Gln Pro Val Ile 225 230 235 240 Asn Gln Val Val Asp Phe Tyr Gln ProThr Cys Ile Val Leu Gln Cys 245 250 255 Gly Ala Asp Ser Leu Gly Cys AspArg Leu Gly Cys Phe Asn Leu Ser 260 265 270 Ile Arg Gly His Gly Glu CysVal Glu Tyr Val Lys Ser Phe Asn Ile 275 280 285 Pro Leu Leu Val Leu GlyGly Gly Gly Tyr Thr Val Arg Asn Val Ala 290 295 300 Arg Cys Trp Thr TyrGlu Thr Ser Leu Leu Val Glu Glu Ala Ile Ser 305 310 315 320 Glu Glu LeuPro Tyr Ser Glu Tyr Phe Glu Tyr Phe Ala Pro Asp Phe 325 330 335 Thr LeuHis Pro Asp Val Ser Thr Arg Ile Glu Asn Gln Asn Ser Arg 340 345 350 GlnTyr Leu Asp Gln Ile Arg Gln Thr Ile Phe Glu Asn Leu Lys Met 355 360 365Leu Asn His Ala Pro Ser Val Gln Ile His Asp Val Pro Ala Asp Leu 370 375380 Leu Thr Tyr Asp Arg Thr Asp Glu Ala Asp Ala Glu Glu Arg Gly Pro 385390 395 400 Glu Glu Asn Tyr Ser Arg Pro Glu Ala Pro Asn Glu Phe Tyr AspGly 405 410 415 Asp His Asp Asn Asp Lys Glu Ser Asp Val Glu Ile 420 42529 1954 DNA Homo sapiens 29 ggaattcgcg gccgcggcgg gcgcgggagg tgcggggcctgctcccgccg gcaccatggc 60 caagaccgtg gcctatttct acgaccccga cgtgggcaacttccactacg gagctggaca 120 ccctatgaag ccccatcgcc tggcattgac ccatagcctggtcctgcatt acggtctcta 180 taagaagatg atcgtcttca agccatacca ggcctcccaacatgacatgt gccgcttcca 240 ctccgaggac tacattgact tcctgcagag agtcagccccaccaatatgc aaggcttcac 300 caagagtctt aatgccttca acgtaggcga tgactgcccagtgtttcccg ggctctttga 360 gttctgctcg cgttacacag gcgcatctct gcaaggagcaacccagctga acaacaagat 420 ctgtgatatt gccattaact gggctggtgg tctgcaccatgccaagaagt ttgaggcctc 480 tggcttctgc tatgtcaacg acattgtgat tggcatcctggagctgctca agtaccaccc 540 tcgggtgctc tacattgaca ttgacatcca ccatggtgacggggttcaag aagctttcta 600 cctcactgac cgggtcatga cggtgtcctt ccacaaatacggaaattact tcttccctgg 660 cacaggtgac atgtatgaag tcggggcaga gagtggccgctactactgtc tgaacgtgcc 720 cctgcgggat ggcattgatg accagagtta caagcaccttttccagccgg ttatcaacca 780 ggtagtggac ttctaccaac ccacgtgcat tgtgctccagtgtggagctg actctctggg 840 ctgtgatcga ttgggctgct ttaacctcag catccgagggcatggggaat gcgttgaata 900 tgtcaagagc ttcaatatcc ctctactcgt gctgggtggtggtggttata ctgtccgaaa 960 tgttgcccgc tgctggacat atgagacatc gctgctggtagaagaggcca ttagtgagga 1020 gcttccctat agtgaatact tcgagtactt tgccccagacttcacacttc atccagatgt 1080 cagcacccgc atcgagaatc agaactcacg ccagtatctggaccagatcc gccagacaat 1140 ctttgaaaac ctgaagatgc tgaaccatgc acctagtgtccagattcatg acgtgcctgc 1200 agacctcctg acctatgaca ggactgatga ggctgatgcagaggagaggg gtcctgagga 1260 gaactatagc aggccagagg cacccaatga gttctatgatggagaccatg acaatgacaa 1320 ggaaagcgat gtggagattt aagagtggct tgggatgctgtgtcccaagg aatttctttt 1380 cacctcttgg aagggctgga gggaaaagga gtggctcctagagtcctggg ggtcacccca 1440 ggggcttttg ctgactctgg gaaagagtct ggagaccacatttggttctc gaaccatcta 1500 cctgcttttc ctctctctcc caaggactga caatggtacctattagggat gagatacaga 1560 caaggatagc tatctgggac attattggca gtgggccctggaggcagtcc ctagcccccc 1620 ttgcccctta tttcttccct gcttccctcg aacccagagatttttgaggg atgaacgggt 1680 agacaaggac tgagattgcc tctgacttcc tcctcccctgggttctgacc ttcttcctcc 1740 ccttgcttcc agggaagatg aagagagaga gatttggaaggggctctggc tccctaacac 1800 ctgaatccca gatgatggga agtatgtttt caagtgtggggaggatatga aaatgttctg 1860 ttctcacttt tggctttatg tccattttac cactgtttttatccaataaa ctaagtcggt 1920 attttttgta cctttgatgg tttagcggcc gcgc 1954 30967 PRT Homo sapiens 30 Met Leu Ala Met Lys His Gln Gln Glu Leu Leu GluHis Gln Arg Lys 1 5 10 15 Leu Glu Arg His Arg Gln Glu Gln Glu Leu GluLys Gln His Arg Glu 20 25 30 Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu LysGly Lys Glu Ser Ala 35 40 45 Val Ala Ser Thr Glu Val Lys Met Lys Leu GlnGlu Phe Val Leu Asn 50 55 60 Lys Lys Lys Ala Leu Ala His Arg Asn Leu AsnHis Cys Ile Ser Ser 65 70 75 80 Asp Pro Arg Tyr Trp Tyr Gly Lys Thr GlnHis Ser Ser Leu Asp Gln 85 90 95 Ser Ser Pro Pro Gln Ser Gly Val Ser ThrSer Tyr Asn His Pro Val 100 105 110 Leu Gly Met Tyr Asp Ala Lys Asp AspPhe Pro Leu Arg Lys Thr Ala 115 120 125 Ser Glu Pro Asn Leu Lys Leu ArgSer Arg Leu Lys Gln Lys Val Ala 130 135 140 Glu Arg Arg Ser Ser Pro LeuLeu Arg Arg Lys Asp Gly Pro Val Val 145 150 155 160 Thr Ala Leu Lys LysArg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser 165 170 175 Ser Ala Pro GlySer Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser 180 185 190 Val Ser AlaGlu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala 195 200 205 Glu ThrSer Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala 210 215 220 ProLeu Pro Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly 225 230 235240 Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Thr 245250 255 Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro260 265 270 Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu ArgAsp 275 280 285 Gly Gly Ala Ala His Ser Pro Leu Leu Gln His Met Val LeuLeu Glu 290 295 300 Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Gly Leu GlyAla Leu Pro 305 310 315 320 Leu His Ala Gln Ser Leu Val Gly Ala Asp ArgVal Ser Pro Ser Ile 325 330 335 His Lys Leu Arg Gln His Arg Pro Leu GlyArg Thr Gln Ser Ala Pro 340 345 350 Leu Pro Gln Asn Ala Gln Ala Leu GlnHis Leu Val Ile Gln Gln Gln 355 360 365 His Gln Gln Phe Leu Glu Lys HisLys Gln Gln Phe Gln Gln Gln Gln 370 375 380 Leu Gln Met Asn Lys Ile IlePro Lys Pro Ser Glu Pro Ala Arg Gln 385 390 395 400 Pro Glu Ser His ProGlu Glu Thr Glu Glu Glu Leu Arg Glu His Gln 405 410 415 Ala Leu Leu AspGlu Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu 420 425 430 Ala His AlaGln Ala Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser 435 440 445 Asp GluGlu Glu Ala Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg 450 455 460 GlnPro Ser Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu 465 470 475480 Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu 485490 495 Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg500 505 510 Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro Val Ser Val GlnGlu 515 520 525 Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr AspThr Leu 530 535 540 Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser Ser SerHis Pro Glu 545 550 555 560 His Ala Gly Arg Ile Gln Ser Ile Trp Ser ArgLeu Gln Glu Thr Gly 565 570 575 Leu Arg Gly Lys Cys Glu Cys Ile Arg GlyArg Lys Ala Thr Leu Glu 580 585 590 Glu Leu Gln Thr Val His Ser Glu AlaHis Thr Leu Leu Tyr Gly Thr 595 600 605 Asn Pro Leu Asn Arg Gln Lys LeuAsp Ser Lys Lys Leu Leu Gly Ser 610 615 620 Leu Ala Ser Val Phe Val ArgLeu Pro Cys Gly Gly Val Gly Val Asp 625 630 635 640 Ser Asp Thr Ile TrpAsn Glu Val His Ser Ala Gly Ala Ala Arg Leu 645 650 655 Ala Val Gly CysVal Val Glu Leu Val Phe Lys Val Ala Thr Gly Glu 660 665 670 Leu Lys AsnGly Phe Ala Val Val Arg Pro Pro Gly His His Ala Glu 675 680 685 Glu SerThr Pro Met Gly Phe Cys Tyr Phe Asn Ser Val Ala Val Ala 690 695 700 AlaLys Leu Leu Gln Gln Arg Leu Ser Val Ser Lys Ile Leu Ile Val 705 710 715720 Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser 725730 735 Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg Tyr Asp Asp Gly Asn740 745 750 Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val Gly Thr Gly ProGly 755 760 765 Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly Gly Leu AspPro Pro 770 775 780 Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg Thr ValVal Met Pro 785 790 795 800 Ile Ala Ser Glu Phe Ala Pro Asp Val Val LeuVal Ser Ser Gly Phe 805 810 815 Asp Ala Val Glu Gly His Pro Thr Pro LeuGly Gly Tyr Asn Leu Ser 820 825 830 Ala Arg Cys Phe Gly Tyr Leu Thr LysGln Leu Met Gly Leu Ala Gly 835 840 845 Gly Arg Ile Val Leu Ala Leu GluGly Gly His Asp Leu Thr Ala Ile 850 855 860 Cys Asp Ala Ser Glu Ala CysVal Ser Ala Leu Leu Gly Asn Glu Leu 865 870 875 880 Asp Pro Leu Pro GluLys Val Leu Gln Gln Arg Pro Asn Ala Asn Ala 885 890 895 Val Arg Ser MetGlu Lys Val Met Glu Ile His Ser Lys Tyr Trp Arg 900 905 910 Cys Leu GlnArg Thr Thr Ser Thr Ala Gly Arg Ser Leu Ile Glu Ala 915 920 925 Gln ThrCys Glu Asn Glu Glu Ala Glu Thr Val Thr Ala Met Ala Ser 930 935 940 LeuSer Val Gly Val Lys Pro Ala Glu Lys Arg Pro Asp Glu Glu Pro 945 950 955960 Met Glu Glu Glu Pro Pro Leu 965 31 8459 DNA Homo sapiens 31ggaggttgtg gggccgccgc cgcggagcac cgtccccgcc gccgcccgag cccgagcccg 60agcccgcgca cccgcccgcg ccgccgccgc cgccgcccga acagcctccc agcctgggcc 120cccggcggcg ccgtggccgc gtcccggctg tcgccgcccg agcccgagcc cgcgcgccgg 180cgggtggcgg cgcaggctga ggagatgcgg cgcggagcgc cggagcaggg ctagagccgg 240ccgccgccgc ccgccgcggt aagcgcagcc ccggcccggc gcccgcgggc cattgtccgc 300cgcccgcccc gcgccccgcg cagcctgcag gccttggagc ccgcggcagg tggacgccgc 360cggtccacac ccgccccgcg cgcggccgtg ggaggcgggg gccagcgctg gccgcgcgcc 420gtgggacccg ccggtcccca gggccgcccg gccccttctg gacctttcca cccgcgccgc 480gaggcggctt cgcccgccgg ggcgggggcg cgggggtggg cacggcaggc agcggcgccg 540tctcccggtg cggggcccgc gccccccgag caggttcatc tgcagaagcc agcggacgcc 600tctgttcaac ttgtgggtta cctggctcat gagaccttgc cggcgaggct cggcgcttga 660acgtctgtga cccagccctc accgtcccgg tacttgtatg tgttggtggg agtttggagc 720tcgttggagc tatcgtttcc gtggaaattt tgagccattt cgaatcactt aaaggagtgg 780acattgctag caatgagctc ccaaagccat ccagatggac tttctggccg agaccagcca 840gtggagctgc tgaatcctgc ccgcgtgaac cacatgccca gcacggtgga tgtggccacg 900gcgctgcctc tgcaagtggc cccctcggca gtgcccatgg acctgcgcct ggaccaccag 960ttctcactgc ctgtggcaga gccggccctg cgggagcagc agctgcagca ggagctcctg 1020gcgctcaagc agaagcagca gatccagagg cagatcctca tcgctgagtt ccagaggcag 1080cacgagcagc tctcccggca gcacgaggcg cagctccacg agcacatcaa gcaataacag 1140gagatgctgg ccatgaagca ccagcaggag ctgctggaac accagcggaa gctggagagg 1200caccgccagg agcaggagct ggagaagcag caccgggagc agaagctgca gcagctcaag 1260aacaaggaga agggcaaaga gagtgccgtg gccagcacag aagtgaagat gaagttacaa 1320gaatttgtcc tcaataaaaa gaaggcgctg gcccaccgga atctgaacca ctgcatttcc 1380agcgaccctc gctactggta cgggaaaacg cagcacagtt cccttgacca gagttctcca 1440ccccagagcg gagtgtcgac ctcctataac cacccggtcc tgggaatgta cgacgccaaa 1500gatgacttcc ctcttaggaa aacagcttct gaaccgaatc tgaaattacg gtccaggcta 1560aagcagaaag tggccgaaag acggagcagc cccctgttac gcaggaaaga cgggccagtg 1620gtcactgctc taaaaaagcg tccgttggat gtcacagact ccgcgtgcag cagcgcccca 1680ggctccggac ccagctcacc caacaacagc tccgggagcg tcagcgcgga gaacggtatc 1740gcgcccgccg tccccagcat cccggcggag acgagtttgg cgcacagact tgtggcacga 1800gaaggctcgg ccgctccact tcccctctac acatcgccat ccttgcccaa catcacgctg 1860ggcctgcctg ccaccggccc ctctgcgggc acggcgggcc agcaggacac cgagagactc 1920acccttcccg ccctccagca gaggctctcc cttttccccg gcacccacct cactccctac 1980ctgagcacct cgcccttgga gcgggacgga ggggcagcgc acagccctct tctgcagcac 2040atggtcttac tggagcagcc accggcacaa gcacccctcg tcacaggcct gggagcactg 2100cccctccacg cacagtcctt ggttggtgca gaccgggtgt ccccctccat ccacaagctg 2160cggcagcacc gcccactggg gcggacccag tcggccccgc tgccccagaa cgcccaggct 2220ctgcagcacc tggtcatcca gcagcagcat cagcagtttc tggagaaaca caagcagcag 2280ttccagcagc agcaactgca gatgaacaag atcatcccca agccaagcga gccagcccgg 2340cagccggaga gccacccgga ggagacggag gaggagctcc gtgagcacca ggctctgctg 2400gacgagccct acctggaccg gctgccgggg cagaaggagg cgcacgcaca ggccggcgtg 2460caggtgaagc aggagcccat tgagagcgat gaggaagagg cagagccccc acgggaggtg 2520gagccgggcc agcgccagcc cagtgagcag gagctgctct tcagacagca agccctcctg 2580ctggagcagc agcggatcca ccagctgagg aactaccagg cgtccatgga ggccgccggc 2640atccccgtgt ccttcggcgg ccacaggcct ctgtcccggg cgcagtcctc acccgcgtct 2700gccaccttcc ccgtgtctgt gcaggagccc cccaccaagc cgaggttcac gacaggcctc 2760gtgtatgaca cgctgatgct gaagcaccag tgcacctgcg ggagtagcag cagccacccc 2820gagcacgccg ggaggatcca gagcatctgg tcccgcctgc aggagacggg cctccggggc 2880aaatgcgagt gcatccgcgg acgcaaggcc accctggagg agctacagac ggtgcactcg 2940gaagcccaca ccctcctgta tggcacgaac cccctcaacc ggcagaaact ggacagtaag 3000aaacttctag gctcgctcgc ctccgtgttc gtccggctcc cttgcggtgg tgttggggtg 3060gacagtgaca ccatatggaa cgaggtgcac tcggcggggg cagcccgcct ggctgtgggc 3120tgcgtggtag agctggtctt caaggtggcc acaggggagc tgaagaatgg ctttgctgtg 3180gtccgccccc ctggacacca tgcggaggag agcacgccca tgggcttttg ctacttcaac 3240tccgtggccg tggcagccaa gcttctgcag cagaggttga gcgtgagcaa gatcctcatc 3300gtggactggg acgtgcacca tggaaacggg acccagcagg ctttctacag cgaccctagc 3360gtcctgtaca tgtccctcca ccgctacgac gatgggaact tcttcccagg cagcggggct 3420cctgatgagg tgggcacagg gcccggcgtg ggtttcaacg tcaacatggc tttcaccggc 3480ggcctggacc cccccatggg agacgctgag tacttggcgg ccttcagaac ggtggtcatg 3540ccgatcgcca gcgagtttgc cccggatgtg gtgctggtgt catcaggctt cgatgccgtg 3600gagggccacc ccacccctct tgggggctac aacctctccg ccagatgctt cgggtacctg 3660acgaagcagc tgatgggcct ggctggcggc cggattgtcc tggccctcga gggaggccac 3720gacctgaccg ccatttgcga cgcctcggaa gcatgtgttt ctgccttgct gggaaacgag 3780cttgatcctc tcccagaaaa ggttttacag caaagaccca atgcaaacgc tgtccgttcc 3840atggagaaag tcatggagat ccacagcaag tactggcgct gcctgcagcg cacaacctcc 3900acagcggggc gttctctgat cgaggctcag acttgcgaga acgaagaagc cgagacggtc 3960accgccatgg cctcgctgtc cgtgggcgtg aagcccgccg aaaagagacc agatgaggag 4020cccatggaag aggagccgcc cctgtagcac tccctcgaag ctgctgttct cttgtctgtc 4080tgtctctgtc ttgaagctca gccaagaaac tttcccgtgt cacgcctgcg tcccaccgtg 4140gggctctctt ggagcaccca gggacaccca gcgtgcaaca gccacgggaa gcctttctgc 4200cgcccaggcc cacaggtctc gagacgcaca tgcacgcctg ggcgtggcag cctcacaggg 4260aacacgggac agacgccggc gacgcgcaga cacacggaca cgcggaagcc aagcacactc 4320tggcgggtcc cgcaagggac gccgtggaag aaaggagcct gtggcaacag gcggccgagc 4380tgccgaattc agttgacacg aggcacagaa aacaaatatc aaagatctaa taatacaaaa 4440caaacttgat taaaactggt gcttaaagtt tattacccac aactccacag tctctgtgta 4500aaccactcga ctcatcttgt agcttatttt ttttttaaag aggacgtttt ctacggctgt 4560ggcccgcctc tgtgaaccat agcggtgtgc ggcggggggt ctgcacccgg gtgggggaca 4620gagggacctt taaagaaaac aaaactggac agaaacagga atgtgagctg ggggagctgg 4680cttgagtttc tcaaaagcca tcggaagatg cgagtttgtg cctttttttt tattgctctg 4740gtggattttt gtggctgggt tttctgaagt ctgaggaaca atgccttaag aaaaaacaaa 4800cagcaggaat cggtgggaca gtttcctgtg gccagccgag cctggcagtg ctggcaccgc 4860gagctggcct gacgcctcaa gcacgggcac cagccgtcat ctccggggcc aggggctgca 4920gcccggcggt ccctgttttg ctttattgct gtttaagaaa aatggaggta gttccaaaaa 4980agtggcaaat cccgttggag gttttgaagt ccaacaaatt ttaaacgaat ccaaagtgtt 5040ctcacacgtc acatacgatt gagcatctcc atctggtcgt gaagcatgtg gtaggcacac 5100ttgcagtgtt acgatcggaa tgctttttat taaaagcaag tagcatgaag tattgcttaa 5160attttaggta taaataaata tatatatgta taatatatat tccaatgtat tccaagctaa 5220gaaacttact tgattcttat gaaatcttga taaaatattt ataatgcatt tatagaaaaa 5280gtatatatat atatataaaa tgaatgcaga ttgcgaaggt ccctgcaaat ggatggcttg 5340tgaatttgct ctcaaggtgc ttatggaaag ggatcctgat tgattgaaat tcatgttttc 5400tcaagctcca gattggctag atttcagatc gccaacacat tcgccactgg gcaactaccc 5460tacaagtttg tactttcatt ttaattattt tctaacagaa ccgctcccgt ctccaagcct 5520tcatgcacat atgtacctaa tgagttttta tagcaaagaa tataaatttg ctgttgattt 5580ttgtatgaat tttttcacaa aaagatcctg aataagcatt gttttatgaa ttttacattt 5640ttcctcacca tttagcaatt ttctgaatgg taataatgtc taaatctttt tcctttctga 5700attcttgctt gtacattttt ttttaccttt caaaggtttt taattatttt tgtttttatt 5760tttgtacgat gagttttctg cagcgtacag aattgttgct gtcagattct attttcagaa 5820agtgagagga gggaccgtag gtcttttcgg agtgacacca acgattgtgt ctttcctggt 5880ctgtcctagg agctgtataa agaagcccag gggctctttt taactttcaa cactagtagt 5940attacgaggg gtggtgtgtt tttcccctcc gtggcaaggg cagggagggt tgcttaggat 6000gcccggccac cctgggaggc ttgccagatg ccgggggcag tcagcattaa tgaaactcat 6060gtttaaactt ctctgaccac atcgtcagga tagaattcta acttgagttt tccaaagacc 6120ttttgagcat gtcagcaatg catggggcac acgtggggct ctttacccac ttgggttttt 6180ccactgcagc cacgtggcca gccctggatt ttggagcctg tggctgcaag gaacccaggg 6240acccttgttg cctggtgaac ctgcagggag ggtatgattg cctgaccagg acagccagtc 6300tttactcttt ttctcttcaa cagtaactga cagtcacgtt ttactggtaa cttattttcc 6360agcacatgaa gccaccagtt tcattccaaa gtgtatattg ggttcagact tgggggcaga 6420agttcagaca caccgtgctc aggagggacc cagagccgag tttcggagtt tggtaaagtt 6480tacagggtag cttctgaaat taactcaaac ttttgaccaa atgagtgcag attcttggat 6540tcacttggtc actgggctgc tgatggtcag ctctgagaca gtggtttgag agcaggcaga 6600acggtcttgg gacttgtttg actttcccct ccctggtggc cactctttgc tctgaagccc 6660agattggcaa gaggagctgg tccattcccc attcatggca cagagcagtg gcagggccca 6720gctagcaggc tcttctggcc tccttggcct cattctctgc atagccctct ggggatcctg 6780ccacctgccc tcttaccccg ccgtggctta tggggaggaa tgcatcatct cacttttttt 6840ttttaagcag atgatgggat aacatggact gctcagtggc caggttatca gtggggggac 6900ttaattctaa tctcattcaa atggagacgc cctctgcaaa ggcctggcag ggggaggcac 6960gtttcatctg tcagctcact ccagcttcac aaatgtgctg agagcattac tgtgtagcct 7020tttctttgaa gacacactcg gctcttctcc acagcaagcg tccagggcag atggcagagg 7080atctgcctcg gcgtctgcag gcgggaccac gtcagggagg gttccttcat gtgttctccc 7140tgtgggtcct tggaccttta gcctttttct tcctttgcaa aggccttggg ggcactggct 7200gggagtcagc aagcgagcac tttatatccc tttgagggaa accctgatga cgccactggg 7260cctcttggcg tctgccctgc cctcgcggct tcccgccgtg ccgcagcgtg cccacgtgcc 7320cacgccccac cagcaggcgg ctgtcccgga ggccgtggcc cgctgggact ggccgcccct 7380ccccagcgtc ccagggctct ggttctggag ggccactttg tcaaggtgtt tcagtttttc 7440tttacttctt ttgaaaatct gtttgcaagg ggaaggacca tttcgtaatg gtctgacaca 7500aaagcaagtt tgatttttgc agcactagca atggactttg ttgtttttct ttttgatcag 7560aacattcctt ctttactggt cacagccacg tgctcattcc attcttcttt ttgtagactt 7620tgggcccacg tgttttatgg gcattgatac atatataaat atatagatat aaatatatat 7680gaatatattt ttttaagttt cctacacctg gaggttgcat ggactgtacg accggcatga 7740ctttatattg tatacagatt ttgcacgcca aactcggcag ctttggggaa gaagaaaaat 7800gcctttctgt tcccctctca tgacatttgc agatacaaaa gatggaaatt tttctgtaaa 7860acaaaacctt gaaggagagg agggcgggga agtttgcgtc ttattgaact tattcttaag 7920aaattgtact ttttattgta agaaaaataa aaaggactac ttaaacattt gtcatattaa 7980gaaaaaaagt ttatctagca cttgtgacat accaataata gagtttattg tatttatgtg 8040gaaacagtgt tttagggaaa ctactcagaa ttcacagtga actgcctgtc tctctcgagt 8100tgatttggag gaattttgtt ttgttttgtt ttgtttgttt ccttttatct ccttccacgg 8160gccaggcgag cgccgcccgc cctcactggc cttgtgacgg tttattctga ttgagaactg 8220ggcggactcg aaagagtccc cttttccgca cagctgtgtt gactttttaa ttacttttag 8280gtgatgtatg gctaagattt cactttaagc agtcgtgaac tgtgcgagca ctgtggttta 8340caattatact ttgcatcgaa aggaaaccat ttcttcattg taacgaagct gagcgtgttc 8400ttagctcggc ctcactttgt ctctggcatt gattaaaagt ctgctattga aagaaaaag 8459 32716 PRT Homo sapiens 32 Leu Arg Gln Gly Gly Thr Leu Thr Gly Lys Phe MetSer Thr Ser Ser 1 5 10 15 Ile Pro Gly Cys Leu Leu Gly Val Ala Leu GluGly Asp Gly Ser Pro 20 25 30 His Gly His Ala Ser Leu Leu Gln His Val LeuLeu Leu Glu Gln Ala 35 40 45 Arg Gln Gln Ser Thr Leu Ile Ala Val Pro LeuHis Gly Gln Ser Pro 50 55 60 Leu Val Thr Gly Glu Arg Val Ala Thr Ser MetArg Thr Val Gly Lys 65 70 75 80 Leu Pro Arg His Arg Pro Leu Ser Arg ThrGln Ser Ser Pro Leu Pro 85 90 95 Gln Ser Pro Gln Ala Leu Gln Gln Leu ValMet Gln Gln Gln His Gln 100 105 110 Gln Phe Leu Glu Lys Gln Lys Gln GlnGln Leu Gln Leu Gly Lys Ile 115 120 125 Leu Thr Lys Thr Gly Glu Leu ProArg Gln Pro Thr Thr His Pro Glu 130 135 140 Glu Thr Glu Glu Glu Leu ThrGlu Gln Gln Glu Val Leu Leu Gly Glu 145 150 155 160 Gly Ala Leu Thr MetPro Arg Glu Gly Ser Thr Glu Ser Glu Ser Thr 165 170 175 Gln Glu Asp LeuGlu Glu Glu Asp Glu Glu Glu Asp Gly Glu Glu Glu 180 185 190 Glu Asp CysIle Gln Val Lys Asp Glu Glu Gly Glu Ser Gly Ala Glu 195 200 205 Glu GlyPro Asp Leu Glu Glu Pro Gly Ala Gly Tyr Lys Lys Leu Phe 210 215 220 SerAsp Ala Gln Pro Leu Gln Pro Leu Gln Val Tyr Gln Ala Pro Leu 225 230 235240 Ser Leu Ala Thr Val Pro His Gln Ala Leu Gly Arg Thr Gln Ser Ser 245250 255 Pro Ala Ala Pro Gly Gly Met Lys Ser Pro Pro Asp Gln Pro Val Lys260 265 270 His Leu Phe Thr Thr Gly Val Val Tyr Asp Thr Phe Met Leu LysHis 275 280 285 Gln Cys Met Cys Gly Asn Thr His Val His Pro Glu His AlaGly Arg 290 295 300 Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly LeuLeu Ser Lys 305 310 315 320 Cys Glu Arg Ile Arg Gly Arg Lys Ala Thr LeuAsp Glu Ile Gln Thr 325 330 335 Val His Ser Glu Tyr His Thr Leu Leu TyrGly Thr Ser Pro Leu Asn 340 345 350 Arg Gln Lys Leu Asp Ser Lys Lys LeuLeu Gly Pro Ile Ser Gln Lys 355 360 365 Met Tyr Ala Val Leu Pro Cys GlyGly Ile Gly Val Asp Ser Asp Thr 370 375 380 Val Trp Asn Glu Met His SerSer Ser Ala Val Arg Met Ala Val Gly 385 390 395 400 Cys Leu Leu Glu LeuAla Phe Lys Val Ala Ala Gly Glu Leu Lys Asn 405 410 415 Gly Phe Ala IleIle Arg Pro Pro Gly His His Ala Glu Glu Ser Thr 420 425 430 Ala Met GlyPhe Cys Phe Phe Asn Ser Val Ala Ile Thr Ala Lys Leu 435 440 445 Leu GlnGln Lys Leu Asn Val Gly Lys Val Leu Ile Val Asp Trp Asp 450 455 460 IleHis His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Asn Asp Pro Ser 465 470 475480 Val Leu Tyr Ile Ser Leu His Arg Tyr Asp Asn Gly Asn Phe Phe Pro 485490 495 Gly Ser Gly Ala Pro Glu Glu Val Gly Gly Gly Pro Gly Val Gly Tyr500 505 510 Asn Val Asn Val Ala Trp Thr Gly Gly Val Asp Pro Pro Ile GlyAsp 515 520 525 Val Glu Tyr Leu Thr Ala Phe Arg Thr Val Val Met Pro IleAla His 530 535 540 Glu Phe Ser Pro Asp Val Val Leu Val Ser Ala Gly PheAsp Ala Val 545 550 555 560 Glu Gly His Leu Ser Pro Leu Gly Gly Tyr SerVal Thr Ala Arg Cys 565 570 575 Phe Gly His Leu Thr Arg Gln Leu Met ThrLeu Ala Gly Gly Arg Val 580 585 590 Val Leu Ala Leu Glu Gly Gly His AspLeu Thr Ala Ile Cys Asp Ala 595 600 605 Ser Glu Ala Cys Val Ser Ala LeuLeu Ser Val Glu Leu Gln Pro Leu 610 615 620 Asp Glu Ala Val Leu Gln GlnLys Pro Asn Ile Asn Ala Val Ala Thr 625 630 635 640 Leu Glu Lys Val IleGlu Ile Gln Ser Lys His Trp Ser Cys Val Gln 645 650 655 Lys Phe Ala AlaGly Leu Gly Arg Ser Leu Arg Glu Ala Gln Ala Gly 660 665 670 Glu Thr GluGlu Ala Glu Thr Val Ser Ala Met Ala Leu Leu Ser Val 675 680 685 Gly AlaGlu Gln Ala Gln Ala Ala Ala Ala Arg Glu His Ser Pro Arg 690 695 700 ProAla Glu Glu Pro Met Glu Gln Glu Pro Ala Leu 705 710 715 33 2233 DNA Homosapiens 33 ccctgcggca gggtggcacg ctgaccggca agttcatgag cacatcctctattcctggct 60 gcctgctggg cgtggcactg gagggcgacg ggagccccca cgggcatgcctccctgctgc 120 agcatgtgct gttgctggag caggcccggc agcagagcac cctcattgctgtgccactcc 180 acgggcagtc cccactagtg acgggtgaac gtgtggccac cagcatgcggacggtaggca 240 agctcccgcg gcatcggccc ctgagccgca ctcagtcctc accgctgccgcagagtcccc 300 aggccctgca gcagctggtc atgcaacaac agcaccagca gttcctggagaagcagaagc 360 agcagcagct acagctgggc aagatcctca ccaagacagg ggagctgcccaggcagccca 420 ccacccaccc tgaggagaca gaggaggagc tgacggagca gcaggaggtcttgctggggg 480 agggagccct gaccatgccc cgggagggct ccacagagag tgagagcacacaggaagacc 540 tggaggagga ggacgaggaa gaggatgggg aggaggagga ggattgcatccaggttaagg 600 acgaggaggg cgagagtggt gctgaggagg ggcccgactt ggaggagcctggtgctggat 660 acaaaaaact gttctcagat gcccagccgc tgcagccttt gcaggtgtaccaggcgcccc 720 tcagcctggc cactgtgccc caccaggccc tgggccgtac ccagtcctcccctgctgccc 780 ctgggggcat gaagagcccc ccagaccagc ccgtcaagca cctcttcaccacaggtgtgg 840 tctacgacac gttcatgcta aagcaccagt gcatgtgcgg gaacacacacgtgcaccctg 900 agcatgctgg ccggatccag agcatctggt cccggctgca ggagacaggcctgcttagca 960 agtgcgagcg gatccgaggt cgcaaagcca cgctagatga gatccagacagtgcactctg 1020 aataccacac cctgctctat gggaccagtc ccctcaaccg gcagaagctagacagcaaga 1080 agttgctcgg ccccatcagc cagaagatgt atgctgtgct gccttgtgggggcatcgggg 1140 tggacagtga caccgtgtgg aatgagatgc actcctccag tgctgtgcgcatggcagtgg 1200 gctgcctgct ggagctggcc ttcaaggtgg ctgcaggaga gctcaagaatggatttgcca 1260 tcatccggcc cccaggacac cacgccgagg aatccacagc catgggattctgcttcttca 1320 actctgtagc catcaccgca aaactcctac agcagaagtt gaacgtgggcaaggtcctca 1380 tcgtggactg ggacattcac catggcaatg gcacccagca ggcgttctataatgacccct 1440 ctgtgctcta catctctctg catcgctatg acaacgggaa cttctttccaggctctgggg 1500 ctcctgaaga ggttggtgga ggaccaggcg tggggtacaa tgtgaacgtggcatggacag 1560 gaggtgtgga cccccccatt ggagacgtgg agtaccttac agccttcaggacagtggtga 1620 tgcccattgc ccacgagttc tcacctgatg tggtcctagt ctccgccgggtttgatgctg 1680 ttgaaggaca tctgtctcct ctgggtggct actctgtcac cgccagatgttttggccact 1740 tgaccaggca gctgatgacc ctggcagggg gccgggtggt gctggccctggagggaggcc 1800 atgacttgac cgccatctgt gatgcctctg aggcttgtgt ctcggctctgctcagtgtag 1860 agctgcagcc cttggatgag gcagtcttgc agcaaaagcc caacatcaacgcagtggcca 1920 cgctagagaa agtcatcgag atccagagca aacactggag ctgtgtgcagaagttcgccg 1980 ctggtctggg ccggtccctg cgagaggccc aagcaggtga gaccgaggaggccgagactg 2040 tgagcgccat ggccttgctg tcggtggggg ccgagcaggc ccaggctgcggcagcccggg 2100 aacacagccc caggccggca gaggagccca tggagcagga gcctgccctgtgacgccccg 2160 gcccccatcc ctctgggctt caccattgtg attttgttta ttttttctattaaaaacaaa 2220 aagtcacaca ttc 2233 34 112 PRT Homo sapiens 34 Thr IleVal Lys Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu 1 5 10 15 ValSer Ala Gly Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly 20 25 30 GlyTyr Lys Val Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gln Leu 35 40 45 MetThr Leu Ala Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His 50 55 60 AspLeu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu 65 70 75 80Leu Gly Asn Glu Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser 85 90 95Pro Asn Met Asn Ala Val Ile Ser Leu Gln Lys Ile Ile Glu Ile Gln 100 105110 35 80331 DNA Homo sapiens 35 ttaaagacat actttgaatt tcaatgatcttctgtaaaga aataacagca ttcatattcg 60 ggctttggtg gagaatatct tctgcaagtggctccagctg caagaatagt agataatagt 120 atgagcagaa tattatgact ttatagtaagtctcacagaa gcaaagcaaa ctgaaacaac 180 ctaatcctca ggaaaagctt gctccgagaactagttaaca ttttgctgat attagttcta 240 gaagtgtagc cagttttatt ttctgttttgtatccatgta attgaattcc aaggggcttt 300 tccattggtc acaagactaa tctatgaagtccctgaagca ggtgcatgtc tgtgcattat 360 tcattaaaaa tctgagttat ttgtgtaatttttgtaggtt cctgacaaac caaattccat 420 catgtctgta tatgcagctg ggccctgcaaacaaaacctc agggaagttg caatagacag 480 aaagtgggca ctctattatc catactttcacagtgttttt acatccaacc accttataca 540 tttgaacact tcacgataga aagccatgagacacagctgc ttttattcaa aggccattga 600 ataaagtagt agagaaaggg ttcaaataaccaaatgtaaa ataactgtac agtttcattt 660 aacttctact ttattcataa ctatgcagatgtctgtgtgt aagcacaggc caaactccta 720 ccttgcaaat ctatcataat cttctggaattacactaatt tttcatggag aagctcagca 780 agcattgctt tgcaagaaat gaagagaagctttaaataat ttacagagcc tatctgttag 840 gcctaagtct gataacacat ccctcagaatgctgtggtga ttagtttggc atgttgcagc 900 agaaagcgca tggctagggc ccttgcaaataaaatagttg tccagctatt gtgacccaaa 960 aagcaaataa agtaatagta acaaaaggattaacaaaaaa gtagttttcc tagaaacatt 1020 aaggttaatc atctcaaata agaactggtgatcaaactat aatatggcac gaatgggaag 1080 cgatgtcact agacgcatca aagcatgaactcatctatgt ctcttcatct gtaggaaaac 1140 ctaaaaaaac acagggatta ccagtttccaccacatatgt gagtgaatct tcccctcagg 1200 gtccctctga attgattatt ctattcttcaatcatgaaat ctacaacaat agcaccttta 1260 ttccagatgc cacaggataa cagactagctcagggatatt tatacacggg taaattcact 1320 aactataact ttccagagtg tttttcttagctgccaaaga aaaactttta aacatcaaaa 1380 ggtttatttg caatacagtt tggtgagaggaaaaaaaaaa aaaaacatca ccaccaccgc 1440 tctgtggcag tacaaggttc tgaaataaactcttaaaact tgttaaaatc attttttaaa 1500 atgtggtatt tcaaattgta tcttcaagaatatgttagtc tagtaacact ctcttaactc 1560 agaggaacta ctgaatcata aactgaagcttacttggaaa actcttatgc attagacaag 1620 gttcagaggg ctactttgct tataaataatttttcactcc tttcttggag cttagagaaa 1680 ataattttta atagaaatca ggtagattttactaataaaa tatcttgaaa tgacactcta 1740 tgttccaata tttaagaaca aaagcacaaagcgatgacag cttatttagc tcttcaaaaa 1800 gcttccctgt gactttgggg taaaaatcctgacaaactga aaggtgctgg ctcctggaaa 1860 gaaagctata ggcagatcat atatgtaaaacatctaactt ctggtctctt gcacactgag 1920 gtctgggcta ttttaaagac tcaggttatacagaaagcat acgtgattca gagtattgag 1980 agtaaaatac aaacacccct aaacccccaatttagaatct tcagttagat gcaaaagggt 2040 tgtgtctatt ttaaaaagca attcagagaattaaggcaat taaattgatc atttaaacct 2100 cccaaaccat ttccctgcat gttttagttgaatgtcattt agaggattta accttcagta 2160 aattgcccca atttgtttca ttttgagtgtatacatacag acagagctga attcagaaat 2220 ttctcaatgt aggttcttta ttttttctctggcaggtatg caatggataa tattctctcc 2280 gttggcaaga aggcaagtgg catttagagtctgtttttat aaaattaaaa tcttgtatgg 2340 cgggaccaca gaactggatt gtcttttctagacatttatt taatcactca caattatagg 2400 cactaacaac atctgattga agcatccacttaataaatat ttatgagtgt tgtcattatt 2460 cataatttaa taactaataa aataatattaaatattcatt ttttataaat ttggagcaga 2520 aaataagaat atgtggtaaa gttttgctatgtatttaatt taggtgatta gatacagcaa 2580 aaacattggt gatggagatt aatcagcattactggaaatt attaaaagat aaataaggag 2640 taatttatac aaacaagaca acttttgcatgcaaaagtta cagaaagatg aagcagatgc 2700 aaatgtagga aatagtacac acccgtcatgccatttctgt caagcaattc tgttaaataa 2760 tggtaattat catggagtta taagatacactagataattt taacacaacc tcttgacact 2820 taaagctctc atccagctta attgtatctaaagcttaatc acaagcatta ctcatagcaa 2880 ttctttacac agattttcag gctcagtgacagggaaattt atttttctac atcattttca 2940 gaaagttgtg ataatgtatt ggcatgattcagatgtttgt taagttgcat ataccatata 3000 cattctaagt actgcagcta ttttaaaacaccataaaatt gtggccatta tcatcttata 3060 agtaatttcc aggttcttta gaatcagatcatttaaatcg tcaaaaatca ttttagttgc 3120 ctaagattca tctatagaaa gaggcgagggatattcttgg agaagctgtt gagtaagatt 3180 tttaaaattt acgctgtact gatgagctatgaaaaacagc tcactgattt tttttatttg 3240 catgacttag aacagaacat aaaagaagctaaacagagcc tttgcaaatg taacaggtgt 3300 gtgaggatgg atgtatacat caatcaagcaaaggatctat taaatagact tgttagcgtt 3360 tttgttatgt gttgacgttt cccaaatatgccaagtattt taatatttct gtacttttat 3420 ctattctgtt tcctctgaat tctatttttttcattcttct ttgaattggt aaaaccttac 3480 caagcattca aggaccaccg caaatattgcgtgctcctca aattctccac tagagcaaat 3540 ttcttcccct cctatggccc tttcccccacaaatattctt atttactaaa tacattatgt 3600 agtagaaagt catttttatc ccactctctattttgttgtg agccatttaa agacgaagat 3660 ggagactgta tatgaaagac attttaaaaatgttgaataa atggagaaat acttaatcga 3720 aaaaataaca tgaagaggtg gcctttattctgctcaccat agctaacaag acaaaataaa 3780 atgggttctt cctcttggtt tcctgctgtaatcaggatat ggttttaaga tgaagaatta 3840 gaacagcagt gataactcat tttgttttctaaggtgaact gctcttgcat aatttccaca 3900 caattatttt ctcctatgca ttggcaaggtttcctgacat gcaggcagat atttctatag 3960 atcagaaatg cagggaaatg caaaagaaacaaagacccag ggcaagtaga ggcagaatgg 4020 ccatgccaat aattagagga gaaaaggttgcttccaattg agcggaagaa aaagcaatag 4080 aatgacaata aaatggaatg aaattttgaaaggcattgaa attaatcttt aatccaattt 4140 gaggagaact gggatcatct caatacctagacctctaatc cataacataa tgtattctat 4200 aatttattta gatgtttgtt aacttctctaaaaatattct acaattttat gaatagggtc 4260 atattttcag atagatttat tctaggtatttggtttgttt aatgcttttg taaattatgt 4320 atgtgtatat atttacacta tatatataaaatacgtatat ttataattta attaaaaaat 4380 tttcaatcct ggtgtgattc tgtcctgtgtgtttgttctc tggagtagga gtcatttatc 4440 tccattcgcc ttctctccca ccacagtgggtgccacaaac ccatagaaga tttgatggac 4500 gtggacatga gccctctaag gcctcaaaattaacttttta attgtgaact aaagctgaca 4560 aatattatca ctttaatgtg gatgatgatgaaaatgagca ccagttttct ttaagaatgg 4620 ccagttcagg agctggtacc tatgatgaattgcacatcgt tgaagcagaa gcaatgaaat 4680 ataaacgcag tccaaataaa agtaacactggcaactttga aaatgtctgt acagccaaca 4740 gtttcctttg tgggctttga aataccaccacctatggtct tatggttgaa gcatagttca 4800 gggccagtgc atattaatgg gcagcacttaacagctgtgg aggaagatgc acagtgagaa 4860 gatgaagagg aggaggatgc aaagctcttaagtatatctg gaaagcgagc tgcctctaga 4920 ggtggtagtg aggttccaca gaaaaaaagtaaaaacttgc tgctaatgaa gataatgatg 4980 atgacaatga agatgacgat gacaagggtgaggaagatga agaaaaagct cagtgaagaa 5040 atctatataa gatactccag ccaaaattgcacaaaaatca aaccagactg aaaaagactc 5100 aaaaccatca acatcaagac ccaaaaggtcaagaatcctt caaaaaacag aaaaaaaacc 5160 ctcccaaaac gctaaaagga cctagttctgtagaaaacat taaagcaaaa atgcaagcaa 5220 gtacacaaaa aggtggttct cttcccaaattggaaaccaa tttcatcaat tatgtgaaga 5280 actgcttcct aatgactgac caagaggctattcaagatct ctggcagtgg agcaagaagt 5340 ctccttaata gtttaaacag cttgttagaaaatttctgtc ttatttcatt tctctatcat 5400 ttgatatcca cctgtctttt tgtaatgcagagtgagaaat ttacatacca tatctgataa 5460 atgttgtcca ggttccattg ccaagaatgtgttgtccaaa atgtctgttc agttttctaa 5520 gatggaactc caccctttgc ttggttttaagtatgtatgg aatgttatga taggatatag 5580 tatagtagtg gtcagacacg gaaatggtggggatacaaaa atgtgtgtgt gaaataaact 5640 cattattaaa atgttttttg aagtaattttatatttatag aaagtttcaa acattgtaca 5700 aaattcccat gtactcttca cccagtttcccttaacgata actggttaca taaaaccagt 5760 gtattcttaa acttttattt tctacagttatgacagttat atagatatat aattaatttt 5820 tactaaacct tttaagtgag ttttaaattttcactgattt ttaattaact acccactttg 5880 ttaaatttac atattaattc ataatttaaatgaacatctt ttaatagatt ttcttcatac 5940 tcaattacaa atcatctgta aatagtgaaagatttattta tttttctcca atactgatat 6000 ctttttcttt tttttacaat atcgcactgtctaggattcc ctgaacaatg ctgaaatgaa 6060 gcagtaagag tatcttcgtc ttgttttcgatttaaaagaa taatttctat atttcccctt 6120 taaacctgat gtatactgtg gaatttattttgtagctatc ctttatcaag ttaataaaca 6180 ttttttattt ctatttgtaa aaattgttcattatgattgg gtagtttatc agctgctttt 6240 aaaacattta ttgaaatata tttcttcctcattgtcttaa tgtgatgaat tataatgaat 6300 tagtttggaa agttgatatg ttatatttctagagtaaacc caatttttat gaacatttaa 6360 gatcttgatg aactgctaat attttatttagggttttaac tactatgact atgagaaata 6420 ttctcttata atattccttt cttgtgatattctgttaagt ttttggtatt ggtatcacat 6480 aggcctcaaa aaattatttg tgatggattcttcctaccat ccattccttt attctaaaac 6540 aatttgtgat tggtgttatt ttttccttaaattcctggta gaatttcctg gtgaagctat 6600 atgggttttg tgttttctcc tggtaaatttagttttaaaa acccagtttt gtaagtaatt 6660 aaagaaccac tcacatttgc tgtatttttattcagtcttg caaggttgca tttttattat 6720 aatttttcca tttaatatat tccatttcataagtttttga aatgtttacg taaagtttat 6780 tttaatattt tcttgtcatc cttttaataacattaaaatc tgtagtgaag tctccttttc 6840 tttcccagtg ctgggcatgc atgctttttctttgttggtc agtcttacta gagttcgatc 6900 aattttacta cttatttcaa agaatcaacctctgacttta aaaatcttac atatatgctt 6960 gttttctatt ttatcatttt atttatatcttctttggttt ctttgcattt aatttgctgc 7020 tttgattctc taatgagata tatgcttttaaacattaatt ttaagttttc ttcttttcta 7080 atatatacat ttaaaagcat atgtttctctaagttcagct ttatatatca cacaagtttt 7140 cacatgttat attttcataa tgctttatttcagaatactt tctagtattt cactgtgatt 7200 tctttggaca catgaattag agtatatttgaaatctcaaa atatatacga ttttctaatt 7260 acctcactgt ggtaagaaat tatactatgtatgaattcaa ttagttcaaa tttattgaaa 7320 cttgctttat gctccatata cggtctatttttaaaaatgt taagaatgtc cttgaaaaga 7380 atgatattct gtcatgttag gggatatatactccattata tatttaaatt atagcaagtt 7440 tatcaagtgt ttaaatcttc cacatcacccttcactttta ttttcttcat ggtttatcag 7500 ttactgagag acgtgtacta aaatttgttatgatgattgt ggttttgcca attttttcat 7560 ttggttcttt ccatgtatac ttaatatgttttcatgctgt cttagacaca aaaagtttga 7620 attgttttat cttcttggtt catagaatattttatcagta tgaaacacct cttttgatct 7680 ctattttctc ttttttcttg ccttaaagtccatttttatc tgatattaat atggtcacat 7740 gaattttcct tcagttagtt cttgtggataaatttttttt catttccttc attcaaagtt 7800 tccttataat tatattacag aaagcttcccttcaaagagc atctgttatt acaatgttat 7860 cacctttgtc ttaattggtg aactaaatccatttatatcc acttatatgt gatttgtaca 7920 accacccaag ctgattctaa aattttatataaaaatgcag tggggccaaa tgtagccaag 7980 actgtcttga agaagaaaaa caaacagaaagatttgttct agcagatatc aagacgtttt 8040 ataaaactac agtagttaag acagtctgataatatcacat aaaaagagag aaacctgtga 8100 aatagaatag actctccatg tatacatggataaagttaac actactgagc cataatgaat 8160 ggatggtctt tttttttttt tttttttttttttttttttt ttttttgaga cggagtcttg 8220 tactatcacc caggctggag tgcagtggtgctatctcggc tcaatgcaac ctctgcctcc 8280 tgggttcaac cgattctcca gcctcagcctcctgagtagc tgggaataca ggtgcgcacc 8340 accacgccca gctaattttt gtatttttagtagagatggg gtttcaccat gttggttagg 8400 atggtctcaa acttctgacc tcgtgattcgcccaccttgg cctcccaaag tgctgggatt 8460 acaggcatga gccactgtgc ctggctgaatggatggtctt ttctataagt ggtacttgat 8520 caactgtata ttcacattga aacaaacaaacctgacctct atattatgcc atatacatat 8580 tcaatgccag atgaactatg catctaaatgttgaagtcaa aaaataaacc tttcagaaaa 8640 gaggaaggaa agaataaaaa taatcttttcttgactttgg gaatccagaa agaatactta 8700 aacagattac aaaaagaacc aatcctacaggaaaagattg ataaattata ccacattaaa 8760 aagttacttt caattatcaa aggtcacctttaagacggtg aaaagacaag atatttcaac 8820 acatgaaact aacactagaa cctataaagaattgctaaat cagtaaggaa aaagacaata 8880 tgaaggtgga ccaaagtttt gaatagatacttcaaaaaca gtatgtacaa atgatcaata 8940 aatagatgaa gaactgcttt accgcattagcgtctgggca aatcaaaacc atggtgatat 9000 actactacac ctccaacaga atggctaagattttaaaaga ctgacaatat ggagtattag 9060 aaggatacag aactgtgtaa acacttgtatgccactggta ggagtacaaa ttgtaactgc 9120 cactatggaa aacacattta aacacatgcatatttcagga ttcagcaata ccacttgtag 9180 aaatatattc aacaaaaatg tcggtacaagtgcaccaaga aacacatata aaatgtccat 9240 cacaacatta gatacaatag cccccaaactggaaaaattc cctttatctg tcaaaagcag 9300 aatatgtaaa taaactgtga catttccctaaaagttattt ttatagaatg gaatactata 9360 tgtgaatgga aatgaatcaa atatagctagctgcaataac atggataaat ctcttaagca 9420 aaatgagtaa gaattatata ttgtatgatttcatggatat aaagctacaa attaaaatat 9480 agtcttagac atcagaaaat tggttactttcagaaaagag aaaggggata ctagttagaa 9540 aaggaatgtg ggggcttttc atagagatagagctgacatt actctatctc ttggttgatc 9600 attacatatg tgatctctgt gatatttcattgagttgtac atttgtgttt tgcagttttc 9660 tgtataattg ttatatttta caattaaaaacagtgtagca aaaattaaaa atccaaaaaa 9720 aattaaaagc actgtgatgt aagagaatagggaaacaaag tctagatctt gagttcatgt 9780 tctttccact gtattactgt ccttccaggaaacaaagtga gattatatat tttgcataag 9840 agcaacatgt tatattctta ggtacaaggccacaaattta cttacaaaga aagctgaaag 9900 tccccctgca acatgcaaag cgactcagacaaaatgcaga aagggttcag ttgtcagagt 9960 caaagatatt gtggaacgtt ggaagaatatgataatcaag accaagagga caagggaagc 10020 agattgtaat gaagacctga ctctccatgctaatgaacta ttatcaattc cctagtgagg 10080 agggattggt ggtggaaact caactctcatttgaataatt gtcttagaga agtctgcaat 10140 tagttgtgta tgtttaattt gattgtgtaagtaaatctgg ttataatttt atccaaattg 10200 tgattcatga gtcattcttg aaataacctattttatttgt ttgaagtcat taaaattctt 10260 gaccaaatag attgggggaa atatcagaatcagggtgatt gtattgacaa tcaagttact 10320 acactgacaa actattgaaa ttattcagattgcgtctgcc tgcatcctac ctacatgtgg 10380 atgacatagg gtgatatcaa cacagcaataaagaaatatc tctggtcaat agcagtgaca 10440 taagtcttat gagagtaaca ggaagaccaagaggtaaagg gaacagtcat ggtcatcagc 10500 tcacatgaga tattgcagga attccttgaataaggtaaga gggaccagtg agtcagactc 10560 cgagattatt actgtagtta ttgttctattaactgagttt tgtccaaaac tactatggct 10620 tagagaaatg taggttaaac aatacatcagccaatgaatg aaaggaggaa gactatgaga 10680 agatgcctct gttccatatc aaacccaaatagtatcccat aatttccatg atgcttaacc 10740 atggacagtt tgcacatgat atatttaaacatctatggca gtcaccaact aagtaattaa 10800 aaataaacct aaaaataaat ggaagaaggcatagcggtca attggaaaga ggataataaa 10860 tacaatttgt tggatgattc agattattgatattcttgtt taatcattaa ggtaagtttg 10920 tagatataca acataatgag aaaacagttagaaccacaca gtagagttag gaaaatacta 10980 catatgttga aaagtgcatg tcaaactaaagttctaacaa cattgaaggg aagttcgttc 11040 agggctgtat gtgtagtttt ccaacataatgtctgtagtc tggatatcaa ttgttatgaa 11100 gaaggcttgg ctcacattaa atgccaaaaatcttgtttac ttgcccctgt ttctgcaagt 11160 aagtttaaat ttgacagtca aatttgttaagtcctgtttc actttgtgtg ccttagtatt 11220 ctctttattt gcttttttaa tctcttcttcctttaatctg ctaattttat atttttcaat 11280 attttcttta atttttttta ttttattaaagagattttgt atgatactct tttccaagtg 11340 ttgacttttc tgctaacaag acctgtttcacattatgtag cagtggtgtg ccggtaaatg 11400 ttgaactgct aactgtccaa gtagtagtcctaatttgtag tatttgctga tttctgtggt 11460 gtaaatattc ccaccatggc ctatttcaagctactaacgt gatgttatta aacttagatt 11520 taagcagaga tacacacaat tggctttcacaagtcattta cagtcagttc cagcatattg 11580 tggttagagt ataattttgt ttattgattatctgggaaaa ttgctaatag ttattttcat 11640 agtaagcttt gttttcttct acaagcttctgccatctcca aaacaaacaa acaaacaaaa 11700 tgctgttttg ttgctgttgt tgttttacaccaaagcttgg gattcattta ttcaaagctt 11760 ccatattttt tcacagaaat tctaattccttatgatattc cattacccag attcagcccc 11820 agtatatact tttattctac tcaacatacctctcctctac caaaaacaaa acgaacaaat 11880 ccaaacagag ccatccacaa ttccaagaagtcttaatgtc tttatctatg ctttcccatt 11940 acatgataat cttttcctta gacattagctcatattagtc tgattttttt attcaagacc 12000 aattaaatgt taaaatattc ctcgatctctgtagttaaaa acaatggttt tatgttatat 12060 tcccaaagca ctttgtttta cttttacttatattgaaact tttgggcaca aaatacatgc 12120 ccaataaaag actaatgaat ggtcagataaatgaatgtca tttcatgttt gtttcaccat 12180 ggcaaagaac tgctttcttt cttttattggttaccacaac ctgtgaaata tccaggtccc 12240 tggcccatat tctccttaac accctctgaaaaacctaaag actatataga aaatttatat 12300 aatggagttt tgaattatcc aaacaacgtccacttcattt ggcatttgat aaaagatata 12360 aacaaaaata aatccacaac caatttggctctgccttgtt gaatataaga aatgcaacat 12420 cacaggccac atctacactg aaaagtatcttcaaataata ttttccccaa acagttttat 12480 tctctttaga ttacccacac attctctttcagagtatgga gagccttcaa agtttaaaag 12540 aaaaccatag aaaaacacta ttctgacatatcatacattg tccctgtatt cagttcctcc 12600 ttcctttact catgaatggc aactatttaggagcttgtaa gctttcccag attcacacca 12660 attccccaat ggactaagct tcagccatacataatctaaa ggatgaaaaa gatggcaaaa 12720 caacttccct attcggaatc caatgaaaacaaacccctga tgagcaactt ggacaacaac 12780 atctcaagag ttcacctcag gggtggttgtcaacacttac tagagtcaat tcaagagact 12840 gtttcagcag ctttagagca aaacgtcatctttaaaagat tatcaaccaa cacaatcact 12900 aagtttagcc actgtttgtg aaattcaagtcaaatagaag cagctgagca tactcaacag 12960 gagatagcag ttattaaaaa gaaactggagagagggaggg agaaagggag agagggttga 13020 agggagtgag gaagtgaaga ataacgggagggaggcaggg agggaaagaa aagaaaaaaa 13080 aaagaagaga caaaaaaaga aatcagaatccaaattttaa aaagagtgag ggaaatcaaa 13140 acatgctata tgctccaagt gtaaatgctgaacttgcagt actagaggat ttaccataat 13200 ctcaacagct tccagaccta tgacaatttgttttgctttt ttcctctaac aagcttagaa 13260 atcatcattt attcggtatt gacaggtgatcttctaatgg ccatgttctc aactcactac 13320 ccaaggcttc tactactaca tgtcctctcctttctttgac ttgcttgaag tttttcaatg 13380 tttttgtttt agattccata ggaatggcaactgcttaaag cttttctcac ctcttgggaa 13440 aatttctttc agaggaagta acccggggtgccactaattg gctttgcata acagtaggca 13500 aatttggcct taaagcaact gtgacactgtttgccaatca gctcaaatac agattaccaa 13560 aatcagattt tctgggaacc tcacagatgtttctattatg aattctaaaa actatgtggt 13620 tattgacaca agtatcccta atgcctttccaagcaactta atgattcttc tcatttaaat 13680 attcacttca atttcttgca aaccccaagctggtgtttct aagtgcttca ttgaaaaaga 13740 tcaaaaatat tcatcatgca ctgattggactgataaatct aagttctaaa ctttgccaag 13800 aaaaagaaaa aaatggactt ctggtatgtcttcaatatca gttgcctcca ggaatttcct 13860 gtaccatgct caaattagtt ttaatccaatagtatactat tttgactgac cttgtacata 13920 tttctgaaaa gaatagttaa gagatgttttgctaagtaga tcattttcat gataaagata 13980 tttaaaaaga agaaaatgca tgttttgggtgcaacactca gataactaaa atttttaaaa 14040 atcaagtttt ttggtacccc tctatgtgtctacacagatg cacagctaac ggttcctgct 14100 gattttataa ttactttggg ttatgtaatacatattattc tgctgatcat aagccctaag 14160 aagcaaaatt ttgctgtatt gacatggcctggccaaaaac aacaagggaa agaaatagca 14220 ttcaaaaaac tggcaaaatg tttatgaattctaatcctct gcacatgaat aaatacatct 14280 gacaaagagc agaggccctc agaaaggcccctcttgacct ttctaatggg agttcaattg 14340 caagttcagt gttgagaaac taaagcgggttctgccaatg ttttaagttc aagctttact 14400 acattttgtt atttgtaaaa gtgaaatcccagataatgag ttctaattgc tctattaatc 14460 actgaataaa gggtttggag ggaaactgggatttgaaatc gcaatctgaa agacatcctt 14520 ttgtattttt ttacctacag cttaccatataaaactactg tgaaaactac atatatgcac 14580 tttttaaaaa atggtgaagt acatgtaatacgccttatat attacttttc taaaagaata 14640 aaatttaaaa cttcagtgta gtcataatgatctttgacct ggaaaaaaat acagaaaacc 14700 aggccttgga ttataaatta tattgtcaatgaaagtgaga agaactctcc attctttaat 14760 gtgttttatg tattatattt tcatttcctttttccaaatg aattataatg tacaacacat 14820 ttgtattttt ctttaatttt tcacttttaataatctttct ttttcttaac tttgttcttc 14880 catatactga tagacctgac acaacaaaatttacctttca aaaattcaat aatcccatat 14940 tcattgttac ccttaaagta tctgctaggaattctatatt cttatttatg ttcccaagaa 15000 agtttaatgc aaaaaatata gaaaagcatacattatttaa acctcccttc ctttagttta 15060 tattgaaaaa attttaggtt gtgcttatgcaactgaagac caccaaccaa aagggacaag 15120 ctggtattta gggcatcata ataactaactcaaatttacc ataagacata catattaatt 15180 agtaagttca atagtcaata tagccaaaaataatcatttc agttagcact tactggaaat 15240 tttagcaatc taaacactca catggtcaggtttaatattg tccagcaata cctttattcc 15300 tttctctttc tcaagcctgg tctttctaaacatatagaga aaaggcacag gtctcacact 15360 ttaaatcagg tgacatcatt gtcattctttctgcgttctg gtctccaatt aaattccctt 15420 tccttcttag gcccaaggct ttgactatcttttgcaatat gcagtagatt attaatgttc 15480 aaactctgac cagttggtga ttttcaaacagatgcctcca aggtagccaa cagttgcagt 15540 attcactctc ctttttctat ctttttggaagtcattcata aatttaaaag ggtggtttta 15600 atatttaatt cagcattttg agatttttttttattattat tttttttgag acggagtctc 15660 gcctctgtcg cccaggctgg aatgcagtggtgccatctcg gctcactgca agctccacct 15720 ctcgggttca tgccattctc ctgactcaggctccggagta gctgggacta caggcgcctg 15780 ccaacacgcc ccgctaattt tttgtatttttagtagagac agggtttcac agtgttagcc 15840 aggatggtct tgatctcatg acctcgtgatccacccgcct cggcctccca aagtgctgcg 15900 attacaggcg tgagacaccg cgcccggccagcgagatact ttcatatagg aatatttaag 15960 aatatgtaat ctctcatatt gccatcaatttttttttttt tttttttttt ttgagacgga 16020 gtctcgctct gtcgcccagg ctggagtgcagtggcgggat ctcggctcat gccatcaatt 16080 ttaaagtcac taattgctct acaaaagcagtgtatttcat ctccacgaaa agcacgtgta 16140 ctaaaatggc cagagttctc ccagtcaaaaggtcatagaa tggcagcaag gtacaaaaca 16200 cactttgctt tacagtaaac acagataaattaagaaaaac atgtaactcc acacagttga 16260 atctgttctg aaacataatc atttcttaaagaaagagatc ataggggaga tcactccatc 16320 ctcattggaa atgttgggtt aagagcaaaagattatgagt atagagacat ttgaatgcat 16380 gtgttcaaag aaagccagta aaatccctgatttccttcca cataggaaga aaagtagttg 16440 gcttttgcaa tcaggtaaca tttctttctggctaggtcaa ttatccatgg agctacagat 16500 ccacaaccta ttctgattgt ctgcacatctggtgtaagcc tttataatgc aaatattaat 16560 attattatgc ttctgtaaca tatttctataattaaaatca aataagtgat ttcagaatac 16620 aggtgactat gcaaaaaatg ttatctaggggacaaagaag caccccaaca tcaacttata 16680 aaataaaaat agcatttatt tcttgcactcccttactgcc acaaaaaaac actcaacatc 16740 ctgtttgaca ttattggtgt acagggatcacagaaagaca ctaacatttt agaaaatttt 16800 acacacgttg aattgtgcgt gatctgaaacagcagcactt tgttgacact aatcattaga 16860 taattacatc ctttgagtta ctgtgctgtctaaaattaac aagacagcca ggcacggtgg 16920 ttcaggcctg taattccagc actttgggaggccgaggcgg gcagatcacg aggtcaggag 16980 ttcgagacca gcctagccaa catggtgaaaccccgtctct actaaaaata caaaaattag 17040 ctgggcgtga tggtgcacac ctgtaatcccagctacttgg gtggctgagg caggggaatc 17100 acttcaaccc gggtggcgga ggttgcagtgagccgagatc gcgccactgc actccagcct 17160 gggcgacaga gcgagactct atctcagaaaaaaaaaaaaa aaaaaaaaaa aattaacaag 17220 agcaaagtac ttgagcaatg cttaagttttctctctcata ttttttcttc aaattaacaa 17280 catacatttt tacttcaata tatatgaaaaataatcatat ggaaacatta caggtttgta 17340 aaataatgat gacaatagta actatgtgttctatgtgcag aagaaaaggt acattttgtt 17400 ttataaaata ctacaggcaa aggcatgcattacagttaaa aaaatgatat gaatgataga 17460 tttttaaaaa gattttgtat atgtttatctaataagcaaa atcatattgc aaattcataa 17520 aagaaaggca aaatgcatat gatagtcttaacactactgt ataatcacta tagaaaatag 17580 attaatggat aatattaatg aatacatagaaactttgaaa tatttgctga attgcaacta 17640 attggttgaa aatgttgcca tgagctggaagtgaacctca tagcaattgg atctgaattc 17700 tgcagagtag tcagaaagta tgttgcaatgtagccatgtg atgtgaaaga aaatataatg 17760 gtctttggcc atttagattc atgttcatgtcttggatctt ataatgcatt ctgactgcat 17820 gactttggat ggatttctca acatttttgagactcattct caccatctgt aagatggaaa 17880 tacctacctc ttagcataaa gaattcttaaatggtgacaa aaatagttta ccaattttta 17940 aaacagtttt tttttcccag aaataacataaccctacaag aaacctccag acatttttta 18000 aagttttatt tcttattcaa tgtttccgtactcattggtt gggtcagtag acaaaatgtt 18060 cttatttttg agctccatgg ctaacctgattgaagggagt gagtgctatg tggattctgt 18120 acctgggata acattgtagt atacgagaacatgtaaactt atctaaggct taccttcttt 18180 cttaatggta agagcaatgt taagctttctgagtatgcag aatttttttt tagtttaaaa 18240 atatgcatgc atacatccct gattctttacccctgcccct ttgtactttt acttttttac 18300 ctcatttcct agaagggcat ttacacaggcttctgatgca tcacagatgg ctgtgagatc 18360 atgtcctcct tctagagcca acaccacacgtccatcagcc aatgtcatca attgcttcgt 18420 caaatgacca aaacctacca taatacaaacagaacatttc aaagtattaa atcaagagaa 18480 agtgatcact agaatctaac attgagcatgtattttgagt aagtcattac taagcatttt 18540 ctgtgtgcta actcatccaa tacttaaaataactttatgg attaggtcct attattatct 18600 ctattttaca gataagggac ccaaagcccaagatcccaca gctaagaagt atcacaacca 18660 agactggcac caatctagct cttcaccagtgcacagggct gcttttcata acatggtctg 18720 tatgtatctg gataaaaaaa ctgaatactcttcagcaggt gttaacaagg taaactcttc 18780 catttgctta ccatatgctt cctgtcgctatcaatggcct ttattataga aagttttcta 18840 tgccccaaat tgctatatat tacaaatttacattatctaa tataatattt acattatcta 18900 atgtaatgta aaatctatta cattagattttataagcatt attttattat gaaacatttg 18960 ataaatgcaa aatatgaata acatctatacgagttataaa atacaataat atgacaaata 19020 tctgcttttt taccttccaa cttaaggaaaattaagttag caacactttt tcaaccccca 19080 tgtgcctttc tctgacagta gctatcctcctccttgtggg agatcaggat cctgagttta 19140 taattccatt gctttccttt tctaaatttccttgtttttc aactttataa aaatggtttt 19200 acacttttgc aacttgctat tttcatgtattttgttagct catctttgtt gatccctgta 19260 gctatagttt ttttgctgtc tagtaggccattatatgtca acagaggtta cccattcttc 19320 tattggcaga gagttggttt tcttgttatcaccaaattcc agtttttttg tcgttacaaa 19380 taacgtcgcc atgaacattc ttacacgggtcttctggtgc acatatgcac atgtgaaaca 19440 gaattgttga gtcttaaaaa tctgctaaataatgccagat tatttccaaa gggctattac 19500 caagccccac cctcagaaac agtatatgtaagaattccag ttaagtcaca tccttgccaa 19560 catttggtat ggtttgccaa gtgggtggcaaaaaaatggc atcttattgt gttttcattc 19620 agtgtaagag gggagttttc tatttctaatttaacttaga gatttcatta caaatgtaat 19680 ttaatctaat tatttcttta cacagatagacttttcccca taatttcaca gtgctgttag 19740 ttacattaat taatatttca aatatgaagccatcattgca tttaggaagt aaaataagct 19800 tggtcataat gtattatctt tttagtacacacctggattt gttttgctaa tgctttaaga 19860 tttttttgag tatgttcatg aatggggttaatctgtactt ttccattcct gtattggcca 19920 taatgaattt tgatgtggtt gggaccctctgtttttatta tctgatgcca gaatgttggg 19980 gacaaatctc gtatgaaacc attagggtcttgtgttcact ttgaagaata tttttagtat 20040 tgattgaatt tttaaaggga ttatatcactacacctgctt tctatatcgt cctaagttat 20100 atttttacag gcgtttcctt cttttatttcattgtttaaa tttgctgaaa taaaatgttt 20160 gtttactcta ttacattatt ttgaagttccacatagatgt aggtggacat tgtctgtaaa 20220 tatttccttg atctaagttc tctttcatattttccatctc tctctgtcct gcattacgta 20280 tatttttgaa tcagagctgt cttccagactttccctcttc agacatctct aatctgctac 20340 atcacatctt tagtgatatt ttcatttctgtgattgtatt atttaactct agaattccaa 20400 ttttgttcta tttcgtgact tattggtcattatgatactt tcttaactcc ttgtttatgt 20460 ttttatttct tcttttattt ctttcagcataattatttta tattctgtaa ctgacatttg 20520 aaatcttttg gtttagtttg ctctctgttgtttctgctga ttcatgttca tgctgcctta 20580 attatcccct ttttaaaaac ttttattaatttatttaatt tgtggagtac tttgagcttg 20640 tattcattgt aactttatat gtgaaaaatatttgaagctt ggtgcaatgg actgaatgtg 20700 actacacccc aaaatttata tatggaaattctaacctcca atgtgatgtt tttgagaggc 20760 agcctttgat aattatgtag agtcttcatgaatgagatca gtacccttac aaaagggacc 20820 ccagagagag tcctctagct ctcttgttgccttctaagga tccaaggaga agttggcact 20880 ctttaatcca gattaggtag agtcctcgtaaattagattt gtacccttaa caaaaaggac 20940 ccagagtcct ctagttctct tgttgccttctaagggtcca agtctttact tggcagtctt 21000 tattccagaa ggccctgacc agaacctgaccatgctggca agctgatctc agacttacag 21060 taaccagaac tgtgagaaat aaatttctgttgtttataag ctatcagtct atcgtatttt 21120 gatacagcag cctgaactaa gacactggggttgaatatgg tatctgtcat tcaagtctgg 21180 ctcaagtgtg atattgtttg cttttgctggatatctggga cactaccttc taggacctat 21240 tttaaattct tatatggcaa gactggttgtggagtttgct gtttttgttt gcacatgtat 21300 attataaata tggaccttaa aactttattacaaattctca tggagaagaa agtcaggaca 21360 tcctttcttt ctttctttct ttctttctttctttttttcc ttccttcctt ccttccttct 21420 ttctttctat ctttctttct tctttttctctttctctctt acgttctttc tctctctttc 21480 tctgaaactt tctttcggaa attccctttattggtggcaa aagctaagat agatatgatg 21540 ttttatttag gagtattttc ttttctcctatttattctct tccaaagtgt tggccatttg 21600 tcattctttc tttattctgg tctccagttaaattccctcc ccttcttagg cccaagcctc 21660 tgaccctctt ttgcaatatg cagtagattattaatgttcc aactccgacc gattggagat 21720 tttggtatag atgcccccag ggtagtcaacaacttcagga tttactctcc tttttctatc 21780 ttttggaagt caaccacaaa tttaaaaggatgattttaat atttaattca gcattttgag 21840 atactttcac ataaaagtgt ttaagaatatgtaatgtctc atattgccaa atttgaatgt 21900 ttctcattca acatttagaa aaaattatcatggcatccga cctgtccaat ttcaggggca 21960 attgccaaaa ggtacggtaa ataaaaataaatgaaaacac gtgtttcagt agaacatttc 22020 attttttata tgctttgtga acttacagcaaaaaatttta atttttaaat caattgaatt 22080 tttcataatt catagatttt attttttagagcagttttgt atttacagaa aaactgagca 22140 ggaagtacag caagttccat atccagtctctttctttcca tattaacatt ttgcatcatt 22200 ttggtacatt tgttatgatt gataagccagtaccgatgca ttattattaa ctaaagtata 22260 gttgaggttc acactttgtg ttgtacattctgtgggtttt gacaaatgca taatgtcacg 22320 catccaccat tatactatca gacagaatcaatgactgccc tgaaaatttc ctgtgattta 22380 cctattcatc ctccctctct gcccctcaactcctggcaac caatgatctt ttaattgtca 22440 tagtctttag tttgaaaaga aaataaattctcaggatgta ttcactagaa tttaatgaaa 22500 gcctataaaa tcatcagata atgagagcctgaaactaaat taggttgctt ctattttgaa 22560 caataaaata atacattaat cccggtaatgcattaaaata atccacttgg taaacaactg 22620 cctagatttt cccttctggt ctagcacttgatgttcacca tgaacaggat gagtgaatct 22680 cctcaatatc ttgaagcact ttaatgttgattttaaccac ttaactacta tttggatgga 22740 agtcaaatta gtcactttac aattatcacgttttaaaatt cttgacaaaa atacatttaa 22800 aaaggattta aaaattagtt aaaaactgttatcaagcatt ttagtttttc tcaattccta 22860 tggacctcat tatgatgccg ataagaatcttttacccagg ccacttagga atgaggctgt 22920 ccacactaaa ctaccttatt accgggatgacaataaaaag aatgataaac attcagaaaa 22980 gaagtaacgc aaaattttga tccctaatgcttagaaatgt tctttccctg agccaagatt 23040 aatagcacat agtaattagt accattctagaaaatttatg taaaaaacct aataggtaag 23100 gacacatttc tgttaatcat attattaaatattctagacc gctttttctg taacctaaac 23160 cagggctaca gttataattt taaaagatataataaatcaa gccagaaatc ttactaataa 23220 tttctagtaa ctgagaattc aattatctaaagtcactact gaacaaacca aatcactgga 23280 ttaaagaaag aaagagacag agcgatccaaatctggttta agttcactct ttcctctggc 23340 aatgaaaaaa agtcccataa aatgccaaatttagatggga tagtaaaaag tggaaggaaa 23400 gagtggaatg aagttaatct ttgatctctatccaaattcc tctttctttt acctacaggg 23460 tttatttcca ttcacatgtt acccatgtgatctctgcagt cagagactga ggcagctgaa 23520 ctctaagtta tgcatgcaca aaacattcaagtgatgtaag gaaagttcta caaggcccat 23580 gccctttctt caaatcaaaa taagcaattcagtatttttt tttaatttta ttatcctgaa 23640 ttctgctgtg tccactgtta ctgtacatattagaaacatt aaaaatgcca gccgagtgtg 23700 gctacccagg tgaaggtatt atttttcaggacatattaaa ggtttcagtg gcatgtgtac 23760 gtgtgtgtgt gtgtgtttgt gtgtatgtgtgtgttagatt agagcatata taacaatttt 23820 agtaggcatg attgcaagtt tcatgtaatcatatttactt ctagcttcat taaagacaca 23880 aaagctcatc ctacatttga cagtaaacttaataacacct tcagagttga aaaattttag 23940 cacagacctt cctcaagcgg ggttgagtgttttgagtgtg agggctgatg ggctaagtga 24000 ttaagtggaa aacgtgttcc tataccatggtaccttgtag gctcaagcaa tcactggaca 24060 tagagatgga acggggttct caacaaccacatagggcatc agtttcctaa ttgagtgcag 24120 agctgaggga ggagcttgga tgcctcggagcagccacatg tacaggttca tattgggatg 24180 cactgactaa aaatcagcct tgacagacatccctattacc tgtattgact acaaaagaat 24240 ctgtatactt tataggtgtt ggtttctgctaagaaatcat attgtttcag atattttttt 24300 ttttgaggcg gcgtcttgct gtgtcacctgggctagagtg cagtggcgtg atctcagctc 24360 actgcaacct ccacctcccg ggttcaagcaattctcctgc ctcagcctcc cgagtagctg 24420 gactacaggc gtgcaccacc acacccagctaatttttgta tttttagtag agacgcggtt 24480 tcaccatgtt ggttggccag gatagtctcgatctcttgac ctcgtgatcc accagccttt 24540 gcctcccaaa gtgctggaat tacaggcgtaagctaccatg cccagccgtg tcagatactt 24600 tttaaaagag atttggtaac ttaagcttttattttaggaa atattttaga atgaggcatt 24660 aatcaaacac cacatctact actaaagaatcctacatgta gcctggttgt tttaaaaatt 24720 gtctatcagc attaaattat aagcatgagaaggattctac attgtaacaa atcatttctt 24780 ttgatgacca agtggagctg aactggtaattaccatgacc ttgaaaccac tgagaaagag 24840 aattagaagg gccttttcag aatgaaatcctctgtttggt tccattaatt tagtagaaac 24900 aaatttaata tttttgatta taaaaatagaattaaataag ctatcaatat ggtaatggtt 24960 tcaaattatc aatttcaatt tgatttcctgatactttata ggggttggtt tctgctaaga 25020 aatcatattg tgtcagtatt ttctctagtttagaagttgt ttgaaatgaa aagttgctct 25080 aagaaggctc aaagattaag ccttatatacgtatttaata accaagtcag atgacacaaa 25140 aggattcatc cttcaaggtg acatgtctcaaatgcttctc tctaacattt ccaaatagtt 25200 cccagagaat agtggtagtg aaaggaaacaaccttaacta gctttatttt aattttcatt 25260 aaaaaaaact atattaaaaa accaaaattattgcattctc gttgtaagaa atttggaaga 25320 tgatagaaaa taataaataa atagtataataataaacagg ctctatgttg tgatatatca 25380 tataaagtgt tatcttttat ttgataaataaataaaataa atgatcatca tcaaataatt 25440 ataaataata ataaatacat agttccatcgaccagaaata gccaattcta cctttgtgta 25500 tttcatgctt cttgttgtat tttctaaataaaacaaaatc attctggttt tttaaaaata 25560 catttacaaa tatcaaatag tggatacatttttcatgttc tctacaatat catttaaaat 25620 gtacccatgc accaagcaat tctgtttttagatatttaag tgtgctttag gtttttagtt 25680 taatatacaa gatagcaaat aatagcctagtgtataatca aagtgaccaa tgtatgttag 25740 tgtttatctt attctagtgt tattatgtattattagggtt ggaagaagcc ttgctctttt 25800 tattgctaac ttatctgttt caccagagcatgggctagaa cctaaagcac ataaagccaa 25860 aaggagaaca aagtacagtc agaactgtataaactttttt cttttagaac ccatgtatat 25920 ttagcaatgc ctattttgaa taacctaatgttttgataga agctcagaga aatgagagat 25980 tctcccacaa aatctgtttc tattacaaaattgcaaatgg aattggaagt ctctatggag 26040 gccaaaactg agttaatgct gtagtaggttgaacagggaa ttctctccaa cctacaattt 26100 agttactatt gctatcctgc ctccctgtagtaaaatagaa cagactctag aatcagcagc 26160 caattctcag agaaagatac ctcgatcatgattcgtttgg ttaataaaga aatggtgaca 26220 cattgtgatc tattggataa gtcattttacttctacttaa acatttgttg acgttgctga 26280 tgccagtctc ccattcatga caagtctccccccaactatt attttctttc tattgaggaa 26340 agcctctagt taaaaaaaga aacaacaaaaatgattctgg caacctccat cctcactctg 26400 ccattcagca gcagaggcac tggcatcaagataagcagga gtgaaagctt ttgaaatact 26460 cactgacacc tatctcatga tgatttgtattaatttgtaa ctcttctatg gctaaaaagt 26520 ctcactacca atttactcat ttattaacatgtcaattaca tttgggcctg aaatgtttat 26580 gaagacttca ccacacattt aatatagtagggaccaaagg agtcacacat tgttgcccta 26640 ttttcatttg aaattaaatt tttctcatccattggactac cttctgtagt tatatccaaa 26700 aagtattact gaagaatgca catccagggaagtctaatta taaaaactgt agccattttc 26760 ctccctctct aaaccccctg gtcattaagttaccatgtta ttctttagga aaatgcagtc 26820 aggctcaagt agagagagaa attcgggtagcatgtggcag tctcatgtat tgtgaggctc 26880 tccagcagga cttcaaagca gaatctgattgttgcagatg ggaggaatgc tttccacaga 26940 aatacctttt taagactcat ggtgctgtaattcatatggt aggcacttgt gattcattcc 27000 tgatgatgtt gggatcattt aactcacagaaccattgtcg ctaccataaa gtcctttcat 27060 ctgtagccaa aaaggtttat ttcatgcaaatgaaaaattt tcattaaagt atcaccttaa 27120 taacgggtaa agatatatat tatctggttatgtttaaaat gtaaatttat gaacatattc 27180 tgaagattca tttcatgtta agattttacttatttgatgt cccaggactc tttccaagtt 27240 cactgaatcc ggaaatcaat tttataagaaatatggagat tattaccatt aaatctttca 27300 attggcttat tccaagcagc cctataaatactgcatatgt tttaaagaaa gcattttcaa 27360 tcacagtaaa aatcctttta ctcttctagtcagtgatgct ccaggaggta agtttatatt 27420 ctcagcacct tttgaaagca aatgaataaattgtatccta aaaaaagtct gaaacaacag 27480 aatacttcaa tgccattatt ttttgtaagacaaaattgat cctcagaaat tcctgagaaa 27540 ataaatggca agaatgattg actggaactttagttatcca tcaatccatc catccatcca 27600 ttcacccatc cctccatcca tctacgatccaactacaaat caactattat ttacaaaata 27660 cctactctgt gccacagttt tatacataattctgatactt ctattagata tgagttatta 27720 taaactctat ttgaacctca gttatattacctataaataa aattaaatac tacttattct 27780 acatcacagg tttgaaatga atatttaatcattaaaggcc aactgcaaaa tggatacaca 27840 gtttatcaaa cagagtctgg catatggcagatgctcagta tttatacatt tttttggaga 27900 tgaagtctca ctctgtcatc caggctggagtgtagtggca tcatcatagc tcacttaacc 27960 taaaattaca gggcccaaac aatcctcccacctcagtcta ctgactagct tggattacat 28020 cccactacca caccctacta atttttcaattttttttata aggacagggt cttactatgt 28080 tgcccaggct ggtctagaac tcctggcctgaagcaatcct cctgcctcgg cctcccagag 28140 ttctgggatt acaggtgtga gccaccatgcttggccagta tttatacttt taatgaaagc 28200 ttttcattta acaattacag atctagatataattgcaagt ttacatactc caattctatc 28260 gttttaagaa gtggatgagg aaactaaggcccatagtgat accagagagc aattttttga 28320 ggaaaagtaa agaagagcaa gtaaaacatgaaaaatgtta tgctcttatg atatatctgc 28380 tatagaatat ctagtatcct ttttgaacaatgtttttaaa aaagacattg tggccaatat 28440 aagtagaaaa tcatgttcaa agatgggggtgagggtgagg agtgagagat gtgtggggaa 28500 gaagttcaag tccaaataaa tataacacaccaaatgaaaa aggctcaagt ctttctggcc 28560 acaaactctt gcttacatag gtgtatggaaaaaaaaagat gtatttaact aaaaaaattt 28620 aacttataca aaatttcatt gatttagttttacacagggt aaaactaaaa caccatgtat 28680 tcaagaggac tcaaaaaata attgtggtagatccattcaa ttaagagata cctactaaga 28740 agctactatg tgaccaagga actgtgctggcaatgaaggc atagttatga gccaagcaaa 28800 ggtgttcatt acccttatat ggtgtataaactaatgttag tgagacctaa tataaccagg 28860 caccatgcta agtgctgaaa tgcattatctcatttattca ccacacaact tcccaagtta 28920 taagaacatt aacttgccca agcaacaaaggtcaatcaat gacaaagttg ggataagagg 28980 ttgggtcagt tgactttagt gcctgtcatccaagccactc ttctgtggct aaatccaagt 29040 aatattgaag tgcaaattta atgcattagtactacaatca cagtgccagt tgtgcctgaa 29100 aaataatcct caaacgttaa tgactgtaacccattcttct tactcaagct acaacttaca 29160 gtagttaaaa ctgatccact tcgatttttttgctattttt tcagtttgaa aaggaaatat 29220 atcacccctt caaaaaacta attccttttcaaactaaccc ttgcatctaa gcttgcattt 29280 taactttgag cacagcatta attcatggcagtactcccaa aattcaactc aggttatgat 29340 ggccatggca acacttataa ttgaccattgccaaaaagct tatgcactga tttgccataa 29400 tcatcctcac ggtttctgaa tgcctagttgctttttataa actgatattt tcaactagca 29460 tagtacctga cacacaataa gttatctggtctttaaaaaa acaaacaaac aacaacgaaa 29520 atattactat tgaatctcaa tgtgtatattcttcacaaac agatgatcat tcatctttaa 29580 agtgctagat aagtatcagc taaattacacagatttgtta aatggtagaa aaacaaaacc 29640 gctgccttct aaggaaaatg gggacatgtctcattgccaa aaacattcct tggaattgca 29700 tttcccaaat gaccagggtt tttaatttcaagaccaaaat acctgatttt aaaagataag 29760 tatctaccct ctgggcaaaa ctgatgacttcttatttttc ctgccataag tcgaggttca 29820 ggaaccctcc gaattgtaag ttacaagcaaccatttaatt tagattaaat tagacagcaa 29880 ttgtatgtta actaaatatg aaatgcctctaaatgtgttt gttaaagatt aagaattcca 29940 tagtatataa gcttctatta tacatttgttattgatgatt tttaaaataa atcaccattt 30000 aatagaaata cttaaagaat atttgcaaaagaaaggataa catttagcaa aattcataag 30060 catctaataa gcccaatagg atagttaggatagttttttt tttttccttc ctttttttta 30120 aaacaggcaa ttctccaaca tcagggcagaaaatccgcag tacaaacatg gccaagatcc 30180 tacaccattt ttacaaatgc catgattcaacctgtcaata tggataaaat aaaggcttct 30240 tttcaaatac ttatcacagt ggttttgttctgttttaagt ctattcccac ctgccattaa 30300 aaaaatcatt aaaagaaaat aaagactgcctccaatttcc atgaaagatt tccatataac 30360 tatcattctt tggggaataa cattacatattccatagcgt attggatcat tgtttttatc 30420 ttgcatgatt ttcctacctt tccaagttggaggtgtggga catgaaaagg gagtctttcc 30480 tttattatgc cagaggtctt tcatcttaagccatggtcta cttgtgagtg aagcccaata 30540 tccaacttat ataaaatgct ataaaaccttcataatggta aagatagagt atttcgggta 30600 aggcggtgac attttaggtc aaacacttcaagacacttaa ggtatctgaa agaagatgac 30660 aagattgtgg aattgaatga tgagagagtgaggtaagcag aggacagatt cagggtgggg 30720 agatcaaaga taaagaggag ttgccaggactttggggaat agctgggtat gtaccagaat 30780 aaataaaaaa gcactatgct agccattctagaatcgttca aactgagagg tcatggacat 30840 ctttcaacaa gggtctataa tgagattaggcaactacttt tcaaaccaaa gaagctcgca 30900 gatgcattag actgggagtc aagctggaatacactaggga tacgcagctg ttgagtctat 30960 tgctctaacc ttagagtgtg agtttagatttttcaaaaat agttaaaatt tcagaatctg 31020 gatattaacg gatagatgta taagataaaaaaagtagcac tttattaaag tgggaccatc 31080 agcatttcac ttatcccaat cacaagtattatagcttcag aaaataatag caactgggtg 31140 ttcaaaatta cctaattaat aataggtgacaaaagaaatt catagtgact attaaaggaa 31200 taaagctttt atcattatca ccatgtgtcaaaagagttgt gtaactcatc ctaataattt 31260 ccaacttcaa attcattgaa gagacattacttctcttagg agacacccag gcgttctctg 31320 ccagctgctt aaaccctctc tagacatttgtcgattttta ttaccataaa aatgttaact 31380 gcttaggaaa attatctagt ctaccttgggaagcatcagc aacagagcca gggtggcacc 31440 actgattctg aatttggata aaattaatcaataatttcaa atgatattag taactaaatc 31500 taactcaggt tctatagcct actgcataattggacctgcc aattcccatc tctggacttt 31560 gctttgtttc tctaagggtc aaatataagtgtcagactaa ctcatatttc ttaaagtgga 31620 gtttaacctt tggttaatca gaatctcctgggtgtttgtt aaaatgcaga tttgtgagcc 31680 tcatcccaga ccaagtttga atccaaatctctgcatttaa agtaagttcc tctactgagg 31740 tttgagtttt tccactgagg tccttctacctgcattgagg tttgaaggtc atctgactac 31800 aaaatcttga aggcttcctt ctagctgtgttatttgagtt gatcctctca caacattttt 31860 tatttttttg ggaaaaagaa attagactatcattacatta taaataatag gtttaattat 31920 atagaaaaca tatagaattt aaaaataggataatttagca cagtgtcttg ttataaaagc 31980 aatttataat aattaatgtt ttttaattattattattata gtttaagttg tagggtacat 32040 gtgcacaacg tgcaggtttg ttacatatatatacatgtgc catgttggtg tgctgcaccc 32100 attaactcgt catttagcat taggtatatctcctaatgct atccttcccc cctcccccca 32160 ccccacaaca ggccccagtg tgtgatgttccccttcctgt gtccatgtgt tctcattatg 32220 cagttccaac ctatgagtga gaatatgcggtgtttggttt tttgtccttg tgagagtttg 32280 ctgagaatga tggtttccag cttcatccatgtccctacaa aggacatgaa ctcatccttt 32340 gttatggctg catagtattc catagtgcatatgtgccaca ttttcttaat ccagtctatc 32400 attgttggac atttgggttg gttccaagtctttgctattg tgaatagtgc cgcaataaac 32460 atacgtgtac atgtgtcttt atagcagcatgatttatagt cctttgggta tatacccagt 32520 aatgggatgg ctgggtcaaa tggtatttctagttctagat ccctaaggaa ttgccacact 32580 gacttccaca atgattgaac tagttaacagtcccaccaac agtgtaaaag tgttcctatt 32640 tctccacatc ctctccagca cctgttgtttcctgactttt taatgattgc cattctaact 32700 ggtgtgagat ggtatctcat tgcggttttgatttgcattt ctctgatggc cagtgatgat 32760 gagcattttt tcatgtgtgt tttggctgcataaatgtctt cttttgagaa gtgtctgttc 32820 atatccttca cccacttttt gatggggttgtttttttctt gtaaatttgt tgagttcagt 32880 gtagattctg gatattagcc ctttgtcagataagcaggtt gcaaaaattt tctcccattc 32940 tgtaggttgc ctgttcactc tgatggtggtttcgtttgct gtgcagaagc tctttagtct 33000 aattagatcc catttgtcaa ttttggcttttgttgccatt gctttggtgt tttagacatg 33060 aagtccttgc ccatgcctat gtcctgaatggtattgccta ggttttcttc tacggttttt 33120 atggttttag gtctaacatg taagtctttaatccatcttg aattgatttt tgtataaggt 33180 gtaaggaagg gatccagttt cagctttctacatatggcta gccagttttc ccagcaccat 33240 ttattaaata gggaatcctt tccccattgcttgtttttgt caggtttgtc aaagatcaga 33300 tagttgtaga tatgcggcat tatttctgaatcctcaataa aatactggca aaccgaatcc 33360 agcaacacat caaaaagctt atccaccatgatcaagtggg cttcatccct ggtatacaag 33420 gctggttcaa catacgaaaa tcaataaatgtaatccagca tataaacaga accaaagaca 33480 aaaaccacat gattatctca atagatgcagaaaaggcctt tgacaaaatt caacaacgct 33540 tcatgctaaa aacgctcaat aaattaggtattgatgggac atatctcaaa ataataagag 33600 ctatctatga caaacccaca gccaatatcttactgaatgg acaaaaactg gaagcattcc 33660 ctttgaaaac tggcacaaga cagggatgccctctctcacc actcctactc aacatagtgt 33720 tggaagttct ggtcagggca atcaggcaggagaaggaaat aaagggcatt caattaggaa 33780 aagaggaagt caaattgtcc ctgtttgcagatgacatgat tgtatatcta gaaaacccca 33840 ttgtctcagc ccaaaatctc cttaagctgataagcaactt cagcaaagtc tcaggataca 33900 aaatcaatgt gtaaaaatca caagcattcttatacaccaa caacagacag agagccaaat 33960 catgagtgaa ctcccattca caattgcttcaaagagaata aaacacctag gaatccaact 34020 tacaagggat gtgaaggacc tcttcaaggagaactacaaa ccacttttca aggaaataaa 34080 agaggataca aacaaatgga agaacattccatgctaatgg gcaggaagaa tcaatcttgt 34140 gaaaatggcc atactgccca aggtaatttatagattcaat gccatcccca tcaagctacc 34200 aatgactttc ttcacagaat tggaaaaaaccacgttaaag ttcatatgga accaaaaaag 34260 agcccgcatt gccaagtcaa tcctaagccaaaagaacaaa gctggaggca tcatgctacc 34320 tgacttcaaa ctatactaca aggctacagtaactaaaaca gcatggtact ggtaccaaaa 34380 cagagatata gacccatgga acagaagagagcctttgaca acttttatta ctttttagta 34440 gtcaacaact taagcatacc aaaacaaaaataaaagacag tcagattttg atttgcttat 34500 caacaagata aataatagta tacattgttattccaggtct aggacttcca tgaaattgta 34560 taggaggtgg aatttcatcc tggtcttttgcttctcccct gcctcccacc tccctttcaa 34620 gtgctctttt cttcttccct ttaatccctgtgaaatcttc tttgaaacaa tgaatttaca 34680 tcaatgggtt gtttttatca ggtggctgtagatttgggag acacatccca acatttaaat 34740 actaatactt gcaaaactca tagaaaagtgcctaacattg taagacttat gtaactgctt 34800 gttaattcta gaatgataca acattttttcttctctagga agattgctta agtggacttg 34860 tgtcctggct ctcacaaaat atagtcctaaaggaaactat ttactcacat ttaacaccaa 34920 actggttacc atcatattgg ttagctttatgatgaagtat aaacagttac atgccaacat 34980 gaagaaaacc ttccaaaaat agtaaataaatagtttaggt atcacgataa ggggcaactc 35040 cttggaaatg ataatttgca aaatgatacataagcgccct tctgactttg tgtttctgac 35100 aattataaat tttccttgaa gtgcattggctattctttat aattaggcct ttacattaat 35160 tgtggcttat tactgattaa ctcaagtatttattgcaaaa agttttctat gttgtaatta 35220 cctctttatt accaacgact taaaagggcaaagacttgat ttgcacaggg gatctgaaac 35280 atgtaatatt actaaacaaa agcaacttgggctctattga accaaccaga gaactaaata 35340 tgagaggccg tgattctcaa cacaaaacaattgttcaggc ccctaggatt aaaactaagt 35400 ttttaaacag gagaactctc attaattccaccgtaatcat ttaactacaa ggaaaagcag 35460 gttctttgga tacttcatca tttcagctagttgattcaat agaataattt catgttttgt 35520 ttctggtgaa aacaatggag gtggcacaatttgtagagct atgcggtcaa actgtgttat 35580 gaatgcatta cccaagagta tattaatcttttagtggagg agagacagac aataagtgtg 35640 aaaaggtagt aagactgtgg ttattttggtggcttaactt aggagcaact tttaatgatc 35700 acctgaaaaa agtctaaaat tcttatgtctattcttaacc tgagtaataa aagctataaa 35760 aatcatatat taagtgtgct atataaaatatttctagaat aatactctgt tattaacagt 35820 tttatctctc ttgctttatg aaacactcttctcacctggc ctagtgccat cacattcttg 35880 gatttccccc tttcccctcc atcccccccatgtcaagctg ccagctcctc tacctccttc 35940 cacctgagaa acatgggtac tcctcagagactggcctcag cactccattc tccctctgca 36000 aacatggttc atcagtgaat gttttcattgtcacagttat acccattatc actgaaccaa 36060 agactgaaat ctccttttct tcctgttcgccttttctagc ccttatctcc aatcagaaat 36120 ggccagaaat gcatttcttt gcacatcgacttgattttaa ttgaatgtgt ttaaatatta 36180 tccattatcc gtcatcctcg gtttctcctcctgatgtcac tactttggcc aataggtaat 36240 caagattgtg aaaccttaat gtctgtcaacgctaatgaca cactatctca aactacccaa 36300 tgacaaatga gcttaaactg ctcagtttggtaatcagggc cccaatatgc cgttattgtc 36360 aaaatgactg cactgaatag gctttccattgcatgtatta gataagagca tagatttggg 36420 ggcctgaatt tcatctctct cacggtcatcagtgtcatct cagacatatt tttaatttcc 36480 ctgagtctcc ctttcttctt caataaatcggggatagtaa cacccaaagt taaggtgaat 36540 acatgaaaaa aatgtactta tttactttgtccaatgaaag gacacagtaa aagcagcaaa 36600 tggttgctgg agaacaaatg tgatctcttcactcgtgtcc ttctttccat ctgcttttcc 36660 tcctcctctc atctatgtct aacttaccactcaagaggaa ctctgctgcc cccaccacaa 36720 cgttcagaca agtggctctg atcactagacattttgcttg cagaatttgc tcaatcagat 36780 actgtctttt ttcatatata cgtgtcttttctattttcaa tttatttgtg agattttgaa 36840 agagtagttc aacatcctaa ttcttggcacatcaaccaat aaataaacac agtagtattt 36900 actgaaaaaa aaatcccagt tttttttcaaattcatatcc agaggtccag agggatgctt 36960 caattgtgca gtgcccatgc ttgatcctgagttctccctc atgactgact gcaaaaacca 37020 tgacagtgtc tgagcggaga gatcagtgcttggaccttct ccttgctctt tcctaagtaa 37080 cataagatga tttcatattt gcgagctttgaaagcatttc agctcatgtt tactattttc 37140 tgtctaccac aaatattcac agaacttctaagagcatatt gaaactgaag tgtatcatct 37200 ctgattgggc acaatatact ctcagaatgtattctaacat caataaaatg tggactcttc 37260 cccagcaata ctcaggaaag cctcttaggttccggaaata aacattctgg gatgctctgc 37320 aggccagatg tgcagactgt tgagatggcattgtgggaga gaaaagaaag aacccaagcc 37380 cattaaactt aggatattcc cagagtggctttacttttct ctgcttttct ttgcgaagac 37440 atggccagca agtcctttac tcctgttttctatgtatgta cactttttgg ttgtttgtga 37500 atattgatta aataaggaag gcagaggtgtttgggagtaa tggctctgat aggcgggtag 37560 aatgctgcac ttaaatccaa agcatttgtgtgcccgtttc tctctgaagc tcaatagctt 37620 ctatatctat ctcattagcc acataatagaattcatcaac attttacacc actttatgtg 37680 cctgtttctc tctgaagccc agtagcttctacctgaagtt tcaatagttt ctctctgaag 37740 cccaatagct tctatctcta tctcattagccacataacag aattcatcaa aattttacac 37800 cactttacta actgtattat tttgagcaaaacactttgcc accctgagac acagtgtcct 37860 cactttctca tttgtaaaac taagaaattattgcagatga tatcaaagtc cccttgcatt 37920 tatgattcta cattagtcaa agattcatctctaccaccac atcacagagc tctgtgggtc 37980 aaactctaat tactctcttc aatgctccaagaaatggctg ccaaatttct ggctagtgac 38040 tgacatttca tattcacgct agtacactttcaaacacaaa ccatccctga gcctttcttt 38100 gttctttgga gatgtctgct tccgtcatcccaagaaaatg caagaacagc caaatgcagg 38160 tgtttgggta tggcctaacg actaaggttctttgtctttt tctgtttttt tttttttttt 38220 ccagcggggg gtgagaggag ggtctgttttaaagtacaga aaaagtcaca aaggctgatg 38280 cgaagcctta acatctactc tcgtttcctgaaattccctc tgaagtctac gggaactctg 38340 cactctaagg gcccagtccc ataattggtaaatgagaaaa tatccaaagg aacacaattt 38400 taaagttaac aaaaaaacca taaatagagaaaaagtgatt ttgttgttgt tgttgttgtt 38460 gttagggaaa aaattggagt taaaatggcatatttatttc gttttaattt ctgggctgtc 38520 agacatcagc tctgaagccc tgattcagaacacatgcggg gtcgctttga agttccgact 38580 gctttttttt tttttaacaa tggcagaaagatataaagaa attaagctgc aacataatca 38640 taaaacaaaa cttctggact cctgatttgcaaactgtcat tctttcattt gttcaatgct 38700 tcattttcaa agcttcattg tggcacataattttttgtaa ttttttcctt taagctcgac 38760 cttagctatt cttttcctct ccaaagtgaggcattctact tttattttat tcaacttaaa 38820 aaaaaaatag tttgttgcgg ttttctgaaaacaagaaagg aacaggaaaa tccagagcaa 38880 tatagtaaat ggaatctttt tgataaaagccatagcaata tagggtttag ctcttaaagt 38940 aaccagttct cttggcataa agacaaaaatgtaccttaaa ttttcaggca atctaaagaa 39000 aatgtctact tggttttcat gctctacttataaaatatcc ttacagaaga ttttaggatc 39060 cttaataaaa actgtgcatt tcaaatatggcctgacagat gccacatttg aaaacacaca 39120 tcccctacac atacagacac atgcacaaatgcgtacaaat tgatttattg ttgtcagtca 39180 gtggtcatat atctttattt gaacaagatacacaagattt tgtaatccaa ccatcccttt 39240 taaatcttaa gcccacaaac aagctacaagtttcttagtc cccaaaatca tgtttctcat 39300 tctgcttttt tcctataatc tcttcttggttgtattatgt aaagtattcc aatatttata 39360 ctctttccaa atactgctat accaattctatagtgtaact tctattccag aggttttttc 39420 tgctatatct ttaacggtca aaatttcaaaaaatatgttt ctctcccagc gtaatgacct 39480 ttaatacact tacagtgact actagtcatcttttacatca agttccaact caatacatca 39540 aagttaagtg ggaaattgaa atgactatcccatcaatggt gtgctaaagc cagctcatac 39600 tgacttgcaa gaactgacag ctaaatcttcagaaatttgt gagcctggtt taaacaccat 39660 tataaatgtt aaattatata aacttacaacttaaaaatta tattagaaac aaaggcatta 39720 tgtaccccaa attcattatt tctgaattattttactatat ttgctattat ttgtgctatg 39780 ggggttactt atgtctattg tacagatagagttgaaatac tggactatgg attgctgttg 39840 catgtcttgt ctcagctgtg ctagttacttccacattgaa aacctgaaac gaatgaatag 39900 ccgggtggaa tgccttcgtc tgtctgggctgctgtaacaa aataccataa actgggtagc 39960 ttacaaacaa caaagacgta tttctcatatttctggaggg tgggaagttc aagatcaagc 40020 agaagaaaat cagattgata ggagattcagtactgggtga aggcccactt tctggtgcat 40080 agacagcacc ttgtcaccac gtcctcacatggtgtgagag gcaagacagc tctcgatggc 40140 ctcttaattg agggcactaa tcccatttatttagggctct gccaccctca tgacctaatt 40200 agctctcaaa agccctacct cctaacattataacattggt gataaggttt taacatatca 40260 attttgagag gacacaaaca ttcagaccatagtagtgtgg atattttcct tggttttgtt 40320 tttttgtttt tgttttttaa gagctactttttaaatattt acctgcaaat tactaattgt 40380 cttctgtacc agaattattg aaagagctaatttacaattt acaatgagta cttatattga 40440 atcgtggatg cttcatcctt aacttccaactgttttttaa tccattcact gctagtcaat 40500 atattatctt tttaaattct tatcttctagggttttaact tctcttctgc ctagaatgaa 40560 actgcatttt cacatctact gaaccacctctcaaagcttt aatgaaaact tacatatgct 40620 gtgatgtcaa tattaattag gaaggctgctataagcgtcc tcttattttc tggcacaggg 40680 tcaggcacat ggagtccaaa ggaaacagaaagaaaattac gcatattatt tgtttaaagg 40740 tgggtggaac aaattgtgta ttgctatgtcattaccttag aattttggac tgtaaatgtc 40800 tagaagggag gtaccacgta tgtcaagtagcctgattcct taagtattaa ataatcatca 40860 gatagattgc caaacatcct cccattctattttgacaaca gcctacatct ataaatgaaa 40920 aacatttgtg catcaagtag tttaaattctattattctga cttgagtgac tgtcttgaat 40980 acaaacagat tttagacatg gcgaattaagatatttttat ccagaaggga tgtggaagat 41040 atttggataa gaactggaga aagttcaaccgtggaaatta gccacgtgtt gaaaagtttg 41100 cattatttat atatacttat acagcctttgttctagtact caaaaatgct agagtcctct 41160 ctgacacaaa agagaaatag aaagtttttaagcagagaaa atatccattt gtatgtgcta 41220 caactaaata gcaacgtttt cactgaaaactctttagttt tctaatagtt aagatcagta 41280 ttatttacag tgcagtgaat tactaaacacattatttaag ctctagcaga acatacattt 41340 caaggtgcat gagcatattc ttggtgaaattataatacct acctctcaaa ccttctgtaa 41400 gtttaacaca aatctgtctt acccaaacttctgagtaata ggggattact ctaatttttt 41460 gttagaatcc ttgcgattta tgcaatttacagttgtctca tttttgtttt ttaaaattaa 41520 aatctgacca atatttctta atgtccatactattgagatt tcagagcaga cgatgctttg 41580 atatagagaa ccgtccagtg cactgtagaatgttcagcaa tatccttggg cactacccac 41640 tggatgctag tgggaccttc aagttgtggcaaccacaatg tctctagata ctgccaaata 41700 atccccagga aagcaaaatc acctccatttgagagcaact aaattaggct aattttcaga 41760 gaaagtggta attcaatgca taacatattttcaaatgttt cttatttatt gataaagaaa 41820 acaaatttaa tattaatact tatacccacttattggatac ttttatagtt ttctacagtt 41880 ttaaaatatt atctcatttt attctgataaaaacttaggg gtaaaggttt ttatgttcat 41940 tttcacagct gagaaaagtg aacataagagaggaaataac tccctaaagc tcgctcatct 42000 atagtgctgg tcattacata ttgataataagatgaattga gcaagagtat ttaacaattg 42060 taaataccca acactggagc acccagatacgtaaagcaaa tattattcta tgtaaagaga 42120 gagagatatc ccaatatgaa aatagttagggacttcaata ccccactctt agcattgaac 42180 ggattatcta gatagaaaat ccacacagaaactttggatt taatctacac tagacctagc 42240 agacgtttaa agaatatttt atctgacaactgcagaatac acattcttct cattagtaca 42300 tggaacattc tctggaatag atcatatagtaggctacaaa acaagcctca aaagattttt 42360 aaaaattgaa atcatatcag atatcttttctgaccacaat ggaataaaat tagaaatcaa 42420 taacaagagg aattttggaa actgtacaaatacatggata ttaaacaaca tgctcctgaa 42480 taaccaatgg gtcaatgaag aatttaaaaaggaaatttaa aaaattcttg gaacaaatga 42540 aaatagaaaa acaactcacc aaaacccatgggatacagca aaaacagtac taagagggca 42600 gtttatagca ataaacaata gatttcaaataaacaaccta acaatgcatc taaaaaaaaa 42660 ctagaatagc aagaaaaacc aaaccccaaattagtaaagg taaagaaata atgtttcaga 42720 gaagaaatga acaaaataga gaccaaaaaatacaaaagat gaacaaaatg aaaagttttt 42780 aaaaataaaa gataaacaaa attgacaattagctagacta agaaaaggag acgagatcca 42840 aataaacaaa atcagaaatg aagaagacattacaactgac accgactata caactacatg 42900 acaagacatt acaactgaca ccaactatacaactatacaa caacaagaca ttacaactga 42960 caccaactgt acaactatgc aacaactataaaacggacac aagtataaac caacaaatta 43020 gaaaacctag aggaaataga tacatttctggatacataca acctaccatg attaaaccag 43080 aaaaaaaaaa aaaagcctga acagaccaataacaaataac aagatagaat cagtaataaa 43140 aagtctccca acaaagagaa accaagaactggaggtcttc aaagctgaat tctaacaaat 43200 actggaagaa taaataacac caagtcttctcaaactattc caagatatta aaggggagaa 43260 aattcttcca aactcattct atgaggccaatattaccctg ataataaaac caaataagga 43320 caaaacaaaa taagaaaact ataggctcatacccccaatg aatatagatg caaaaaaatc 43380 ctcaacaaag tactagcaaa atgaatacaaaagcatatta aaaagattat acaccatgat 43440 caagtgatca tggatgcaag gatggttcaacttagacaaa acaataatca aggtacatca 43500 cgtcaacaga ataaaagatg aaagccatacgatcatcaca atagacacag aaagagcatt 43560 tgaacccgca gccaactgtg atgaatactatactgaatgc tgaaagcttt ttctgtaaga 43620 actggaatga tacaaggatg ctaactttcaccattcttat tcaacctagt actagaagtc 43680 cgagtcagag caattaggca agagaaaaacataaaaggca ttcacatggg aaaggagaaa 43740 gtcaaactcc ctgcttgcag ataatataatcacatataaa gacctaaaga atccatcaaa 43800 gaattccttg aattgacaaa ttcagtaaagttacaagata caaaatcaac ctacaaaaaa 43860 tcagtaatct ttctgtatac caatagtgagctacctgaaa aagaaatcaa gaaagcaatc 43920 caatgggcaa tagcttcaaa aatatatgagaaaatattta accaaggagg tcaaagattt 43980 ctatgatgaa aactgtaaaa cactgatgaaataaattgaa gaagacacag aaagtaaaaa 44040 acatcccatg tttatgaatt ggatgaattaatattgttaa aatagccttg ttacccaaag 44100 caatctacag attaaatgca atccctatcaagttaatgta aagatgtaaa gagagagatt 44160 gatcccaata caacaatagt tggggacttcaacaccccac tctctcagca ttggacagat 44220 catctaggta gaaatatcat tctctgcacaaataaaaaaa atcctaaaat ttgtatgaaa 44280 ccacaaaaga ccccaaatag ccaaagagtcctgagcaaaa aaccccacaa aaaaaacgaa 44340 agctaaaagc atcaaactac ctgacctcaaaatatactac aagcctataa taaccaacat 44400 atcttggcag tggcataaaa acagacacatagatcagtgg aatagaagag aggacccaga 44460 ataagcccac atatatagag tcaactgatttctgacaaaa gtagcaagaa catacgttgg 44520 ggaagggaca gtctccgcat catgcaatatatccatgcaa tgaacctgca catagtatgt 44580 aatgaatcta aaatttaaaa aatagataaatagtgctggg aaaactgaat atccatatga 44640 agaacaatga aactagactc ccatctctcaccatatacaa aattcaactt aaaatggatt 44700 aattacttaa atggaacacc cacaactacgaaactactaa aagaaaacat aggggaaatg 44760 ctttgggaca ttcagctggg caagaactttatggataagg cttcaaacac caggcaacaa 44820 aagcaaaaat aaaacaatga aataatatcatactagaaag ctgcagagca aagaaaacaa 44880 tcaacaaagt gaaaagacaa cttgtagaatggaagacaat gtttgtaaac tattaattaa 44940 ttaatttcca gaatatatat acaaggaacccaaacaactc atcagcaaaa taaaaccaaa 45000 taatctgatt taaaaatgga caattgatcagaataatcat ttcttaaaag aagacatacg 45060 aatggctaac aggcatatga aaatattctcaacctcccta atcatcagga aaatgcaagt 45120 caaatccaca atgagatctt gcttcaccccggttagaatg gctattatga aaaagacaaa 45180 caataactag tgctggtgag gatgtagagaaaaatgaact cttatacact gttcatggga 45240 atataaatta gtacagccag tatggagggtcctcaaaaag ccaaaaatag aatgactgta 45300 tgctccagcc atctcacaac tgtgtgtatatccaaaggaa ggaaatcaat gtgttgaggg 45360 aatatctgca cttttgtatt tattgcagtactattcacaa tagccaagat atggaatcaa 45420 cctatgtgtc cattaatgga tgaatggatagagaaaatgt ggtataaata gacaatggaa 45480 tcttatacaa ccattaaaac agaatgaaagaatgaaattt ttttttgtca tttgtggctc 45540 tagatgagcc aagagaacat tatgttaagtaaaataatgc aggcacaaaa aaaataaata 45600 ccgcacaatc tcacttacat gtggaagccaaaagagttga tgtcatggaa gtagagagta 45660 gaatagtgtt taccagaagt tgggaagtgagtggagagag ggagaaatag gaaaaggttg 45720 gttaatagat acaaaattac aggtagataggaggaatacc ttctagcgtt ttacaacact 45780 gtagagtgac tacagttaac aacaatttattctgttttcc aatagctaga agaagggatt 45840 ttgaatgttc ccatcacaaa gaaatgataagcgcttgagg tgatggatat gttaatttaa 45900 taatcacaca ttgatttaat cattacacactgtagagatg tatcaaaata ttactctgta 45960 ccatataacc atgtacaatt atgtgtcaattaaaattttt tttaaagagt acaaagaata 46020 aaaaaattaa gctctgaata cataaaggcactataattga tgtggctggg agcttctata 46080 ttatgcttat ttctagaata ttaatgtttttaaagaatat gcataatttg agacatttca 46140 tgtctcaaat taactaacta ttccatgtgacatttaaaaa tggtccatat aaagtgtttt 46200 tctactatat tgtaagaggc agtataataaatgatgcctt ttcctttaga ataaaacatt 46260 ctatcctgga aaaatcactg taaaaatggctaaatacatg atatatacat agtatgtgta 46320 cagaataaaa tacattatga tgataccagaggtataaatt taatcagatc caattctagg 46380 ggagtggctc cgtttcaaac ttctgcatatggataatgct acaaatgacc agacattcta 46440 agaattactc tcaagatgtc actaccctaacaaaagtaaa gtaaactgta agaatggctc 46500 atgctctctc aagtttgccc tttggtgagttttgttttct ttccagaatt atctgattgt 46560 gcattattgg tggtatgata cagaggattataggtccacc tttgcccaag gaattatcta 46620 gctatagctc caaagccctg tggcccttcccagaaagcct gtggtccttc ctttgacctt 46680 ttggcaaatt ttgcttgtca aataatatgacatcacaaaa tctgcaggga attcttacac 46740 tagcaataag gctcaactag gaataaagctaggtgatata atcttgacat gcatcatagc 46800 atcttataat gtgcccctct ttaaaaagtcattgtaaaca aaacttcatc actcgtgaat 46860 taagtaattt agaattccca ttctagctcatctagtgaca aatgtgttta acagttgttc 46920 tgggcattgt tctatttcac ttgggaaatatttttcaaat cacagaattc cattgattta 46980 tgtgagactc tcccttctct tctacattgagctaaattgt tttccattca aacagaatta 47040 taaagaaaaa atacaccttt ccatgctctgcatgggacaa catcctgcag gattgactcc 47100 taccctcgag atcatttggg tttaattgcaggtggtttcc atagtgcctc cttgtggttt 47160 ctatgctttt ggatgcactt gcagctggtttcttcttttc ttgtgagggt gctcccgatg 47220 tgaaaagaga gatcttcctt ccatcttgtgttttctcttt ccccaagtat acttccaaac 47280 tgttgtacct ccagcacagg agtttctggagaatcacagg tttaaatcag ggctttccag 47340 ggcttaaaaa ccttatgaaa agtgcagtgtactcatggcc atatcagctg ttatcacatt 47400 ccttttgtca gtggtcctcg aaattgattgtgtgtgtatt gaataaagaa caggtggatt 47460 gtaatctcta gctgttaaga caaggaatctgcattttaaa caagactgct caggttagtt 47520 gaatctattt gtaggaggcc gtcaaacaaggtcttcagag tcactgctgt atattttctg 47580 gagctgtgaa ggagcaaata aactgggcttcctttgccac tgttgcatcc tgtaatctct 47640 ttaccatcat tttccccacc atagatcctctacaaactct atttcatgca tttgtagcag 47700 ggcagaaaac tatattatct taacaactcaaaatgtttct tggcagagga actatctgta 47760 cttagaaaaa gacatttata tctgtatttagaaaaagaca tttggcaaca tggctcacgt 47820 ctgtaatccc agcactttgg gaggccgaggcaggtggatc acctgaggta aggagtttaa 47880 gaccagcttg cccaacatgg tgaaaccctgtctctactaa aaatacaaaa attagccagg 47940 catggtggca agtgcctgta atcccagctacttgggaggc taaggcagga gaatcacttg 48000 agcctgggag gcgtctaggt tacagtgagttgagattgtg ccactacact ccagcctgcc 48060 tgggagatag agtgagactc catctcaagaaaaaaaataa cgttaaaaaa aaaaggaaaa 48120 agacatttga aagtgaagaa ttagaagcagaggttatggg tcaatgagac aaagcaaaag 48180 gagagaaaag aaaggataga aaagagagagagaaagaaag caaaaagaaa gaaaaaataa 48240 agagagagag agaaggaagg aaggagagaaggaaggaagg aaggaatgaa ggaaagaaag 48300 aggagaaaga aaagaaagat gagaaagaaaagaaagaaaa gaaggaaaag aaaggaaaga 48360 aggaaaagaa aggaaagaaa gaaagaaagaaactattcag cattagaaat aactataaaa 48420 cttgatgagg gagaaggaag aaggagtgcgagtgctaagt aatatgttaa gaggttgtag 48480 tttaaaatgc acagatggct gaaatacttctagaaattgg aatgttacat ttctgtctca 48540 tctgcaatgg aaatcccttc catttccctgcatacaataa atgctttcat acacaaaaac 48600 ttgcaggttt gtttcttcat gaaaacattttaaaagggtt taattttaca ttagcattga 48660 tattatgcaa tgtaaaaatg gcactgttgagctgtggcaa taatctttaa cataaagtta 48720 ttaagaggaa gcaggcacac agagctacaacattcaagaa actataagta tcacactatc 48780 ctcaccacct cacttgtaca atcttaagtagaaaaatgga ctttcaaaaa tctacgtgaa 48840 gaagctttga atttagctta tctagcttctgagggacaac attgtcttaa tgaacatcta 48900 ctctgtataa aatgccttat taaaccttcaagtgcctgca ggctggtaag agatatatgg 48960 caaggccaca gcttacaaca gcaaaaaaagaagtgagcaa caagagggat tctgacagtg 49020 tcatgagtgg ttaacaagaa atggggaggctgggccgggc gcagtggctc acgcctgtaa 49080 tcccagcact ttgggaggcc aaggcgggtggatcacttga ggcgaagagt ttgagaccaa 49140 cctggccaac atggtcaggt tgctaaaaaaccaaaaatta gcctggcatg gtggctcatg 49200 accgtaggcc cagctactca ggaggctaaagcagtagaat cccttgaacc ctggaggcgg 49260 atgttgtagt gagtggacat cccgccactgaactccagcc tgggcaatag accaagactt 49320 tgagaaaaaa caaaacaaaa caaactagttaaaaaaaaga aaagaagtgg ccgggcacgg 49380 cggctcatgc ctgtaatccc agcactttgggaggccgagg cgggcggatc acgaggtcag 49440 gagatcgaga ccatcctggc taacatggtgaaacctcgtc tctactaaaa atacaaaaaa 49500 ttagccgggc gtggtggcgg ttgcctgtagtcccagctac tcggaaggct gaggcaggag 49560 aatggcgtga acccgggagg cggagcttgcagtgagcgga tcgcgtcact gcacttcagc 49620 ctgggagaca gcgagactcc atctaaaaaaaaaaaaaaaa aaaaaaaaaa gaaatgggga 49680 gggtagaggg ttccccatta acttatgctgaggatctagc aagtaggaaa ctcagatgat 49740 aaataagcca atgcaatatt ttatggatctaaatgtttta taacaaattc atccctgtga 49800 catatttcca tatagatttt aacttttatgagatttgaga gcacatctta tgtcacacac 49860 actttatcat tacagtggca acgcagcaccctgatcatca tagataatct gtgaattctt 49920 tcacctggta gcagcatttt tttaaatcctccttttataa catggttgga ctgggaagaa 49980 gaatgtatct ctcataatta tcttctacttttattgtatg aatatgtaaa gcagaaaacc 50040 ttactatttc agtaaattca tacttgccactaaagtagaa agtaaacttt atctacttaa 50100 aagaaatcgg gaaaatacat atttttaatccaaggaatgc taaagctcgt acttgttcca 50160 attgttgggt gtttggggaa ggacaggaattgtgtgtatt gtaattatga ctatcgaaac 50220 tacagacttc catcagaatc tctgttcccaatcgtagcca gcattattct catcctagat 50280 ttgttgccag ttgtgtaagg gtcatgtggaggtgaacaga atatgaggta tctggctcca 50340 attccatttg gaacattaaa gtgactccagattgataaaa tagagagaga gaacagcatg 50400 cttgactaca aagatcctaa gccagagtgagccaaatggt acattctcga ctaacggtga 50460 ctaacaatga aagagagaag agatcttaggagtggaattg aagcttcatt ttatcagggc 50520 ttactttagg atgtaggtag aataaatgagaatgtttgtc agaaagatag tgaggagtaa 50580 atgggcgtaa atagctgaca caaagataagaaagctgtca acattttctg caagggtatg 50640 aaaattcacc ttttcagggt cacatgctggctgccagtga aacgatggta aaaaagagtt 50700 aaggaagcta aaaacagaaa ctctagggatggcctcagaa tgtggaagag aggaaattcc 50760 actggatgtc tatttgaaag attgacaagaggaaggatat gtaataaaga agtcaaaaaa 50820 gatgaaaatg gattaaaact tgaaaggattattaccgatt ccctgatttt ggtctaacac 50880 cattgcttag gcgccacaca agtattttacgtaaactatg aataaaatgc agttgtcatc 50940 tatgttttac aaatgagaaa actgggatttaaaaaaatta acaacttgcc taaagtcatg 51000 ttattgctta gaagggccaa gtcaggacccaaatgcaggt ttatttagtt ccacagccct 51060 tgctatagtt aaccatcagg ctgaaattccatcatttctc aaagcacctc ctttctccta 51120 ctctgatcaa acatgtattc tctggcctgaacatgtaaaa ttgttttcaa attgctcatg 51180 caagaaaatt gctgaatata tttgttcatattcccctaca taactgtgta tcatgcttta 51240 ttatatcaga ctgactagct ctgcacaattggttttgctt accccttagc acaatgccat 51300 atgtaaataa atactattac tatagatgattatactcatt agaaaacact caaaggaacg 51360 agactgcaga gattcctgga atcagaaaatttgtacatgt aaactagaga catatttcac 51420 ttataaatag tgtgaaattt ctttttccaaacttttccat tcctcagata ttaaaatcaa 51480 aagtgttcct tatttgttta tgtgctaattcaaatacgta gctaaataat tatattttag 51540 gaaatccaac aagatatcct gaggtaagcatatttttatt tatttcagtg atgcagttca 51600 ttcaatcatt tccccctgcc cttgtcaattgtttcagttg ctcacaggca attctattag 51660 aaataaaata ttgttagagg gggttctcaaaactgcttta tcttcattat attgaaaatt 51720 ctattccaaa cgaatctttg gggaaatcttttttactcac atacttttct ttcatagttt 51780 ggtttcaaac acagagagtt attcctgccaaagcctcatt tttctccttc ttttttggct 51840 aaaagcaatc ttctggagcc tgttcattcccctacccctc cacagatctc accatgatga 51900 ctctcctaag gacacattag agggctttgccctaatccat attttactaa acagccccag 51960 gagtgagaag aaccttcact aggatttgattaaacaaatt cttaaagcca ataaaacgtt 52020 ttcaagttgt aagagaaagc agcattagtgcatgttccca agcagggcag acatttcact 52080 gttgtcatcc ttaaggaaga cagtttgggatgcagtacat tctccctgag actcattcca 52140 gaggcttcag cctccagcaa cagttgcctgtgagggtagc tttattgcat agcacaatgc 52200 agttgtgact gaagctgttt ccaaacactttagggcaatt tcatgtgtaa cttttcctct 52260 gccactttac agggttcctg aaagggtagaagaaaataca gtaggtaagg ccagacaaaa 52320 cttgtgacta aattgaatct ggcataaaataataatatga catactcttg ggacaaataa 52380 aaaagaaagc tgcttgttaa atgcagtagattagaaatgt atatatgcag atgtgaacat 52440 ttaaaagatt aaaaatactg gactgatatatggaaacaac ttttatgatt aaataagata 52500 agttatgaaa acaatcctat tggatgttcaggaaatgttt aaaacgaacc aagtgggttg 52560 agatatagtt ggttcatggc catatttatatgtggtaaaa tacccatact atacaatgag 52620 gttaagtcta gcaattatgt ggttaatttggtcactctcc ataatcatag agattcattt 52680 gttgggggtg ggatccccta caggcattggattctcccag ttgactggta ataataacaa 52740 acaggcttac cagaaacaaa cagttgtaaagtctccacta tattacgtgt tcaattgatg 52800 cagttgaaat atcaaaccta gcttttcttttccctaatgt cagcaatgca gacaaataac 52860 aggcgtttgg aaaaaagagg attttttttaactctgagat attttaattc tgtcccagca 52920 gagagtcaaa gaatcacagg aacaaaatatattattcata caattttata tatatatata 52980 tgtatatgta tatatgtgtg tgtgtgtgtgtgtgtgtgtg tatatatata tatatgtata 53040 tatagtatat atacagagag agaaagagagtctgatctgt tgcagtattg gagccttggg 53100 aataaagtat ctttttggga atctctgtagtatattatta gaagatcatg attaatgtca 53160 caggacttaa gcaatctttg aaaagaagtcaaaatgtgcc acaaaaattc acttgattgt 53220 gccagtggga atatttccta acatagtcccaaacttcaaa aacagtataa agcatgcaaa 53280 tggagtaagg ggcggggtcc atccatttcttcccaagtat atttaatcta tttaacagaa 53340 aaatgttggg aaagttgtgg ctcttattagcatgagaaaa gggcatccag tggtatctat 53400 acactagact gttcacatgt tgtttttcccagggtagggg tggtattcgt acttcttatt 53460 gctttatgtc accagtctgt aacccagattgtaactttaa gatgttatct tctggctgct 53520 cagataaaca gcccattatg tttttatggtgggcagttct gaatcctcag ggaattagaa 53580 gatattggct aaagtttgtg gctccctgctagactatcaa ggggtccatg ggatcttgtc 53640 cggactatga ctttaagcaa acacctctctcataatggta ttctcacact gccttcttgg 53700 ccatggactt caaaagctga ttgcagggagggccagaaag gcaataaccc ttaatatagc 53760 aggactagcc tagaggggac agacagggcaaaggtaaggc gtctctgagg ttggcatttg 53820 tgtgtttagc cacatggggt gattaagggccatctgttct tcagtgggct aaatcatcgt 53880 tttcacagca tcccaggatc aagtacatttcatgcttaga aagcatgaag aagcacccta 53940 gagttttccc agtcctaatg agacatattttaaatttatt tatctttgat ttctaaataa 54000 tgatagtatg cataggtgca ttagtgtgtgtgcacctgtg tgcgcatgta tagatttgag 54060 ttgtttttgt agacttgaaa ttaagagtatcacaattaaa gcaaaattct tgtatgtatt 54120 catacatctt ttggacaggg aaaaaaacctctggaatgtt atgctgatag aagtctttgt 54180 tttgttttga atatatcgtg tgaccagttcattttttttt aaattagaga aactccttgt 54240 ttgaaatcca tgtacagaga aatctatcatctttctgtgt gtgtattatc aagtctttca 54300 aacaacactt tatttcagaa aatgcacattatcaatttgt gagaatagaa atttgaattt 54360 ttctgatagt atttccacac tgaagataatttttttatat tacaggtcac agatagtatg 54420 aagcttgtta aaagttagat gtgattagtgtggatatcca tctttatcca tactactagg 54480 gctatataac cctagttata taacaaattacactgataat ttgttaaata acaaattaca 54540 ttgaatagtt caaggcttat agatttttaaagactgtatc attaactcac tgtattcaca 54600 ttatttataa ggtaagctaa ccaccatgtcttccaaagaa ataattaata tactattaat 54660 tttaactgga ctaaaccaaa tgattaaaatctgtagattc tgaatctata aaatttttga 54720 agtacgatct atttaattgt tacatagttgaaacttacta ttggcaatcg acagtcttcc 54780 atcatgtcaa catctttaac atgatctagcctaggttgtc agattcttca tcaatctcag 54840 aaaagataat aaaaaagaag acatcaagttcatgtttggc tatagggaga gcaagtaact 54900 ttcagggaaa aaaaaaatta taccagtacatcaggtgagt aaactcagtc ctactaatta 54960 ctagttacca cataggagct cacttcaaatctaagcacta caagaaaagt gtcctctatt 55020 gacaagacac ccaaacagca tttttattaatagggacgac agtctagctg tcatccaaaa 55080 gttatgtttt caatcagcca aaccatagcaaatatatcct aacattaaaa catgtttttt 55140 cattaataac agtttgctta gtggagattccaaaacctaa gccatacttt ggaaactttc 55200 cctatgcaat aacttcctaa ctcagcaatcttcatacttt ttggtagcat aagcgtaaca 55260 gaatttgaaa aactatatac cttctttcgtcttttaaggg gatgtctaat atttttatga 55320 gttagtattt cttaaaggat atacttttaagcatattgtg taagtgattt aaaaacattt 55380 cctcaaaata ttggacctct ggatttagctgattcaattt atggaaaatg tccactatgc 55440 aatcagatag acaataccag tcttccttgtcacaccaatc aactaaatca gactcactta 55500 taaaaaaaaa gtcttatcct ttttttccattcaaatgttg taaatgtgaa ttccaacata 55560 agcagactga tgatcaatgg atagataagtaagtagatat atatacagta aacacccttt 55620 ctctgagtac ataccctttc tctgagtttgtaacttagat aaaatgagat actgcctctc 55680 tcaatatttc tttataaaac tcacagtattttgtggtcaa aggaaacgcc ttcagaaata 55740 atatgttctc ttaattactc tccttcacatacctcaaaca ctattaacat gaggccactc 55800 attatttttc tgaaaatata acatgcttttagaattttta aaatatttat gtaaaaaatt 55860 tttagctatt tgttccattt ggctgtgtaccactcatctt tttatgccat atacaagtta 55920 ccttgtcagt gaggtcttta ctcaaccaggtaatctgatg tacttcttca tctatgttcc 55980 catagaatat tattttacaa atatattgtcataattgtgt atgtgtctgt cttaatagac 56040 tatgaatgct tccccaatgt taaaaactcaataaatgttt taaaacaaaa caaataaatc 56100 aatgaatgat tcaatcatta agaaataattccaccaagaa atgtctaaaa tggtgcttta 56160 caaggtcagt tgccatgtat gactttatggtccagaggag atgattaaag aaatgtgtga 56220 aatatatttt actattcatg catatacaaaaatgtatttg ttcctgaaga gattgactta 56280 tagggaacat tttaaaagtg acagtaaaaaactgtgtcta gaaagatcac acatggacac 56340 gatatttaaa agcattggat ccatgcatggttccctggtg gcaaagaccc ttagctgaaa 56400 tggagggatt tttttttttt tttttaagtaaccatatttt aaaagagcaa ttagatagag 56460 aaaacataac atttgtttta taaccacttttaaaacttca ttatactcat tctacacata 56520 taatgagtag caaataaaat ctttaagtagactccaattc ttaaaatatt atgtagagaa 56580 ttatagccca ttattcaccc ttttaggttgccaaatcaag cagtttagca agatcttctc 56640 cagtaaaaca tggttgaatt gatatgacctacaaatatga ttattagata ttctgcagaa 56700 aaaggtagca gagcaaacag gaaggatcagaaacctccgc atagcattct ttaaacaatt 56760 tttagtaaat tgtaacactg cattttaggagtcacattat ttttatttat tatcttatag 56820 ctatattcta agaaaacaaa ggaaaaagttataaagtcct agagttttga caaatcataa 56880 attcttccaa gtctttgttt agattttcgagaattattca ataagcgatc atttgaaagg 56940 ctttattacc ttttcttcaa aagtcatctttaaatcagat gtacacattt cttaaccaca 57000 ctctgttaca aataattatg tagaaaaatgtcagtaaagc tatttctgaa aaattcagtc 57060 agaccagatt ttttcagcca ttattttccccaaatttaat taaatttttt ttctattttt 57120 aaaatttatt atattcagga aattcaaggaagatataggt tgtggtttta aactagaaaa 57180 aatgagcata tgcatactct agacttaatgaatacatatt gctaaatcct ttacaatgtc 57240 attgtatgca gaagtagttc aaaacaccttatttttctgt gttcatgttt atggtctcag 57300 gaattgagaa tgaattttcc tcagtggaaaatttagagtt tatttacctt cactatttct 57360 ccatagatac ccattgtagt aaaagtttcaacagtggaat ttgcagtgtg aaggaattgg 57420 gtctgagaca atgttcttgc tagttctctaacaagccagg tccacaggag tggcgtgtga 57480 cccgatgtca ctatctttaa caaaatggcttttgcacaaa aagaaagacc tttataccta 57540 aaaataaaat cttataacac attgttaaaattatttagtc tggcatggag ttttattaag 57600 ctttgtgtta ttcatgaggg acaaagaagatcatgcccaa gaatgaaaaa gaaaacactt 57660 aatggggtct gggcagtttt aacagcataagtgaaataca acaccaaaca ggatgtctct 57720 cttcctttga acttgaggca ttccatagaccctaagctac tgaattctct ggttagttat 57780 gtggtgccag acattcagtg gcacttaatgaagataagtt tctaccttgt gcttttaaag 57840 gtaatggtga atgaatcctg cctgaccaaattgagtgttt cttaaaagtt actgtaaagt 57900 tggaaaaaat atacatattt ttcttggctcttaaagtgat tagtctcttt tctatgtttt 57960 tatgatcaaa tgctaataaa tcttcaaattagtaagcaga aatatttcta tatttttatc 58020 ttaagcataa atataaatat ttgtccatttttgaaacata aataagactc taatggaaaa 58080 taaaatttac atttaaacgt caacagatcatatttcataa aatagtttct tccttcataa 58140 ataacacttg gaatttaatg tacattaggaaaagtatctt cttgatgttt cccttcggca 58200 ttaatgaaaa ctgcagctgc tcctttttgagattttcttg attatccaaa taaacaaatg 58260 ttttctttat gcttgtatag tcaaggaatacaaaatccac acctaagaaa ctgctacctc 58320 tcccttttgg aaatatgtcc atttaaaaagtggttaatca tgattaaata atgacttatt 58380 gttactaagc tgcatttcaa gtctctaaacaggaaactct tggaaattga gtataacaag 58440 aagcttaaag cctcagatca aatgcgaactccaactgtct aaccttacaa gagaatagac 58500 agccaaagag agctgttcga tgctaagggaaacatgctgc cctgctgttt tttattttta 58560 aatctcagca ttaactgaaa gtatcaagtcaaaactttct tctttcataa aaagataaca 58620 ctcatattca aaggaggagt acactcacctaataagaatt taaagtgact cacttcatga 58680 gctgatcttt agaataggat ttagtgactcacttttgtaa tcatgctctc gtccttttga 58740 ttaacaaaaa tcagaactct ttcatactatcaattccaag catcctcctc tcttattatc 58800 accttctagc ttttcaattt actctctttactgccacact gcagtatttc taggatctac 58860 aatccattga tcctaccaat ttttcatttctcttataatc tacattgtct cactttcctt 58920 ttaaaccagt ttaaaatcct tagtacatcagataatcact tgtctctttt actctaactc 58980 aatcctggtt acatccagct ctctgcctagcggggcctga gccctatcga atatggctgg 59040 tgaaatggta ttgttatttg acatagttattctgactggt ctcactttaa agttatatgt 59100 gaaatttaca tgggctcata agttgttctaagctattttc cgctagtaga tccccttttt 59160 cactcctgta gataattatg ccataccttctctcatgttt tcaagcctcc aaaatgttct 59220 tgcccattcg aattctcagt gattacctttgttcctgttt cactgagaaa aaagtcagaa 59280 gcacacttca tatatctccc accattacacccatcacctg ccagcatctg gacccacata 59340 ctctgctttt tcaactgctc ctgtggataaattctcctgt atctaagccc aagccttcta 59400 cctgtgtcct agaactcaat tctttcacaaattcaagaac atttgtatag caattctctc 59460 ttctttttac agcagcatca attttccctctctactagaa gatgaccagc atcacataaa 59520 tatgctgtca ttttattaag attattttttcaagtactca tcagaccctt tcctccctct 59580 acctactgct ccattgatct cttccccgttagaataaaat tcctcaagag cagcagtcta 59640 tatgtgcagt ctacaatttc tctcctccaatttctcctct aatcaggctt ttaactcatc 59700 aaactcctta tcttgtctag gtcagaagtggcctgcatgt tactgaatct agtggtcagt 59760 ttttatctta cttgaccctt taaggacatttgatagagct aatggcttgt gctcctcttt 59820 gaacggcttg cctccattgg gctacaggacagcacactct gccagtgaaa atcaatcagg 59880 cttcatatgg ctccccctca tggctccaatgtcataatgt tagagtgtcc caagcaacag 59940 tctttgcatc tcttttctac ctacacttgttccctaggtg atctcatctg ggcttacggc 60000 tttaaatagc gtctatatgc tgataacaactaaatttaac tctcagctta aacctttttc 60060 cacatctttc cccatttcag ttcagagccactcattcctc tctggtgccc agacccaaaa 60120 ccctgaagtc atcctttact ccattcccaccttctgatct tctctcatac ccaatccagc 60180 ctgccagcaa atccagttca ctcacctttaaaataaatca aactatgact acttttcccc 60240 acttctatca cccttttctc ttgaacatctcatacttgcc ttcttcttcc tttggcactg 60300 tgggcttggt cctgcctcag ggctattgccctttctgttc cccatgccta caatgttcct 60360 ccctatgata gtttcacagc ttgctcctttatcaccttca gctcttcagg caaacatcat 60420 ttataagtga ggccatttct gatcacccttttaaaaatca caaacctccc ttgtcccagc 60480 aaaatctgac cctttccctg cgttcattttattcatgaac tcctaatgta ctctatgttt 60540 gcttacttat tttgcttagg ctttaaccactagacaatgc tccccaaaag aactttcagt 60600 gacgatgcaa atgttctata tctgcaatgtccattgtgga agctgctagc tgtgaatggc 60660 tattgggcag ttgaaataca tagtttcattaagttaaatt taaataacca tatggccagg 60720 gagtaccatt ttagacagca cagtttaaatataagccaca tgcaaacagg gagttttgac 60780 ttcttcagac tgatgtagct ccagcactagatgcctgatg tatacctgtg aattgaatta 60840 gtcactttct tttctttctg gttttatttctctggttgaa tattgcccca ggccatggta 60900 tttggttgat aaggagagcg aaggttatgttatgttcctt cacgctgctg ccccttgtgt 60960 aaagcacaaa ctacacaact acaggttgtgaccctgagta acttggtttt gcagatctcc 61020 ctgtagctta cggtttacag ctttctctctgctttttgac actactgtca ccatcaatat 61080 gaaaagaacg ttaggggtac agtgagagagctctagatat gaaggtgttt gcatgtctgt 61140 tcttctcact gctgtaatga caaaagcacttagggttctt ttcttttctt tttttttttt 61200 tttttttttc ggcctattac ctacttgaaacactgtataa gctctcaaca cagctgcaga 61260 aggaaggcca aatatgagaa gcaacaagtaacaacctggg aggaaaaaaa aatgatctga 61320 cataaactta agttccttaa actcagtattaattaatgct agaatataaa tcacatctct 61380 ctatcaagaa agaagtttca tcagtcttacatggggtaga tttaattgca ttttatgtct 61440 gggacaaaaa caaatatacc ttcctgagccttcagaattt atttctgggc aataattctc 61500 cttttcccac tttgtattgc ttcttaaaaattatccttta ataaagcatc ataagagaat 61560 agatacacga ggaaccaaat ttacctctttccgtctttgc agggcagggc tcaagacctt 61620 acagtggaag agttatgctc tccataaacaatatgacctt ccaggagaga agaaagaata 61680 gcggtaagga cagagaggga gagagactgcctctctttgt tttgaaggtc aatttctgat 61740 ataaatgtag acagaaagta tattccactagctctgatgc cagaccacct gtgaattcca 61800 tctctagctc tttcataaat ttgaccctttcttatctttt ttatgcttta gtttcttcat 61860 ctataaaatg aggatcatgt tgatattgtttatcttatag cattgttata aagattaagt 61920 agtaaatgca atgtgcttac tattgattataaacacgttt taaatgttcg tagctcttga 61980 tattctagat agagaatttt aaaccattgtatgagttggt ccaaatactt cattttccag 62040 atgacgactg aagacatcaa ttcttcaaatagatacttcg tgtctgtaga acgcaggtct 62100 cctatttcct agtttgtgtt tcttccaataaactccttga aagctcacta tttcccctca 62160 ttctttttca ttcttttctt gattgttacatgggagtaaa tgaagtaatc agagcttgga 62220 aataagtggt aattgtgcct ttggttgcaagtaaaaaatt acttatttta ctctccaaga 62280 tttatttttt atttttattt tttacctacatgggtgtcat caaatagata agctggatct 62340 aatcaaatag atcaccccca gagggaatgaatccattcat acaaagacct gccaggctgt 62400 ttgacactag tatctctgtc ctatgtgtcctatgtggaag gtgggtctag ggctgccctt 62460 aaatagatgt gaatagtgta gacttttcaggttccaagtt gatgaaactt ccaaaccttt 62520 ggtgatctat tgggattgaa agttgattacaactttccca ttgctaaata tctgaacacc 62580 acctcaagtc agtcacacaa ggagctagggccccaagcac cctggaaaga ctaagaagcc 62640 agacttgcca ccatccttag gctattactttggcctggta cttactagct cttaagcctg 62700 gtactcaatg atttactgtt caagtgcctgcagtggttct tcctaattgc tgatctcatt 62760 ttgcacccaa gtgccaaata gtcccctggagactactgag taaaacaaca ggaaaagttc 62820 taataaccat caggatcctt agtaaaatgcagctcttaaa gtagaggacc ttcctggaac 62880 catcccaagt agcctgacac tcctgttttctttaggcact tcatgtgctt gtcagttact 62940 gaaattaact acatttcata aatgattccctctgctggct acttgggcga caaagtggtt 63000 ttagggactc actttattta catgattaccctaaggcagg aaggaaatat tgtgcataag 63060 gaaagtgctg tggggagaaa tctttgactaaagagtaaca acatctgaga aaactgttta 63120 tagtagatcc agaaaagtgc aaacaaatgaacagagctgg cagctcattc tgaatctgag 63180 ataagcaatt ctaaatgaga cagctggattttatatagcg cacaaatacg tgctatgaaa 63240 cccagatcag acagactcgc caaaatatcctagactgctg gaggtcagta caggtcagct 63300 aaataaatta aatcctgagt acactaccttggtctaattg cctggtctct ctgggcttac 63360 ctttgtcttt tcatcactag ctccacctatcctttcatct attttctact ttcgcttaaa 63420 gtttatatta cggtgccatc aaagataagtttctatgtta cagccccaaa gtaaatatta 63480 atacttctat gttacactgt agtgaatttcctttttagtt taaaaaatct gcttttcaaa 63540 aggtaatcga ccacaatgga tgtggtataattccaatcat caacagaaac gttccctctg 63600 tttcattctt tgtatttatc ttgagcagcataaactcttc tttcccacat atgaaaatct 63660 ttgaaatgtt tatggaaatg cttactaaatgaagaagttt gctaaatgtc ccaaatatta 63720 ttaaacctgt actatttacg tgtgcttggctatcaaaact gactccttgt tacatagatg 63780 tctgggagag tcatcctatg ggcagatctccaaaactctc caaaacaaat ctccaaaact 63840 ctatgactcg tgtattgtag acttttggtggttgctcatt acagcagttt tcatctgtta 63900 ggtggtttga agcatttaaa agtcagatagttatatgctg ttatcaaaac acagatctag 63960 aactgttcaa ctgtcatgca ttaagagttgctatgcaggc attaaagatg ttataatcca 64020 gagctctttt gaggcacatg gacatgataagactatctaa tattggctaa catttgttga 64080 gtgcttgcta aatgtcaggc tttaggctgagatgtttaaa tgagtttctg tatttactct 64140 tcataaatct atgagatata gtcctatttgcatatgagga aattaaggcc cactaaaagg 64200 gaaagtaagt tgcccaaggt cacgcaattagaaaagtggc agtggccagt ggcggtggct 64260 cacgcctgta atcccaacac tttggaaggctaagaggctc acttgagcac aggagttcaa 64320 gaccagcctg ggcaacataa caagatcctacctctacaaa aaatttttta caggaaaatg 64380 agttgggcat ggtatcacag gccggtagtgctagctatgt agaaggctga ggtgggagga 64440 tcacttgagc ccaggagcta aaggctgcaatgaaccataa ttgcaccact gcacttcagc 64500 ctgggtgaca gagcaagaca ctatctcaacgacaaaacaa agaagaaaag tggcagaccc 64560 atgtgttggt cctataaagg tgtatatactgtggagcctg ctttttgaac cactgccaag 64620 tactggtctg gcaggctgat cattgtttccttttcttttt tttatagcaa caagcacaat 64680 acaacatgga tgcttattat gaaaatatcttgaataaaca cccatgcagc aaacttttca 64740 agtaaaagaa aaaataaaga gattgactttaaatatattt ttaaatagat catttttttt 64800 taaatcactc catacatgaa agtcaataaatatttctgga gcctagacaa tagctgaggt 64860 gatattttag cccctgggga cacatagtagttaacaacac acagtaacgt caaagaagtg 64920 atagagcatg atggaggatg ggtacactggtcaggaaaat tgacctgaga aggtgatatc 64980 tgagctgaga agataaccag gttatcactaaagaagagat cctttgaata ggatcttttc 65040 atgcaaagac cctgatgtga gcctggtctgttagagagac agaaagattt tccaggctgc 65100 agaatagtga aaaaagggtt ggcagaggagcatagagtag ggtagagagt acatagacat 65160 cacgtgtggt aagaggtgta cattattgtagttgcaggaa aagaatataa agcagaggaa 65220 tgatacgcca cagatagtca attgtttggtaaaataattt ctgaaatagg taatttctgt 65280 agcttataga caaatttcac caaggcagagaaaagaggaa aacagcatgg aataaagacc 65340 ttatctatag actctattgt tatatatgactagacaaagt cgttcctgaa aaagggttga 65400 acattacaca agcatgcagc aatcaaagccagtatttaca aaattcatat ttataaccct 65460 aggcatttct ttttcacttc tatcattaaaataaatatgt attttacaca ggtggctcat 65520 ttagactaaa aagttacatt aaccatgtaaagagatgata ggaggagaga aataatagtt 65580 ttaatctggc tagatccaca caatttctcatggaagaagc tgatactaag atctggggat 65640 agtgttaagg tgggaggtcg ataggatatagacacttgta agacaagttt tgcattttaa 65700 aaacaacttg gaggaaaatt aatacatctctattatgtca cttttcctat tgtttattga 65760 aaacgtatca aatcctgaga gccagtgaaagctcatttct tattttattt tattttttga 65820 gacggagtct cgctctgtcg cccaggctggagtgcagtga cacgctctcg gctcactgca 65880 agctccgcct cccgggttca cgccattttcctgcctcagc ctcccgagta gctgggacta 65940 caggcgcccg ccaccacgcc tggctaattttattttttta tttttagtag agacggggtt 66000 tcaccgtgtt agccaggatg gtctcgatctcctcacctcg tgatccgcct gcctcggcct 66060 cccaaagtgc tgggattaca ggcgggagccaccgcacccg gcccagtgaa agctcatttc 66120 tatagagctc tttctattaa tactgacagatcaggaagaa tttatggcgc tttaccaagt 66180 aacagttagg tgacttggga taagataaatgagggagttc ataaaagtta ctcttggtct 66240 gaaactacgt gggagaaata ttgggtaaaggtggctaaat ttctatcatt ctgaggaatt 66300 ctaagagctg ttggcatgag aaccactgcaactcctgatg acttctctgt ggccacaaat 66360 cttggcgttg catgggacaa gtctagaggttcagttggaa agggattagg tagaggaaga 66420 aaatatatgt ggaatcctag ccacttcctataaaaaccaa caaaaataac taaatatttc 66480 aaatgttttt agaaatataa aataattatgttaaacattt aaaaataact aaatagctta 66540 gtattaattt tcacataaga ttccaaatgtattttgacat atgaattctg accccagctt 66600 atatgtgtga aaacaatagt agatttcgtggggatgatat catttatacg ttattatatg 66660 tagagtgtca cattttgcaa agcattttatttaggtccat tacctcattt gattctcata 66720 atggccctat atttagccaa agcacacgtgatttgtacta tttctgttag gaataaaaag 66780 aacatcaaga cacaaaaaaa gaagttagttggtagccaat tagacccaaa ctgcagatca 66840 accgattcca aatcctgttt cctttttttcaatcactagc ccagtggttc tcaaagcctg 66900 gtccctagat caggagtatc agcatcacctgagagcttgt tggaaatgcc aattgcagta 66960 ccctctccag acctactaag tcagaaattctggaagcgga acccagcatg cctaacaggg 67020 cctccaggtg atactgatgc ttgttaatttggaaacctct gtagtagtcc atagtgactc 67080 tccagcccat gacagtagtg tgaggagaacttcctataga gggaagctgc acgtccattc 67140 cccaagattt ccttgattac ttcatcagccacacacgtat taatagctga ttcttggtca 67200 catactattc catacactta acactgctggcaccaggcca tgacattact taacaaagga 67260 tttgaccaac tgattctttt ccgtattgatttgatttgta agatgaatca taagccaatt 67320 attttactta tagcaatcat cataataaagggtcaaaatc tacggttatg gagatgtcag 67380 gccaaggaag aaccattttt tgtctgagctcaaagcaaac tcacagtaag agaatcaact 67440 attatttaaa atttgtccct ggcaatattttttgttcatt ttgttatttt aatttttgct 67500 tctttgggat tctattcagt cactggaagtctgtaaagaa aatataaaat agaaatctaa 67560 gctattagat taggaaggcc attggctgggattttacaaa catctcaaag agtaaaatat 67620 tattttccat tgaatctaag atgccatcaattgtggcaca aaataaatgt aaccattatt 67680 ttatatacca ctatgaaaat taaaaaaacagcctcaatct catgatgaaa caccatcaag 67740 tgtgagagac attccaattt cagatatgtcaaaatatgaa aaagtatatc ttagtattaa 67800 tggaatacag tacacattag ctgcagttggcatcttcctc tggggcaaac tctgcttaca 67860 tattttcttt tcataagcaa tgttgaaatggcctgttatg gtacagttat agtaactgtg 67920 ttcttcaaag ttaagcagca gtcatcctagcctaaggatt gtttcatgac atcagtaact 67980 aaacagtgca ggtggaaaat attcttctacaatttggtat ctgagttatc atgtggtatg 68040 aggaaatagg caattgagca aggaagtgaatgcagagtaa gagcgaacat ggagcactca 68100 ttcacttgaa taaatctttt gattgtaatttaaaaataaa atcattctca aatttgtgtt 68160 tttatatcct gacaggtttg ccttcttaatcagccatgtt gctttttttg ttagctgtta 68220 aatatatatg agtgaactct attacatgcaatcataaatg tcttgcatat tcccttcctc 68280 tgtccttgca ggaagccatg tacttgcttgagaatataac aaagagacat actggtttgc 68340 aggaattttg agtcaaagag taagtccttgattcgttctt gtgaaaaatg ctccatgaga 68400 aataggaaac atggtctgta aactgctattatattataaa gcttactttt ctgacctgga 68460 aaattttatt tacacaaaaa agtcattgttggaaaaattt tcttttcgaa aaatattttc 68520 acaattcaga gaagcttcta tagtaattaaaaagtgcgta catatttatt tgagatattt 68580 ttaataaccc attaaaccta gtgaaaataaatgaaggcgg aagtctagag acatgagatc 68640 tggttgtggt tttgttagtc ttcatctctgtgacttaagc atagttactt aatttttctg 68700 ttacttttaa aattagaaat ataaacggttgtaaaatttt gtaatggttt cagagggatg 68760 agaacatctt aaaaaatgat attaatacaaaaaatacaca aaggtactat gtatatatta 68820 tctcatttaa tcataaaaac aaaataagatagtgcagaga agcattgagg catagtgcct 68880 agtgcatgga aaacgttcaa catcactggcaggtattata attctatcat caataacaac 68940 aacacagcca ggatgaaatt aatgttcccttttcagtcaa gaatataatc ttcaagaggt 69000 tgggtggcat tcctgggata attctgatggcccaggccag aattatgatg ttttctgctg 69060 gacgaccagg ctgtgctttc acccttacgaccacattgcc ctccgcagtc cttgataact 69120 taagcagaat gtttcgagca gaaagtcatcttttctattt aaattgtaat tcccaacgta 69180 ttgcttgaaa acacctcaaa atggtattttacatatctac tgcatgactt ttgacctgct 69240 tttcccctaa agtttggatt aaacttgaagaatatcagta tacagaacca ccctttctgc 69300 cagttttaac tggaaccgaa gaggtgtgatatacagagta ttaaacagta aagagaggag 69360 gagagatttg ttgtgtgggt gtgtgcatgtgtattgagaa acagggatgt ggactgaagt 69420 ttgaggaata ggtaaggaag gtcgaaggcattctttcctt attttcctgc ctcccttcat 69480 gttttcaagt gctacatact aaagaagaaacagaagcccc aactgactaa aaacatcagc 69540 ctaaggtaac tttaacacac atgcagagggagacttgtaa aaggatgttc acttcaacat 69600 tgtttataat agtaactata gccataaatcttttctatgt tttcttctat taatgttaca 69660 atttcaggtc ttacacataa atctttgctccattttgagt tgattttttt tacatggtat 69720 aagacgaggg tctaatttca ttcctctgcatttggatatc tagttttccc agcaccaatt 69780 atcaaagact gtcttttcct catggagtgttctcgccatc gttgtcaaag atcaattgac 69840 catggtgtat ggatttattt ctgggtcctctattctgttc cattggtcta tgtgtctgtt 69900 tttatgccac tgtcatgctt ttatgattgctacagtttca cagtagctgt taacattgga 69960 aagtatggta cctccagctt tgtgttttttgatcaagatt gcttaggcta ttcagggtct 70020 tttgtggttc cacacaaatt tttgggttgattctgctatt tctgtgaaaa atgtcattgg 70080 gaatttgaca gagattgaat tgaatctgaagatagctttg ggcactatgt aaactttaac 70140 aatgttcatt cttccaattt aggaacaggggatatctctc catttactta catcttcttc 70200 aatatttttc atcaacattt tatagttttcagtttggaga tctttcacct ccttggttaa 70260 atgtattcct aaggtttttg cattttttcctttttgtagc tattgtacat gggattattt 70320 tcttcatcat ttttcagata ggtcattgttagtatacaga aatgctattg atttttgtat 70380 gttaatatta tattctgcaa gtttactgtatttaattatt ggttttatca ggtttttttt 70440 gctggaacct tttggatttt caatatataaaatcatgtca tttggaaaca gagacagttt 70500 aacttctccc tttccaattt ggatgcccttcatttctttt tcttgtctaa tttctctgga 70560 tagaacttct gttagtatgc tgaatagaagtggcgagagt gagcatcctt atcttgttcc 70620 tgaccttagg aaaaaaactt ttattttttcaccattgagt atgatgtatt tatagcctta 70680 tcatatatgg cttttatttt gttgaggtacattccttcca tacctaattt gttgggagtt 70740 tttattataa aaggacattg aatttgtcaaatgccttttc tgcatctatt gaagtgatca 70800 tatagttttt gtccttcata ctgttaatcaggtataacac atttgtggat ttgcctatgt 70860 tgaatcatct ttgcatccca tagataaatcccacttgatc atggtgaatg aaccttttaa 70920 tgtgtttttg aatttgattt ggtagtattttgttgagacg tttttttctg actctcaagt 70980 gtgtttcaga tagttaactg tcagttaactaaaattgtag tcaattgcta aaaaagcatc 71040 actggactat ttattctgca ttggcatattcataatgtta agagcagaac atacctcaat 71100 gtatcataac aaaatgcaca gtttttaggcaagcaatgac tgaggtatcc tcatcacaaa 71160 ataataatgc tttattttct tttaaaaacattaccacttt ttcaattgtc tctggattta 71220 ttataaagta ggaatacaaa cagatatagaaatgtgaaat gcaggcactt attttgctaa 71280 actggctttt aattaaatgg acaatacacttactatttac ctaaaatcct gcattgcttc 71340 caaagatgtc tgcccatcct ccttccattttcttcaaaca ggagtctgaa acaccttcaa 71400 aaaagctaca gaatttgtgt tgtatattttgtgctcaaat atatcatcta aacacccaga 71460 ctttcactga atatttagaa ttgttgaaatgatatgaaca ataaaattca aaactattaa 71520 ttcacaacct aatcatttat tacataggttgtaggtaaaa ttattatctc ccttccccac 71580 ccactttttt tttttttggc tgattaggaaactaacttga ttacaaaatt agtgagaaac 71640 atatttgaga tccgaacaaa tattttccaataccaaaatt agctattgtt tactctcctt 71700 taattcttac tgtttatttc cagtttaataattaaaggac cctatcatct cccatgtcct 71760 ggttttctga gcagagatta aatgagtttctcaccaatta gattcaagca ggtgttaaca 71820 gctgggtctc cgcacttttg cccaaggcccactgttacaa ggagaccatg acttccctga 71880 atacaattcc tattaaaggg aaatattaaacaagtgtcca ttgtcagaag cagttttcag 71940 aaaaacaagg ttttgttaat taaaatattatagaacacag gaatatgtga ttcaaaacta 72000 agaaatggca gtgatgggga agatagcaatggcaaaaaag aaaaaaaatt atgaactcct 72060 atttcaagaa acatcgaata tagtggaagaaatcatctga cttactttaa aaaaatcatg 72120 gattcttttt agccttactc gtttttaaaaatgctattta gactatgttc caggcacttg 72180 gccagttttt gaaacacggc acagaagcagatgaaagagg ttaatctgat ggtagctgga 72240 taagacaata cttcgaagaa ttaatgctgcatagtattcc cctgtgttca ccctaatcta 72300 aaagaactga agcccttcaa gtttaaggttgacccttcat gaagtggtac ctggtgggta 72360 ggtgacttct agacactcct tttctccatacatgtttgct gtggcctgaa atgccattat 72420 gagaagacaa ggcattgagt ccctgattacagataagtaa taaaagatac aactgctaaa 72480 cagagctact acgttctgaa tagttacagaaatattacaa ccataacatt aggtgaaata 72540 cacttacatt taaagaccat agtcaggtaattagtgaagc atttaagtaa atatgattag 72600 gttctttata gattttgata atgtggaaaaaattagacac ttaggagagc catggacatt 72660 ttaagatagg tatagagtca ttagtaaaaagtcattagta aaaaagaaca agaaaaaaag 72720 cagtcaactt caccaaaaca cacctagttctggctcaatc tatattcaac tctgtggaca 72780 caagaaatgg aaaagtggag ggtatttgagctacataccc atatatgacc ttttattgag 72840 tatctgcacc ttgataaaga ataaatatccattgagaaga gaggacctta gaatccaaac 72900 agattgtaat caaggctatc taaaaaagtttatatgtctc atagatgagg aaactaattt 72960 atcttatcct ctgtaataac tggagttaaaactgaagtgc ttattcagaa cttgtagtta 73020 gataaaactt catgaggcac ttgggataaagcatgtacac gcattgttag cagaagacgt 73080 agacaacatg gccttgtgta tttatcagtttgtttcttgg catttgttta tcggattagt 73140 actcaagttt ttagagtctt acttttggatcattgactga ctaaacaagg aatctttgta 73200 cttccctaag aataactcac tgttaagtctaaattcattt atacaggtat cttcccccaa 73260 attatgcttt ctcattgcta aacaggcactcggtggggga aagagaatca gaagatactg 73320 aaaagaaata caattttctg tttaaaaaaaagatggtaat tcaagatgct aagctttgtt 73380 atttggttcc cccccccccg gcaactattaactattcttt tttaaatcac ttaatttttt 73440 ttttaacttt tacatttggg ggtacatgtgaaggtttgtt acataggtaa attcatgtca 73500 caggttttta ttgtacagat tatttcatcacttaggaatt aagcccaata gttatctttt 73560 aagttcttct tcctccttcc accctcctctctcaagtaga ccccagtatc tgttatttcc 73620 ttctctgtgt tcagaagttc atcatttagctcccaattga aagtgagaac acacagtatt 73680 tggttttaca ttctggcatt agtttgctgaggataatagc ctccagctcc atccatgatt 73740 ccacaaaaga catgagcttg ttcttttttatggctgcata gtatggtgta tatgtaccac 73800 attttctttg ttcagtcaat cattgatgggcacttaagtt gattccaggt cactgctatt 73860 gtgaatagtg ctgcagtgaa catttgcgagcatgtgtctt tatggtcaaa tgatttatat 73920 tcctctgggt atatgcccag taatgggattgctggatcaa atggtggttg tacttttagc 73980 tctttgagga attgccacac tgctttccacaatggctgaa ctaatttaca ttcccaccaa 74040 cagtgtctaa gtgttccttt ttctccgcaaccttgccagc acctgttatt ttttgacttt 74100 ttcttaatag ccattctgac ctgtgtgagatggtatctca ttgtggcttt gatcgcattt 74160 ctctaatgat cagtgatatt gagccttttttcatatgctt gttggctgca tatatgtctt 74220 cttttgaaaa atgtctgttc atgtcctttccccacgtttt aatggggttg tttttctctt 74280 gtaaatttgt ttaagttcct tatagatgctgaatattaga cctttgtcag atgcatagtt 74340 tgcaaaaatt tactcccatg ctgtaggctgtctgttaacc ctgttcatag tttcttttgc 74400 tgtgcagagg ctatttagct taataagatctcacttgtca atttttgctt ttgttgggat 74460 tgcttttgtg tctttgtcat aaaatctttaccaataccta tgtccaggac ggtattgcct 74520 aggatgtctt ctagggtttt tatagttttgggttttatat ttaagtcttt aatccatctc 74580 gagttgattt ttgtgtatgg tgtaaggaaggggtccagct tcagtcttct gcatgtggct 74640 agcgagttat ctcagtacca tttattgaatagggagtctt ctccccattg cttgtttctg 74700 gcagttttgt caaagatcag ttagtcataggtgtgtggcc ttatttctgg gttctctatt 74760 ctgttccatt agtctatgtg cctgtttttgtaccagtacc atgctgtttt ggctactgta 74820 gcctggaagt atagtttgaa gttgggtaacatgatgcctc cagctatgct cttttcgctt 74880 aggattgcct tagctatttg ggctctttttttggtttcat atggatttta aaatagtttt 74940 cttctagttc tgtgaagaat gtcattggtagtttgataga aatagcattg aatctgtaaa 75000 ttgctttggg cagtgcggcc attttaattatattgattct tcctgtctat gaccacggga 75060 tgattttcca tttgtttatg tttcctctgatttctttgag cagagttttg taattctcat 75120 tgtagagatg tttcacctcc ctgattagttgtattcctag gtgttttatt ctttctgtga 75180 cagttgtgaa tgggattgcc tttctcatttggctctaggc ttaactgttg ttggtgtgta 75240 ggaatgctac tgacttttgt gcattaattttgcatcttga aactttgatg aagttgtttg 75300 tcagccaaag gagcttttgg gccaagactgtggggttttc taactataga atcatgttgt 75360 ctgcaaacag ggagtttgac ttcctctcttcctatttgga tgccctttat ttccttctct 75420 tgcctgattg ctctggctag gatttctaaagtgtgttgaa taggagtggt agagagaagg 75480 catctttgtc ttatgccagt tttcaaggggaatgcttcca acctttgccc attcagtata 75540 atgttggctg tgggtttggc atagatgggtcttattattt tgagatatgt tccttcaata 75600 cctagtttat ttagagttgt tatcaagaaggggcgttgaa ttttatcgaa agccttttct 75660 atgtctattg agatactcat gtgttttttgtctttagctc tgtttatgtg atgaatcaca 75720 tttattgatt tacttgtcaa aataacccttgtatatttgc tgagagaaat ggtttctgtc 75780 tcaaggacta taaaatgttt attaaaggaatgtatttcac atgtttataa aaggaacata 75840 ctttttatca gatatggcta tcatctcacaatgattttgc ataattccaa aggaaaaaca 75900 tattcttgtt cacatgacaa aagcaatttgaatatatgaa ttcactgcct gacaccaaca 75960 aaagcagtga acgcatgtat gtgttgaaagggaagaaaaa atatatgttg tggcaaaacg 76020 aatttaaacc aaagaagctt ttttttaaaaaaaaatgtta acaacactat aaagccaggg 76080 ggtggtagta tatgatgaat taattttattgtttgaatac agcacttagt tgtcatggca 76140 acctgattaa gctgtaacct gaagacaactatatctgaat cagcatattt agaaagataa 76200 actgataact tcaaggtaca gtttgatgctgggtttaggg caggttaaaa agctatttag 76260 tcatttcggg ttgggattta gccttggtccttaaagagca gcactgatac taagtaagta 76320 attcagattg ttgattaaaa cttcagcagaaaccaatgcc aaaagttttg tagtttcata 76380 acagaaaaca cttaatatat aaagaaaggagaggagaaaa gaggaagaaa gaaaaacatc 76440 actagtgaaa agaattacct ttaattttaaatcacctcta tatttgggct gagatattgg 76500 tgattacacc aaccttttat tattatttttcaatcaggta acaatgttta aaaacaaaca 76560 aaaaccctag ttattttgac ttcatttctcttttcctttc agagatagca aacaaaacta 76620 ttttaaaaga ttgactcaat gtgctaagaaaatataattt tagcatctct gacatggata 76680 gcatcctcaa aaccactctc tgtaattatcaaatattcta cttggagcag gaatgagttt 76740 tgctagaatt ggaaaacacg gggagaagaacttggttgtg tatcttgttc ctacttttta 76800 ctttagaatc tagcccattt ctaacttcgttttgggatca ccctactccc acaataaagg 76860 atgacttcct gaacaagaca gtgaaagtccagtgttaatt gcctgtacag aacttttcga 76920 ccaaagcaat atgaatgcat ctgccaggtggttagaaagc aaacaaagat accaagtggg 76980 gagtgtttta gggaacaact attgagctatctagtaatcc cagcttctac ccacttgttg 77040 gggcagcatc tctagaaagt atagctgagaaactcaggct tccatgaaat aatatataca 77100 gttgcccaga tgtgaggctt tgttgtgtttcacttaagta tcacaaaact agtcaatgtc 77160 tgtcatagac taagtttggg ggattaagggtcatgggcac taatatgttc tctgtagtgt 77220 gcatcgaaat tctctattct caactgggtgtggtggctca tgcttgtaat cccagcactt 77280 tgggaggcca aggcaggtgc atcacctgaggtcaggagtt cgagaccagc ctgaccaaca 77340 tgatgaaacc ctgtctctac taaaaatacaaaatgagcca ggcatggtgg cacatgcctg 77400 taatcccagc tactagggag gctgagggaggggaactgct taaacccggg aggcagaggt 77460 tgtagtgagc cgagatcatc ccactgtgctccagcctgga caacaagagt gaaactctgt 77520 cttaaaaaaa aaaaaaaaat ctattctcatccattttatg aaacattttc tttttaatgg 77580 aaaaaataca gaaaatgcct catgcaatttcacctaacta ctgattcagg ataagaactt 77640 tgattttaac cccagttatt tcagattttaaaataaatta gtttcctcat ctataagata 77700 tgtgaagagt ttcaactaca atctgtttagactctaagga cttctcttct cattgtatat 77760 atttttcctt attaaactgc aaatacgcaaaaggtaaagt atgatatcac ttaaaatatg 77820 tctgcttgat tttcctagga aataggcacctagcagagaa catatggttc ttgagtagga 77880 aagatacaca aggggtatgg agggactgggaacgagggga ggggagttgg aggcattcta 77940 gacaaactga ttctgagatg gaacacaatgaagagcttcc tctccaatga atagatatat 78000 gtaaatgggt aaagaatata ttgaagatgctattatactc tactaaacct agaagtggta 78060 gaacccacgt ctcctatacc taatggccaaaagaaaccat gcgactattt tcaaggtaac 78120 atttgagatt tgaacttgac ttggccaaaaatgaagacac aagggaacaa aatgatcaat 78180 ccctttaact agttctgacg aagagtcttgttacaacctt tccctgtggc aaggagaaag 78240 actaaacata gacactcctc tcttctgagtgagattcttg gatttaatgg caaggaacaa 78300 cttttccaga gttccttctt tcttcgctaggtattttgta tttttttggg tttatctcaa 78360 cttgatgtac aaactctctt tgtctttgtttatttagaca actgtttacc agttctgacc 78420 cacaagtgag gtttatctgc gatggaaagactgacttcca ttgagttgag ttccatggat 78480 aataataaca attttttaaa aaggccatacagacatttaa tctcagcaaa cacctctcta 78540 ttcaatttta ccaaaatcat gaattattttgctttgtttg tctttgtaga gtttcctgtt 78600 ttaatatgtt tttaatagac aacaaggcacaaagaatcct gggtaaataa tacatgttaa 78660 aaatagttac tacctaacaa tgttactagaacaattagag tgcagaaaac tctttcacat 78720 gagaagccag ctaaaaacaa aggttggcatgacgctattt ctttgattct ttttaaatta 78780 atacagcaca tttgctccaa actcatctctcccacttaaa agtatttggg ttttttgttg 78840 ttgtctgctt tgcaatgctc cctaaaatacaccactgtgg gccctattct ttgtgtaatt 78900 ttactttttt cttctatttt taaatagatacccctggtgc caatgtacat ttatatgtga 78960 gctatatata tatacctttt ttcccactcagagagcaagg gaattatttt taaagaaatc 79020 ctctttctag ccagattcca ttaggttgtattattcaaat gcactgtaac ataaaattta 79080 tttcttcatg tggtgtccag ttgctaaggaacacagccaa aaagtccaac tttgcaacac 79140 aacagaagac gagtagagat tatgagggttgcccatagac acatacagag gctctgagca 79200 aggggaatta cacttttgtt ttcaaacttggaagtgcata atattattaa gaaatagtta 79260 tttttatccc atgtacaatg gaacttccattctccctgga aaagcacagt agcttttcta 79320 gactcatgac ctctcaagtc atgcagcatattttaaacag aagccctatc atttctgcct 79380 ttaaatgtaa aacaggtctc ctgaaaagcatacgatttct gaaatgtgct gtcatgtcca 79440 ccaaacaaag cactttaact ttgtttttcttaaaggcaaa tttctacaga aacatgaatc 79500 cgacagagca ataaacacca cctgaatcattttcaaatgt ctcacccaag tttactggac 79560 acatgtaaaa ggtggtgtct atcataaagacctaaaagat ggtatgatat cagagccttt 79620 cgtaaagtcc tgaaagaggt acttacattttgccgtcact ttgtaccctc ctagaggagg 79680 ggtgtggcct tccaatgcat caaatccagcagatactaag accatgtctg gatcaaactc 79740 tttggccaca ggcttcacga tggtcctgcacagtaaaaat gcaaccggtc acacgtggga 79800 ctggtgaata cctttaaaaa tcgttcagtgaaaacgacct ggcacaacaa taggaacctc 79860 ccaagaataa agaaaagggg aataaaaacattatttgaat gggacaaaag cgtatcattt 79920 ccttaataat aaatcgctgt tattttagcatcccaattca gtcttttttg gttcatcttt 79980 tttcctccaa atggaaaaaa aaaaaaaactgctttgcagg tacattctaa agcccatcat 80040 attacacata cgtctgtggc tgttttatcccactgcctat aaaaaactgc ttcttccaag 80100 ggagtgacta atgttttaca gaggaaagtcaaagctttag tgaaaacccg gcttgctcca 80160 gttagtgaga acttggtgta aatttgaactataaatttct tttgggaaaa gtttgctttc 80220 ccaacttaaa aaaaaaaaaa acatttttaaatatttatca tggtaggggg tgactcttgc 80280 aaaggagaaa cacaaagttc ccttaatagaatccagacta caatgttaag t 80331 36 122186 DNA Homo sapiens 36 ggatcccaaatatctcagag ctggtaggac ctggggtttg aatactgacc tttgacacaa 60 tgcggaagagtctacgtgac tcagagatca cgttggtccc agaaggaaaa taaggaaaat 120 aagcctggccaccctggata ggggtaggtt gttgggcctc aaagaggttt gcctgagcaa 180 gagtggctcaggcctgggca ggccactgtc cccaggagca ccctccctgc ccatcgcgtc 240 cctctgcccctccctcctgc acatgtcaca ctgaccacat ctgtagacat cttgagttgt 300 agctgcagatggggaccagt ggctcccatt ttcattttag ccattttgtc tcctgcaccc 360 actcccttcatacaatctag tcagaatagc acttctaggg cacacgttct cagtccaagc 420 tgtgggaaagctccccttat ccaagagagt ttaaaggtag tgacttgggt ttttgcgagt 480 gttttgtttagtaaggactt gtggggagga accgtgctaa gccataacca atgaggagaa 540 gcaagacagcctgtctgccc ccaggagcca gtcctctgct cttctgcagt caggccactg 600 ccttggggctctagtcattc cagtggaaga tgaatgtaac ctgcctggtg acgtgacaac 660 cgtttcctccctgaccccag aggagctggc tctagaaggt tgggatcaat cctgaattta 720 gtttatgtgttagatttata tatatatata tatataaaat atatattaca tacataatat 780 atataaaatacatattacat atatgtaaaa tacaaaacaa taacctttct ggggtttctc 840 gtggcagttgaaatagtccc tcatgtggtc gtcagaaaat aagccattcc tcatactaat 900 atgggataagctccttgacc tctgaggagc aggagtgctt cctgctgtgt gttttagaat 960 ccctccccgccttgtttcgt ggcagtgaaa tgcctcttgg tcctgtccaa atgtgtcttt 1020 cactgattttttgaatcatg ttctagttgc ttggtcctgc cacatgggtc cagtgttcat 1080 ttgagcataactgtactaaa tcctttttcc agatcagtat aataaaggag tgatgtgcaa 1140 ttaaaaaaaaaacaaaaaac cgtggctcag gcctatgtgg actcaggctg cgggtcccag 1200 cgttaagacagatgcttagc ctggagggag gcacacaggc acactggaag ctgggcttgg 1260 gagtggcttggaagcagctt tctcccgctg tcttgagctg cttttttgtt tttgtttttg 1320 ttttcagagaaaatcccatt tagccatcag ctgcactaac actagcagta gtttgggtct 1380 ccccaaagaagggctggacc tactctctcc ctttggggat gccccagttt ctatttcttg 1440 gtctccaagtcactgaacaa atagcctcct tgtctcatca acttttccct gtagcagata 1500 tccttgggaagtacccccat gctagtgtcc caggaagacc cacctggagt agagaaagct 1560 caggccaggcgtatcccact ttcctctaaa gtactccctg tcttgagttc ttgttcatgt 1620 ctttggccacgggagctgaa gccaggagct ggagttagtc gggcaggagc atgtgggtga 1680 tcctagcaacatttttgttt ctctgtgttg attgtaagaa tgtagtcaat gctgggagga 1740 cctgctgcagtctgcatcag gcctcctaca gggaactctc agccccaaag ggagagtaca 1800 caccagcttccatggcccat tcctacccca caccacatcc tcgccctgaa gctgctcagg 1860 caggcgattgggggtactgg actcggccag gctggaggtg agaaagtata cttccttact 1920 gtgtggccttggatatgtca cttcctctct gattacctca gaggagactg agaagagact 1980 gaggccatcagagaggaagt gacatgtcca aggccacgca gtaagggagt atacttctcc 2040 tctcttgtttttattgactt tcttagaatt ttttcttttt atttgtagtt gacacataat 2100 aattgtacatatggaataca gagtgatatt tcaatatggg tacacaatgt gcagtgatca 2160 aatcagggcaattcgcttat gtattgcccc aaacatttat catttctttg tgttgtgaac 2220 attcaaaatcttctttccta gcttttgggg aatagaaggt aaattatagt taaccagagt 2280 caccctgcagtgttgcagaa aaccagaatc cattcttcct gtccagcttt aatttggtat 2340 ttgttaaccaacctctcccc atcttcccct ccctgctacc catcccagcc tctaaatacc 2400 catggttctactttcacggc ctccgtttct tcagttgtaa aaccagagag attgaactgc 2460 agcttctaaatgggccagtc ccctatgcgt caccggccac tctccagcag tgacgggcat 2520 agcctgcctgttacctggag agcagtaatc agcccagaaa tcttgttgac aaagctaagg 2580 gcagagtttccattggaaaa aagcagcttg caggaaaaat tgttgataag aagtggaaat 2640 ctatctaagtaagccatata tctcctgctc cactgcctga ggcctcatgg gctccccact 2700 ctgagtcctgccacgctcca agaagctgct ggagttcccc agagtagcct tggtgaatga 2760 gagtatgtagcctggtttcc atggagtgac ccactagccc tgtgatatgg tttggctgcg 2820 tccccaccgaatctcaactt gaattgtatc cctcagaatt cccacgtgtt gtgggaggga 2880 cccagggggaggtaattgaa tcatgggggc cagtttttcc catgctattc tcatgatagt 2940 gaataagccttatgagatct gatgggttta gcaggggttt ccacttttgc ttcttccgta 3000 tttttccgttgccactgcca tgtaagaagt acctttcacc ttccgccatg atactgaggc 3060 ctgcccagccatgtggaatt gtaattccag ttaaacctct ttctcttccc agtctcaggt 3120 atgtctttatcagcatcgtg aaaacagact aatacaccct gatactgcag ggggtgtcag 3180 tccatggcttttagcaggtt ctcaaaggtg atgcatagtc ccaaaagggt taatgaagaa 3240 caagcttcaggggtaaactc cttcctacaa ctactgtgtc atcagccact gaatttccca 3300 tcgttcagtcagtcataact ggtgagcctc ttaaatgttc ttagaggttc ttagagctgc 3360 gttgctggggcccagcctcc tctggaaaga gccaagtggc agacagagga ggtggcagcc 3420 ctgctgggagcacacccagc actcacactg ctccatgggc cctttccata gaacagacac 3480 tgttctctccaggtgcaggc cacaaaggtg gacgctgtct gtgctaccac cttactcact 3540 cttcttgtggggatcatgat caaacctggg aatttgatgg agtctaaatc aaaattaagt 3600 gtaacccaggctatcttctg ctgcttctcc cctgcaactt cactcacaac ataagcatta 3660 tagagtgttctatttttata attttctgac tgatggaagt gaagtgtctt agggcttagt 3720 gtcttagaaaagtctaagag tcttagaaaa agggatcctt ttccttttta atttttcttt 3780 tcttctcctttgtttttttt tttttttttt tgagacggag ttttactctt gtcgcccagg 3840 ctggagtacaacggtgcgat ctctgctcac tgcaacctct gcctccctgg ttcaagagat 3900 tctcccgcctcagcctcctg agtagctggg attacaggca cccgccacca aagccggcta 3960 atttttgtattttttctttt ttttagtaga gacagggttt cgccatgtta gccaggctag 4020 tctcgaactcctgacctcaa gtgatccacc cactttggcc tcccgaagtg ctgggattac 4080 aggcatgagccaccgcgccc ggccagggct cctttttcta atgtgcatat ggtaccatat 4140 ggtggccccctaagccctcc tctagagctc ctgtgcgaat ggcctagtag ctttgtctaa 4200 catggctacaaagagctatc taggaggagc cattgaaagc tatggggtgc tgttccatct 4260 gtgcatgatacagagctttc taagcataga gccatccaaa gagagtggat tgccgtggga 4320 ggtggttctccactaggaaa attattcaag catgggctag aaaactgttt ggctagaata 4380 tcatagaagaaatttaagat gattggacta ggtggtgctg ttgccttcca atcttgagat 4440 tttcagagctgaatgttatc tcttgggttt tactgtggac attgtggtct gtagaaaata 4500 atttccaatcgttcttacac atatttaaaa gatgtgtgta tgaaggagct ggggagacag 4560 tcggggcaggaagtagtttg gatatgttct atttatacag taaaccctct ccactcccca 4620 ttattatcactctgttctct gtcagcttct tctgggaggt actgagactg ttctggacaa 4680 agaaaatggatacatggtgg ggatggtgga gaagaaagag agggtatcac cttagctggc 4740 catgatattattatgcctga gttatgcacc agaataaaga gaagacaaaa agttaggtag 4800 gtcatgcagtgcttagcact cgatggggca gagtttaatg gatgatgaaa cgaaaaatag 4860 caagacaagggtgtgtacgc acaagtacat gtgcggttgt ggctggcgga cacacaggca 4920 tatcttctcctggaaaagcc caacacttgg ttgactctgt gtgtggcaat tttaggaaga 4980 agaagaattgtctcccactc tgtggggaaa tagcttagct ttccatttct ttctagaagg 5040 agtaggaactttggaacaat gtcaacaatt agaaagccca gtttagatca ctccagtccc 5100 aacctggcagagagaggacc cctctcctgg ggtcgattag gggccacatc ttttgtgccc 5160 ttcctgctcattggcatctg aggatgagtg agtctcactc actgaggcat gaatgttgtg 5220 gttcatctggctaatgaggg atcagggaga aagcttcatc tcatttaagg tcttctttcc 5280 tggcgtggctcacacctgta accccagcta cttgagaagc tgaggtggaa gattgcttga 5340 gcccaggaattagaggctgc agtgagctgt gattgtgcaa ctgcactcta gcctgggtaa 5400 cagaggagaccttgtctctt aaaaagaaaa aaaaatagtg cttctcatga tgggaattcc 5460 agtcttggagttgcatgctc tcagagctag aaaagacatt agcggtcaga cttcttgtcc 5520 actccatggtccttctcaga gtcacagctt taccaccctt aggagggtcc agtcaatgtg 5580 gagttaaactgagccatgag ggactttgat ttttgtcctc ccagggctct gcccaggaca 5640 cctggcaattgccaccctgc aagactgccg taggcgagat ggccccgggg atgcccattt 5700 aacagaagctgccgcaagat ggggccgcct gtggtgtggg ctgacaggca gacgtgtagg 5760 agaggcaatggttgtggctt cagtgactgg aaggaaacgt gttatcttct catttcttgc 5820 taaggcaaggtcagcactgg ggtcagggtc aggcagggtt tttgatgtgg gatgcaggcc 5880 ctggagggatggaagccagg ggctttctac agagttgagc tcctccccct ctgcttctct 5940 gaagcttagtgctgggggtt tggtatttct aaagcagggt caggagaggg ttgctctggg 6000 gacggtcccagcaaaagcag tgggatgttc tgtgtactca gaacatgaat tgctggtggg 6060 gtgggcgtgtgacgtggcag agggcaggta ttaagcagtt tttccacctg tcctcctttc 6120 caccttatgtctttgcccca ctttcctata ggcttgcact tggacttaga ggctgaatct 6180 aggatatctctcctaaaagg accgtccact attggaaagt cgagtgagga ggagaggccc 6240 atctattgaatgggattttc ccagatgaga ggggctgggt gacagaaagt ggatggaacc 6300 tggctgaggcctgccatccc ttggcctggg gatccttgga aggaaaagaa caatccccag 6360 gttcttccctcatgacctgg ggattgttct ctgcattgct cctgacttag tggaagtgaa 6420 aggtgtccacggcttagggt tgcagaaatg actcagagct aagctaccta gattcaaatc 6480 cagctccaaagacaatcacc ttccctgcgc ctcagtttcc acccctaaga taggggcaat 6540 aaagtacccactggaggagg ctcttatgag agtgaagtga gtgaggacac aggaaaacca 6600 tggagcagggcccagtgcgg agcagtaggc atctgctctg atgattgtca ttgcaaaagg 6660 acccagttgggcactacaat cagcctgtcc tcatttggcc ccaggaacca ccacttgcct 6720 agctgtgggaccctgggtaa gtcactcaga gtgctctgaa atttggcttt gctacaagta 6780 ggactgctccctgcctcaca gaactgttgt gagggctaaa tgaaataatg tatgcagagc 6840 ttagcaggcctggcatgtag taaatactcc ggaaacattt tttttaagtt ccagggtggt 6900 tgtctatctggatgtcacct ctgacctctg aaaaccacag ggattgagga taggaaagca 6960 gtgctcctttctgcatccac ccggtcccca cctcaccttc ctgagcacca ggaaaggagc 7020 ctgaggaatcaataaggcca gaggaggaac cctgcagagc gtggtcagct gggaaggact 7080 tgggcagtaggagcagaggg ggcaaaggag ggcctgggtt gggggtacgt ggcagcatgc 7140 ctgtcctcagcagacacctc ccactgccca tgcttcttgt gggggtgggc cagcccagct 7200 taggttatcttggctcattg tccactagtg ttttcctcag atgctccctg ggagctggca 7260 gtactggagggggtggcaag tggcctcagt cggctcacag ttctaggacc gggcccaggt 7320 cttggaagccccttgagctc tcccccttcc ctgcttaggc cactggaaga cagaggtctc 7380 caaagaaagacaaaagctgg ggtctagaca taccccatct ggggtctgac ttaaaggcct 7440 ttgccagggtcacctcctgt tggcatcaga gaaggaaaga agtgtgtgtt tgtgtgtttg 7500 tgtgtgtgtgtgtctgtctg tttgtctatg tctgcaggtg gacaagtagg gccgggtgtg 7560 agtggaagtggaaaggatac tattctgccc atccctcctt gctggccccc cagccagctg 7620 ctaagatccagagtctgggc agcagagtca accctactgc agctgggggt gttgagcatg 7680 tctggggaagagctaaaagt ggcagaaaac atcctgtttg aaagcaatgc tttgctgtat 7740 ttaacccctgcaacacctgc tccgcctaca cccggtctcc acagacagga gatctcagac 7800 acctgcctttgaagctgtcc caagaggcca aggctgtggg ctgccatcca agcctgcccc 7860 attcccagctcctgtgcggc acctcctctg ccctgcctgg ggcagccgtc ttcccgctct 7920 tagcagcaggacacatggcc cagttgctct gcttcctgag ctgcctacaa tctggagatg 7980 gagggggtagtgagagtgtg ggtctcccta acgaaaaggc ccttcctccc tcctgacacc 8040 ctgggctgtgagaggagaag gagtgcctag gcgggaggct gtttccttct gcctggggct 8100 ggttgccgccaccgcttccc actgctcctg ctactccctg cctcgaggga gggccatcct 8160 ggctgctgcccagccgccac ccccacaccc ctgccagcga tgacatggca tgcctgctcc 8220 caacaagccacttctgtttg cagtcactga tctggggact aaagtccctg gaaagagcct 8280 ctcgtgcccacttccttaga gactggggag gcggtcagcg ctccgcctta gataaaaggt 8340 ttccccttcttcatttcaga agcctttggg tctgaagtgt ctgtgagacc tcacagaaga 8400 gcacccctgggctccactta cctgccccct gctccttcag gtaggtgttt cctcatcagc 8460 cgcaacttccctggctttct gttttcaagg ggcggggtgg gggggagggg cataagaagg 8520 tggtgggcaggggaaggaag ggataccacc caggattttg caaggtgggt cccgggccag 8580 cagagtctgcaactgagatg catgagtgtg tggggtgcgg gtgggagttc agagaagggc 8640 tcaggagatggggcttgctg gctccagcca cgaccctggc tgggctctcc tgtgcgtctg 8700 atgtttcctatccagccccc atctcctctt tctctttgct gccttcttta gtctctgcct 8760 gtcattcctgggactttcag ctctcaagcc acagaggctt ggacatctcc acatgtggac 8820 tctggtcctgggcgctggct tcttgatagc agcaaataac ctcaagcagg gttgggtctt 8880 ctgtcagctcccctgaaatg gtctcattca ctgtgggcct ctggctgctt gatccagcct 8940 ttccagccttcacccccagc atagagactt cctgatgtca aggcagcacc ccaccccatt 9000 gcaggactgccccgttgctg tgctgtggta gtatgttgtt ccactcgctt gcatcatagc 9060 atctccaaatgagtccatgt gatgctgaac atgtgttgac tgatttaaca gatattcctt 9120 cctaccccccatttgatttc tctgttttcc acgaaatcca ccggatactt gggagcctgg 9180 atgacccagactctgtagca acaccacgat gactcggagc tgcagcatct cagctgaccc 9240 agggttaagccacaagcatc ctggacagtt tcccctatta ccccacaatg atattgggcc 9300 tccgggatgctggccacatc ttgaatgtgt gctatgttct aaaacctgca ggcatcagct 9360 tggacttgggatggtctttg gggacaatgt tgatagatcc acaagcactt tttctatttt 9420 taattgttttttaaattatg aaacgttttg tatattcaga agggcatgca aacacagata 9480 tacaaaacatagatgtagtg ttttgctaat aataataaga agaagatacc atatgctcac 9540 tactcaaaaaatagaatact gctactatat aatgcacacc cctccccgat ctcatctctc 9600 caaaggtttctgttaatcat tcctttgttc tttttttctg aacttttctt ataggttcag 9660 ggggtacctgtgcaggtttg ttacaaaggt atattgcaag atactgaggt tttgagtatg 9720 aatgaattgtctcccaggta gcgagcatag tactcaatag gttgtttttc agcccctgcc 9780 cctgtccacttgtattccca gtgtccattg ttctcatctt tatgtccata tgtacatgat 9840 gtttagttcccacttataag tgagaacatg tgctattttg ttttctgttt ctggctttgt 9900 ttccttaggataatggtctc cagctgtatc catgttgctg caaaggaaaa aggacagtgt 9960 atgtgtgtaaaaaggacagt atacgtgtgt aaaaaggaca gtatatgtgt gtgtatatat 10020 atatatatacacacacacac acatatactg tattttcttt atctagtcca gagttgatgg 10080 gcacctgggttgattctgtg tctttgctat cgctgcaatg atctttgttc tctttctgaa 10140 agtgcttctctctttatata taggtatata tttatacttg ctaaacttta atgtatatgt 10200 agctgctaaaatttaatata tacattaaat atgtatttat atatttaata tatattaata 10260 tataatatatattaatatgt atttatatat ttaatgtata tattatatat acattagagt 10320 ttagcaagtataaatctagc tgtgaaagaa attagcaata gtgtcactat tactattagg 10380 atagttcaaaagtaattgcg atctttgcca ttatttttga tggccaaaac cacaattact 10440 tttgcaccaacctaatacat taaggtttcc aggaaaagaa aagctaaatg aggttaggga 10500 atctccgaggtctgtgaccg ggattccctc tgtccctttg ggactgatga taacatattc 10560 ttgcttatctgcaccacttc tttcccttgg tgtgaagctc tttggggaat ttttagaaag 10620 tatttgttttattcatttgg cagtagtggt ttctagacat atcttaaggt ttgggcctct 10680 ctgggcctcatttgtaaagg ggatgatgat aatagcatct acaccatgaa gtggtatgaa 10740 ggtgaaataagacttaatga gctttgatat tccacaccct agatcagaga tcatgggcct 10800 agtcattgaaaagtagctca gagcctccca agggccccca gaatctgcct ctgtcaccca 10860 agggcaggaggaaatggtac cctggggtgg agtgggttct tgtctcttgt ttcctggctt 10920 tctctcttatttttcttctg acaagaagga ccctttgcct agggtcaaag gggtcactga 10980 aacctgtaatgacccttttg aggattcaga taaaattggg agaactggga ggcagtaggg 11040 tctgaaagcatttcagggca gtctgaggta tcccagaatc atctctgagc ctgacagtag 11100 acgggatcagacgcagcaga caaagctggg ggcccagttt tggctaatga aagagtcaag 11160 ccagctgcttcctgagaagg ccttcccaaa gctgtgggct ttcgttccgt ctgtctcttc 11220 tccttttcctcaagtatgaa atccatctct agatgataat gcctgtttag aaaaaccatc 11280 tctgaaaacacaattaattg tataggactc acatgactca gaaggacatt caaaataatg 11340 ttttaagtgttattgccaaa aaaagggggg ggaaatatct tgaaatgttg attgtcttgg 11400 tacaggaacaccaggggcat aagcctatta gccctgagct ttatggttgt gaggagctgg 11460 ggctggaatgaccagggcac ctaaatcctc aattcccccc accctcaaga ggaggagacc 11520 tgagggtttctctccacatg taggtgctga ggctgaggga ggactctcat tttcccttgg 11580 agggggcgttgggcaggata gaagcccctg acctggttca ggtctgtgcc tgaggcagag 11640 ctagtgccagtagcatgaat gggttcatgc atatgatcct tacaccctgg aagtaaaaca 11700 cctcttccaatgcagacagc gggggcatgc agaggtgaac cactaaaccc aaattaacct 11760 gacagatgcaacatctgaaa ccaggcagct gattccaagc catgctctga gccagctatg 11820 tagggcgaatcatgtatgag ggctccgaag gcactgtgct caggcctggg ccctggggag 11880 atgcccacccttgctgagct ccctggtggt ggggggtggg ggcggtggga tgaggctggg 11940 ggtgggtggcaccaaggatg ccagctggcc ctggcactga ctctggctct gaccgtggcc 12000 tgcttgctgttcttacaggg atggaggcaa tggcggccag cacttccctg cctgaccctg 12060 gagactttgaccggaacgtg ccccggatct gtggggtgtg tggagaccga gccactggct 12120 ttcacttcaatgctatgacc tgtgaaggct gcaaaggctt cttcaggtga gccctcctcc 12180 caggctctccccagtggaaa gggagggaga agaagcaagg tgtttccatg aagggagccc 12240 ttgcatttttcacatctcct tccttacaat gtccatggaa catgcggcgc tcacagccac 12300 aggagcaggagggtcttggt gagtggtatc ttcttttccc tcctctcagc tccagatgtt 12360 cctctgactctcttggaaat cgctttcctg aggttgctgt gtgggtctct gtctttccat 12420 tacgcctgtaacccacagcc tcctacacca acccacgtgt ccatccttcc agagtgaacc 12480 tcctccctgttgatgatcac agcttcctca cccaagagac aggcatgtct ttggggaaag 12540 cccaagaacttggtttcaga gcttgccttc ccatccaatc caaactgttc cttggaacaa 12600 gggaaatggcacctcttgtc gggtcatcac gatctgtacc catatcttca cccaaggact 12660 gtttgtcctggtctgaaagc caaccttgga acatccaggc agtgtcagga atgtacctgc 12720 attcctgtttgatcagggcc agtttcttta ccaacacact ccccttacat gagcccagga 12780 ttacagatgtgaaaggtgtg ggaaaagcac tggaggttcc cattcaaagc cagggtggga 12840 gcgtgggaaagggatgaatt ggggcaggaa ctgggaatca tgagaaatta gcatttggca 12900 tgtattggagagagagagag agaatagcct gaaagaaggc agccaaaaca gatcttctgt 12960 ctagcggtctagactggagg tggctatggc agggctctaa ccatcaaatg aggaaagcac 13020 aaatcaagtccagaggagga tgctgaggtc ggcttggttg ttgtctaaac cggagtgctc 13080 tcctcgccttgggggcacag tgaattcaag tccaggcgct tgtgtgggac tcttactcaa 13140 ggacttggggtctctctgtc aacacaagct cctgattcac ctgccctctg cctcaggaat 13200 cagcaggcccagagtttcat ggccttgagc aattgctggg cagtggggtt tctgtgggtg 13260 ctaattgcctgtttggcctg gcactggctg cccgcttggc ttcccggcag cctactctcc 13320 agctcggggaaccagacaag cagcatcgct ggctctaagt cgtgttgctg catttgccaa 13380 tccttgggcctgaggtccac acatcctgca gggtgggcct tctagagccc cagttgtgtg 13440 tcccaggtgacacatggacc ctttcctgcc aggtcctcta acttgggggg ctgccttgag 13500 tgctaatgagaggggaatct aacgcacacc tcagcgcctg cttactacca tgaaacccat 13560 cagaaaggcatggtctgggg tgctggccat ggcaataatt tatgggatgt ccttgctcaa 13620 atggatgtccttgacatatc taggttttag ttaactcaac taatggcatg catgtattga 13680 tatccaccccctctgctaca tagtgttaat ctgaggatta atgagatgac atgtaaaaaa 13740 gtgctttgaaaaacactttt tcagtctgat gaaaaaagct gagatttttg agcctgatgg 13800 gtcaccactgctgcccttca tggaaccatg ctctcataaa ataaacaaaa gcctcgcagc 13860 cagccagccagccactttcc tcgtgtgtgt gtgtgtttgt gtgatttttt tgtagtgatg 13920 gggcctccttatgttgccca ggctggtctc aaactcctgg gctcaagcga tccttccatc 13980 ttggcctcccaaagttctag gattataggc atgagccacc atgtctggcc ttgtgtttct 14040 ttcactcattccgtcaccag acttcaatct gcatttataa tctggcattg ggctaggagt 14100 tgtcaatatggagattctca ccgaaggtca tatcttgtca gtctgcaacc aaagcatttg 14160 gttatggagtctctaccccc aaatccactc tctcctccta ggcctcctcc cccctgagat 14220 tcagctctgggaaatgagaa tcttaggtgg cagctggttg ggtggtgaca cattggaggc 14280 cagttcctcactggagtggc tctgactgct atgcatctgt agttgctgcc cttggacaca 14340 ccactaggctgggaatcctc aggacaggag catgtgaggc atctgggtgg agagaggaca 14400 ggtcctgtcatgccccaggc tgagtgtgaa agatggcaga atgaacaagg atggtatgtt 14460 tgtaatctgtgtcaccacag actgacagag tggctgtgtt gcttgtgggc acatgatgcc 14520 accttaacccactcttagtc caccttgaca agagccctta gagtctgttg ctggctgttg 14580 gtcacaaccactgcctgcaa tgcctggcac tatgggctgc aggctggttt tgtcttgtta 14640 ccctgtcctcagtctacctt acttagatct ttactgtctc tgtcttgatg actaagctag 14700 gctgctacattctaaagagc caacatgtct gtcatttgct tgaggatgtg gatgaaagag 14760 aatgagtggggttatctatg gattgttcaa gagtaatgtt cagaaacttg agggaaggtc 14820 actgaagctgtcaagaaaga cagctgcaag gttctgaatt ttgtttgata tgtacataaa 14880 caaacacacacatgcacaca cacacacaca cacagtcaac cttcattatt catggattct 14940 gtatttgcaaatctgcccac ttgctaaaat ttaccaaaat caatacttgc agcccctttg 15000 tggtcatttgtgaacatgtg cagagcagtg aaaaattcac atgacttggc acctatcttc 15060 ccagccagggtcttcacaat ctatttagtg ctacattttt tgcctttttt tgatttttat 15120 tggtgactttgctgtttaaa acagttccca agcgtagtgc tgcactgctg tctggtgttc 15180 ctaagtgcaaggccgtgatg tgcctcacag ggaaactatg tgtgttagac aagcttcctg 15240 aggacaacagtgctgctggc tgtttgatca atgttaataa ctcaaccaac aatatctatt 15300 gaataagatatctttaaaca gaaaactcac ataagacaag gttatgtgtt gatcagttga 15360 tgaaaattttgtgaccagag gcttgcagaa acctcaccct gtgtttcctc caggaacagt 15420 gtttcaatattcactaatcc agtgtccaca gtgactatag accataacta ccatgaataa 15480 tgagaatcagctatacatac atcatttctc ctcttcttcc acccctgatg cctgcttctc 15540 cttctttgcttcatccaaat tttatttgga agttttccat tttgatctgg tccaaatagt 15600 tgcttgagaaccctgtggtc actcatatct gtttgtgaaa ctctgatccc aggaagcaag 15660 gacaatgtcagtggtctgta ccttctctgt ggtgggtact gcatccttgc atccttggga 15720 acacagagatgacaggaacc aagtccttgc tctcaagaag cttgcttgac catttcctga 15780 tagttattgacagacagcat tgcttgaata ttgggtcact agctcttttc caagccctgg 15840 agaccagtaatccaatccca tttgaccatt tagtatttgg tttggcttct aagatagtta 15900 actaaactgctctaggagct agttgttatc atcaaaacga gtctaagact cataatctag 15960 ctgaagtgtgatgatggtta gaaggttaga gagggatcac agttctattg atctatgatc 16020 aggcattagaggccattgct ggtcaattcc tcctgcaagc tatttcatgt tgcttgtgct 16080 tcctgttattctggaataca gggacatcct cagagaaaga tgatatttcc agtgtgaata 16140 taaggttggcacaggcaggc ttatagatgg ccagacacct cttggctata tgttaacaac 16200 taaagcataagtaagagcca gaggaggaaa aacatttgga ataggtctat tccaaatgac 16260 atatatagtggatgatccat atatgtatat gcatgtggat gcatatggtc atggatggct 16320 tcgtccggagtctgatataa aggaaaaggt gtaatggaca gagaagaaaa tcagaggaac 16380 ccctttgatgaagagaatga aggtggatgg tgaggtttaa gagctgatcc tggaaggcaa 16440 gatgagaaacaggtcatcgt ttgcctgctt atcttgtctt cttcctccct gttgggatgc 16500 ttaaataaggactctgtgca gctacaagct aacaaagaca gtgcagagaa gtgcgttttc 16560 gcttcctagctccaaggttc ttgaggactt tgttaattat gggtcatgcg gagtgcaggg 16620 ggcaaaaggtaggctggcga ggatccagga agatgaggaa tgttctggca ttcaggaagg 16680 tcaccccactgatatttgta gctcttctag caacctgatg tgaaaggaag cagagaaata 16740 gggcagatgtccaggaattt aaaacctaaa ctgcttaaag gagagaaaat agagaaaaaa 16800 gggaggaacagccacacagg gtattctatg ggcacaagta aatgagtgac caagaagtca 16860 gtgttgctggagagactttg tccaggtcca ctttggcagc tgacctccat tcacagatat 16920 tcaaggatgtgaatgaaaga gaatgagtgg ggttatctat ggatgttcca agagtaatgt 16980 tcagaagcttgggtagagga ggccaaaata tttggagagg gaaggtcact gaagctatca 17040 agaaagacagctgcaaggat aggattttac attacctttt tgtcattctt ttatttcttt 17100 tgaaattcagcactctaatc agggctcatt tgcatgactt tgcactcagc acacacttga 17160 gatcttccctgtgcttgggt tatacagggc cagtggagag catggtcaga tgtgacccca 17220 cacttccaaagcatccttct agagactgcc tgaatcccta gagggatttg tcctagagga 17280 gtccttcaaacagcctctgc ttcatgctcc tggactttgg gaaagcatgt ttttgactgc 17340 tgctctagcttggattgaga gatggtacat tcctgatgag aaccatagta tatatgaaga 17400 tcagtgtattagtccatatt cacactgcta taaagaacta cccaagactg agtaatttat 17460 aaagaaaacaggtggccggg cgcggtggct cacgcctgta atcccagcac tttgggaggc 17520 cgaggcgggcggatcacgag gtcaggagat cgagaccatc ctggctaaca cggtgaaacc 17580 ccgtctctactaaaaataca aaaaattagc cgggcgaggt ggcgggcgcc tgtagtccca 17640 gctactcgggaggctgaggc aggagaatgg cgtgaacccc agggggcgga ggctgcagtg 17700 agccgagattgcgccactgc actccagcgt gggcgacagc gagactccgt ctcaaaaaaa 17760 aaaaaaaaaaaaaaaaaaaa aagaaaacag gtttaattga ctcatggttc tgcatggatg 17820 gggaggcctcagaaacttac aatcatggcg gaaggtaaag gggaagcaag gcctgtctta 17880 catggcagcaggagagacag agagcaagtg aagggggaag cgccacactt taaaaacatc 17940 agatcttgtgagaactcact cagtatcaca agaacagcaa gggggaaatc tgtccccatg 18000 atccaatcatgtcccaccag gcccctcctt cgacacatgg ggattacaat tcgagatggg 18060 atttgggtggggacacagag ccaaaccata tcagtcagat tccttggagt caaacagttc 18120 ttgattctaattccagcttt cagacttgct agctgtgact taaagcaagt tatttaactt 18180 tcccgtgcctttttgtgtca cttgtaaaac agggataata tctacccaaa ggttgtcgag 18240 agcattggagatagtatgta aaatactgac ctagaaagct tccagtggtg atagctagta 18300 tcattatccctttttagtgt cttagttttg aggacagatg gtcctttctt ccttttctct 18360 accatggaacttggaaagta taactatgtg atgtgttggc agtggtctct gaaaagaggt 18420 tcctaaacagaaggagttaa atatcaggta tgaagaggga agggctgggc caggggctct 18480 gagagagcttcatgtcggtc aaaggctggg tagaactggc tggtgctcaa cagaactgga 18540 cagtggttgctgtaactagc acaggggctg tggctctaga catcaggagc tacagcacat 18600 gaaacagaaatatggtttca aactctgctg cctgcaggct cccatgctag gcacccagag 18660 agcaggcctaagacatggtg tctgcttcag gggtctcaaa ttcttaatga gatgtttaaa 18720 atctactttaaaatctactt tcacccactc tcagcactcc ctcccactgc ctctttctgc 18780 tagtttctcttctttccctt tatttagggt ttcctttgtc caggtcctgt tcccttttcc 18840 tttatttagttcttacaacc ctctctgaaa tgttgctccc attttacaga tgtggaaact 18900 aatggatgggaaggttaagt aacttgccca aggttgtgct ttaagattta aactcaaaca 18960 tatcgatctaaccaaagact gcatttcatt tttaatgttt aggtagttgt agtgggtagt 19020 ggattttttaaatgtaacgt cataatatgg ctttttaaaa agccaacagt ttaagaggat 19080 atgtaagtgaaaagtaaatc acctattcaa cccaattctt agttccctac ctcctccagg 19140 aagctgtcactgttgccagc tcatcgtgtt cgcttccaga ttctttatgt aaaagtgcat 19200 atgtgtgtgtgtgtatgtgt gtgtgcacac acgtcaccat tctgcatctt ggttttatct 19260 gctaaagaacacttcttcaa gctcattccc atttcagcat tcttcctctt tctttttcat 19320 agtcacagagtattatatgg aggttctgtg agataagaaa ccagtgcctg gctgggcacg 19380 gtggctcatgcctgtaatcc cagcactttg ggaggccaag gtgggtggat catttgaggt 19440 caggagttcgagaccagtct ggccaacatg gtgaaacccc atctctattg aaaatacaaa 19500 aaattggccaggcgtggtgg cacatgcctg taattccagc tactcgggag gctgaagcaa 19560 gagaatcgattgaacctggg agccagaggt tgcagtgagc ccagatcgtg ctgctgcact 19620 ccagcgtgggtgacagagtg aaattccatc cagaaaaaaa aaaaaaagaa agaaagagag 19680 aaaagaaggaaggaaggaag gaaagacaga tagacagaca gatagaaaga gagaaagaga 19740 ggaaggaaggaaggaagaga gagagagaga gaaaggaaag aaagaaagaa agaaagaaag 19800 aaagaaagaaagaaagaaag aaagaaagaa agaaagaaag agaaagagaa agaaagagaa 19860 aagaaagaaaccagtcctct gtcatggtca tttaggttcg gtctttggct tctccagaca 19920 gagctgcagtaaccaccatt gcgcccatgg accgatctac ccacaggata aatacctgga 19980 agtggctttactgcgttaaa atgtctgtgt gtttaacatg cttcgcattg ccaattgccc 20040 tccaaaaaaaaaagtctgtg ctcttttcta cagtgctaac catcctttaa tgttttttta 20100 aacccacctgaggagaaccc cctgatgctg cctctcacat acatgtaggc ccctacatca 20160 tttgatgtaggtctttttat tcctttagat ttgctggggt ataattgaca gatagacatg 20220 gtctatatttcaggtgcaca actcgatgtt ctgctataca tatacattgt gaaatgatca 20280 ccataatcaaactagtaagc attcccagca cctcacatag ctttcagatc aggagctctc 20340 gctagttcctgtatcctgag cagacgctgg aatctctgtg acagtgcagt ggagatggag 20400 cccagaggggatagttgacc ctacgcctgg gttatgcaac gtgcgtctct gctggcagag 20460 gccacctactggagaaaggc ccaactgtcc caggcctgag gccctggccc caggctcttg 20520 atgcttttgtgaggtttttg tctctttctg ttttgataaa ctggtctctg gcatgagaat 20580 cggtcaatgtcctctctcac ccctggcttt ctagaaactg catctatatt tagcttggtt 20640 gccccacccctaccccccct tcctgagctg gggtataaat gccaaccaac cagaggatga 20700 cagggtccaggctcagagag cagctgaggc aatgggctct catggaaacc tgaagctctt 20760 gtttctcaaatccaaaccag ctcacaggca attagtattg ggaggaaggc agggtagggt 20820 gtagaccttcaggacaaagc acagagccag ggttgggcag tctggctgcc ctgactcctc 20880 gtgggcagagagtaaatgac agccacacat gtggaagtgc ccttggaagg caggagaaca 20940 gggaagaacaggacctctga gccaagagga tctgtggccc agcaaacaga catgttgggc 21000 cagacacacctgaaaggcca gctctgggat ctgagttcca gagagcctct gggtctggca 21060 gttggagctggggagcaaac tttctatacc ctgaacactg accccacgct ccagagcgta 21120 atggtgtcctcttccttttc agtgttctcg ggcttcatat gacaactctt aagcagaagc 21180 aagggcgccaaacttttttt ttacccccag tactttctct tttatttttt atttctagag 21240 acaggatctcactttgtcac ccacactgaa gtgcagtggc acaatcttgg ttcactgcag 21300 ccttgacctcaccagctcaa gcgatccttc caccttagcc tcccaagtag ctgagaccac 21360 aggcgcatgccaccatgcct ggctaatttt ttttaatctt ttgtagatac agggtttcac 21420 catgttggccaggttggtct caaactcctg agcctaagct atctgcccac ctcagcctcc 21480 caaagtgctgggcttacagg cgtgctcacg ccactgcacc cagtcccagt actttctctt 21540 aattcagctctgcactattt tctcttccta ttcctttttt tttttttttt ttttttttga 21600 gatggagtctcgctctgtcc cccaggctga agtgtagtgg cacgatctca gctcactgca 21660 agctccacctcccgggttca cgccattctc ctgcctcagc ctcccgagta gctgggacta 21720 caggcgcccgccaacacgcc cggctaatgt tttgcatttt tagtagagat ggggtttcac 21780 cgtgttagccacaatggtct cgatctcctg acctcgcgat ccgcctgtct cggcctccca 21840 aagtgctgggattacaggtg tgagccaccg cgcccggcct tctcttccta ttcctagcct 21900 cattcctgttgtcaggcaaa gtggggctga gtggcaatct ccaaccctcc tgcgtataga 21960 catctgagatggagcttcat atttaaagtg acatgagaaa aatgagagaa agatggcgaa 22020 gcagtggaatctcttttcag gcaaccctgc agctgggggg gctgccccca agtgagggtc 22080 aaaggcaggctccctggagc ctggggaagg acagacgggg cctctgatag gccctggggc 22140 ctcaagaagctctcagtccc gggcccagtc tggtgagagg ctttggctca catcactgta 22200 ggtggtggctgggctaggct gacgatgtgc tgtcttcttg gtgcccatgg ccttgcaggc 22260 ttaacaggaagagctctgag ccagacaaga cagccagtgg gaggacagag cagcccctca 22320 gtgaccagagcgaaatgccc ggttgttgaa aaacaaaaaa aaaaaaaagg aaatgagagt 22380 ttcttctgaaatagaaactt ctggtccttg agtaagttta gagaattacg ggcattctga 22440 ggcctgagcatttgtggtga cggatgaagc ctcaagaacc acaaggttgg tgggagggac 22500 accaatctcatgtcctggaa catacagatg tccctgtggg gataattgta tctcgtttct 22560 ggggaaccctaacagttccc aagatgcttc catattctct tgtccctcca gaaaagcagc 22620 agtaaacaaatagaggtgaa cggcaaaagg ctttttgttt ctacgaagat ggaaaaaagc 22680 ctggcgtataacttctttct tgttagctac tgcagggtta ggactgggcc tgaggcgggc 22740 tagacttggagctaaggagc ccctgatagc ctggtgctgc tccacctcct gacaaccctg 22800 gctctgcagtaggccccttg ggtgatgagg gttgtcacag cagggtacca gagccaaggt 22860 ccaaaaccaacagcagctgc ttccttgact gttgggtcat tcttggcatt gagccacctg 22920 gggctgtttggggcatcaac ttcactgagc actttaagtt tctggggttg aaaacaatcc 22980 aggaagctaaaggctaagcc ttagatccct aagacttcca gacctaggag cctgcacttc 23040 ttgctgaatatcctcacctg taagtttctt aacctcagtg gtcccacgta taaagggagg 23100 gagttacactgacggtctct tgggccctct gtggatctaa gagtctgggc ctgcctggga 23160 ctgccagtagagccctactc tggtctcttc tctatcccag gggctgagtc ggtgtggtcc 23220 ccagctgtccatttgctaga gcaagcttga caattgatga gtgcgattcc cctcaacccc 23280 atgtatgttctagtgaatgt gaacagtgag tcatgtttta ccaagaatcc taactaatgc 23340 ctggcccctgagcagatgac gtcagtagct catctccagg aaggaaatgg ttgggcctgg 23400 gctttggcttggaaggcttg ggcatcttca cactcagcag ttccttggaa gatgctgctg 23460 ctcatgcagacagtgattct gccaccatct ttccccatct aactatgtca gaaaagtggg 23520 gcctactcctgctggggctg ggaggaggac aggactctca ggacatggat gatgaaaagc 23580 ctctagggaggtgcctcagg gaggtgtcct ttatgcagcc tcccaaagtc cacgtggtgt 23640 ggctggcagtgggagagaat gttcgaatta ggaaaatgag cccttaaatg tgcacacttg 23700 tgcacacacacacacacaca cacaacttac ataggctaca agggtgccac ttttcttttt 23760 cttttctttctttttttttt gagacagagt ctcattctgt tgcctaggct agaatgcagt 23820 ggcacaatctcggctcagtg aaacggccgt ctcccaagtt caagtgattc tcctgcctca 23880 gcctcccgagtagcggggac tataggcatg tgccaccgtg cccggctaat ttttgtattt 23940 ttagtagagatggggtttca ctatgttggt caggctggtc tcaaactcct gacctcatga 24000 tccacccacctcggcctctc aaagtgctgg gattacaggc ctgagccacc acacccagcc 24060 tcaagggtgccacctttcta gctaagaaca cttcagtagt tttctgggtt ttttttgttt 24120 tgttttgttttgttttttga gacagggtct tgctctgttg cccaggctgg agtgcagtgg 24180 catgatcttggcctactgca acctctacct cctgggttca aacgactctc ctgcctcagc 24240 tcccagcccccaagtagctg ggactacagg catgcaccat catggccaac taatttttgt 24300 atttttagtagagacggagt tttggcatgt tggccaggct ggtctcaaac tccttacctc 24360 agatgatccgcccacctcag cctctcaaag tgctaggatt acaggcctga gccactgtgc 24420 ccagctctagttttctgttc ctacagagct cctgcttcct cttcctttca aaaaacccaa 24480 ggccaggcctcaggatttcc acctgcttgt ctggcccctt ctttttctgg gcaggttctg 24540 ggatgtctagagctatggtt tgggcctttt cttccttcca tgtacacatc tatccctgga 24600 acaggagctattccagtcac aggtctctag aatctagaag acttcatgct gagactagca 24660 tccttacttctcatagcggc tcattaaatg ttattatgct ggctactctg gagatttcaa 24720 tatttaaaaaggtttcttcg gccaggcaca gtggcttacg cctgtaatcc cagcactttg 24780 ggaggccgaggcaggcggat catgaggtca ggagatcgag accacagtga aaccccgtct 24840 ctactgaaaatacaaagaat tagccgggtg cggtggtggg cgcctgtagt cccagctact 24900 cgggaggctgaggcaggaga acggcatgaa cccaggaggt ggagcttgca gtgagctgag 24960 atcgcaacactgcactccag cctgggcgac agagcgagac tccatctcaa aaaaaaaagg 25020 gttttttctagggaaatgca cttttgttat ttcctgttta attttttaaa atgggaaggg 25080 gaacagagtactgtaaaata agtataagag tcggggcgtg gctgtgcgcg atggctcacg 25140 cctgtaatcccagcactttg ggaggccaag gcaggcggat catgaggtca ggagatcgag 25200 accatcctggctaacacggt gaaaccccat ttctactaaa aatacaaaaa aaaattagcc 25260 aggagtggtggcgggcgcct gtagtcccag ctactctgga ggctgaggca ggagaatggt 25320 gtgaacccgggaggtggagc ttgcagtgag ctgagtgagc cactgcactc cagcctgggt 25380 gacagagcaaaactccgtct caaaaaaaaa aaaaaaaaag agtcggagtg cagtggctca 25440 cacctgtaatcccagcactg tgggaggcct aggatagagg attgcttcag cccaggagtt 25500 ccagactagcctgggcaaca tagtgagacc ccatttttac aaaaaaatca aaaaattagc 25560 caggcatggtggtatgcacc tgtaatccca gctatactgg aggctgaagc aggaggatta 25620 cttgaacccaggaggtccag cctgcagtga gctgagatca tgccactgca ttccagcctg 25680 ggctacaaagcaacaccctg tccccccaaa agaaacaaaa attaaaagaa aaaaggtaag 25740 tacaagccatgattggagct gggcaggcaa tgaaaggaga agtaggaatc gtttggtgcc 25800 cagcctagaggtgagagtga ctggcagctg gggtgggcct catgtcttct gttggagaaa 25860 tggagaccagggggcccaga agacaggtct ccgtgatgac agggtgagga gccggaagtt 25920 cagtgacccagggcagggtg tgtgctctct cggcaggcga agcatgaagc ggaaggcact 25980 attcacctgccccttcaacg gggactgccg catcaccaag gacaaccgac gccactgcca 26040 ggcctgccggctcaaacgct gtgtggacat cggcatgatg aaggagtgtg agtgtccagg 26100 ggctgggcagggtttgggcc tgaagtggag tcagggaaag gccttggcca ctctcctgca 26160 agtttgggcagagggtctgc ctgcccttcc tctgtagctg ccagcatctg gggccagggc 26220 ctcagtgggaccagcagctg gtgacagggc agctggaagt ccagggtcag atgcactcag 26280 cggccctgtgcacctcttga ggatctgtgt gttggtgtca gaggccctgg aagggtccct 26340 ccagagtggggcctgagagg aaggagaggc cggacactgc cttcaagagt cccttctact 26400 cctgggtcagggtcttcctc caggatgtca ttcttttttc acagctccct gttactcgga 26460 cctagagggaagaatgaggt tcaaggaccc ccaggttcta tgggcttggg aagagagggc 26520 tgatgtgggttaggaagggc aggagtgatg gggagaatta gtattcagag catagttggc 26580 atccacgttctgtcccaccc cagcctccca gcctctctgg cgccttgagc agatctgagg 26640 gcttgtgccagggagagacc aggaggaaag agtctgccag gggaagcact gggttctagg 26700 acgaccctctgaatccagat ggagaaagag gagtgattct ataggacttc ctgtccctct 26760 ctggggttggagaagaccaa catggcatat ttacatggat attttgaccc atcactgaaa 26820 acaacacttgaactttgcat cagagctcta ggacagttat ttggtaacta gagtaggcat 26880 tgaattcagtagatgctggg aggggccagc ctggccctct ctgggctgga gcaaggccag 26940 ctgggcatgggtgctctctg tacactcatt cctttttctc cttctcttgc tcactcctgt 27000 ctgccatctgcatccagacc cccacccggc cctaggacag aacccaggcc ctcctagctg 27060 tgggtctgaggaatcggagt cggagtcggg gtggggatgt tgctcagatg cggaccctcc 27120 tggctatgggaccgtttgga gtggttgggg atggggagag gtcaggtaac aggaagatgt 27180 gtcagggacagaggataagt cacagaacag ggcttagagg atagcaaatt tctccgttaa 27240 tgggaaaaaaattatctgtt gttgggacac agaggcagag ctgaggccct gaccctgggc 27300 ttcctctttgggccttgacc taggcttctc ttctgtgggt catgactcct ccctcctgat 27360 ctgacggctccccagccaac actggcagcc ctgaaaggtg tttccagggc tgtggtttct 27420 ccacaccatcacagggtgca ggcctgggca cgctggtcgc tcctacccta gtccctgcca 27480 cgccctggctcctgtgttta tcctggagag aataagaagt ggaggctgga ggcccgggtg 27540 ccttaagaggcttcacacac attctcagtg ggccctgctc agggtgaggc gttagggtgg 27600 gcaccaacaaggtgtgctca gcacagtccc atctccgcag agaagacagc ctctgcaaag 27660 cagggagtccggtttctaaa gctccagcta accaagactg gcacgaggtt ccactgcagt 27720 ggttcgtaaggcactgccac aggagttccc ctcaggacta agctcactga tgcccaagag 27780 gcccctctcctacctcagga ggaagaggat gtcttactga cttaaaatag aaagaacatc 27840 tgagactcagagaggtaaag acctcaggtc tggggtcaga aagcaagttg gtggccaagc 27900 tgggactagaatcagacttc atgtcccctc ctacctgcct cctggtcccc ataaacagcg 27960 ctgcatccatggtgaagagc agcaccagcc tggggtaaat cagggggccc tgcccaggag 28020 caccctaccacgtggtggga acccagcagc ccagaagcga tgtccacccc atccctcagc 28080 cacgcccaccccagcctaat tctctcctgt ggagtcctgt gtccccatcc tgctgtatgc 28140 ccaaggtagcttctcgccac accaccctcc tcatcccagt gcagggagca gtactcagtt 28200 ctagatgggctggtggagcg gggatccagt taaaatagaa acgtcctgat gctttttact 28260 ttcctgaagggaagactgtc caggaagaga cattcccagc ctcaggttag tccagcttca 28320 ggaggcctcaccagtgtgaa gtcccccggc ctcagaaccc tgggagagct gcacatttct 28380 tatctgggctgggttttgtc cccaaggcat agcatcccag agacaattga gtgtctcaat 28440 atttgtaaaaccacaggaag aaagctaaaa gcccaggctc ctgctgtccg agcaaggagg 28500 tgggccttccatagaagagg cacaggaagg gaaaggatga ggacagaaac cctgtgtatt 28560 gaccaactactgtgtgtcag atagcacatc aagcacatgc attttcttct gaaattctca 28620 caacactccctaaatacgta aatactttta ttttttcaat agctgaggaa gctcagagga 28680 attaaaatatcatggctctc agctaataag atgatggtat cagcattcat tctaatctag 28740 gtctttctgcttccaaaggg caggcttgtg ggccacaccc gaggcagcct ctcgtggccc 28800 cagtgggtcggagctcactc cattgtgcat ttccaggcac tttcacatgc tctaagagat 28860 ggattgaagagagcttggtc ccaccaaaga ctcattttct ctcttttcca ttcttagttg 28920 actttataccctgggaaccc aagaaatttt ataactgagt tcttgctttt tgcttatact 28980 attacctgtcctgcacagaa ccacacattg tggtaacttg tttgatgttt ttacagatgt 29040 atgtcttttctccctggtgt tagtaaagta cctggcacat agtaggtgct caataaatgt 29100 gtggaatcaatgaatattag ctcctcatta tgcttctttc tctctgtata tcttccacag 29160 gtctatagatcagtaagatt ctcccaaacc tgatcatgtc tgtgccgttc atttggaaac 29220 attttatgtcctcttcctgt ggttgttctt agcccatcct tggcatcttg aaatgttttc 29280 aaattgtttatgttgcagat cttggcttcg ttaaggagag aacatgtctt gcatgggaat 29340 aacttgcgcaaaattatttc acactcagca aggagcttaa aatgaagtca aaaaaagctt 29400 ctgagcagccatgtaggttt tacaaagtcc acatgccaaa actcatgcac tttagacgcc 29460 tgatcaccagacagcccaac actctttcag aacctgttta ctcttattct aggtcaatgg 29520 cttcatatatcatatagtgt cttcctatat gatagtaatg acatcttagg ttcaatccat 29580 tgaaaaaatgataagaaatt tcccatgaaa ttaacaagat ctttaaacaa attatttcgt 29640 aaatcacagtgcatttgcat atgtgaaaga ctttagactt attcagtcct caagcaatgt 29700 tgccttgcagaaggctcatg gattgggcct gtgtgaaact ggtagatctc agcatttctt 29760 cctctgttacctccatagaa gatggaggtt gctatttgat gcaagtgact gggaggaatc 29820 atgttatagggttaaacttg aactttcttt gtctctttaa agtgggtaat ttacaagctt 29880 tgtgacttaattttattttc acactcttca gatggattgg aacacaatgc ctgtcaaaac 29940 tccatggctgaaagccaaag tccgcttata accagatgta atcagacaca gtagaggcta 30000 gtggttatgaccttccactc cagaaccaga ctgcccaggt ctaaatgctg gtttcaccac 30060 tgttagctgtgtgactttga gaaaggtaga aagcctctct gggcctcagc tccctcatct 30120 gctaaatgggaataacaaca gcacctgcct taaagggttg tcatgagggc taaatatatg 30180 agttaatatacaaaaggctc tcagaatagt gccttataga tagaaaaact ctttatgtgc 30240 catccagcattacgaatatt ttctttttat tacatcaaac ttgatcacca gaacttctag 30300 ctcccaagagatcagaagta agtcttaagg gggagaaagg cacacatcca gaggcagaca 30360 ccaataagaagacaacgcat agtttaacag ggaggtggac actggaagca agaaaagcag 30420 cccaagaactccaaagccca gcacgccaag ccatgcaatg cggggcagac agcctctgac 30480 aactctgaggctgtaacctt gtcctgcaat gttcagtaat tattcagaat gatacctctg 30540 aatcatcagggaaaggttat atgacgttaa aagtgttccg ttacaaggtt ttctgtcttg 30600 aaaatctttccataacaatt gtttcaataa aagaggtcag ctttctcagc tctctggtgt 30660 gccaggtgccattcactaca ttgcaggaga caagcagcac tagagtactc actagccttt 30720 cctgaaccaggaaaatgatt tgcacacagt tggtgtaatc tgtgtggatg catttgatat 30780 ttggtgtcagactattgagc agacaccacg gccaggtagc ccctccggtc tagcctttat 30840 gggggaaatataagaattgt aagacaaagg ccgggcatgg tagctcacgc ctgtaatccc 30900 agcactttgggaggccaagg cgggcagatc acctgaggtc aggagtttga gaccagcctg 30960 gccaacatggtgaaacccca tctctactaa aaatacaaaa aaattggcca ggcatggtgg 31020 catgtgcctataagcccagg tactctgtag cctgaggcag gagaatcgct tagaacccgg 31080 gaggtggaggttgcagtgag ccgaggtggt gccactgcac tccagcctgg ataatagagc 31140 gagagtctgtgaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga 31200 aagaaagaaaaagaaagaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag 31260 gaaggaaagaaggaaggaag gaaggaagga agggaaagga agggagagaa aagaaagaat 31320 tgtaagacatggaccctgcc cttaagtaac ttgtaatcta gagaaagaga ccttgaactt 31380 cttgggctccgtctataggt aatgaattga aaactgtgct aaccatgagt cttacagagc 31440 agaagataattgggtgtcaa tgtgtgtggg aaagactaaa tatgtagcag gcataggaaa 31500 tgaggctcagcagaaaaaaa caaggcttga tgcagatcag ggcaatcaag aaatgcttca 31560 tggaaaaagatggctatgat gtaggcactg aagaactggt agaactcata caggtttggg 31620 ggagagaaaacccagctgga cgggcaccta gcacaactgg aaatgcaggg gcgagcatga 31680 gcaggtcatgttcccaggcc agcagcaatg ccagcatgcc cagaacagag gctgtgtcca 31740 gaagcactaagacatgaagt ctgaaagtta ggaagaggcc aactttagtt tggacgtggt 31800 catcagtaggggccgagaaa agtatctggg caggagaatg gcatcacaga atcactggaa 31860 agttagcaaagtccagtcag gctgagctac gtgcctgtag acaccatggt gtggctggca 31920 gaaacaggtctccctaactc tggtccccag gtgagcagga aagacaagac acctaatctt 31980 gggctccccaagcgagggct tacccccatt gccttccctg gatgctccct gccccttcct 32040 ctcccaccctgcctgacctg gtagggtctg tgcagacacc cactgtggga ggagagttgg 32100 cagctgtttgggcaggtgag tcagtcacct gggtgtggtc tactcccagg ctccctgtgg 32160 agggaagcaccatctcttgc agtagcgctc gctttcctgc catgcctgtg gcattggctg 32220 tccactccctcccagcatag gctcttcctc accccacagc aacttctctc gtcctccccc 32280 tacctgagggcctgggccaa tggacctttc tcaaagcctg gaactcaccc accctgggct 32340 tctggttcctttctctgctc ttgtgaaact ccccagttct gtgggcagat gccctggcag 32400 cagcagcaccaagcaagtag ctacaggcca aaggccctgg tgcccactcc tgccgtcagc 32460 actcagcaagccacagccag gaggtctgtt tgcccagccg ccgtgccagg cacctttgct 32520 cccagcatcccctccacccc cacagctgcc ccagcacagg gaggcaggca gaagcctgca 32580 ggtggtggtggggctctcta tggccccaca ccctgattag tggctggaga gaacttctaa 32640 gattagagctgcaaggcctc accctttggg gccttcaaga ggacttgaaa acttccatgg 32700 acagaaatgtcaaggctgta catgctggag gaggggtggt tttgcagaga accaaagagg 32760 tctagtctttctatattcca cagtcccatg tctggaaacc tggatgtgga gacagccaca 32820 tagaggagtcctctccacat ctcacttcca gcgctatgag agctctggca tcctctcttc 32880 accctgatatcttcttcagg atcatggaac atcagggtag ggaagagaag agaactaaca 32940 tttagtgagcatctgctctg ggccaggcat gcatccagtt ctcaaatcag ttgatccttt 33000 gaggcaggtattattacttc ccccacctgc atgtcaacac acacagacac acacacacac 33060 actttatggaggaaggtaca agaaaggaac cttggaagaa cttacatggt ccaaatctct 33120 cattttacaaacaaaagaac aaaagcccag agagtttgcc caaggtccca caacttgttc 33180 ttgagaaccccgactcccta aagcccagat catcccccct ctcaaatcct ctttttcttc 33240 ttcttgcatgtgccttcctt ttcaccatag caaacccaat ttttcttcac acagtggagt 33300 gggagtctccgtggcaggag gacccccgag ggagccccga gtgttaaagc ccctcctatc 33360 ttggacctttacccccaacc gcaggaggaa ggtttcctgg aggagctgct ggccagccct 33420 cctgactccccttcccaccc cacagtcatt ctgacagatg aggaagtgca gaggaagcgg 33480 gagatgatcctgaagcggaa ggaggaggag gccttgaagg acagtctgcg gcccaagctg 33540 tctgaggagcagcagcgcat cattgccata ctgctggacg cccaccataa gacctacgac 33600 cccacctactccgacttctg ccagttccgg gtatgtctgc ctgctgggag gatgagccgg 33660 tccagaggagaagcactagt ggagccaggg cccagggagt agggacagag ggcaggggac 33720 atcctgaacagaactggggt agggacggag gctgctctgc ccctggcact gggaggcttc 33780 gccttcctgtagaccttcct caaagccatt cctatcagag atcagggcca aggtaggaag 33840 gcaaccccaaaatgtgggtc tgagacccca tctttccctt ccagcctcca gttcgtgtga 33900 atgatggtggagggagccat ccttccaggc ccaactccag acacactccc agcttctctg 33960 gggactcctcctcctcctgc tcagatcact gtatcacctc ttcaggtaag caggacttca 34020 gtcctccatagagtaaggga gcgggggcga ggagtccacc gcacctgccc tggggctgct 34080 ggatggaaggaggtggaagg ctccctaatg gaaacttaca taaatactgt gcgctatgca 34140 gcgtcttcacaacagcccct ctgttacaga aaggggtgac ttacccaagg gcccacactg 34200 gggaagaggccaagctggga ttccagctgt gtagcatcag cctcccgggc ccatgctgtt 34260 tcctctaagccaggcttcag cccatggccc cctccgtgga ggtgacctgc ttcctttacg 34320 tgatattttaatcctgggcc cttcagaagg tgaaatttgg agtgggaagg tgaacgtgtt 34380 ggtcctattgaggtccacct tccacttgag ctctggggac cactctggcc ctggaggacc 34440 tgtcccctccagctcagctg agagtctggg aggcatcatg ctttccttcc tttctttttt 34500 tttttttttttaaaaaaaac acatatgtat atttagaaaa gaaattgtgc tgtatacaat 34560 ctgatgacttgctttttttt atatggcatt gtttttccat accagttagt acgcatccag 34620 aatataatttttaagggctg catagtattc tggaatacaa taatgtacct aatcccctac 34680 cattggatatctggattatt tctcagcatt ttaataagaa aacagtatac ttgtagccaa 34740 atatttacacttatcggaaa ttttccctta caatgaattc caggaagtgt gactactggt 34800 caaagagtacacacaattat ttgactaatg tcaaatagct ttctagagta ccttcagtaa 34860 tgtgcacctcctttagcacc ccagccctca taggcattgc ctaatttcct gcatctttat 34920 aaatactggcatcaatattt aaacattttt gtttctggtt tgtaggtgaa aattatagat 34980 gttctacactgcagttcttt gaccattagc aaggttgaac atttttttcc atgacttgat 35040 gggtcccaaattctttcttg attgagatcc ataggaacag cacacagtct gcttgaggaa 35100 gtctcattgctctgagtgtc tctggctctt tgattttact gccttatgct gctgaaagag 35160 gcagagagagtcccagaggg aagcctgggg ctgaagggtg acctgtggag tcactgtggg 35220 attcccagctggctctgctg ccagggcaca ccaggttttt gcagggtctg gcaggagggg 35280 gcctggtccaagtatcctta aatagctcct tctcttccct catctctccc agacatgatg 35340 gactcgtccagcttctccaa tctggatctg agtgaagaag attcagatga cccttctgtg 35400 accctagagctgtcccagct ctccatgctg ccccacctgg ctgacctggt cagttacagc 35460 atccaaaaggtcattggctt tgctaagatg ataccaggat tcaggtaaga aacttctgca 35520 atctctggggaacagagtca gagtcctaga ctgagctaca agaagggttg gagatcactc 35580 atccaccacttctttttttt attttttatt tttttaaacg gcatcttgct ctgtcacgca 35640 ggctggagtgcagtggcgcg atctcggctc actgcaacct ccgcctccta ggttcaagcg 35700 attctcctgcctcaacctcc caagtagctg ggattacagg caccagacac cacgcccggc 35760 taatttatttatttatttat ttatttattt atttttattt tttttccaga cagattctcg 35820 ctctgatgcccaggctggag tgcagtggca ctatcttggc tcactataac ctccgcctcc 35880 cgggttcaagtgattctcct gcctcagcct cctaagtagc tgggattaca ggtgtgggcc 35940 accaagcccggctaattttt ataattttag tagagacggg gtttcaccac gttggccagg 36000 ctgctctcgatcacctgacc tcgtgatcca accaccttgg tctcccaaag tgctgggatt 36060 acaggcatgagccatcgcgc cctgccctaa tttttttatt tttagtagag acggagtttc 36120 gccatgttggccaggcttgt ctcaaactcc tgacctcaag tgatccaccc acctcagcct 36180 cccaaagtgctgggattacg ggcatgagcc acagcagcca gcctccattg cttctttaaa 36240 atagagattcagaccctacc ctagacctgc gaaatcagaa tctctggcgt aggcccagaa 36300 atctgtatttagaaagtgca gcctgtcttg cgttactctg caggccagca ctggagagct 36360 agtccatccccgcactttct ggatgatggt gtggaagccc agagaggtcc aatggccagc 36420 caggatcccttccaggtgtt ggagccagca tgtcagagcc aggcctagaa ctcccagctc 36480 actgctgtgttcactccagc tggcttgact ggaatcctca tattatctct ttaaattcaa 36540 cgatatgattcctccacacc ccaactctga gagcagaatg aagtgataga gagaagggct 36600 tggccatgtagacttgtgaa acagtctagg aatcctggag agagataggt ttactggcat 36660 atatgaccctggcatccttc accaaaatgt acatttaaag accatttcct ggctgggcac 36720 agtggcacatgcctatccca acactttgag agactgaggt aggaggattg cttcagccca 36780 ggagttccagaccagcctga tcaacatagt gagacctctt ctctacaaaa aaaaaaaatt 36840 ataaattagccaggtgtggt tgcacatgcc tgtagtccca cctactaggg aggctgaggc 36900 aggagaatcacttgagccca ggaggtcaag gctacagtga tccatgattt caccactgca 36960 ctccagcctgggcaacagag caagaccctg tctcaaaaaa gaaaaaaata aagaccattt 37020 cctaaccatactgatacatt tttgccaaaa tatataagta taaggagttc tactggagaa 37080 gggatcctcctttatcaatt cattcatata aatttcattc atttattcct atgtttcatt 37140 gttttaacactagtactgta tataatactt atatttaaat actcatgcag tgttaatttt 37200 ttttttcttttttgagacgg tttcgctctt ttcacctagg ctggagtgca atggcgcgat 37260 ctcagctcactgcaacctcc gccttccagg ttcaagcaat tctcctgctt cagcctccca 37320 agtagctggaactacaggag cgtgccacca tgcctggcta attttttgta ttttttttga 37380 gacagagtttccctcttgtt gcccaggccg gagtacaatg acgcgatctc aacttactgc 37440 aacctctgcctcctgggttc aagcaattct cctgcctcag cctcctgagt agcagaaatt 37500 acaggcacgcaccaccacgc ctggctagtt ttgtattttt agtagtagag ttggggtttc 37560 accatcttggccaggctggt cttgaactac tgacctcagg tgatctgcca gcctcagctt 37620 cccaaagtgctgggattaca ggcatgaacc accacgcccg gccaatattc tttttttttt 37680 tttttttaattgaggcagag tctcgctctg tcgcctaggc tggagtgcag tggcatgatc 37740 tcggctcactgcaagctccg cctcccgggt tcacgccact ctcctgcctc agtctcccga 37800 gtagctgggatgacaggcgc ccgccactac gcccggctaa tttttttgta tttttagtag 37860 agacagggtttcaccgtgtt agccaggatg gtcttgatct cctgacctcg tgatccgcct 37920 gtctcggcctcccaaagtgc tgggattaca ggcatgagcc actgccggcc aatattctta 37980 aaacaatagagtattgacac atttaataga tgtgttggga aatggctata tttatgtata 38040 tttgtatcttcattcttccc caaagttcat ttggtatatt gccataaaat acataaacaa 38100 tatggttgagaaagagaagt aaatcaatct caagcaatgt tattgtcttt caagtagcag 38160 caatagctgtatttacggca gaaggggcaa aatgcttcct agatactaat gctcagattc 38220 agtgctggaatatggggagc tggaaaatga gttaacattg ccggctctgg atggaaacag 38280 attatgaggtgccatatatt ggtgtatggc cctcttagct gtgtagaaaa gccatgagtt 38340 attgccgaaattaatgcctt gccagtgaga tgatggtcat tcacagagct aaacccagaa 38400 ctttccagtttgtttctgcc ctgagaaaac tggctctgtg ttattttatg cctctcacca 38460 acccaaataacagaaatttt tcgatgctct tcccctggaa ttaatgtgaa aatggtgaag 38520 aagagaaaactggcagacag tgctgagaca ctcctactgc attgcacatt ttggttgtag 38580 tgataggagcgagggcccct ctggcaggca ggcaagcagg agcaagcgac agatcttgtg 38640 tgagcccggcattgctctga gcccagggtt taccctcaga ggctttcttt ggaactgaca 38700 acacattccgtagagcacaa gttccaactc cctcctccac gcttcacgtt actgtttgca 38760 aactccacatattccaaagt cttgttttgt gtaaacagct agggaaaaaa cacagaagca 38820 ctcggcttccatcctcatgt caggcagcag tccttgtcta cacaggcttc atccttccct 38880 gctctagtggggagtaggac agagggcccc cacggccctt tccagataca gtgattccag 38940 gttcagtgattccaatggtg gctgagattg catacacggg aaagctgccc taaaaagaaa 39000 gttactcattaaatcggatt actccaatgc tgcccccttc actaaggaac cccagcctcc 39060 aatttctcccatgctcaagg cccctatcca ttgccctccc acatgtaccc tgacacaaat 39120 agcactactctcagtttctc ttcccgaggt taagttgaag tctgccctct tcctttcatc 39180 atgttctcctctgtccccta gtctgtcctt gcaactcatg gctaaagtga ggtacatatg 39240 gcaggtacaggagctgccca gccattgatg caaaatgggt taaactgatc ctgaacatgc 39300 tagggttggcttctctgtct tcagtatgac ttgagaagtc ccagagcaga aggtatgcca 39360 atgaaaatggagcaggcctt gctaagagag cttgcaggga cactggtatg gacgctctct 39420 gtgactggacagaggtgatg ctgagcctgg actggagccc aaacctaggc tccaactggg 39480 cccagggtgggccagcccag tagctctctg gttctgctgc tttccacact taggggttct 39540 attgttccaagacatagaag aacagtggct gcatccctgg tggctttgat cttgctgcct 39600 gcaggcaggggcggagggtg tggggaaggc aggatgagac ttctgtgtgg gtgtgtgggg 39660 gcacaggatgagtctccagt gggggcatga gaccaacgtg gggcagggct ggatgggctg 39720 ttcttggtgtgaactgtgct acagtgtggc cttggcctgc tctctcctcc catctctcct 39780 cccttagcctctcagtctca ccccacaaat ctccctccct gctggcactg caaatgaaat 39840 gcatggaggaggtggcatca gcagcagcat ctaaatggcc aagagcagcc ttagatctga 39900 ggacttgggacccccaggct tcactgacaa gtaaagtaca caagagacca ggccacataa 39960 gctgcagccctgccctcttc tgctaaatgc cttcaccttc attgccattt ccatacctag 40020 ggaagagccctgggggttat catgcttcct tcgtgctgtg ccctttctcc acattcattt 40080 cttcatccatccaacaaata gctttcttac ataaactgtg agggacaaaa gttgttgaga 40140 agacagtccctggcatccag ggatttggtg tctgatgaaa gagatagaca tgtaaacaat 40200 tgctgcaaggagataagagc cctgctacaa gcctgctgga ggtaccgtgg gaatgcggga 40260 ggggaggggaggggccgggc tctgcctgtg ggggtgggaa agacgaaaca gcaacacaat 40320 tccagtcacatctcgggtgc ccagaagcgg ctgcaggcgt gaagacagag gagggtgtaa 40380 atgtcacacaggtgagggag ggggaacgga gctgtgctgg tgcctatcat cgtggaacaa 40440 gctctcttatggcttcccct gtaactccac ctctactccc accacgccac catccctggt 40500 cctggctgtgagctgtattt agaaaggccc tgtatttcca ggctgtgggc agtcatttgg 40560 ggtcgttttgggtttgtgtt cctagcagca ggatgtctgg atcacaaaag cagtgatccc 40620 actaaaacctctctggcctg catccatgga agatgtgttc actgctggcc atctgtttga 40680 gtggggcactgaacaaaagg ctatgtataa agttattcct cccagaatta cctatgatag 40740 caaaaattggaagcaatcaa aatgttcaaa aatagataaa tggaagactg gctcaataac 40800 ttagagtatactgttatgat gtaacatcat gcaaccctct aagaactggg ctaaataatt 40860 ttgagtgatataggaagtag gataaagaat tagtataagc tccagtatgt taaatgtata 40920 ctccctctctctatgtatat ttgtgggtat atatatattt gcatagaaaa aagacaggaa 40980 ggtgccaggcacggtggctc acacctataa tcccagaact ttgggaggcc aaggtgggca 41040 ggactcacttgaggtcagga ttcaagagca gcctggccaa catggtgaaa ccccatatct 41100 actaaaaatagaaaaattag ccaggtgtgg tggcacatgc ctgtagtccc agcttctccg 41160 caggctgagacaggagaatt gcctgaaccc gggaggcaga ggtttcagtg agccgagatt 41220 gcaccactgcactccagcct gggtgacaga gcaagactgt ctcaaaaaaa aaattaaaat 41280 aaataaataagaaaaaaaga taggaagaaa atacgccaaa atgtgaagtg tggttatgag 41340 caaatttaatttgtttttac atttttatgt attttccaaa gatttgataa tgagtatgtt 41400 ttacttgtataatgagtcaa aacaaaaatg gggatggtgt tcatttttgt gttttaaatg 41460 tggattgagcatctagagaa aagtgacaag gatggtgaga tgttagacat tgtgtcatta 41520 gactatctgaaggaggacac ggcagttttc ctttttaaaa aactccatta gttatggttc 41580 aaaggaagtcccatggctag tggagaagtc tggttctggg tttattgagc acaaaactgt 41640 aaaccacaaatgagtgtact atcacgtgga ttgtagctca atagaagagg tcattaatct 41700 cggcgctaacaaccccatgg ctgtgtccag aggccctgag ctccctgacc ctaggagagt 41760 cctgcagaggttatgtagga gccatctcta agagttccta agaggggccc tccaactcta 41820 gcacgttgtgattttttttc aatacagatc ctttgctggc catcctgatc atgcaagcct 41880 tctcatttcccaccatctat cacccattga tacaacactc tcatcagtta atatcagctt 41940 cccatctttatatataaaca tgcagccatt gacggggtga cagcctatct gcaggatatc 42000 caggaggaagtagacagtca ggaagagaaa gggagtaaaa gccagaagca agctgatttg 42060 tgagccctgccttttcctcg ccattgttca gacaagccca ttcctgactc agaatagtgg 42120 aactagtcattggcctctca aatcatcaac gcatctctat tgatcatctt gtgctgacgg 42180 ctcaatggtcagtgtgtggg caacagtaag gtgattaaga ggaggtgctg gcccccaagt 42240 aacttacaaacaagagtaga aaacaagtgg ccgggtgcag tggctcacgc cgtaatccca 42300 gctccttgggaggctgaggc aggcagatta tctgaggtca ggagttcgag accagcctgg 42360 ccaacatggcgaaaccccgt ctctactaaa aatacaaaaa ttagctgagt gtggtggcag 42420 gtgcctctaatcccagctac tcaggaggct gaggtaggag aattgcttga acctgggagg 42480 tggaggttgcagtgagccaa gatctcacca ctgcactcca gcctgggcaa cagagcaaga 42540 ctctgtctcaaaaaaaaaaa aaaaaaaaaa aaaaaaaagg agtagaaaac aagcatgtaa 42600 agagcagaactggaggagac gggcaaaata agagcaccag caatgttcaa ggcatcacaa 42660 tgacatggccctaactgtgc taaagagtca gaaggtgcgg ggctccagtg gaaaacacag 42720 tggattcaggaccagaaaaa caaaatggag aattagaagg gtattcctgg ctggagctgt 42780 agtatgctgaaaggcgtggt gatggctggg tgcagtggct cacacctgta accctggttc 42840 tttgagaggccaagatgaga ggatcacttg aggccaggaa tttgagacca gcctgggcca 42900 catagtgagacaccatccct acaaaaaaaa tttaaaaatt agctaggcgt acacctgtaa 42960 tcccagcactttgggaagcc taggcaggca gatcacaagg tcaggagatc gagaccatcc 43020 tggctaacactgtgaaacct cgtctctact aaaaatacaa aaaaaaatta gctggccatg 43080 gtggcgggcacctgtagtcc cagctactcg ggaggctgag gcaggagaat ggcgtgaacc 43140 tgggaggcgaagcttgcagt gagccgagat cgcgccactg cactccagcc tgggcgacaa 43200 agtgagactccgtctcaaaa aaaattagct aggcgtgatg gtgtgcacct gtagtcccag 43260 ctacttaggaggctgaggca ggaggactgc ttgagcccag gagtttgagg ctgcagtaag 43320 ccataatcattctgttgcac tccagcttgt gtgacagaac aggacactgt ctctaaaaat 43380 actaataaaagaaattagct gagcatggtg gcgcatgctt gtagtcttag ctattcggaa 43440 ggctgaggtgggagactcac ttgagcccag gagtttgagg ctgtagcatg ctatgatcat 43500 aacactgcactccagcctca gcaacagagt gagatcctgt cacaagaaaa aaaaaaggca 43560 cagtgagaacacacagcatc tgaatgtgga gtggcatgat gctgctagaa tggaaggttg 43620 gtggagtttaccatgggaaa gggagttgga atgagaggtt ggagccaagt tagggagtgt 43680 gggcctgatcctagggtgtt tgagagtcag tgaagatttc tgagtgcaag aggacattga 43740 cctgcagcagtggtaagaaa gatgaatgag agactggaga gacacaagtc tgggattcct 43800 gtaagaggctattggaaaag acgctggagc tctgaaccag ggcactcctg gtaggagtgg 43860 gaataagatcacgggcttga gagacatcct agagacagag ttggctgaat ttactactga 43920 gaaggactggaggacagtag gagggagagg aggagaaaac ttgggtgttg ttgaagatac 43980 catggccctaccttttgcag accaccatat tcatgcctca atgctgggaa cttccctggg 44040 ctccgtttcctgtgccccat agctctggct gcttggtctc tgagtttttc ttgtcttagt 44100 aactgagctacttcacttct ggccttggca catgatcaca gtgttgaact gttctctctc 44160 aaggaacactcttgtccctt ccagccagcc tgcaagctcc tcgatgaaag acccagggtg 44220 catgttggtgcccagcaggt gtatacctgt caaagcacta aactgatttg tgtggcttga 44280 aggcgtttactggtaacctg acctccttcc ctccctcccc tgcagagacc tcacctctga 44340 ggaccagatcgtactgctga agtcaagtgc cattgaggtc atcatgttgc gctccaatga 44400 gtccttcaccatggacgaca tgtcctggac ctgtggcaac caagactaca agtaccgcgt 44460 cagtgacgtgaccaaaggta tgcctagact ccacctcctg gggagtcttt ttcagctccc 44520 agattctggctccacccgtc ctggggtttg gctccaatca gatacatggg agggagttag 44580 gcaccaacagggagagaagg gcgagggtca gacccatggg gttggaggtg ggtgggcggc 44640 tcctcagctctgcccgcagt acctggccat tgtctctcac agccggacac agcctggagc 44700 tgattgagcccctcatcaag ttccaggtgg gactgaagaa gctgaacttg catgaggagg 44760 agcatgtcctgctcatggcc atctgcatcg tctccccagg tatggggcca ggcagggagg 44820 agctcagggacctggggagc ggggagtatg aaggacaaag acctgctgag ggccagctgg 44880 gcaacctgaagggagacgta gcaaaaggag acacagataa ggaaatacct actttgctgg 44940 tttgcagagcccctgtggtg tgtggacgct gaggtgcccc tcactgccct tagctctgcc 45000 ttgcagagtgtgcaggcgat tcgtaggggg gattctgagg aactagataa gcagggttcc 45060 tggggccacagacaggcctg cgcattccca atactcaggc tctgctcttg cgtgaactgg 45120 gctcaacattcctgttattt gaggtttctt gcgggcaggg tacaaaactt tggagcctga 45180 gagatggttctgcctatata gtttacctga ttgattttgg aggcaatgtg cagtgaccct 45240 tgacctcttccgctggttag aggtgagaag agggagaaaa ggccgaagag gaagttattg 45300 tgaccttggggacatgatgt cggtgatgag gtccaaagag gggcggccct gcctcagcct 45360 gtgctagtggcctgtgccca gggatgcttt cctggactgg aggctcaagg aatggagatg 45420 ggctcctctacccctgccca gccagccttc tctcattcat tcatccactt agcaacaatt 45480 tattgagcacctattaggta ccaggcacta tgctaggtac tggggttcag cagcaaatgg 45540 gacacaggctcctctcccat gaagcttagg aggaaacatt aaacaaatgt tatttaatta 45600 ttaattcctaacaaggcaag agttttaaaa ataaagtaag tgatgctaca gaagggtaga 45660 atagaaggagggaagctgac gtggtctggg ctacagaggt agagtgttgc caggaatggc 45720 cttttggaggaagacctttt aagctgttat ccaaaggatc agtaagagtc tggcaaagat 45780 agcagagcagagttccaagc agagggagca cagatgtgaa ggctggtggc cagagagcat 45840 ggcgcatcgggacgctgagg gatggacaga gcatggacag ggagcaaggc caggcaggga 45900 cagggccaggtgcgcccatg gaaggaccta ggtctggatc ctaaatgcac ggagaagtca 45960 ctggagggctttggggccag gcagtggtat caccggtcag cagtcataga ggggtggcct 46020 agggggtgctgccgttgagt gtctgtgtgg gtggggggtg gtgggattga gcagtgaggg 46080 gcccagctgagagctcctgt gccttcttct ctatccccgt gcccacagat cgtcctgggg 46140 tgcaggacgccgcgctgatt gaggccatcc aggaccgcct gtccaacaca ctgcagacgt 46200 acatccgctgccgccacccg cccccgggca gccacctgct ctatgccaag atgatccaga 46260 agctagccgacctgcgcagc ctcaatgagg agcactccaa gcagtaccgc tgcctctcct 46320 tccagcctgagtgcagcatg aagctaacgc cccttgtgct cgaagtgttt ggcaatgaga 46380 tctcctgactaggacagcct gtggcggtgc ctgggtgggg ctgctcctcc agggccacgt 46440 gccaggcccggggctggcgg ctactcagca gccctcctca ccccgtctgg ggttcagccc 46500 ctcctctgccacctccccta tccacccagc ccattctctc tcctgtccaa cctaacccct 46560 ttcctgcgggcttttccccg gtcccttgag acctcagcca tgaggagttg ctgtttgttt 46620 gacaaagaaacccaagtggg ggcagagggc agaggctgga ggcagggcct tgcccagaga 46680 tgcctccaccgctgcctaag tggctgctga ctgatgttga gggaacagac aggagaaatg 46740 catccattcctcagggacag agacacctgc acctcccccc actgcaggcc ccgcttgtcc 46800 agcgcctagtggggtctccc tctcctgcct actcacgata aataatcggc ccacagctcc 46860 caccccacccccttcagtgc ccaccaacat cccattgccc tggttatatt ctcacgggca 46920 gtagctgtggtgaggtgggt tttcttccca tcactggagc accaggcacg aacccacctg 46980 ctgagagacccaaggaggaa aaacagacaa aaacagcctc acagaagaat atgacagctg 47040 tccctgtcaccaagctcaca gttcctcgcc ctgggtctaa ggggttggtt gaggtggaag 47100 ccctccttccacggatccat gtagcaggac tgaattgtcc ccagtttgca gaaaagcacc 47160 tgccgacctcgtcctccccc tgccagtgcc ttacctcctg cccaggagag ccagccctcc 47220 ctgtcctcctcggatcaccg agagtagccg agagcctgct cccccacccc ctccccaggg 47280 gagagggtctggagaagcag tgagccgcat cttctccatc tggcagggtg ggatggagga 47340 gaagaattttcagaccccag cggctgagtc atgatctccc tgccgcctca atgtggttgc 47400 aaggccgctgttcacccaca gggctaagag ctagcgctgc cgcaccccag agtgtgggaa 47460 gggagagcggggcagtctcg ggtggctagt cagagagagt gtttgggggt tccgtgatgt 47520 agggtaaggtgccttcttat tctcactcca ccacccaaaa gtcaaaaggt gcctgtgagg 47580 caggggcggagtgatacaac ttcaagtgca tgctctctgc agccagccca gcccagctgg 47640 tgggaagcgtctgtccgttt actccaaggt ggggtctttg tgagagtgag ctgtaggtgt 47700 gcgggaccggtacagaaagg cgttcttcga ggtggatcac agaggcttct tcagatcagt 47760 gcttgagtttggggaatgcg gccgcattcc ctgagtcacc aggaatgtta aagtcagtgg 47820 gaacgtgactgccccaactc ctggaagctg tgtccttgca cctgcatccg tagttccctg 47880 aaaacccagagaggaatcag acttcacact gcaagagcct tggtgtccac ctggccccat 47940 gtctctcagaattcttcagg tggaaaaaca tctgaaagcc acgttcctta ctgcagaata 48000 gcatatatatcgcttaatct taaatttatt agatatgagt tgttttcaga ctcagactcc 48060 atttgtattatagtctaata tacagggtag caggtaccac tgatttggag atatttatgg 48120 ggggagaacttacattgtga aacttctgta cattaattat tattgctgtt gttattttac 48180 aagggtctagggagagaccc ttgtttgatt ttagctgcag aacgtattgg tccagcttgc 48240 tcttcagtgggagaaaacac ttgtaagttg ctaaacgagt caatcccctc attcaggaaa 48300 actgacagaggagggcgtga ctcacccaag catatataac tagctagaag tgggccagga 48360 caggcccggcgcggtggctc acgcctgtaa tcccagcagt ttgggaggtc gaggtaggtg 48420 gatcacctgaggtcgggagt tcgagaccaa cctgaccaac atggagaaac cctgtctcta 48480 ttaaaaatacaaaaaaaaaa aaaaaaaaaa tagccgggca tggtggcgca agcctgtaat 48540 cccagctactcaggaggctg aggcagaaga attgaaccca ggaggtggag gttgcagtga 48600 gctgagatcgtgccgttact ctccaacctg gacaacaaga gcgaaactcc gtcttagaag 48660 tggaccaggacaggaccaga ttttggagtc atggtccggt gtccttttca ctacaccatg 48720 tttgagctcagacccccact ctcattcccc aggtggctga cccagtccct gggggaagcc 48780 ctggatttcagaaagagcaa gtctggatct gggacccttt ccttccttcc ctggcttgta 48840 actccaccaacccatcagaa ggagaaggaa ggagactcac ctctgcctca atgtgaatca 48900 gaccctaccccaccacgatg tggccctggc ctgctgggct ctccacctca gccttggata 48960 atgctgttgcctcatctata acatgcattt gtctttgtaa tgtcaccacc ttcccagctc 49020 tccctctggccctgccttct tcggggaact cctggaaata tcagttactc agccctgggc 49080 cccaccacctaggccactcc tccaaaggaa gtctaggagc tgggaggaaa agaaaagagg 49140 ggaaaatgagtttttatggg gctgaacggg gagaaaaggt catcatcgat tctactttag 49200 aatgagagtgtgaaatagac atttgtaaat gtaaaacttt taaggtatat cattataact 49260 gaaggagaaggtgccccaaa atgcaagatt ttccacaaga ttcccagaga caggaaaatc 49320 ctctggctggctaactggaa gcatgtagga gaatccaagc gaggtcaaca gagaaggcag 49380 gaatgtgtggcagatttagt gaaagctaga gatatggcag cgaaaggatg taaacagtgc 49440 ctgctgaatgatttccaaag agaaaaaaag tttgccagaa gtttgtcaag tcaaccaatg 49500 tagaaagctttgcttatggt aataaaaatg gctcatactt atatagcact tactttgttg 49560 caagtactgctgtaaataaa tgctttatgc aaaccaattt gccttatcct tataaggacc 49620 ttatgggagatgaatcatta ttacccccat ttgacagaaa ggatagcttg agcaatgcca 49680 cactagcaagggatgggatt tgaaccttca gcagctaggt tcagaagcca caaattaact 49740 gctacattgtcctgcttcct attgagttgg gggacctgac agacgactga tggtcttgct 49800 agctctctcctagagaggag ataaaagagg ttcccattcc taaagcaggc cctgagccag 49860 gaaaattagaggtgctggac caaactgtgc tctactccca ggaagtgtgc agtcaatata 49920 tgacacctacgtgagaccct caaaaatgaa aaccaaacag ctactggcaa aactgtgtct 49980 gccattagagatggcggctg tgccagtgac ctggaggatt acaaatgact gctgtgcaga 50040 aacaggactcctaaggggcc caacttatgc cgatgcactc cattctgctt cccaaggaag 50100 tggggtttatgatgaagggt agcattgcta ggcacagtaa acaagaacac agcattgtga 50160 tctgaaaataaggaaatcat gccagctaat gtattgattg aggataagtt ggcctgggga 50220 tgtgattcactctaattttt cagaaacatc tgaaaatatt tcaaaccaaa ggctaaaatg 50280 tgtttcagtgggatgagatg gacttagggg aattggggtt agaacttgag ggttattttg 50340 tgaaacatgaagggacttag agaaaggaaa tcaacagctg cataaatggg catgtctctg 50400 gctggagaaatgtggagaat ggagttctga tacactgtta gaaggatctt atgtagcatt 50460 tttatagctgacctagaaga acacaaaatt tccaaggctg tgttataatg cgcttttcca 50520 ggtaaaccaagaggaatata ccccaggaag gttgcataat taggatcaag tgttttcaag 50580 ttttcatattccaagctttg gttctatgcc tacactgttc aatccagtag ccactagcta 50640 catgtgagtatttaaatgaa ataaaggtaa acatctagct tgtcaaccgc acaagccaca 50700 gttccagtatttgataacct cagggctacc gtaagagaca gtgcaaatac acaacatttt 50760 cttccttttttctttcttct ttctttcttt tttctttctt ttttcttctt tttttttttt 50820 gagacagagtcttgctctgt cacccaggct ggagtgcagt ggcacaatct cggctcactg 50880 caacctctgcctcccagttt caaaccattc tcctgcctca gcctcatgag tagctgggat 50940 tacaggcacctgacaccatg cctggctaag ttttgtattt ttagtagaga cagggtttca 51000 ccatgttgtccaggctggtc ttgaactcct gacctcaagt tatctgcccg cctcagcctc 51060 ccaaagtgctgggattacaa gcgtgacatt ttcatcatcg cagaatagtc tatggggcag 51120 cactggtctacacaatgcat tcttatctgg tactaattgt gaatgactcc atgaggatgc 51180 tggcgtcatgtgcttctgtt gatctgtagg gcagaatggc cactaacttg acatcatatg 51240 gaagtgctatagggaacatc ctccccttac aatgggctat gccacacctg gggtagttcg 51300 aatgagtctgcttcttaaaa gagacataaa gcaaaaacac tgcacagacc atggggttga 51360 taggctcaaagcatcatgtg gtataaatag ctcactggtg tgctaggagt attgattcct 51420 ttagccctggagcaagcaaa cagggcctgc caggagtgac cacagccctt caatttcccc 51480 agcttctaccaggctccttg caggctgcct gtgcagtgca ggtcggtctg cctgccccat 51540 ggtccctgcagatgacaaga aggatggatg ctgtctgaca cctccagcat ggccaaggag 51600 atggctcatcatgctgacat cctataggca actagtcctc attgtgggca gggagcccgt 51660 gaggctgatggggagtctgt gctcctcaag acccagaagc acagcagggt gtggagcctg 51720 tggctggcagggggaatctg agagctcgct gctccagaca gctgctccga atctctgtat 51780 gcacgcatgtgatatatgat atacgggatg gtgttgcaag ttgggttcca gggacgtaga 51840 ctctgaaatgcaggttgaag tgcagggagc ttgttaggga gcagtctcag gattatcagc 51900 cctggtggaagggaaagaag tagaattagc agtgggagaa gttgggctgc aaagcagtct 51960 cagtgaaggtctcaatcaac ccgtgtgggg atctctgaag ctgggatggc cctttggatt 52020 gccccaagatgaagtgaggg agacacttct atattcctgc atcaggtagt cattggacgc 52080 aggctgttccctgaagagca tgtgatttca ttgacatgac ctcagctagg cggctctttt 52140 cagcctgtggcccataggac atgtccataa ggggtgtttt cttcacattc tatacaacct 52200 ggtgagcacttctggagtga gctgctctgg cttggggaga cgctggaaga gttccaggcc 52260 ctctcctgtggctctatcca aggagagtgc tgactccaaa ggagggggtt cccagcctcc 52320 cctcagttatggattagctg ggttattttt cctaaatcat cttgagtttc accacgaggt 52380 ggtgctactgccctacaggg atagctttga gccacttgcc tggccccccg cccccaaagc 52440 cccaatcacatcccccttcc accctttctc tatctccatg atatgagtga gattcagcaa 52500 ggctctgagtctctgctact gagggcatct ggtggtgctt acctctcctc atgccagcga 52560 catggggttagggatctgct ctctggcttc tcctcccagg caacagggag tatctgaccc 52620 tctcacacctcacccaaggg cctcccaggg tcttgtgccc cgggcctctg agcatagtcc 52680 gtgctgacagtgagcgaggc tgcaggttcc ctctgaggtc cagccaagtt atgtagtcct 52740 tccagtgtttctaaccagcc acaccaccga gctcagtgct ggggatatgg cgatgaacaa 52800 gacagtcgccacccccaaga aaagcactgt gcagtgggag aagacagccc tacagacaga 52860 tgagtactaggcatgccaag tggaagctgc aaagtgttaa caagttaaaa gtaacagtta 52920 acaagtaaactgctgtctcc caggcctggc tctgccattt gctatttgta tgaccctggg 52980 caagttacttaatgtttttg agcctcagtt tcttcacaga atggtaacaa taatagtacc 53040 tacctcatagatttgctgtt gttgtgatat aatctgtgta aagcatttat aacagtacct 53100 ggcacgtagttatcaatcat gtgttggcca acatcactat tgggttgctg agatggccaa 53160 ataagtttttatcaaggagg tgacattgct cccacattcc gacctccgat ccctgatggg 53220 ccctctagattcactccagg ctgatttttt ggggcgcctc ttccggatct cagcttcttg 53280 gtgctagggactcctgctcc atgatatcta ccagaactga gagaaggtgt cattgtacca 53340 cctggccaccagggggcagg tgtgccactt aataaaccaa attggcccca gccgaaagct 53400 gcctggggagaaaagtgtgg gaaagaggtg ggaagatagg aatataaatc tgaaatgcat 53460 ggaactctagtgactactgt ccccaacttc tttcagtcat gttctttatt tgtcaatgtc 53520 aatccttcaacaatcaccaa cacctggact tcactacatg cgtatttact gacctataat 53580 taatgtcagtattctctggc aaggggtggc ttatgcccag agaaaaggga atcaagacaa 53640 gtttcaagaatcgggtttga tcgattcatt tatccccatg tttgttggaa ccctgcttct 53700 ctgatgaggtataaacccca ccatgatctc ttcagtgtca tttgtctttg ttccagacat 53760 tgaaacttaaccgaccaccg tgtctgggta cgtgcagttc tctgaacgtg cagctctgtg 53820 gcttgcctctaaaccagagt ttctcaagca tttgggtcct ggcatccttt tactctctta 53880 aaaagaaggaccccaaagaa cttttgtgtg tgtgggttag attcatcaat atgtaccatt 53940 agaaattaaaacagacattt ttaaagtgta ttctttaaat gtggcaataa tgaatctatt 54000 aaaagttagaacaaataaca catttttttc tttaaaataa ccagtttcca aagtaaaact 54060 aatttaatgacaagacagta ttgtttcaca gttttgcaaa tctctttaat gtctggttta 54120 gtagaaggcagccagattct catattggct tctgcattca acctgttatg atatcatgtg 54180 tcaagaagcctccggaaaac tccactgtac acttgtgaga aaatgagagt caaaaaggct 54240 aataatgtccctgctagaaa atgaaatgca aacagactta tgcaaattta aacaccttcc 54300 tttcaacttcagaacctgtg aagttaattc catgtggctt cagaaacttc atactaactc 54360 ctctccctaaagtgtctgcc acatccccct cattctgtac ttggctaatt cgtgtgtgtg 54420 tgtgtgtgtgtgtgtgtgtg tgtgtgtgtg tatgtgtgaa agagaaggac agaaagagag 54480 agagatggtctctctgtggc ctaggccgga gtgcatgatc atagctcact gcagactcaa 54540 actcctgggctcaagcaatc ctctcatctc agcctcctga gcagctggga ccaccggcac 54600 actcagctaatttttttgtg ttttgtaaag acgaggtctc tctatgttgc ctaggctagt 54660 cctgaactcctgacttgaag caaaccccct cccttcctcc caagccttgg cctctcaaag 54720 tgctggggttacaggtgtga gccaccgtgc ctggccacca atttgttttt gactaaatgc 54780 agaatgtagcatttgtccct ctttatattt atctgatttt attatcccac actggcctgc 54840 tcgaatgttttgaatcctca ttttgtcatc cagtattctc accatccctc ctgctcttgc 54900 atcttccaaaagctaggtct gcagaccata ttcagagttg actgagacag agccaaagac 54960 tgtgtcctcttgcaggttaa cattagctca tgaaccagaa gctctttggt tcagttgttc 55020 aagacctcaccgataaggaa gggaagcggg tgggtaatga gagactgagc ctcaggtgag 55080 gggagtcattggaaagactc aggtaccaca ggaatgcggg gaacttgtca atgctgccac 55140 agcccctccctcctcaggac tcaacagcct cactccaagt ctgaacagac tctttaagaa 55200 ttagacagatctgagccaag ggtcacagat ccagggttat ttgatctagg ggatgcacaa 55260 ggggtggatcaagtatcaaa tttcaagctg ggttgttctg caaattgtct gagctggact 55320 ctgggaaggaaggcatggcc tcctagatac tggttgctga gaggaggaag gcaggaagaa 55380 gctcccgtgagctcctgggg gtagtgggca gagctcccct tagacctcca gaccttggtg 55440 gtgaaaggagaagtcacaca tagcctggtc gacagccctt atttagctcc gtagggcctc 55500 cccgctgcactcttcacttg cactcagaag cctactgggc ctctggaaag gcccatgcca 55560 ccctgacccaatcccaaatc ctggctggac atggtggctc atgcctgtaa tcccaacact 55620 ttgggaggccggggagggag gattacttga ggccaggatt tcaagaccag cctgggcaac 55680 atagagaggcggcatctcta caaacaaatt ttaaaaataa attagctggg cctggtggca 55740 tgtgcctgtagtcctagcta cctggggggc caaggtggga ggactgcctg agctccggag 55800 gttgagtctgcaatgagcca tgatcgcacc actgcactct agcctgggca atagagcgag 55860 agcctatgtcaaaaaacaac aaaaacaaaa gaatcctgca gacacctgtg aacatctgtg 55920 gcagccggcatggggctagg gccaaagtga gggcaggtgc cccaactttg tcaactcctg 55980 actactatttccccatttgc ctactaggct ggccagatag atcaagcggc ctatcaggaa 56040 gggcttggtcccctaagcca ctggcccagc ctggcaagga ctgtgagccc caggttaagc 56100 gtgtaggggaaatgctcctg gtatcctttc tgcttcctcc acttccccta gccccactga 56160 tttacatgtctttccctctc ctacccagga gcccccggag agggacaggg aggggattgt 56220 ggaggccctgggtgataaag tagggatggg ggagaagtga taaagggggt gggggagaag 56280 ccagctgcacttcctccctg atagggaccc caccccaaga ggctcctgcc tctgctgtgt 56340 tcacaggaaggactggaggt ggtagaggag tggatgggga gggcggtggg caggatatca 56400 gtggcttctgcaatcctttg ccttggaaga tgacagttca ttattttgtc cttcggttgt 56460 tcattcatcagcaaatactt accacactcc tcctaccacc gctggcagag ctctgggctg 56520 ggagggccaaggaggcagat tgagctcagt agctctgctg gtctcccctc caccccactc 56580 ttcagccttgagggaggcaa tgagtgaata agagatgaac tttaacagca ggtcattgga 56640 atcctgatagtgtctcttac tgactgtgta accttgtggg aaatgtgtga gctctctgat 56700 cttcagctttctcatctgtg aatgaccatg tagagctggt aaagataacg gaaggaaggc 56760 tcgcagcacgccgcagggcc tggccttgtc tagggcagca atgaagagca gcagaagtgg 56820 catctagcaggagcaggatt tgaaccctgg cagtcccctg agtcgctgtg gaactgctgg 56880 ctatttgtctgtcttctgta aagcaaagag agtaatggta cttacttcct aggtgttgtg 56940 aagaccacatgagctactat gtagtattta gaattgcgct tggcatggag ttcggtgctc 57000 ggtaaatgttagcctttatt actgtaattt tcatcatcct ctggggaccc tctcctctaa 57060 agagataacgtctaacctga tatcgtcttc cttataagca gctcctccaa cacattccaa 57120 gtcagggatagacggggtag aagcagggat tcacaggtgg acccctcttg tgaaaggcca 57180 agctggccctcaacccagct cctaggatgg cagacgcacg cctggcccgg cccatggtgc 57240 caacaactccgcttactccc ccagctccac ggtgttgtgc tggtgggtag tgcggaagac 57300 ctgaggtctgccccattatc tcctcctgca aagcctcctc cacccgttaa cccccaaccg 57360 agattatagagcctcaactg tctccaactg ctctgattca gggataaggc tggaccttcg 57420 agcccatcagccccacagtg ttgaggggag gctgcctggt tccctgggag ctggcgagct 57480 ggggaagttggaccacggca gaggctgggg acacccccct gcccacctgc ctgcctgctc 57540 tggtgttgcctccagaactt gaggaaaaaa gtgatcctcc tctggggaga ggccttcctg 57600 ggttcactaaggctcttttc tcccatctct gtctttcctg tctacctcgc tggctccagg 57660 ctgcttctactgtttctact tctctctcag gctgctcttc ccccaccccc agagcctcga 57720 agctgcacacctgtctcctc acatcagata acccgaccac agcagctcct gtcaccccag 57780 ccaggctcccagcagccccc cagctccctc gcccatcgcc ctcttcctct cctgccaccc 57840 ccaccttctagctccctgac acacctacac agccctgggg agggactggg aggggaaccc 57900 caaagccttactgggtaatg agggtgtgag aagacagctc ttcctactcc ccaacataca 57960 cgcgtgcgcgcgcacgcgcg cgcgcgcaca cacacacaca cacacacaca cacacacggt 58020 ggaaactctatacccctgtg cctagtcaga aacagtgacg gggagggacc cagggaccag 58080 gcctcgaggtatgaggaaaa tccatcctgc ccaagtgagg gggttgggga gtcacagaaa 58140 ggggcagcttctggggctga gggttccact gcctcctgtt tttaggcaaa gagtttccag 58200 ggcttcatctccaagtccta aggctagagg cccccagcag ggccctcctc tggtggagct 58260 gggctggggaggtgggtggg tgccatgtgg acctgcccca gccccttccc actgttcctc 58320 aagaggccaagtggggagga ggttgggggg tggttgtggg ggcagcggcg ctgagtttgg 58380 gatgctggggctcagggaga ctgggtaaga gctgggcagg acaccgtggg aaggggagtg 58440 gtgggacctaggagggaggg gaacaaagac cagggtgcct gggagctgga ggttttaata 58500 cctcttgacaacaaatgaat cataggcaaa ttctgtggaa atgatggcgt aaagaaagat 58560 gtgttatttcaaggccccag tgtgttgttg tgggaagaga gtggaacggg gaggagcagg 58620 aggcctaatggcgcctgtag gtgggggccc gggtagagtt cctgggggcg ccgtgaaggt 58680 gatggcccctgcatctcatg tcaccttcag ggggtgatgt gaaacagcag gtggccgacc 58740 acagcccgccaacccccacc ccaaagcaga gaggccctca tacccgctga gctcacctca 58800 ctgtgatgctctgttcctcc tgcagtcagc cctgtcctct gggggctgtc cccacaggcg 58860 cctgccatggcctgctcctc agcagtagta gaggagacta tggagctcca ggagcctccc 58920 atatatgggagggaatctgc agtgagcacc tggccatcac ccctcacggt gggctttttc 58980 ctatcaggagaatgctgagt tgatacccac agtgaccgca cctgccttgc ggtcggagct 59040 cagtctattaagttgccaga taaatgcatt tgtggcctct ggaaggttgt cagggccctt 59100 gctatagctgagacccaaat ctcagcttct ggtcaaccct cattcccgct ctccgcaatg 59160 ttaagactcattaaatgaga ccaaaaccat atatacccat tccaccctac ataatcatta 59220 cctatgacacatatttcctc ttcaccttct cctccatgcc tatatgtttt ttaatacagt 59280 tgcaatcatggggtatgtac caatctctat tctcttgtga tgctgtgttg catataaaca 59340 tcttcctaacagcttcatag ttttctatta agtggaaata tagtatcata atttacctcc 59400 acaattttccaatcataagt gttcaaattg tctctaattt tctatattat aggcagtgtg 59460 atgggggacatcattaggca catactccgc tcctcctccc ccaattttga ctatagaaat 59520 ctagtttaggatacactggg tggggttatt gagccaaagg gtaacagcac attatagctc 59580 ttactatatattgccaaact gatttcaaaa gaggttacgc cattaccgac agcacacaca 59640 cttcaccgagctctcgctaa tgtttcaaaa aggcacctac ctttgtctca ttttaattgg 59700 cattactttgaggacgatca ggttgaacat acccctacct ctgcttgtga gttgtgtttc 59760 ctctgtaccaggagagtctg tttctgggct ttgaacttta gtctccactg ttctagtgct 59820 tcttaacagtttgtgtgagc tctctttata agaatgattt tagggccggg tgcggtggct 59880 catacctgtaatcccagcac tttgggaggc cgaggcaggc agattgcctg aggtcagacc 59940 agcctggccaacatggtgaa accctgtctc tactaaaaat atagaaatta gccgggcttg 60000 gtggcgggtgcctgtagtcc cagctactcg ggaggctgag gcaggagaat cacttgaacc 60060 tgggagtcggaggttgcagt gagccctgat catgccattg cactccagcc tgggccacag 60120 agcaagacttcatctcaaac aaaaacaaac aacaacaaaa aaatgatttt aaagcattgt 60180 caactgcaaccgtgtgcgag tctctccttc ttgatattct ctcccacttg ggattccgat 60240 gcacttcctcttgcttcatt gaaatctgtg actgctcccg gcctgctcca gcttccactc 60300 ctcgcccatctgaagtcttt gttttctcag gtttctgtat ttagccatct tccctgccct 60360 ccccttctctcctctcttct cccctgctct tgtggtgtca ttcattccta caatttcctc 60420 tctcactgatgacctccaaa ttcttccctg agctccagat accaactgtc cactcaacaa 60480 ccccccttgctcatcccacc aacacctcaa actccacctg tgcaaagctc cattctgcat 60540 tttcctccaaatttgcttct cctcccatat tccttaactc agctactcaa atacctttgg 60600 gtttggagtcgcttttggaa gaggaaagag gaaggtggag gctaatgcgc ctgaagaggt 60660 aatcggattctatcaacctt ctgctcagag aaggagcact gggaagggca ggagaaggcc 60720 agttgtcagggaagatgctg ctctatgcct caatttcctt gcctgcctgg acactaaaac 60780 ggatccaggtctagagatag atgcttgaaa cccaaaggga gtggtcaccc tcctagagca 60840 aattaacccttaacactggc ctcaccagct ttttccttca cctcttgagc ctcttcccca 60900 ataagagactggaagggatg aagaagaggt aaagctataa gtctaaactt gtgctgtcca 60960 tacagtagccagtggccaca tgtggctact aagcacttga aatgtggcca gtcagaattg 61020 aaatgtgctgttagtataaa atatacactg gctttcaaac acttagtatg gaaaaaaaat 61080 gtaaaagatttcattagtaa ttttttattt tgattgcata ccaaaataat gttttagatt 61140 tactatattaggttacataa atatactact aaaatgaatt tcacctgttt atttttcctt 61200 tttttgatgtggctaataga aaataagtta catatgtggc tcacattccg tttctattgg 61260 acagcgcttatctagaccct cccagcaggt gaagtgtggg gctccaggct cgggagacaa 61320 gggcagtacatgacagacac aggtgcaggc cctactacag gtgtgggcca gccagagctc 61380 caaccagatgtctccagaca gacactgaag gacagattct cagtggccag cctcactcag 61440 gcgaagcaaagccaggcaac atttcctgga taattccttc agtctttgac ttcatgaggg 61500 tctctggactgaggcttagc tctcctgagc ttgtccctgt agatgcccca ttattctgga 61560 aaaacactcacccaggacca cccagacctt tggatcccct caccttgata gttcattgga 61620 agatttttctatcactccac ctgggccagg tcctggatct ctttccagaa gcccagaggt 61680 gtccttcctcctgtctagag ccctccctcc cacgcactct gtcttaggct tagctcacca 61740 caggctgggaggggatgaga gatggaggtg tgctcaactt gacctcgaac ttccatgtac 61800 actacctgggtcacaggcac attttgagct ccatttctaa tgcctataga agggaacagg 61860 aggggacgaggggtggcaga tatactccat tgggctgccc ttctctgtct cattctcctt 61920 ttcctgtgccccggctgcgc catttgaggg cactgaagct ggggcccagt ctgcgtgggt 61980 ctgcccctccctctccttgc ctagatgact ccacctctcc caggtcctgg ctgggatccg 62040 aaggccccaggcaagtgggg gaaggggagc cactcccact ttcccagaag ctgctgctgc 62100 ctcttcctgttttgctaaaa ctctggctct ggactcaagc aaagaggggg aagtcaccag 62160 ctcctgccccccgccccaaa aggtcaacct tgcccccctg gtcctcttat ttatagcccc 62220 cactacccaccaccccccca ccccccggcc ccaggccctg gctaaggagc tggatgtctc 62280 ctccctcaaatagcagctgt ggccattgcc ccagggatac agccagatgg gcagatcact 62340 ccagatgtgcagtgtttcgg gaggggaggc caggcccttt ctgcagtccc tgtggtactc 62400 cccgcagcctggtcctggtt cccctcaact tcaagacaac acttgaggat ttcaggagga 62460 tcaggaaggttgcacctatt ttcccatttc tgtagcctgg ccaagctacc ctgtataccc 62520 tagaaaggtcagcttgggcg ataggcccta ctggattcat ttgcataaat cagctcagtg 62580 ctcactttgagacctcaaat tatagaggaa aacaggctta gggagacaga agagacagga 62640 cactgtctctcttctattac tgatgtgagc attggagctc tgtccctaac agcccaatgt 62700 gtgccaggcactgtagttaa gtacttcatg tcccaatctc atcggtcctc gcaaaaccct 62760 aatatagcaggcacttcata ccctaatctg cagatgggaa accaagactc ctcaaggtta 62820 aataatatacgtaaggtcaa gcagtgggga agcaacaagc tccagcccaa gcagctcgac 62880 accaaatccttgctcttaac cacagtacaa cacctcctca ctctgtccat tcttctgggt 62940 acttttaaatgatctctttt tttctttctt tcgttttgag gtggagtctc actctgtcac 63000 ccgggctggaatgcagtagc acgatctcag ctcactgcaa actctgcctt ctggattcaa 63060 gcaattctcctgcctcagcc tccggagtag ctgagattac aggtgcctgc caccacgcct 63120 ggctaatttttgtgttttta gtagagacgg ggttttgcca tgttggccgg gctggtcttg 63180 aactcctgacctcaggtaat ctgcccactt cagcctccca aaatgctggg tttacaggtg 63240 tgagccaccacgcaggccta aatgatctct taaaagctca gtgcaggggg ccaggcatgg 63300 tggctcacacctgtaatccc agcactttgg gaggccgaga caggtggatc acctgaggtc 63360 aggacttcaagaccagcctg gctaacatgg tgaaaccctg tttctactaa aaatacaaaa 63420 aaattagccaggtgtggtgg tgtgtgcctg taatcccagc tactcgggag gctgaggcag 63480 gagaatcgcttgaacccgga aggcagtagt tgcagtgagc cgagattgca tcattgcact 63540 ccagcttgggcaacaagagc caaactctgt ctaaaaaaaa aaaaaaatgc tcagtgcagg 63600 gaaccctggagcccaggact cagggcctgc ccaagggaga tgtctgcaca ttgtctctgc 63660 ctcctctgccttcccacccc tagccattta gaccaagctg gagtgaggga tctgttgagg 63720 cagagatttctagaatcact gttctgggtt tcctcagacc ccaagcacaa aggagagcag 63780 gtgagggcagaactattgcc ccaacccaca ttgatcccag gatccattag gtgtctccca 63840 gcttggaactctggtgactc tgaatcctcc ctctcctttg cagcatatgt tattcgagtc 63900 cctcatccaaccgttttctc cactccaggt tctgttctta gattgtatcc tgctccccag 63960 gaggtgatgaattcctcact gtggcttttt tttttttttt tgcctctgtg cctgagagtc 64020 tgacacggtgcctggcaaag agtagatgct caacaaatgt gtgttgatga agaggagtat 64080 aatggtgatcatcatgggtg gagtttttca aggtctcagc cagggcaccc tcgctcacct 64140 cccagcttagccaccctcag ctcattgctc tctttcctgc ctctagtctc ctgactcaca 64200 ggtgcataatccaaactcac cctaaaagac actcctgggg aaagagaggt gagtgtcttc 64260 aggccaagaccttctcaggg gtctctcctg gagattctgg agtcagaggt atgtgcttcc 64320 aaagaagaagcattgagatt tgtagtaaag tgggaacctg ttgaccagcc aatatagccc 64380 ctggggcaactggagggttg tgttggggca tatggcaagg ccgaagctga agcctgccag 64440 tgggaggaccacagcatccc tgcaggggcc cagtggagca agtaatggtg agctggctgc 64500 agaaaggcattttgcaactc agacgaattt cttctcactc atgattagag tatggcccag 64560 tggctgcctccctgaccata atctctgctg gcacaggcat ctctgggctg ggcagcccag 64620 gctgtggaaggagcgctgac ctggaaaccc tggggcttga gttctctgcc tgccctggcc 64680 ctgattaaccgtgtcatctc tggcaattta cgtcctcctc atgtcctccg tttcctcatc 64740 tgtaaaaggaatggtttgga ttagaccagg gagtcccaaa cttaaccaca ccttagaatt 64800 acctgtggtgctgcaggttc ctgggtacta tccaaccttc tcaaagagtc tgatggggtc 64860 ggggatgggactcaggaatc tttttttcac aggttctttc aagtggtttt tatttactta 64920 tttattttttgagtcagagt cttgctctgt cgcccaggct ggagtgcagt ggtgcactac 64980 aaccttgacctcctgggttc aagcaattct cctgcctcag cctcctgggt aactgagatt 65040 accggcatgtgccaccacac ctggctaatt tttgtatttt tagtagagac ggggtttccc 65100 catgctggccaggctggtct caaactcctg acctcagatg atccacctgc cttggcctcc 65160 caaagtgctgggattacagg catgagccac tgcgcccagc ctacgtggtt ttgataaagt 65220 gttaggtttaggggatccta gagactagat aatcttataa aacacttgca gcttttggga 65280 gcaaatattctcgtaaatgg aatgggtaca tcgtgaggtt ttgctgctga ggggttttat 65340 cagagagcaggtgatgggta gtttatttta tcattatcat tatcattatt attattttgc 65400 tgctggcattattgttatag aaggatgtgg cacctgccca tctgtgtgtt tctgccatga 65460 acaaggttctggcctaagcg gggcctcgct tacctcaggg ttgggagtga agctgggaga 65520 ggagggtagggagggaaggg ctttccctgg tgggtggggc ctcttggcaa ggggaccctg 65580 ctttccctctctcctgggtg gagtttggct ccacaggctt tggcaccaaa ctctggggct 65640 gagagcgtctctccccaccc atattcctcc cccactttca catcttagcc actcagtcct 65700 ggggactgcccccttctact cttcctttcc cgacttcctc cccaggcccc tccaatcctg 65760 ccaacctcattcctgagcct ggctaatctg tttgccaccc tctgcttcct tgcctcgccc 65820 ttgcacatgccattctccct acctggaatg tcaccccctc ttctctcccc actctgattc 65880 acatctctgggctctttcaa aacccagttt gaccgacact tgccagcttc atggaggccg 65940 tgttctgtcccgatgtgctc cggtcttccc tctttgcgac gcactcattt gcgcttggaa 66000 taatagaatcagaaaactgc tttagactca gaaaaataaa tatagatgat ctaaagcagc 66060 cccctcatttgacagatgag aaaactgagg cccagggtgg ttgcgacttg gccaagatca 66120 cacagtgagattttttaaat agttggcttt gcaagaggct ttcaagtatt ttatgtgttt 66180 gttttgtttcctcaacgctc tgtgaccaat agaagggcag gtgctttgtt tttgtttttg 66240 tttttaatgttcttatctcc acactcttgt tgtgttgtgt atccaggagc taaagtacgc 66300 aattgtaatatttgttatgc catcaggaaa ataattctaa aactcacagt ggtacaaatc 66360 ttttcatgtattattcatct gatttcaggc cagccctgtg aggtaagtag ccaagatatt 66420 gctatttacaaagcaggaaa ctgagactta gaaaggtgtg acccaggaag ttaatggcag 66480 agctgggcctaaaactcaag ttccctgact cccagcccag gctcctgatc cccacaatgt 66540 ctcctttctagctctctcct gatgctcctg gctggggacc tggcatagtc aagggggtga 66600 ccgttgccgtcttttcattc atggtacctt ctttgtcttg ggcttgagga gactgtctgg 66660 cttcctgcccctccccatcc tgtcccagtg ctttctcctt gtgtcccctg ccacatagtt 66720 ggcacatagacacatacatg tatattcaga actgcaggtg tctagggcaa cagaccacag 66780 gggaaaccacatcacctttg ttgactctgt agggagatgg gggtaagggg aagggaccag 66840 cttagttctctccacctgcc ccagtcccca cagtcatcta ccctcccaac ctgagaccct 66900 ggtacttatagccacactgt agcctcttct tgatctagcc atccaattct ggcccagaag 66960 gatttggcacctcttctctc agatcctgac atcctagata ggggtctgcc tgcctgtacc 67020 ccaaagtcacacccccaacc ctactcagaa tacttatacg gttcccctga ttctgctggt 67080 gcagtgcaacagagaaaggt gggaaacagg gatgagacca catggctggg gtcagaaact 67140 tggcatctggaatgagatgt acagggacct caaggaagca ggctacactg gaacaggaga 67200 ccctggcaatgcgtccttca ttattttgac ctgctaggaa attgcacagg ctctgaatca 67260 gacatacttgggattaagta acttactggc tctgtggcct tgggcagatc attttgtctt 67320 tctgagttttactttgctca tggaaacaat ggggataata atgagattta agtgaaaggg 67380 ctttgaacagcgtgcgatat gtagaacatg ctcaataaat cctaaattat ctttccttcc 67440 ttctttttcttccactcctt ccttccctct ctccttccct ctctccttcc ctccctcctt 67500 cctttccttccttccttcct ttttttcctt ttcttccttc ctttcttctt tccttccttt 67560 ctcccttcttcctttttttc cttttcttcc ttcctttctt ctttccttcc cgtacttctt 67620 atatctcttatgtctggtcc catgaaaccc tttatttgga gttggggacc taatctccct 67680 tactaatctgcaagtcccaa accctgagaa ttggcatttg attccagatc cagaaactga 67740 aatgcaagatccaaactaac ccaatacaat gagtgtccac tgagatctca ctgaactgag 67800 gccttggggaaggagcactt tctggttggc tttgtgcgaa gtgtgtgagg ataagtgcag 67860 gctggcggaggaattgtggc tatggccccc acatctagaa ggttgggaac ggagggtatc 67920 agaaagtttggataattttc tggggcttta aatcctggca caaagtaggc acccaataat 67980 atttgttgaatgaatgaatg gccctgtcac ttactagttg tgcaactttg atcaggtttc 68040 ttaaccataaaggccatgct ttactcatga gcataacaag gattattgtt aagaataaat 68100 gatctaatgtttgtccaggg gatagcaagg actgctacgc agtaaatggt aaacagtagc 68160 taactaaggaaagaaggaga ggaaaaggag aagagaaggt caagtaggcc cagagtccca 68220 aagggaagcagattggggtg ccctcaggct ttgtgctggc cggagactct agggaaggct 68280 caggaagccaaggcacgtct tttggggcca gtctcttctg ctaggtgttc agctgagaaa 68340 gctatgagaggcctggactc aagagctttt taaaaaaagg ctccccacgg taaccaggct 68400 agaagagagagaggtagctt gcatttctct gtctcatgtc tctaaggttc ttggaggctt 68460 tctaatttatcctggtaggg gacatgtgac ttagaaactg gcttaggact ctgccatgag 68520 gcggggtctggtaagtaaat ctggcagggg aaggagagac acagtccagc tttcccagat 68580 gcaggttgcacatgctgtct ttttctctga ctatatgttg gaggcagtga gtcctggtgt 68640 gtagaaagccacatgttggg cactgtgtgg acagacaggc agggagatag cctcttaatt 68700 cagatcactcaaaactcagt gatgagttta aaaagagaaa gaagactcac aaataaatgt 68760 atgcacaatgcacatggtag aaatgagcat aaaagggcct ggctttacta cagaaatagc 68820 tacagaaaagctacggatat gtgtgtgttg ggggttggga tcaattgtgg agctagacaa 68880 gggagatagcaggcatgtcg ctgggggtct gcagtaacca agcagttttt ctggagtctg 68940 tggacaccaaagaggcattt ggaaggagga tgatctggct tggaattgag ggctggggat 69000 gacatacctaaggtggaaca gcatgtgtct tggagagtca gcatgggtag ttatggggtg 69060 aaagaatgtactgtaggtgt ccagctggag aagggttctt gaaagtcatg aacatctgtc 69120 ccaattcaacaaataactca catcaagttt gaattctgtg caagacacta caagaaatgc 69180 acccatgaccaaggcagtag ctggactcag ggatatccac tcttgaatgc tcttggaagg 69240 aagagagttgagacaagtag actaggtggg cgaaggtcaa tgtataaaga ccacacagtt 69300 cagggaagaattcctcttgg ctatgggaat ccgggaaagc ctcccggaga aagtggtatg 69360 ccactttctttttcttccag tccttccttc cttccttcct tccttccctc cctccctccc 69420 tcccactagatagggagtgg gtcttgagga ttggaaagat ttcaacagaa ggagaaaggg 69480 gctgggaggacatttctttt ggaggcagca tgatgagcga aggcaaggga gtgtggaagc 69540 gtgaggacaggatgggaagc agctagcagc ccagtctggc agaaataatg atagtaataa 69600 tagtgactaacactactgag ccctaagtac caggaggcac tgggcaggga tgtgtatgga 69660 gtgtggtgccaggttgtagg aggacttgaa tgccaggaaa ggcttttggg agggtaagtt 69720 aacaagcgcagaggggttgg atctgcctgc cgaaggagaa ctgggacaag gaaaggggct 69780 gaagtaagaagtcccacgct gaatatgccg gtagcaacag atagtgagtc ccgagctgtg 69840 cctgagggaagggaatagaa tctatggttt gaagttcacc gccagcatgg ccaagccctc 69900 ctaggccactgtgggctctt gcttccaatc agacatgact ccacctctgg ggctgcctca 69960 atttttccttctctggattc ttggggtttc ttaggattgc gggagataga atggggtcag 70020 gggaagctgctccttggttt acaatggtgg cgcctcacgc tgcagagagc ccagtgttcc 70080 tgcgtggtggacctctcccc ttcctaggag cagctccaga ttgctggagg cagacacggc 70140 tgaccggctagcccaggaag cacaatggcg aggtccttag cccctgaccc ctgaatctga 70200 ccttctctccagctaaaagc ggagggagag gcagggaggg ccactgccta aagccggccc 70260 tgagctgagtttattagctg agggagggct ggaggcggct gcattccgac tcacagactg 70320 gaacatttctgtgatccgct gtaatgcact gggggacact gggcacattg ctgaagtttg 70380 actcatagggaccgggaggg ggaaagaggg gggttgtgga gggagaggaa tgggaggaag 70440 agaggaagaggagaggaggg aaggaagtcc cttgagaaat ttctttaaaa aaagaaaact 70500 ttcaaaatctgcaccacccc cacacccttt ttcttttaat aggaacaggc tggacccttc 70560 cgttcccctcagcaggcatg gtgtgtgtgt gggggtgcca gtgggggagg gctgggcagt 70620 gattcaaatcagatcctgga actttcctga ggcaagtcgt gcttatgtgt gtgtgtgtgt 70680 ggtggggggtgtccgtctgg gattccttgt atgggacatg ggacaccacg cgtgtcccac 70740 tgtgcccgcgtgtggctgcg tgcttgtggg ctgtacgggt atgtagtgtg tgcacggggg 70800 tccaccccgaagccccagtg tgtgctgtgt aaatgattct gccccttgta aacatggatg 70860 cgtgctcgtgtacgttgtgt atgcgagggt gcgtgcgccc aggtagctgg gtttccggga 70920 attgtgcacggctcggagcg cctcgcggcg gctggggctc ggagccgcgg ccggcgttcc 70980 gggttcggcgctgcctcccc ggcagtgcgc cgcgccccgc cgcgatctgg ccgcgcgcgg 71040 tgtctgcggcccgcctgtgc gccgcgcggt gcagtgtctg ccggggtggt gtgtcccagg 71100 gccgcgagcgcctgccccct ccctcccctc ccccttggcc cgctctcaga ctcagataaa 71160 gcatttccttccattgtcat cctacccggc cggccgggct gccagggccc tccccctccc 71220 ggccccctcccttcctctcg ccgtctcaca gtcgctctgc agcctccggc gactgggggg 71280 atgtgaggccggcgccccag ccccccgccc cgccatgagc cccccgctct gagggccccg 71340 gcccctggatgcacagcccc ggcgctggtg agtactgggc ggccgccccc cgccccgccc 71400 tgcgcgcggcacccagcgtc gcccgcccag gctcggcctc cggccctggc cccggctccg 71460 gctccggctccggctcgggc tcccgccagc cccgcgggcc cagcccggct tgcgcccccc 71520 gaccgcgcctgtcccgcccg gctccgcggg gctctggcag gctccgggtc ggagctggtt 71580 ccgggggccggagggctcgg gcctcccgcg gggcgcccac atccgcccgc cccggggcag 71640 ctacaggcccaagggaggga gttggaggcc ccggccgccg gtgtgcgggc cccacgtccc 71700 atcacccctgttcccgggga ggacgagccg agggaccggg gagggaggga cggccgcggt 71760 ggcccggcgagggggcggtg ctccggggcg gaaggtttgg aagcgcgagg gcaaagggca 71820 ggacccactgagttggggct gggctttgtg gggctggaca tcagcgcccc catcccgtgg 71880 agccgggcagggccctactc agatccttcg gcggggaaag aggtcccttg gaggggtctc 71940 tggctgggaggtttctctga gcattgcccc ccatccttgc tcacccatca gggtgaagag 72000 acacctgtgccctggtgagc tgtggaggtc aatgccggca gcggcgcggg aagcggggcg 72060 ccgcaggctgtgtgaggggt gggggacagg atgtgcaccc cccaggcctg gggtctgttg 72120 gtgttggggagtgtgagagc aggcggcaaa tttggcggat gggctgggtt cccacgacca 72180 gagtttctaggcctgtgggc caggagagag ccctctgggg cccgcaggcc acccagtgcc 72240 ccacccccattgcttcccgc tgtggctgcc cgtttgggtc tgacctcccc agccacggct 72300 gctcctcactccttctcccc gctggctgtc ttgcgcaccc aaaggcctcc ccctgcatct 72360 ggacactggctgtctcgctg ccaacgctcc ctgcccactc ccctaggcaa catctgcctg 72420 aggcccagctctgcctgccg ctttctaggg tgagaatggg gcatcggccc tcagcggccc 72480 tgctgggagctcaagatcaa cttctcagcc tgttccctgg acttgcatct ggacctgtgg 72540 gaccttcctcaggaccccta ttcagctata gggctggcag gagactgtga ctcaggtccc 72600 tgccctccaatgagacgctt tggcggccct ttccccctcc caggactcca taggctgcta 72660 ggctgccgctacccatgggt tattaagtca ttttcttctt ctctgcagtc atttctgagg 72720 gaaactaaggcacagagtag tcccagtgag tggtacccag cccagtgaac ctagactgga 72780 accaggtcttggacctattg ggactggtcc tctgccttta gtcccctgat gtccctcctt 72840 gcccagcagggccaggctca gaggcaagct cagagctgcc tcctgatgtt gcacctggaa 72900 tggtcctggtgcagtgttct ccagaggcct ctgtgtccct tattcggcgg gtgtctctgt 72960 ggccaccgggtcttacagtg ggttttgggg cagggaagtt tgcatgtcta agctgttcac 73020 tccactttgacactgaagtt cagtttcccc atcagtaaaa tggggagaaa attccaagca 73080 cacttctcagagcagagcag aagaggttga ctatggagag gagaatgaag gtactgtgct 73140 attatccaccccctccagtt tgcttaggga taatggacct cagctttagt ccttggtggc 73200 ctcttggcatggaagctgga actttctcaa ttctgatata aaacccttga gcaagagaga 73260 aactcatgtgtgatggggta gggagtgggg accctctggt agctgtgggc aagcatgccc 73320 aaggacttggaagacagaag cctgtggaac cccatctcct ctttgccttc tttctcctgg 73380 cctttcattaagggctggta attttgaagt cggcaggggc ctgagagaag gtgagctaat 73440 gcaaggcccagggtcacaca gccagggaat ggcaggcgga gggggccaga accaggcctt 73500 ctcactctgccagtgcccat tctgctggcc caccctccac agcttggctc tccctggcct 73560 gccctcagttagacttcgga ctgaggcctc cagtggggtg tggggtattg ctggaagcag 73620 ggcctgaataaagtctgggg ctagcgggag ggcatctgtc ctcccggagg ctcccaggac 73680 tgtgcatttgtgtgtgttgg atttgttcac tagatggggc acttcctttg gggcaggaag 73740 ctttgatttcctgtggtgat ggtgaggagg ggttggtaag gattaggagt ggggggctca 73800 gctctgggccatcctcgatg ttgttgtttg gaaccacgga ggggcagagt ttctgcttaa 73860 gactgcttctcccagctctg gggaggcagg aaggagagcc ttggtgagga ggcccaggcc 73920 aaggctggagaaggaggctg tgagagcagt gagctggggg tgggcaacac agcaggaagc 73980 ccggtcagcaggtgaccctg ccgggtattg tgtttccttg taatattttc cccctgtttc 74040 tgtggtaaccttccctggag gccccaggcc ttagggctac aggaaggtgc ccccagacag 74100 ccctttccttagaggcctga gtattaggag gagtccccag atctagccac ctccctaacc 74160 cttttggctccctaggatca ggggcctggg aatctaggcg agtggcctga gtgagcatgg 74220 actcgcgggctgggggaagg ccctttggcg tcttctgggg ggaagggaga gggaaagagg 74280 ggagctggacgcccggaagg gccctgagca acttgagtcg ctggcctagc ctcttgtttc 74340 ctcccaacccatccccactg ccctcctcca gtctccctcc tcctacaagg gagaggtggg 74400 tagcatgctgcctggggcaa ggggcagggg tgggggtggc agaggtggga gggatgtttt 74460 catcagcagagcatagctcc tttggtcctg gaccagttcc cagaggcaaa ataaattcag 74520 gacagcgtctgtttagtgtg ggtctgcatg agatgtgtgt gagcacacac tgggtgcgtg 74580 gtgggtatctgtgtgtgtac ccctcccccc agaccctgtg tatgctgatg tggtggttcc 74640 gggcaatttgtgatctatgt ggtggttctg tgttgggtgt tttgggaata tgcacacata 74700 aaagacagatgtgcatcatc tgtatggtgc acaccttttc aggttatggc cctgtgtggg 74760 gtaaacatgtccatatgtat ggacatgttt tttgggggta tatatctggg caggagtggc 74820 tttttaatagaagtccagat gctggcttgt aaaacaccat ctcatttggg attctcaaat 74880 gcgggttcctggaccatttg cttcagagtc acctggggaa tgtgttaaag ataaagatcc 74940 tgggccgggcgcggtgactt acgcctgtaa tcccagcact ttgggaggcc gaggcaggtg 75000 gatcacctgaggtcaggagt tcaagaccag cctggccaat gcggcgaaac cctgtctcta 75060 ctaaaaatacaaaaaattag ccaggtgtgg cgtgcgcgcc tgtaatccca gctactcggg 75120 aggctgaggcaggagaattg cttaaacccg ggaggcagag gttgcggtga gccaagatca 75180 cgccattgcactccagcctg ggtgacagca agactctgta aaaaaaaaaa aaaaaaaaaa 75240 tcctggctggacgcggtggc tttgggaggc tgaaacaggc agatcacttg aaggcaggag 75300 ttcgagacgagcctggctaa cagggcaaaa ccccatctct actaaaaata caaatttagc 75360 caggcatggtggcgcaggcc tgtagtccca gctatttggg aggctgaggc agaagaattg 75420 cttgagcccaggaggtggag gttgcagtga gccgagattg cgccacctca ctccagcctg 75480 ggcaatagagtgagactgtc tcaaaattaa aaacattcag atcatcaggc ccattccaga 75540 ttgactagtcagaatctgag gggtggggcc tgggaatcca gattttaaca ggtgcttcag 75600 gtgatcctggggcaaggctg tgtttgagga ccactgccct gggtcaacct cttcattttt 75660 tcttttgaggaaatagaccc acagaaggta tgtagtttct ctaaggtgac agggccatta 75720 agaggaagaaccaagagaaa actcaaggct tctaagacct gtccaggact ttgtgctcac 75780 ccatgtaccccctgtgtgtg tgtgtgcatg tgtgctcata actacacttt gtgatgacgt 75840 ggacccgattgggctggtgc taattggggc tgatctttcc tctggggtcc tggctttctt 75900 gttttctgaccttgttcttc ttgctacatt ctgctgcctc ctttttggag aaatcctgga 75960 actgttgagtgtcatcccta aaggtcaatg ttggcaacca gggaaccatg ttgctgagcc 76020 agtcactcagcaattcatcc attcactgga tcctagctga gccttgcaat gttctaggca 76080 ctgggtacagatatgcagtg aacacacagg cacaacatct gacctcaggg aacttccact 76140 ctcgtggagaagacaaacag aacaagtagg caagtaaagg aatgagtatg tgtgactagt 76200 tacacactgtgataagccct aagaaggaaa tgaactgggc atggcaataa agaataacaa 76260 ggtgggacttcctttgatag ggtggccagg ggaggactgc ctaagaaggt gacattgatg 76320 ccgtctcccacctccccagg ttggaagtga gccatcagag cctctggagc cgtgcttgtg 76380 aactccctggatgcaggtgg aggccctggg ctgaccaatg gctaagggtt ggagctgaat 76440 tgccagcctctcacttggca tggaagatgg cagtctcctc cccttaagca gccccaaagg 76500 ttggcagaggggagagcaga agggggagct gcacaaggcc aagatcaaag ccactccctt 76560 gcttggggagcacccttttt cttccatggg gctgagtcca gggccctgtg gccatactga 76620 atgttgagaaggaggcagca tctccccagg agctctcctg tttcaccttc ctcccacctc 76680 cttcccttctccgccatctc cccagttggg gaactactgt gccaagtccc ttccctctgg 76740 tctagcctgctgcctctgtg gccactttac tttacttggc tcaggaatca ccaaagagag 76800 ggggtcaaggcctagagggg acctgggccc tggaagagag gacagaacca gaaaggaagg 76860 ctggggttgggaccagagag gacagggctc aagggaggat ggaggctggg acaggagagg 76920 cacacgggaaaaacctgagc ccagatggcc ctttggctgg gctctccaga gtctctcctg 76980 ggcccttggaatctgctgcc caaactgggg gagactctga gaccagaggg ccagatgggg 77040 ctgattcaagacacgggctc tacatcagct gggaggaaat gcccctgtct ggtccacctg 77100 cagctctacgcttcacccct ctcaggaggt taactttcac atcagcaact tgggtgtcag 77160 gttccggctctaggccagca ggcctcagcc cctctcacct ccaacctctt ctcccaggaa 77220 ggtttttctggggacccaga gcttcaggct gcaggaaggt gttgcctggc ccttgcctta 77280 gattattgagtgtcaaagga gccctgactc caggtccgct tttccccctg cacactgcca 77340 aggctgccttccaccctggg cctctctgga ggctgctcag tgctcttccc gactcccagg 77400 ccttcccgcccaagctccac agcccccaca gcaggatggg gaggggactt ctcctcgtca 77460 ggaaggccctgggctaagct caccatcccc accctgtctc cgcaccactt cctttttcct 77520 ccatcttgcctgcagggatt gtaaaccctg gtggtcagaa gctttgggcc tatagggtca 77580 gcctctcaccctggggatcc gtaggggaac tccaatcccc ttcagttcag cttcctccct 77640 gcaggacccattccaaggag cctagctctg gctcctgagg tgaccccagc ccagaagtcc 77700 cattcccctctaccccaacc cccagaatgg caggaggagc agggcagtct gggagtgaca 77760 ggttcggaaagagtctgggg tgggggaatt cggcgattgg gctgtaaccg tcttgttttg 77820 cttgccccacaaacctgcac gtccgggacg tccgctgcgc cctcccaggc gcgttcaggt 77880 tatagaactgctctcagaat gacaggctgg tggcacccgg ctggggcggg gggtggggag 77940 gtgaaggggggagccccagg caagggggag ctggagggtt aaaaatagca gcagccttgt 78000 ttcggttagcaaatgtggag gcggggagct ggaggcgggg cgggcggcgg acgatgtttg 78060 cccgcagcgcagggctgtgc ttcccctggg tcccgggagt gagtcacggc ggagacgctg 78120 aggaggtgctggcgcagcac cccaccccca ccgggcgagg ggctgagcgc aggcctcgcc 78180 ccccagattccagcgctgaa ggaggtgtga ctctcccttc caggcagccg gggccgcctt 78240 gagagtgagccaggggcatc gtgtgataat agggaagaaa tgtgccattc tgacgccaga 78300 gatctgggtttgaatcttag tcgaaaggtg tgggatcttg agtaaggatg ctgatggctc 78360 tgagactcgatttcctagtt tcaagtgggg cttttctctg tgccccactt agtgcttaaa 78420 gcactctacagatgttaatt atcgccttag accctactgt atatatggca aagcctggca 78480 ggagagcttcctgtaaggac gcagagggag gaatgggatg gccttggctg agtctcggtt 78540 tctcctgcaagtgtgattat gggcacattt tgctctgtgc ctccacttct tcatctgtaa 78600 tgtgaaaataattacagttt caactttatg gagttgctat gaagattaaa ggagataatg 78660 taaataaagttagctctgtg cctggtatga agtcagggct cactgaatat tcatcatcat 78720 tattaatgttattgttcata ttttttgaag gtcagggata gggaatgttg cagacacgaa 78780 gaacagaaactgggcctagc cccagttcac agaaaaaacc aggccaaatc cctgttccag 78840 attcctccacccatcgcggc ctggaacagc cagagagctg tagccagaag tcatagggtg 78900 gacccctgcttctcttgttc actccctctc ccagcctctc ccagtgaggc agggcgagga 78960 gggaccccagggccttgaag ccagctggcc ctggagaggg gctgctgtgc cagcttgggg 79020 agggtctgggatggggctgc ccctgatggc cctgatgtgg agtaccttgc cagcatctgc 79080 tggggtgaactttattttag cccttccctt gttgctctta tgaagaacag aggaggggtg 79140 ggcaggtcagtgatgtcagc agtgagtatt cccagcacag cggctctgga agaggcatga 79200 ggcatttctttcaggaaatg atcattattc agccagaagg cattcattaa gtaagtcctg 79260 actttgtgcccagctctgtg ttataggccc ttggcgagac tcaggagggg cagaggacgc 79320 taggttgtagataacacgga acctcagagg atatatggtc caagaagacc cgggggcggt 79380 gaaaaccctgtggactaatg ctcacgggag cccgaggtca cactttgact ttgctaccat 79440 gggctgtgtctatgtacgta tatatgctgc gtaattatta cagaggcagt ccatgtgcat 79500 tgtggatactcagacaggac agaccagcaa aaactaaaaa ataaaaaaca tcacagacgc 79560 atcagtcagagatcactgca catctttcca tttccgtatg tgtctttatg tgttgtaatt 79620 tttatgaaaatgagattact ctgcatatac tgttttttca gtcagtgatt tccaccttcc 79680 attacagtaaattttcatct taacggaatt cccagttggc cagaaattgt ccttacagct 79740 ggtttgtccaaatcagtacc caggaccatg ccatctgtct gttgagtgac ctgaaggcag 79800 tgtaagcaccctagctggat ttgtgatctg gaaaaacccc ttcaaccaag tctcaagggc 79860 agcctggctgcaaaagggaa tcaggtcacg tggagaatct gcccactaga cttctgctgt 79920 cttccaaagtaataggcaaa aggaggggga ttctagggca ccactgggat gggacctcta 79980 gggtatttactgtcattaat gttaatgtgg catccctgtg agtgtcagga ttcacagctt 80040 gtggctattcacatccgaga tgcctcagtt cggtttgcct ggttcttact gagtgcagac 80100 cagggtctccattgtggctt ctgccttcct ctgccccaga tccagggatg ctgatagccg 80160 tgcggctgtgttcctagtcc ccagaaagtg gccctgaagg taggtgctcc cttttgcact 80220 tgtgggtgcttccagcgctt ccacctgccc aaggcctgcc cgtgagtgag agacagagat 80280 agagatagagagagagagag agagagagag agagagagag agagagagac cttttcctcc 80340 caagagaatttacccccgag tacccactct gagggtgact tgctctggtt atgcaacccg 80400 cattttgtagagggcttgac agtttccaga gagctcacgc agcgtttgat cctctgtggc 80460 agccctgggaggtttgcttg tttagttata ccctgctgga ggcagctaac aggaaacact 80520 gtaaagtgtttaaatggtac actttaaaat ggtaaaatgt acatttaaaa aggaagggaa 80580 atagaagatgaaaaaggaat tgaggatggc aggggtggaa cacagcacac tttgtgggaa 80640 caggctggcattgggagcat accctagggc ctcactgtgt cttgcatccc cttgtcccct 80700 tggtggtctcacctcagcca ctactaggag gcaggctgag taagcagtcc acgccagtgt 80760 accgatgctaagcttaggtt ctggagtccc agcagctcca cataccatct gtgtgacctc 80820 agcaagtttctgaacctctc ttagccttag tttcctcatt tgcaaaatga gaataataac 80880 agtatataggccgggcgcag tggttcacgc ctgtaatccc agcactttgg gaggccaggg 80940 tgggtggattcagtgagttc aggagtttga gaccagcctg gccaacatag tgaaacaccg 81000 tctctaccaaaatacaaaaa ttagctgggc atggtggctt gcacctgtaa tcccagctac 81060 ttgggaggctgaggcaggag aatcacttga atccgggagg cagaggttgc agtcagctga 81120 gattgtgccactgcactcca gtctgggtga cagagtgaaa ttctgtctca aaaacaaaac 81180 aaaacaaacaaacaaaaaaa cagtatctgc cttacagagt tgtgaggact acttgcaata 81240 gtacaattaaaatgtttagt gggggcctgg tgtggtggct caggcctgta atcccagtac 81300 tttgggaggcagaggtgggc ggatcacttg aggctgggag ttcgagacca gactaatcaa 81360 cagggtgaaaccccgtctct actaaatata caaaaattag ccaggcatgt tggcgcacgc 81420 ctgtaatcccagctacttag gaggctgagg caggagaatc acttgaaccc gggaggcaga 81480 ggttgaagtgagccaagatc gtgccactgt actccagcct gggtgacaga gtgggactcc 81540 atctcaaaataaataaataa ataaaaatcg cttagtggga ggatgttgcc ctccccccgc 81600 caaaaatgcctaggataata gccagcacac agtaagcatt aacacatgat tgttgatcat 81660 tattaatattattaattaat taaaataata taactattgt tgatattgta acttaaacat 81720 ttccctggcagtcttgggaa tgggctgcgt ggccttgtgg gtggcacagg tgagaagagt 81780 gaggaaggcacatctcgctc ggcctgcagc tgggagaggc agaaccagtg ggcaaagcag 81840 gagtagggtacacagagggg cagggtctgc atgaggaggg cccaggagct ggggtgacaa 81900 ggagagcaagggaatgagtg tgacacctca gaggggagaa ggagccgccc ctagaggcag 81960 cctggggcggtgactgtgct tcctgttggg gcaaacactg gcccttgaga aagactggct 82020 cacactggctgctaaaggag caactggtct aagtggggca ccagaggggt aaaggcgaag 82080 gggagagatgaaggcagaaa ctggccgact tatccccatg ttacagatag ggcctcaaat 82140 cttgcctgctcaggatgttt tgcttatgat aggaaagatg gtagttagac atcatggtga 82200 acttcctatctcagggactg gagatactgg agcagaggag tgaggatgaa tgtggaactt 82260 atgtctttgagggctttttg gaactgagaa atcttagggt agtgtggact aggggagccc 82320 actggctcaggaattcccta agtgggcaga gcagtgcagg ggcaggccag gctataagct 82380 gaaggccatgggtaatagga agtagatgca ggccctccag gcctgccacc gcaggaagta 82440 gctatgccctccccttcaca atggacttgc agggaaggct gagtggtggc ccgagaggtc 82500 ccgggagttggacagggctg ggaggacccc tgtttttctc tgtcagagga cagcaagggt 82560 ctccagagagtgccagaccc agaaaccgac agccatacgc aactcagaat ggcccagctc 82620 cccggcctcaggttctgcca ggtcttcatc cttgaggaga ggccacaggg tggagctggg 82680 gatctggggtgggggacaaa gaaccaggga ggatgctttc ccacccccag ggagctcaag 82740 ccgctgctgccatggttaca tctgcttcct gtttgattca tctcaaacag cagaagtgga 82800 ggtggggtgggggggcgaca ctggctccca gctcaggcca ctgctgcgtg gggctgttta 82860 caacagccgcatgtgggatt cccagaaaga gactccaaac cggacatcct gcggctgcaa 82920 aatacccaggtgtcaagagc taaaaatagc tgcctcaggg ccccagctgc cctgaggtgg 82980 cggagaaagaggcatgctca ctgttgccac ccttacatcc agcctcctgt ttggtgtgca 83040 ggagcttctctgtcctcttg cctcggactg atggaggcct tcgtctgggt aggcagacat 83100 cccggctggctcacctggca gctgagcctc tgccctgatg ggcagctggc tcctctgcct 83160 atacagagaaatggtgcagc ttgctttggg acgctaatga gagagtccta gagggacttg 83220 ggagcttctagagaagggat atggcagggc actgagagca ggggagttgg agctgagggt 83280 cctctaagaccccaacccat tgccagcccc ctgtttccag cacacagtcc caaatcattg 83340 cttggtttctacaaagtcaa cagttgctcc aaatgattct ttgagattgt cttcatgggc 83400 acccaaagatgacatagctt ctgccctctc acctgcgcag ggctggggat tgctgctggc 83460 acgggtctctgtggggctgt gtgatttttt ttttccatct ttctgcatgc ccatctaggt 83520 cctgcatgtgtcctttgctg gctggcctgt ggcgaatggg aatgctgggg aggaggggtg 83580 gagtgtattggttgagagcg tggattctga agcccaattg cctgggctca agtcccagct 83640 caacctctgccacttgtctg tgacctcaga caagttatct aatactgctg ggcctcagcg 83700 tactcatttatctaatgggg ataaaacagt aaatacctca taggtttgtc atgtggacta 83760 gataagttagcaaatgtagg gtacttagaa caactcctgg cacataataa ggtgttcgct 83820 tacaaaagttcaggtggaag agaaagggaa gagagcatag ttgggagagg ctggggataa 83880 gagatagggcagggggctgg gcacggtggc tcacgcctgt aatcctaaca ctttgggaag 83940 ccgaggcaggcaaatcacct gaggacaggg gttcgagacc agcctggcca acatggcaaa 84000 acaccgtctctactaaaaat acaaaaatta gctgggcttg gtggcttatg cctgtagtcc 84060 cagctacttgggaggctgag ggaggagaat cacttgaatc caggaggcag agtttgcagt 84120 tagctgagattgtgccactg cactccagcc tgggtgacag agcgagactc catctcaaaa 84180 aaaaaaaagagagagagaga gagatggggc aggggcatgc attcaggaga aaatggtctg 84240 tggtagaggagggaggagag ttgggagcag acactgaaac gctaatgcca ggaaggaggc 84300 tgcagacaagtacaggaggc aaactaatac tcgctaccac aagggagcac ccaccatgtg 84360 ctgggtgcatcacagacagc attgctaatc tcaggtgacc tctttgaagt aggtattctt 84420 tttgtttgtttttgtttttg tttttgagac ggagtcttgc tctgtcgccc aggctggagt 84480 gcagtggtgcaatctcagct cactgcagcc tccgcctcct gggttcaagc gattcttgtg 84540 cctcagcctcccaagtagct ggactacatg ctccccgcca ccatgcctga ctaatttttg 84600 tatttttgttagagatggga tttcaccatg tcggccaagc tggtctcgaa ctcctgacct 84660 caagtaatctgcccgccttg gccagggcag aacttcccca aagttctggg attataggcg 84720 tgagccacctcgcccagcct gaagtaggta ttcttatctc ctgattacag gtggggcagc 84780 ttaagcaggttaaattgtgt ttctggcttg ctttgccagt caccgaggga gtcggggctt 84840 aaacccaggcccatctgacc gcaaagccaa tgtcctgtgt gctttagacc ttcaattccc 84900 tcacagtttgtggcctgcca gacttcatgt ggcaggggct tccagcccac tctcagctcc 84960 ctgctgggttctggataaat ctgagcaaga agcattcagt gccaatcaat gagcagtata 85020 gagaatttctggaagggaga cacaagaagc tgttagaaag ggcggcttcc agggaagttc 85080 tagggagtctgggatgaatg agaaacttat cctaacaact tttgggctct ctgaattttt 85140 tttagtatctgcaagtattg tacttgttca aatatgttta aggctgcagg ctgtattcta 85200 aactccttgaaagtgagaac caggtttcac tcatatttcc atcttttcaa cccctagatc 85260 agtgacttcccagggaagta gtacctgcat ttggggttga cctttgggtt tcccctgtac 85320 tggtctggcctggcctggct ggaccactgg ctggctgggt ggctgtgacc tagccccttc 85380 tttctctttgctcctctgtc aaatgagagt gttggtctga acgatctcta aagcctggaa 85440 gaggagcagatcctctgtgc tcagccccca ctctgtgtca gggaggcctg gcaaccacag 85500 tgttctttctcctgtttatt tgttcttgga tcttcctgaa gccatttcac caccagcctt 85560 catcttctctgccagcccca tggagactca agctttttcc agcctatgtc agggaaggag 85620 aaccagagacagcaacctcg ggtgtgaagg gagtcagctc tgaacccagg actatggcct 85680 tctgccactgcctgctttcc tcttgctgct ggggcctagg tcttcttgct gctgcttcct 85740 tttccgctaatcaagagtcc agggaggtgg gaacagcctc aacaaagact ttgaagatga 85800 gcggggaggatcgcttgagc ccaggagccc agcctgggca acaggggaag acttcgtctc 85860 tacaaaaaaaaaaacaacaa aacaaaacaa aaaaaattta gccaggcatc gtggtgcata 85920 ctgtagtcccagctactctg gaggctgagg caggagaatt gcctgagccc aggaggtcaa 85980 cgctgcagtgagccatgttc acatcactgc actccagcct gggcatcaga acaagaccgt 86040 acctcaaaaaaaaaaaaaaa ttaagaaaag acactggagg catcgggagg ggggcgttct 86100 aggtggcagtgctcctgggg aagccttttg tcccactgaa gacatgaagc tcctgggaga 86160 gcaggtggtcggcaaggctc aggttttcat ccaccttttg cagatctagg aggcaaagtc 86220 atacctgctggggagggagg accaagactg gggcctgagg caataaggta ggagcagtag 86280 ggaggtcagtttgttccagg tgcttagaat tgtgtttgtg tttactctgg aggttgctga 86340 gggctggggtgcacctattg gaacaggggc tccataggtt tctgggtaaa atcaggtgtt 86400 ctggtttaagaaggtgactt ggtaggccca catgccccag tgccaagtaa actgttctta 86460 agtctgactgcagttgcctc caaagaagat agaaaagggg agtagccagg attccaaaaa 86520 gaagagctctccaacctggc aaagagccct gtgctagaca gtattcctgg taccttgggt 86580 ccatttacttctcttttttt tttttttttc aggctgaccc caaattagta gtaacagccc 86640 tcggagagaggcagtgatgg gaaaagaggt cccacactca agccagaact gggaggcagg 86700 atgttcatgctctggcttca gttcagctac tgacggggtg ccagtagata cctttcctct 86760 ctctaggacacaaagagagc tgttcctggg tcttaatctc tgtcgctctg cgctcttctg 86820 aacttgatggccctcagcac ggggccaggg agcgggggaa aagcagaact ttttccagga 86880 attgctattggaagcagccc cgttgccaac acgcatgcac acatgcacac agcttttctg 86940 gacagaccttatattatgga ttatcaccac aaaacatccc tttggggcct ggtagcccac 87000 accacagaattcagggtcat taatttttct cctatccaga gagtgcatgg tgtccggaat 87060 ctgtggttaccaggggagca aggcacagag aacctggctc tgctcccaag catgaatgct 87120 gctgaccagcccctgggtag ggactgggga ggtgggacag aattcccagg aggcagggga 87180 ctcagcctgacacagtctct gggagtgcac cctggagccc agtccagaaa cctctgggag 87240 gaccaggtcctgcagaagaa agaagaggta ctaagaaggc ctgggattgg gggttaccat 87300 gtcgtggggaggggagtttg cctctgaggc ccaccacctt gagaaatatg catgctgtgt 87360 ctcaggcaggttgtcaggag agagtcattg tatttgattt gtcagctact aacagagcct 87420 gccacgtgccctgcgaggtg tttggtgcag atgggcatgg cttccacagg gcaccacaga 87480 gatcatgatgaatgaagtgt caaggtggta gacacagagc gagtgctgtg gaaaaggaag 87540 aggggagaggtcagggagag cctcccaagg agatggactt gggctggacc tcagaggatg 87600 ggcagaatttaaataggtag agcagcattt tcggaccgaa ctttgttacc caaagcatgg 87660 gctggtttgaggggcagtcg gtgggagtct ccctgtgccc aggctgcccc ctcccccagc 87720 agcgcctgcctgcaggaagt tctcatttct cggctctgaa gaggaactgt ggctgcctct 87780 gagacacagacccaaaggag caccccggca gtttctcaaa aaatatccct tctgccccaa 87840 gtctggccagcagagcgctt ctgtgtccac ccagtacccc gtccaggcag cctctgggtc 87900 tcctggcctcctgtcccctt gaccctgaac tggacagcaa gagggaaagg tgtctgtcct 87960 ggacaggtggcctcaggact catctctgtc ttctccaacc ccagctggcc tccatgtccc 88020 ctgggggctttctgctgctg accagcttgg gccctactat aggttttctt gctgggctta 88080 ggagcctgagagaggtagcc atttccaaaa gaaaagattt ctatctcaga ttatctggga 88140 aagaggctgagtaggtccct tctctgagga aacaggcagc aggacatagg atggggcagt 88200 gggaggaaaagggtctgcac tatggggtcc ttgggctgtg cactcctgac cttatcactt 88260 cacagttcccaccagatctg acttgacctc cgggccatga cccagtccct cccccactct 88320 ggaaacctctgtgtcccctc ctgctccttt cactcccacc tgggaggctc tgagcaggcc 88380 agggtccctctctccaggcc tgctcctccc tttctcctcc tgtcccccca gccatccccc 88440 cagccaggctctcccacctc tggccccacc tcacctcttg gccttcttct ttccctcggg 88500 cgatgggagcctggtttggc tgcccaggga agattgtatc tgaccacagg agggagggct 88560 gagggcactgctgggtgagc tgaggcctcc ttaggttctt gctgtagtct gagttcaagt 88620 catttagaatgagtgacttg aggaagaggg agctgggagc ccttttcacc agcaggggga 88680 ctggaggagtcgaatggggt ggggtcttct cgttttgatt agcttctggt ggaggtccca 88740 ggctttggcgtgctcaagct tggagtggca gggagcaggc ctggcttgac cttctttcct 88800 tcctgctccctctcctcacc cctccctgca gctctttcac tccgtctctc tctctacaga 88860 tgggacccaggtgagcccgg gtgcccacta ctgcagcccc actggcgcag gtaagagtca 88920 aacccgggggagtccatggt agggagtgga agatgagggg tggaaaggct gtaagaacgc 88980 gagaagctgaggggttagag aagcagggtc gctggctgat ctgccagaga gccaggaggt 89040 ggcggctccagggaggggcg aggagccggg gtaagagagg cagctctgga tgctggctgg 89100 gcacagtgctaggaaacaca acaggaaaag gaaacacagg atgcccgtct tgtccttgct 89160 gggagcagtgaaacaggaag gaaagtaaga agctaatatt tatactgaga cccctacccc 89220 atgtcaggcaccaggcaagg tgtgttcttg tgtgtggact cggtcctcac accggctctg 89280 caaggtgggcatggcagccc ttgcaggact gctctgctgg aggggaagtg ttctctcact 89340 gtctgcgcctcctccctctg ctggcccgag cctcctctgc tgctaggctg ccctggggaa 89400 ggactggacttcctgctgct gctttggttt aggacatgcc catggggcca ggtctggact 89460 agacgcggtctgcccttcct ttagtgtagc cagtatcaac caagggccta ctgagtgcaa 89520 gatatacagcctgatgccta ataattccat atagcaggga gaaatggaac ccaggtatcc 89580 tccttgcttcagtcctggct gttgaaaagc taacaggcag gttagggagg aagcacacac 89640 aaatacaaagcgaaaaaaaa tagaatgcaa taatgtgacc agtgcccaat gagaggacac 89700 tgattcatgagtttatccat ttgttcaaga atcattaatg agttctgtct ctgtgccagg 89760 gtactttcctggacatttta ggagagacac tgatttattc attgattcta tgtttgtgga 89820 gtgcctgtcatgtgctaggt actattccag gtgctaggaa taataaacaa agcatgaaac 89880 caactccctgccctatggag cttaactcag acatggtacc tgcccacaga gcactaatcc 89940 tggtgtggaacagccatgtg attggagtcc aaaagaggga gggatgctag gcgctggctg 90000 ggtccagggatgagggagga ctccagctga gctttgagca aagagtagga tttggaaaag 90060 tagaatgtagggatgaggac agcacaggca gggggacatt gtgagcaaaa ggtcagagaa 90120 cagaagagatgtggatttgt gacaggtgga agctgatggc caaggtggag ggttcatgtt 90180 caaatgcagaccaagttgag agaagccaag ttaggaccag attgtggagc ctcacaaatg 90240 ctaaagcacctcgaaaagta tttccagggc tccaggcaga gcccatcctg tattcccttc 90300 tgctgtggaggcagtggcca tgcagagtgt gaggggaagg gcccctgctg ggggtctgct 90360 cacagtccgtatgtggctga agccactggt cttgggtcca ggtcgctggc cttggttccc 90420 ccaagcccctcttgcataat caggggagtc accccgggaa gccaggacac agaacatgga 90480 aggactgaaacctttcctgg ggcaggagtg ttttggtatt cgaaacccag actcaacccg 90540 aatgagaatccggatttctt gggaggcaat gtgaacaagg ggtggggcat caaagccata 90600 cattttctactgcgggcggc atctgggtgc acagccatca ctgtccctcc aggcctcttg 90660 atattcgggggacatggcgg gcacctcctt gctgggctcc tgtcttgtgt ccatgtcaca 90720 gtcagggaatgttagagtga atgcccttta atgacagcct actgcaaacc cctctttgct 90780 tagtgagaaagccccttgag gggaggtgaa ttcctgaaag ttggtgggaa actggagtac 90840 ctgccttggtaggaccagaa cccatgctag ctctgcccct agcagggtga ctttggacag 90900 ggcccttcacctccgagcct cggtttcctt atttaggata acaagatagt aatgactacc 90960 ccccggggccagtggcttga tgtagctgct catgcacaag tgctgtagat gtaaagattg 91020 tggttaggagtggccagctt gggcctggag gctatgattt ctgactcctg gactggtact 91080 ttgccacaggcctttccagc cctcctcagc cccaatccct gaggacagtc tgtggctgcc 91140 ccactgggagatgcccagcg ttggaattgc tgaaggaggc ctctccagga aggcttctcc 91200 acttgtgtgccctcccatgg ggccggcctg ctcctacccc acccacttcc ccttctccag 91260 gataagcccgctgcaacagc tccgtctccc agtgtctcag cctctctggc tgctcagccc 91320 agcctggtccagctggctat gctggcatgg accctagtct ggtggccagt tataaatagc 91380 ccctgcacccacagccttgg cagggtgctc ctagtgtggg tgcagaggac acttgagaag 91440 aggcagccgtgcctgccatc ctgaccatgc caggcccaga gctgccatgg aggcacccag 91500 gagcaggcccaaggacacat gggccctatg agctgaggaa cctgccctgg gcacagggtt 91560 ctgcaggcccaacgtggccg gtcagggctg gctgtaggct tgaggcatca ctttatctca 91620 tgactggggatagagcatgg gagggtggcg acccagaggg cctgtgaggc ttggggctgg 91680 aggcagaacaaagtgggcct gtttgcctgc ctgattgctt cctttgagcc caactcatta 91740 gagggcagctgggcaaatcc tctgattcca gggagggatg aagggaggga gaaggcaggg 91800 ccaagaatgtcctaccatag gatctgcagc ccatcggaga tcactgtagc cctcagcccc 91860 cggcccagggaggagcatgt ttagtggagg agcactgtgg tggagtcgga agactccgtt 91920 caaacaccaccagtgataca gtgttactgt gcacagttca tgtgactttt ttctcacgag 91980 taaaatggaattgataatac ctaccttgca ggaccacgac aggattaagt gaggaaaaac 92040 ccccatgagagtgttttgcc attgtcaagt gagcctgagg gaggctgagg ggggatcagg 92100 ctgtatcatgcccccgagga caaactttcc agtttaccct gctccctctc tctgtcccta 92160 ggctgccccaggccctgtgc agacacacca ggccctcagc cgcagcccat ggacctgcgg 92220 gtgggccagcggcccccagt ggagccccca ccagagccca cattgctggc cctgcagcgt 92280 ccccagcgcctgcaccacca cctcttccta gcaggcctgc agcagcagcg ctcggtggag 92340 cccatgagggtaaagatgga gctccctgca tgtggggcca ccttgagctt ggtccccagc 92400 ctccccgccttcagcatccc tagacaccag tctcagtcct caactccttg tccctttctg 92460 ggctgccggccctgcccaca gctctccatg gacacgccga tgcccgagtt gcaggtggga 92520 ccccaggaacaagagctgcg gcagcttctc cacaaggaca agagcaagcg aagtaaggag 92580 gtggccaccccagcccagcc cagccccacc agccaggtgc ctgcggctgc ctgtgtggct 92640 tgtgaggggtgaggtgggag ggccgcagcc agctgggcct gagccgaggc tttccctctg 92700 cttgcctgggctctgcctgt gaatgtgtgg gggatgtggg ggtggggggt ggtgtctgga 92760 ggctctagggaggggtaggg cctcgggctt ggctcttgcc tagggagtcc ctgggacgcc 92820 tcctactgaggatggggaca gggcagtggc caggtagtgc cacgaggccg cctgtccacc 92880 cacctccagccccctcctga ctctgcccct acaggtgctg tagccagcag cgtggtcaag 92940 cagaagctagcggaggtgat tctgaaaaaa cagcaggcgg ccctagaaag aacagtccat 93000 cccaacagccccggcattcc ctacaggtaa caccctcctc acctgccctc ctgtccccac 93060 atgcaccctccacccccgcc cccgtgttag ccatgagcac acacacttgc ctccttcctc 93120 cccagttgccacaaccagtc cttacccttc ctctaaacat aatgcccccg agcccctctc 93180 tcaactgatacctgccctcc tctctttaaa ttctccccac cccacctgag cccttctcac 93240 acacacacacacacacacac acacacacac acacacaccc tactggcttt tttcttgcac 93300 atgagccccttctctcttta tattttccct gagcgcaaaa atgtcctggt tcccagagca 93360 ggttcctagtgcaggtgaca gagcccccag tgggctcttc acccacgcac caagcacctg 93420 gcttctatgcctaggtcaga gctctgcact atagctgctg gagcggacag gcggcccact 93480 gctgccacctggagatggtc cccattccta ccagccccac attgcccagc cctgcccgct 93540 gcagcctccccctcaggtcc cagggcccgt gctcagggca gtgcccgtgc agtgtcccca 93600 cacctctgaagcagccttgg cactcgttct gtagaaccct ggagcccctg gagacggaag 93660 gagccacccgctccatgctc agcagctttt tgcctcctgt tcccagcctg cccagtgacc 93720 ccccagagcacttccctctg cgcaagacag gtgagctgaa caaacaggcg gacctttcag 93780 gcaaaggaagggggaagggc ctcggacatg ggggaggagt gtgcaggggt gggcgggctg 93840 ggctgggccaggagatcatc ggtaggctag gatcttcttt ctagttctgc cttctctttc 93900 cttgaccgatagagatgact gggactgagg ggttaaaggg tggaaaaaag aagggtggtg 93960 ggggcctgagtgacgctggt gctccctgca gtctctgagc ccaacctgaa gctgcgctat 94020 aagcccaagaagtccctgga gcggaggaag aatccactgc tccgaaagga gagtgcgccc 94080 cccagcctccggcggcggcc cgcagagacc ctcggaggtg agggccggct gagccagtgc 94140 ggttgccatcctcaaacctg gctggtcttg tccctttggg tcaggcccca cctagacagg 94200 ggtcccctccttaggactgc catgcgtggt tgcatggggg tgtcccacac acttgccgaa 94260 gcgggggagttggggctgaa acccagtccc tgctctgtta gctaaggtga catctcccag 94320 aaaagggggcacccttcaaa aaattatgca aaggtgctgt aggccaaagg tggcctgtct 94380 tcttcctgctctgatgggaa gaaagcagga ggccgggcgc ggtggttcac gcctataatc 94440 tcagcactttgggaggctga ggcaggtcaa tcacctgagg ttaggagttt gagaccagcc 94500 tggacaatatggtgaaaccc tgtctctact aaaaatacaa aaattagcca ggcacggtgg 94560 tgcatgcctgtagtcccagc tacttgggag gctgagccag gagaatcgct tgaacccagg 94620 aggtggaggttgcagtgagc cgggatcgtg ccattgcact ccagcctggg caacagagca 94680 agactctgtctcaaaaaaaa aaaaaaagaa agcaggaagc aaaggtgctc gttaaggaag 94740 ggggtgctcccgggtctcct gcaccaggcg gcctggctgt accctcctgc ccaccctggc 94800 ctctgactgcacttccctct ctccccaacc ctcagactcc tccccaagta gtagcagcac 94860 gcccgcatcagggtgcagct cccccaatga cagcgagcac ggccccaatc ccatcctggg 94920 ctcggaggtaaggccttgcc gagactgggc tctcctgggg cagttctgag gctcagcctt 94980 cttccagcaggcggccctac ctgggctggg gctgcagggt ctgggcagcc cctgccagag 95040 cctcctgggtgttctgggga aggtgcgccg gggtagaggt ctgggaccgg tgaccctcgc 95100 cctgctccctatggcaggcg ctcttgggcc agcggctgcg gctgcaggag acttctgtgg 95160 ccccgttcgccttgccgaca gtgtccttgc tgcccgcaat cactctgggg ctgcccgccc 95220 ctgccagggtgagtggctgg ggtgcccacc cccactccaa gcccccccag cttctttcac 95280 tcccttttcttgctgcctca ccccatcatc ttcattgttc tctgctggaa tcttcttccc 95340 cgtgacttctcccgcctctc ccccaggctg acagtgaccg caggacccat ccgactctgg 95400 gccctcgggggccaatcctg gggagccccc acactcccct cttcctgccc catggcttgg 95460 agcccgaggctgggggcacc ttgccctctc gcctgcagcc cattctcctc ctggacccct 95520 caggctctcatgccccgctg ctgactggtg agtctgctgc ttcttcaggg aaggggctgg 95580 gtccctgcaccctgctaaga gccaagcttg ggatggaccc atccttcctc cccatctctg 95640 tccccctgtcctgcgcattg ccctgctgca ccctggcccc ccaccctata ccctcgcttc 95700 cttccattgctccctgtggt tccctcctta ttccaccccc cgattctttc cagtgcccgg 95760 gcttgggcccttgcccttcc actttgccca gtccttaatg accaccgagc ggctctctgg 95820 gtcaggcctccactggccac tgagccggac tcgctcagag cccctgcccc ccagtgccac 95880 cgctcccccaccgccgggcc ccatgcagcc ccgcctggag cagctcaaaa ctcacgtcca 95940 ggtgatcaaggtgagaggaa ttgggcagtg gaggtattga gggagtgttt aactggggac 96000 ttaggggccaaaagaagagg ggtacttaga aagggcaggg aactggaggg caaaagaggg 96060 ggatgtggcttcttggggcc cagagctgca tggcagctgg agtcctagca agatgactgg 96120 ctgcctggcccagcccacca cctcccaccc catgcccctc gctccaccat ggcttctcag 96180 ccaggttctcccctccccag aggtcagcca agccgagtga gaagccccgg ctgcggcaga 96240 taccctcggctgaagacctg gagacagatg gcgggggacc gggccaggtg gtggacgatg 96300 gcctggagcacagggagctg ggccatgggc agcctgaggc cagaggcccc gctcctctcc 96360 agcagcaccctcaggtatgg cagtccccac ctgcccctca gaaagtgtcc tcagaagact 96420 ctggggcctggcataagatg gggaagggag ggagatacga catcagtgca acaggcagct 96480 ctaggacccatggttgccct ataagatcct gggtgctgga tccacactaa ggtgtaggca 96540 cacacacacatgcacactca cacacccata cacacacata cacacaacag cttgccagtc 96600 tcaggtgaagcatgtccctt ttccaggaag gagtctgtcc tttcctggag ccacacatag 96660 tcctgccctggtatgtctcc cctctatcca gaaaggtggc tagggccaga ggtgggatgg 96720 agccaggctccagcgtgtcc agcagaatgc tctcactgtg ggaatcaaga cccagtgcat 96780 tagcttgccggagctgttgg gatacaggct gggcgcctta aacagcaggc atttaccatc 96840 tcacagttctggaggctgga agtcaaaatc gaggtgttgg tggagttggt tccttctggg 96900 ggctgtgagtgtgagggcag gggctgttcc cggtctctct ccttggcttg tggatggtca 96960 tcttcttcctgtggcttcat gtggtttccc tctgtgaatg cctgttcaga tttcctcttc 97020 ctataaggacaatagtcata ctgggttaag gcccacccta acgacctcat tttaatttga 97080 ttacttctgtttgtaaagac cctatctctg aataaggtca tgtttagagg tactgggggt 97140 tgggacttcaacatataaat ttgagggtgg ggaacataat ttactccata acacatgatg 97200 acaggccacacacatgttct tgaacagtta catagtccag gacaggagga catcctggtc 97260 agcacaagatccagcgcccc tcccctggtt cctggctttg gagccccaag ggcccgggga 97320 gctggtggaatgggtggtca gtctggggtg caaacctgtc agggggctgc aggggacagg 97380 gggcttagagagtcaaaggc cagagcccca ctggacagca ggtctaggtt tatcctggaa 97440 tctctctaggaaaggggcct gcttggcagt tcccaagacc tcaggcagaa gtagagggag 97500 caggaccctgaaacactgga gaccaaggcc ccatctttcc cctaggtgtt gctctgggaa 97560 cagcagcgactggctgggcg gctcccccgg ggcagcaccg gggacactgt gctgcttcct 97620 ctggcccagggtgggcaccg gcctctgtcc cgggctcagt cttccccagc cgcacctgcc 97680 tcactgtcagccccagagcc tgccagccag gcccgagtcc tctccagctc agagacccct 97740 gccaggaccctgcccttcac cacaggtgag accgggagga gggtggcggg tggagggagg 97800 ggctcggctgcacgagtcca tgtgggtgtc ttggtgtcac ttgggacatt tttagaggcc 97860 acagagtgcttagccttgtt aggcccacgt agtacccatg gagcacatgg aacagctggt 97920 tattgcatttggccgatgag gaccaaggct cacgaaatct aaggtgacaa gcctgtggtc 97980 aaatagcaagtggtagtcaa gccaggataa gaattccagt ctcctgccaa tgcactcagc 98040 ccttttaaaaaatgatattt attactgttg ctctgcttgt aaaaagagct cagaagtatt 98100 ttagacattttgaagagtac agaaaaacct aagaagaaaa gaaaaatcac caaccagtat 98160 cccaccacccagaagtaaac cctctgaaat tctgctgtat ttcagtccag gctttgttct 98220 ggccatatgtacatgtacag atgccatgaa cacatgaact acgttttgta tcctgcttta 98280 cttagttaacatattatgaa tccttcttgg cataattagt ctttaaaact gagagtctca 98340 tagtatttcattaatgtatt tcatttttac tgagggatcc cttatcagtt agacatttag 98400 attatagcttatttgaattt ccttatgcat aaatctttcc tcatgcttgg gattatttcc 98460 caaggttcactctaaagaag tagcattcct gggtcacatg gtgtgagcat tttgagagtc 98520 gttggtgtcctagacgcaca gaaattgacc ctcccacccg caatgagcag gaccctcctc 98580 tgaagacttcccacgggtca gactgaaata gtcacttctc caaagctgga tttgtctatc 98640 acatggtccagtgtcatcgt gggcttctta gctcccggtt tgggggtttc ctaggaattc 98700 ttttccctcctgctgcccct tggtagcctc tctgggttca tgacacgtgt gtgagatgct 98760 gtacgttaggcctcatgctt tgctctgagc acttgagggc ctggtgctgg gccctcgagt 98820 cctgggccacccagcagtcg tgtccgcatg tgggaaggcc gtggctctgt ggcagccatg 98880 ttggctggagctgtgttgat gtgttggctg ctgccacctg gggaagtgtc tgggcgtgtg 98940 tggacaggtgtgaggggctg gggctggggt aggggcagga tgaaatgcag gcctgtgtgg 99000 gtgtgaggggtgtgtacccg cccggctcca tgtgggtgcc tgctgtggcg gtgctggcgt 99060 gttctctgcagccaaggcca tggggcgtga ggactccctg ggtccccgct ctgacccttg 99120 ctcctgcagggctgatctat gactcggtca tgctgaagca ccagtgctcc tgcggtgaca 99180 acagcaggcacccggagcac gccggccgca tccagagcat ctggtcccgg ctgcaggagc 99240 gggggctccggagccagtgt gaggtgagga ggcgcgggtg gggcccgagg aatgggtgga 99300 gggaggagtcatgggagggg aggggtgggg ggccctgggg cccatgagag atgaggggca 99360 catggggtggtggtgatggg agggaagggg cgagcatgag ctcagagctc tgtggtcccc 99420 ttttcagtgtctccgaggcc ggaaggcctc cctggaagag ctgcagtcgg tccactctga 99480 gcggcacgtgctcctctacg gcaccaaccc gctcagccgc ctcaaactgg acaacgggaa 99540 gctggcaggtaatggcctag tggccctgtc tccccatgcc agcttacctc acccagctcc 99600 catgcactcctgtctcggct ctgcccgccc agccagcctc ctcctgcacc ctggacgtcc 99660 ctactccagcttgctgccaa gcccctcctc agcccacctc cacctctccc ttccatattt 99720 ctctcccccaatactcaccc ggccctgctc tctgggctcc ctgctccctg ttgggccaaa 99780 ggctgagagtattcacgctg acgtgggctg ggcctctccc cgcagggctc ctggcacagc 99840 ggatgtttgtgatgctgccc tgtggtgggg ttggggtaag tgtgcccagg ggtctcaggg 99900 gggcgttgccagggctctca gctctcctcc ctgtggttct cccaggccca gcccctgcag 99960 aacctctgcttgttgtggtt ctgccagaca gggtgagcca gggacttcct gaggtgcccc 100020 ctgcagcaggaagctccttt tggacaggcg tgtctcggac ccacagtctc ccccgaatgc 100080 ggagtccagcctaagccttc ccctagaagg tgtctggtag atgttgagtg aggtttcagg 100140 agcagggccaaggctggggc ttaggatcat ctctcccttc aaagaccccc atgactgggc 100200 attggccgccaggctgctct gtctgctctt aagtggcaag ttggggtacc tcagcctggt 100260 ccccagaccttgggctgcct ggtgtgacat cacggtggtg cttccggtgt ccttggcgat 100320 cccagcactccccactccgg gacatagccc caaactccgc tcgcgagctt tgcttcctaa 100380 gtcctcacccctttgtgaag ggagcttccc gctccctccg gctcagctct cctcgcctaa 100440 cactatccctgcagtagttt ctcaagcaag gtgtgtagag gcaggggatg gaggcctcat 100500 tccggagggaaagtgggagc tgtagctggt gggggacttt gggagccagt cagtgcccta 100560 ttcacaacttcccatttctt gccactttct ggtttttcca actgttgttg cttctgtttt 100620 ctcctccctcctctccctct ctgtctttct ctctctctct ctttctccag cctcttgcga 100680 ctctctctgccttcctcgcc tctcttggtc tgcctcgccc tccccatctc cccatcatgc 100740 cccccggcccctccctagcc ttgaggccca gggactgggt ttggggggcc tcccagcctg 100800 ggctaggggccctgagtgga agacagtggt gcagacggcc cctccagctc cgaccgtccc 100860 gcagggcctgagcagagtca gctggggctt aaaaccccct cccggcccaa accccaagtc 100920 ccgcccaggtaacgccatgc cccctcccct gaccggggag gcaggcgtga tgctgccagc 100980 agagtgctggccagataatg ggctggtgct gggacttaag ctgggaaaaa gtcatgctgg 101040 gattgggggacacaggaggc cttgcctttg ggcggtgggg cactggggag gcagcactgt 101100 ctgcccagctccctgcccct ggggtcctgg ccgtggggtg gggaccaccc ccttgggccc 101160 tggctcctgtgtgaagcctt ggatgatgcg ggccctgact ctggctcccg caggtggaca 101220 ctgacaccatctggaatgag cttcattcct ccaatgcagc ccgctgggcc gctggcagtg 101280 tcactgacctcgccttcaaa gtggcttctc gtgagctaaa ggtaggaggt ttgggttgaa 101340 ggtggacacaccacaaagga ggaagcagag tggggtagtg gggaatccag gcccagaacc 101400 ccaggcatcgcattcctctt agagattgct acagggtttt ggaggggaaa ttgagggctc 101460 tgggaaccaggttgagattg gaactcttgg ggtacgttca tgcagctgtg ggtcagagct 101520 gtctgttgattgacaagcat tctttctttt tccagaatgg tttcgctgtg gtgcggcccc 101580 caggacaccatgcagatcat tcaacagcca tgtaaggcta agggaagacc tgggtgggat 101640 gaggtggggggcaagccccc aggaacttcc ttcagggaca ttctctcttc ttccctgagc 101700 tttctcaggctgggccaacc caggggcctg gggaggtgag ggcatgtgga gagaatgggc 101760 tggcaggacctgtctctcct tccaggggct tctgcttctt caactcagtg gccatcgcct 101820 gccggcagctgcaacagcag agcaaggcca gcaagatcct cattgtagac tgggtaggtg 101880 cctgtccgtagcaccctcca attcgagagc cctgggggaa aagccctgag cctgatgtta 101940 gagatgcggcttcatgtctt agttctgcag tagcctctct gagcctcagt ttccccttgt 102000 gtaaaatttgggtgaagata acacccacat cacagttggg aggcctagag gggatggcgt 102060 gtgggaacgcattcagccat cgcaaacccc tgcaacgagt aggagctgtc atttgagtgt 102120 tgtcttttgacctctattgg cttcttttgg cagatctagt aatttctgca tttcctgtac 102180 aggtagtgatgataagaata atagcagata acatcagtac accactaatc acatccagac 102240 actgatggttttacacatga tggatttaat cctgactata acccacttta cagatgaaag 102300 tgagcacagagagattaagt aactcacaca cagtcattcg taagtcatga gatggatttg 102360 aacccaggcgggttagctct agagtgcttg cgtttaactg ctaagctatg tcccttctgc 102420 actgacagctgtgtaagaga catttctaag cagaagttga gagcggtgga ggacctttgc 102480 acacttgagttcccgcatgg tcctgtgagt cgagtgtagg gcccagctct ccctacgagg 102540 gatggggctgggcctcgtgt acctgcccct ctgtaaccga gcttggtttc tgatctcctc 102600 ataacttcatgactttatgc aagacagagt ggttcctgat atgtgtaacc ctgaaccctt 102660 ccctctccttgccactaacc ccatgtccac acagttactc tctcaggtgg gctggcctga 102720 gattgggacacctcctctcc ttcaggatct catattacag ccagccctgt ccagcacaga 102780 gaggccgaggttcagagccg ggcagtggat tacgtggggc cactcgaccg tgtggcttta 102840 ggaaccccaggttcctgatc ccagtctagg gtcctgacct cagaatggcc actgaccttg 102900 aaacccttctaacctgtcct ggcccccatc tctctgcctt ccctaatcgc tgcccgtctc 102960 cctacacaggacgtgcacca tggcaacggc acccagcaaa ccttctacca agaccccagt 103020 gtgctctacatctccctgca tcgccatgac gacggcaact tcttcccggg gagtggggct 103080 gtggatgaggtaaccgcatg tcagggccac atcttccagc ctcattgacc tcctcctgac 103140 acttactctgcctctgtcat gacgagctgt gtgatcctgg gcagactgct gagcctctct 103200 gatcctaaacttccccacct ggaaatgggg aggctggatg agctgggctg gcagctctaa 103260 caaactggtgttccccttct gggactctgc tgtcctcatg tctctcttgc ctcctgtttt 103320 ccaggtaggggctggcagcg gtgagggctt caatgtcaat gtggcctggg ctggaggtct 103380 ggacccccccatgggggatc ctgagtacct ggctgctttc aggtacgtgc tctgggggcc 103440 cagaggggcaagtccaccct ctcctgtccc ttctcccaag agcaccaggg gggaggtgat 103500 cagttggattgtcagcctgt ccccaccagt tcctagacat tgtaggtgaa cgccagtgag 103560 aataggacaaacagagagaa gaatgcaaaa gtcaaagggt gctttgcaaa ggcatacatt 103620 accgagagccaatgtcaaac tgattgctgg caggtgggtg gtggagtgag cagagctggc 103680 acatttagtcagagaaggct gccactctat ttgggaaaag agaattctgg aaatggatct 103740 tcaaacacttttctggagtt atctccatga cagctaattc tacgagagcc ctgggctgga 103800 gttcctggagtcttctcaga gcccagggct atgaagaaca cccaagcagg ccccagagtt 103860 ggatcaggggtagaggaagg cagctggggg ggggcctgga agagggagag gatgagagaa 103920 tgtagccaggtggcgcagaa cctcagagga cctagttgtc ccctactcag ctctcaagta 103980 gtgagtagctgggtgtggtc aactcagtcc aaaggactga gcacttgtag tccctgaagc 104040 tttgtgaccagagtccatct ccgcaaggct gtgagattac cctttccctg tggctccggc 104100 cactgcaccccacagatgct tgcatgcaca cacacacatg cacacacaca tggtcacaca 104160 cactcctctttcattccctc tggtgctcca tccttggctc ctttctgcct cttgctagtt 104220 aagtcccctagggggctgag tccttaggct gtgtgtgcca gggacatggg tggccagcca 104280 aggtcaaggaggtcagagaa atctgccagt tgtgctgggg cactgggagc cttggagtcc 104340 taagaacagggtgccccacc gcaaagttgg caggaccgcc cctggcaacc ctgcacagta 104400 cgatgatcgccacttcttgt gacctcacag gatagtcgtg atgcccatcg cccgagagtt 104460 ctctccagacctagtcctgg tgtctgctgg atttgatgct gctgagggtc acccggcccc 104520 actgggtggctaccatgttt ctgccaaatg taagggagcc tcagctgagg gggacgttag 104580 ggacagagagccaggcggtg cggggagttg ggaggcactc ccaagtcaga aagggaaggt 104640 ggcagtggccagcccagggc tttcagcctg aggactggag tatggcagct ggtcctgaaa 104700 ttccccgggatctcctagcc gagcacagcc caagcccttt ctcaggacca ggccggttca 104760 ccacggagggcttgaccagg tcatacccat ggggacttaa gtccagtagg caggaagctc 104820 agccgtgggactccccacca cagctgggtt gattccaggt gggctggcag ctcctccaga 104880 ggaaggggagagagaagcag cactctcaga atagagggtg gccacagggc ccagagtaca 104940 gaaagaagagagggtgtagc tcagtgaaaa agacacaggc tagagtcaat gacccaagtt 105000 caggtcctaccttgctgcca cttactagct gtggggcctt tcccaaggcc cttaacctcc 105060 ctgagccttgagtgaagcat actagtaggt tttgtacgac attcaatgtg aaagcacttt 105120 ggaaatagtgattgatacat gtgagtcatt ctttattagg gaggaagcaa gcagggaagc 105180 cacaggggtagagaacaggg tcacctctcc actcccgccc ctcccatttc tcccctccca 105240 acctctaggttttggataca tgacgcagca actgatgaac ctggcaggag gcgcagtggt 105300 gctggccttggagggtggcc atgacctcac agccatctgt gacgcctctg aggcctgtgt 105360 ggctgctcttctgggtaaca gggtgagccg tctccctccc ccatccatgc ttctgtcagg 105420 caggtaagcccggctctcag gactacccaa ggagcaggca gatgggatgg gacagggtgg 105480 gagtggccaagcctgaaaca aggtaggcga agcggaagcc tctgttccaa gttaggtcca 105540 ggcagcatctcctggcctag gtagagtgtg cttgtggcta gaaggctggg gcccctgggg 105600 tgggagtgagctgggcctgt gggtccctga gagactggtg gctgatgtac tgttttctat 105660 aggtggatcccctttcagaa gaaggctgga aacagaaacc caacctcaat gccatccgct 105720 ctctggaggccgtgatccgg gtgcacagta agtgtggaga tgggacactc gctgagctca 105780 gactgaaggatcttggtggt accctgcccc accgtggcca gatcctaggg cttccggtgc 105840 cagccaggtgacctgctgtt ggtctggagt aagattcctg tgagtgaccc aggcagcaat 105900 ggtgagcaccccccagtgag gggttatcct ctgagccccc ccgatggagc cagcagggcc 105960 taccagacagtggcccctca aggtagggac tggcctccat ctctagcgac agccctagac 106020 cagggccaggtcaagagcaa cactcaggcc ttgtttgcca aaaggcctgg ttcccatccc 106080 tcccctcagtcctggccaca ggcgtctcag gagctctgct ggcttggggg ctgcgtcttg 106140 ggataacccccacatttgta aagtacttta aattttcaac ttcaactcaa catctattga 106200 gcatcttatgtcaagaccca taatctatac tagggataaa aatgagtaaa atagattccc 106260 atatcaagggctgggtaggg gagccgtgat gtctttacat aatggtaaag acatggctga 106320 ttcctcttacggtgggtgcc ctcacactga gccagattcc aggacatggt tcctcacagc 106380 agcaggcaggaggagcattc tcctggcctg ggcacccatg cagagcggcc gtggtgatgg 106440 tcagttctcccatgttgtgt tcgtcccacc tcccaggccc tcctttcctg agtgctgggc 106500 tgagcactggtgggggctgt gtttaagtgg gaggcccgag cttggggctc tgggaggtca 106560 ctgtgacacagaccctgtct gcaggcaagc aggctctcct gatgctctca ggagccccgc 106620 acctgtggggaatgagtcaa aggtggcctt gcagccacag gggatgagag aaaggctggg 106680 cacctgctaggactccctca cagccatgtt gaacccactc tgtgtaccct gtcaggctgt 106740 gcgggagtgggagcgaagtg aggagagggg caggtgggag agccgaccct aagtggagga 106800 caggcccgctcctccggggc cctgggcctg agacaccaac ctcaatatcc ggtctaggac 106860 gcagtgtggaggggcttgct ttctccaacc ctttctgacc tggcatctta ccccaggtaa 106920 atactggggctgcatgcagc gcctggcctc ctgtccagac tcctgggtgc ctagagtgcc 106980 aggggctgacaaagaagaag tggaggcagt gaccgcactg gcgtccctct ctgtgggcat 107040 cctggctgaagataggtaat gccagacccc tggccctggg cccacagcct ctccaccgct 107100 tcattcctccctgcttgaag accccgggtc cgctatgcag ccaccccaac cctcccaggc 107160 ttcctgaccagggttgagag gaagcttagc taaggccctt gctgcagccc tggtgctcca 107220 gcatcccacccttgtccctc cccacaggcc ctcggagcag ctggtggagg aggaagaacc 107280 tatgaatctctaaggctctg gaaccatctg cccgcccacc atgcccttgg gacctggttc 107340 tcttctaacccctggcaata gcccccattc ctgggtcttt agagatcctg tgggcaagta 107400 gttggaaccagagaacagcc tgcctgcttt gacagttatc ccagggagcg tgagaaaatc 107460 cctgggtctagaatgggaac tggagaggac cctgagagga gacgggctgg gcggcgaccc 107520 ccacagggctctcgagaaca gattctcccc tccagtatgg gccctggctg tggcccccat 107580 tcctcaggactgcacagagg aggactggct ccggctccgt cgggctcacc cttaaccact 107640 attcctggctctgcaaaccc cagactttgc acacagcctc aggctccaca cagaaatgtg 107700 aacttggcctcagacaggct ggcccttcct aggctctagg ggctaggggg gagtggggag 107760 ccaagaggtcccatattcct gagtgcaggg gtagtccctc tcacctgctt cctcagacga 107820 ctctggaagcttccctctac cactgggcac tgagacgaag ctccctgaca gccgagactg 107880 gcagccctccatctggtccg taccctcgcc agaggccccc ctacatcaac ctcctggcga 107940 tgccctggtggagcagatgg gtgctctggg agtcctgtgc ttcctgatcc aatggtgcca 108000 aacccttcatctccccaaga agcgcagcat acccctggga cccctcggcc actgcccact 108060 cggggagccttctctgtttc tggggcctcc cccaccatag ctctgattcc caccccacat 108120 aggagtagcctgactgaggg ggaaggggtg ggagagaaga tacagacatg gaggagggga 108180 ggctgctctggcaaagtctt caaggctttt gggggtccag gcctggggtc aagaaggaaa 108240 atgtgtgtgagcatgtgtgt gagtgaggcg tgtgtgtgag cgtgtgtgtg agtgaggcgt 108300 gtgtgtgtgtctttcctagg acccaccata ccctgtgtat gtatgcatgt ttttgtaaaa 108360 aggaagaaaatggaaaaaaa tctgaacaat aaatgtttta tttgctttaa aagtgcctct 108420 gaaagggccccccagaagtg agcagtgcgc cgtcaagcgg gtgtgcaggg cacacagctg 108480 cacggcacagtgtgggtctg agtcactgcc ggaggaggga ccagggtggt ctgggccgca 108540 gcccctttaacaatctgccc ttcctgccct gcaggaagaa cccattctga acacaccctg 108600 gctgtccctggctgccccac tttggggtga caaagaggag gcagccctgg gctgagtcca 108660 cagagaccagccctgatatg gcaggagtgg gggtggggtg ggggagtggg aatacaggag 108720 ctcagccccagctcaccacg gcatccccga agagttgtga ctcagacaca cctgggttta 108780 agtcccagctgggagctcag gtaagtcaaa tcgtcttctg gggcctctgt ttatcagtag 108840 aaggctccagaagtatacac tgttgatggc tccttcccgc tctgatgcac catgcctgat 108900 taagcatacactgagcctag aagagagaag gggtgaggca caggcctgga caagctcacc 108960 cagcctaagcagagaggaag gcgccaggct ggcagcacct gcctttgtgg ttctgagtct 109020 gtccggtttttccagcagga agaggagcac ctcattacct tagacctggc ccaagctcct 109080 ggcagcctggcagagtgtga gggaagaggc gctaatccct ttcccatctg gcctggcctc 109140 tcgggtgtggacaccaaatc ccgcaggggt tgctgtagct atgcccgtgg gcatccttgc 109200 cctggctggggtgtgctaga gagaggaaag ctggaggagg agagctgagc tggtggttac 109260 cccatgccaggagggccaag gcaagagggc ctgcagcccc agagatactg actctgtccc 109320 ctgccctccagggcacaact gaactagcgg aatggcttaa tcagatagct cgagaactgc 109380 cactaccactccctccctgc ccactcctcc caaagtccac ctgttcccgc aagagtccca 109440 cctcacaagcaaccaccaga ggctgataca aatggccgct gtatttttgc taaagtgaca 109500 gtgacacagataaggcaaag agctgagggg caggacacat cagatgggaa gggggagacc 109560 gtgcaaaatggcagtctaac agaaaatcat ccttgtacca acagcccctt ccctcccaag 109620 ttaggtgagcccttgggcca gtgtatgggc agaaaagcag atttgtgtcc ttcagaaggg 109680 aaatgtaaaaaggtgaaagc tctagttgaa gggcagtgag aggggctgga gtgggagaga 109740 aggtctctcctggccggtgg tctgggtgca gcaagggcac tctgagaagg cagaatggaa 109800 acgcagggctggaggggcat gggtacaggt ttgggggctc tttccagcct ctactatgtt 109860 gcccccttccccaaagccct tacaggggca gaagcacatt ccccgtgacc ctgagtctgg 109920 cctcatttgggaagtcttct ggggtgtatg gatgcctgtg tgtgtgagtg agatgggtgg 109980 ggggccacggctatctggct ctagcacact catgggagac cagctctggg aacaacagga 110040 tggggtgctgggatgggggt ttaagaggtc tctgctagat atttctgaac tgacctcccc 110100 aggtgcccaacctggccttg ggaagagagt gcctagggca gcggggatgg aaacccttgc 110160 ctgcagcataggtccaggcc tcatggccct acaccttgac ctcttgactt tgttgccctg 110220 gccttaagtacaaagattcc tcactgcgtg ctaagaaaac agatccaggc cgggcacggt 110280 ggctcacacctataatccca gcactttgga aggctgaggc gggtgaatca cctgagatca 110340 ggagttcgagaccagcctgg ccaacatggc aaaaccctgt ctctactaaa aacacaaaaa 110400 tttgccgggcatggtggcag atgcctgtaa tcccagctac ttgagaggcc aaggcaggag 110460 aattgcttgaacctgggagg cggaggttgc agtgagctga gatcgcacta ctgcactcca 110520 gcctgggtgacagagtaaga ctccatctca aaaaaaaaaa aaaaagaaaa aaaaaagaaa 110580 gaaaagaaaacagattcatt tgaaaaggtc taaagctgcc ctctggccag gctgatgagg 110640 agcaacatggcaggatcccc tctctaccac actcaggttt cctcgaaagg ggacgggcag 110700 gacagcttcctgggagacca cactcgtcct gctgtgtatt ttctgccaca gttctggggt 110760 caccagggggtgggagtagc ctctcccaac atctcagagg ctgagtccag gtcctaaggc 110820 ccccccagggtgcagagacc tcaccccctg ggtcagaaat cgctgaggat gctgatgtca 110880 gcaaagtcagcccggtagcg gtgggcatag aggctgagca ggaaggccca cttgaaggaa 110940 atgaagctccagacgctgga gaggtagtag ctggtggggt ctgtgaggcc tgcagggaga 111000 gaagtaccgacagtgacttt ggcaggccct gccctcggcc tctgcaccgg ccacaaggcc 111060 agggccaccctccccactca acatccctgc aacgtcctgg cagctgaacc aacccttcag 111120 aaagacactgtgatggaggt tttagagcca tggtccccaa cctttttggc accagggact 111180 ggttttgtggaagacaattt ttccacaaaa accttgggat ggtttgggga tgaaactgtt 111240 ccacctcagatcgtcaaaca ttagatcatc aggggcacgc aaccctcgca tgcgcctcac 111300 aacagggtttgcgcttctaa tgcccgccgc tgacctgaca ggaggcagag ctcaggcggt 111360 aaggctcgcttgcccctcac ctgctgtgtg gcctggttcc taacaggcca cggaccacta 111420 ctgttccacagcctggaaca gtagaacgga gctggggacc gttttagagt attccagggt 111480 tttcaggcaggaggccgtgg ggattaggga agggcagggc tggccaatca caggtctgta 111540 tcatccactccgcttttgtg acaaataccc taggccacct ccaacctgct ttagttagca 111600 tcagactcccggaagaagga cctctggtta tttccagcca cagccaccag agggcgctcc 111660 catcccagagctgagcacag actaatgggt cccaatatca ggagtgcttg tatgggctat 111720 gcactgctcaagacttcaca tcagtttcat agaatccacc caacttgcga ggtggggact 111780 tgttttctccacatgaacca taacaaaacc cgtgtccggg gaggttaagt aattcaccca 111840 gtctctttggaggtaacctg tggaaccagg atgggaatgc tgctaaaatc cccgctgctg 111900 tccctcccatgccctctttc cctgggaccc gccctcactc tgatgccggg tgatggccag 111960 cacgaggaaggtgcagaagg cagcgatgga gacggccgag aagaggacgc ccacgaagaa 112020 gaagccgcgcagccccttga gccaggtcct ccaataatct tgcatgtaca tcacgtgcgt 112080 caccaggacccacagtgcca gcacccctgc aggagagaca catcagggcc catccccagg 112140 gtgctccagagccctgcaga tccactagac caggcctatt tgcataagaa taccaagaat 112200 atggtcttgtctctcattcc ctcatagaat ggagttttcc ttttcggagg ctgtgatatc 112260 agaagcaggtaagagactga gctgcctgct agtaagccca acattagaga aacctgcaga 112320 aatacaaaaccctaccattc tctctgattt tattttgttt tggaaaacat gaatatctct 112380 cacaaaaatgttatgttaat tcatgttatt tttagtatta ctttaaaatg ctaaaaaatg 112440 ttctaacttctaatatagta tatatcaata gctaaaactc acatacataa aatttgcatg 112500 gagtttcactacttttcaag aggataaaag gatcctgaaa accagaaagt ctgtgcctca 112560 gcagcccagcctgctttctg gggacttgcc actgtctacc ctgagggcca cagagcaggg 112620 aagccatgctcctgccccat gctcctcctc cacccagccc tcagaggcca cagtctcaaa 112680 gtcacaaggcctgcagggct cttcccaaac tgcctgagtt ggttttgcag gatgaggagg 112740 tccagccatgaagactccag ggccacccaa cccctgagtg gccttattgt tcttggccag 112800 acctcatgccactccctcca ttttgcggca aagggcaggc catcaccacc tgcaccgctc 112860 cccacccccactgcccccag cttttcctgg gcctggcctc tgcgcctggg tggacacttc 112920 ctctaggatgccagctgcca cccagccaat acaatacaaa acaaccctct gtgccaggca 112980 gtgcctgctggtgcagccca aagagtggaa caaatatcaa ctccattggc aagggtccgg 113040 gcagggcggtggatcccggc aagggacaaa tgaggaagga ggcagagcca gctgcaggct 113100 ctcagctggttgggttgcaa ggtgtgggcc actcaggccg ctgcatccta ggagtcagga 113160 ggcctttccaaaaggcagct gcacacatgc cactcagagt agttaccaaa tgtgcacagg 113220 aaggataagcatctggttgg ggaaagtggt tatctctggc aatggagaca aggaagggaa 113280 gttgatggggcggtgggggt ggggaagtgc tttgaatcta tgggaatcta tgctattttg 113340 tttcttaggctgggtgggaa atctatgcta ttttatctac gctgttttct caggctgggt 113400 tataagggtgtttgttaaat catctatcct tttttgtgtg cctaaaatat ttcataattt 113460 gtttaagggggaaaaaggca ggaggaagct tgtcactgtg gagctatgct ctggttacca 113520 gctcagaggctgtcccagtt tggctgtccc cagacagtcc agtgaggaac aaaaacccat 113580 gagactccaagccaagaaac caggagcctg gcactgctgt gtcccaaagc cttggtgttt 113640 ccacatctaaaaatgggtgg gcccaggggt cctgccagtt taggtaactg ggcccagggt 113700 tctaccctagtgagggtgaa ggcctaccaa gcctacagct tccctcagcc cctgccaccg 113760 tttgaccccctgaacactct cccagctttg cccctgccca cctccactct tcctcagggg 113820 gtgggggcctggaatgtggg tccccctcct actgagatca gggtgggcca ggacaagcat 113880 ctgttcctccccacctagtc tggatgctgg agtgggccag aggtggacag gacaatcatc 113940 ctgcagcttcctcttacctc ctacaagatc tggattttta taccagccac ctttcacaga 114000 agtccctcccactcctcaca tgtgtcccat gttttcattt gagggagctg tttggtttat 114060 aaagggccctgggaacaagg ggtgttgtca ctgagcacac tcaaggagca gtctgatggg 114120 cacctgtctggaacaggtcc cctcgccctc tgtctcctcg tgccacagag gggttgggga 114180 agttgagctctaagatcctt tcccactcaa agattctaga agccagcttg ggagaaaaat 114240 aaggtcagaacaattcctct gtgactcagc agtttctggg ttaggaaatg ctgaaatagg 114300 ggcctgtgaagatgccatct cttagtccac tggccacgat ccagtggttc cccaaaactc 114360 ccacccccatgtacatgcac ataccaaaga gggctgaggg caggagggag aggaagacag 114420 ccatttgggggcgttttggg ccctgttctt tgttaacaac aggcatggtt tacccacctc 114480 tcaccttccctcaaccttgc tccaggccct gcacagaggc ctcccctcca gataaacaca 114540 catcaagtgtggaggcaggc ctgctgccca cgccctggct cccaccaccc tcctgggaag 114600 ggagctctccaccagcccta cccaaggggg tcactgaagg agatggagcc cctcactggt 114660 cccctcccacacatcaggca ggaggcaatg tatctcccta atacccttcc ctggcacact 114720 tggggactctaggaagcctg gtttataaaa ctcggggtgg aatggacagg tccccaatcc 114780 cacctggctgcaagcccaca ccagaccaca ccgttgctcc atcctacctg tttcaaggag 114840 cagagcccctgcttagccat gtgagcttat tggctcacag ccgataagct aagggtaagg 114900 aaggcatagggtagggcggt gaaagcatcc ccagtggctg ggctggaggt gaggagacag 114960 gagacacccgggggatccca cagggtaaat gcagacaaga aggacactgg gcctaggtca 115020 ggcccctctattccttccta ggaggaagac agtcctggag ccccagggct cttgctcaca 115080 gctcacctgggaaaaacata gagctgttta gacttcagga gcaacttttc tttttctctt 115140 tccttggtctactaaaccca gagcaagagt ttgtgttttc ccccaggact cccacagcaa 115200 agccagaccaggtagatcca acccacacct gcccgcctcc ccaggaaagc cagtcttgct 115260 tctgccactgcctttctcca aagccacttc ttcgaaggta cccatcagga tgggagaggg 115320 tatccccacccgtgaacact ctgcccacca gacccagggg ctccatgact ctgctccaga 115380 aactggcacatccaatcagt ccttgcctgg tccaacacag gagaaggagc atgctggggc 115440 tacccttgggtgactcagca gattctgagc tataaaacgc tgagtcagaa gtagggtgct 115500 cacacgttagttaatctgct gacactttac ccccaaaaga ggaagaaggt tgactggcca 115560 cagaccctctgagaactcac tcatggtggg gaaggtcgga ggcccaggct tggcaacccc 115620 tctccctgccaccatccacc accaccacta ccaagcagtt ttggctcttc cacagccact 115680 gtcaaagatcagaccatcag ggagatacca ggaccctact ccagctggct gctgccctag 115740 cgagctgctgccctagcgag ctgctgccct agcgcctctc tctgaaggca gctccacagc 115800 tggcctgcctcataggccaa gggaagcctg tggggaggga gagagggcag agttgggtcg 115860 gaagaaaaccccaggcaact ccctagagta taagaaagaa ggccttttcc acagccctct 115920 aggaggcagctggagactca gggagtgggc agcactgcaa gatttcagat ctggagggaa 115980 gtcagatgtcttttggggac atctcctccc actcctaata gatgaggaaa ctgtggccca 116040 ggatagggtcaaacggccag gtagggttca cctccacttg taccaggcca gactcaacac 116100 aaccagctgagatcccaggc tggccctccc tgctcatcct tctcttgcct tcggtcttcg 116160 caatgcaatcatagggctct gacgccgcct tccagagggg aaagcaacag ggccaatagg 116220 aaacaaaaaagtggcaggga gaagtgaacc ttgacaaaca tggagggtgg cggggtgcag 116280 tggggaaaggaactagggct ctgtagataa cgcgcagaga tgggccagtt gtcctcagga 116340 tcccacaggtggtgaggcag ctgggcaggc agagaacacc ctagccaggg tgcccatccc 116400 cccttcttggtgacccagtg ctttgttggc attgtgtagg gtggggccct gtatgcccct 116460 cttctaaggcattaacccca cctcatgctg cgactctacc cagggatggc actcagcact 116520 ccctgtggcagtgagtaaat tagttatttt tagttattcc atttagggtt cttttggccg 116580 aggattttagtaatggaata taatcatcat atgtaaaagt attatacgta ttttcttccc 116640 aaagtcctttcccacacata ttatttcatg tagctgtgta atcccgggta agcaatttat 116700 ttaacttcaggcctcagttt ccttatctgt aaaatggaca taatcgtaag gcctacttca 116760 tgagactaatgtaaggatta aatgaaataa gggaagcagg ttgcttaaca tagtgcctga 116820 cacatagaaagcatttttta aaatgttaga aagtagagat aatatttttc atcttcatac 116880 caattctatggcgcagagag gttaaactgc gagcccaaat gtgcacaaca aggagcactg 116940 gtcagcccagagcccccatc agcgcaccga tgcttcccct tccctcccag aagcacagaa 117000 agggcggctggcctgcagga tttggcagag cttggctgag gagccacagc agacgggtag 117060 caaaaaggcaccaacatggg tggaaagaga atgtccagtt tctatgagat ccctaacgcc 117120 gtcctccctgtgggtctcag cagagggctc tgcgggggag ccctctggaa ggagggagat 117180 gggcttccccagccacccct agccctcttc ctttcccact tcttccctct ctgccctcac 117240 ccagcacccagggaaggggc gcctgggggg caggggatcc ctcagaacaa ccgtgtgtgt 117300 gtgcgtgtgtgtgtgtgtgt gtgtttgggg ataggaggcg accagcgccg cgggcgcgcg 117360 gaggggacactgtcgtgggg caactgggcg gagggcgaca ggcagtgtgc cgtgacagat 117420 aacccgggcggcgcggcagg tctgtgcagc cggcagtggc gggccgtcgg cacccccagg 117480 tggcgcccgggcgggcatcg ggtctcagag gcacccagga atgcccagga gcccgggccc 117540 gcgtggggcctgccgccgcc aaccgctgtt ttcgagtaaa cactccaccc gctccgcggg 117600 gaagcgccgctcgcggggag cgtcctggag cagctgacgg cgcccgcccc gcagccgcgc 117660 acccgccccgcgccgcccag cgtcccgggg tacctgcgag ccctcccatg gccgcggtcc 117720 ccggctgtcggtagaccacc gtccagacga ggaagatgga gaagccggcc acggagctga 117780 tgccggagtaggcggcgcgg aggccgagct gcagcctgga cggggccatg gggctgcggc 117840 gccgggcgggccgagggcga gcgcggccga gagtcacagg tgcagggccc gaagccgcca 117900 gccggagccgcgggagccgc cagagcagcc ggcgccccgc gctccgcccc cggcccgccc 117960 ccagcgccgcccgcacagcg ccctccccgg ccggaggccg cccgcgcccg gaaccgcaga 118020 cgccaccgccgctttgcgaa gctgccgtgt cgtttggggg aatgctgcta aaaaggcgga 118080 ttcctgggcccatccccaga cccgccgtgt ccggattgtt ggaccttgga agggaccgga 118140 aatatgcctttatacgagcg aaccgcgagg attaaaaatc tttacctctg agtacgatgc 118200 gtattttcgtttaaaattaa aattaaaatt tcttgttaaa aattaatagg taaaacttaa 118260 gaaatattagagtacgctgt gaatagaatt ccttccgccc gtccttctat caaccaggtt 118320 ccctcccaccatatcgcaga ggatttctcc acacactaaa gtctgggaac ccctgcgacc 118380 atcaccttctgactgcaaac attctataca ttctatcctc acgcacagct ccccacaaat 118440 ccctacttttttttttttaa acagagtctc actctgttgc ccgggcagga gtacagtggc 118500 gccatcatagctccgcatcc tccaacacct ggattcaagc aatgctctca cctcagcctt 118560 ccaagcagccaggactacag gtgtgtgcca ccacgcctgg ctagtatttt ttgttattta 118620 ttttttgtagagatagggtc tcgctatatt gcccaggctg gtccccaact cctggcctca 118680 agctgtcttcccacctcggc ctcccaaagc gctggaatta caggcttgag ccactgcaac 118740 ggacctcacctttcctttta tcagcacaag ccttatcctc ccaaacccct caccctgacc 118800 ctcgggatcataccattgta aggaagagac agatctgtag caggagggca ctgagctccc 118860 acgtgagcccagcttccggc cgggagctgg agggaaaatc ccagcacaat aacaagggct 118920 ctgccacagcactaaggatc cacatgggga ggcccatcat atacctgcac aaaacataac 118980 caataccccttgcattagtt ttttttgtgt gtgtgctgcc gtaacaaatt accacaaatt 119040 tactgatttaaaataacaca aacttattat tattttacag ttctgtaggt caggaatcca 119100 aataatggtctcactgggct aaaatcaagg ggacatcagg gttgccttgt ttctggaggc 119160 tctaggggaaaatcagtttc cttgactttt tttttttttt tgagacggag tcttgctctg 119220 tcacccaggctagagtgcag tggcgtgatc tcagctcact gcaatctctg cctcctgggt 119280 tcaggtgattctcctgcatc agcctcccga gaagttggga ttacacgctt ccaccaccac 119340 acccagctaatttttgtatt tttagtaaag atggggtttc accatgttgg ccaggctggt 119400 ctcgaactcctgacctcagg tgatccgccc acctcagcct cccaaagtgc tgggattaca 119460 ggtgtgagcccaccgtgccc ggccgccttt tccagcttct agagtgaggc tacccacatg 119520 ccttaactccctcttcctcc ttttcccttc taaggacccc tgtgattgag gggatagtcc 119580 aggataatctccccatcgca agatccttaa ttttatcaca tcagcaaaat aaatcccttt 119640 gccgtggaaggtgacatatt cataggttct gggatgagga cgtggacatc tttgggggcc 119700 attattatcccacccaccac accccctctg gaacataaac ttcatgagca gggacagtgc 119760 cagttttgttcacatcaaca tctaaaagca tgtctggcat ataatgaccc cttaataaat 119820 gtttgttgaataggtgagtg tgagtgaatg aaggtaagaa taaaataaaa acaaaagcaa 119880 ttatacacaaggaatctaga cagggtgtgc ttaactgcca aacaagggat gtaaaccagt 119940 gttaagcacatttgcctcac tctagaataa tctgggagct tctttaaaaa taaaaaaata 120000 aacccagccccacccctgcc tattaaattt tgaatcttgg agtgtgtatt ttaatgagaa 120060 gtgatgtcaaggctgtgagc tcagcagcag ccctccttta ggagctgccg gtggagagtg 120120 agtgctggtcctgtggagga gggagcaagc cccgtggtgc ggagtgcatt tccatggatg 120180 gcttcagagctggccaggat ggacagtact ccaggcagtg ggaaccgcac gtgtgatggc 120240 gcagagggaagaaataaagc ggccgctttg ggaaactgta agtcgtttgt ggctggaatg 120300 tcaagtttgaaggtagagta gcgggtttgg agattagaaa ggttctgaac ataaagggcc 120360 ttgcatgctctgttaagaag gctgtccccc tccccttggg gctgggggag aaaactcaca 120420 attctgtgttttagaactat ggccagagta atagagtgaa ggcgaactgc ctgtgaaaca 120480 ctagaagcagagagatgagt tggacaaatt tcaccccaca gtgctttaat taccaggtct 120540 ttaaaatggagactgcagta acacctactt caaagtgttg tgatgaggag tgcctggaag 120600 agtgcctagcacatggtaga tactcaataa atgtcaggaa gtagaattag tagcagcaga 120660 aggctgccatggcaagagag gatgaggggc ttcagagctg gtccaggcag aagcagagag 120720 aatggaagagacgaaactgc ttcaagagct atttcagcta tctgaaccta aaggtcaggg 120780 gagaattcattagctgagca gacagaagga ggagagcaaa aatattatga gtggacatat 120840 taggagtatgggagagcagt gagcaagctt gctgtgctgg aaagtgagat tgcgcaagaa 120900 aagaaagagaaataattatg taacagtagt actagaccag gttgtacaag gctaaggcca 120960 ggcttaaacattttttaaat tgtggaaaca atgaagagct attgcagagc attagactca 121020 ggtggggtcagaggcctagc ttcaccattt gctgtgaccc tgggcaagtg cccctaactc 121080 acagatgtccaatccaattg actttctgcc tggaagaaaa tattccatat ctgcaccctc 121140 cataatggtggccactaatc acaggtggct attgaatact tgatatgtga ctagtgtgac 121200 tgaagaactgaatttttaat tgtatttaat ttaaattaat ttaaatttaa tgtatttaag 121260 tttagtgtatttaatttaaa ttaatttaaa tttaatttaa ttaatttaag tagctgcaca 121320 tgactagtggctactgtgtt agcacagcta gacccaggac tcctgtccct ccatctgtac 121380 acagggaatgatgatgaaac atcacaggct tgttacaaag atcgagatat attgagataa 121440 tacactcaaagtgctcaaca cagtaattca acaaattatt gctgctgctg ttgaaattgt 121500 tattgtttttattgaacagg gattgcatga catacgccaa gtcttaggaa gattagttag 121560 actataatatccagttagat ttgatggggg aaaattgtag aggataaagc attcacaagg 121620 ttatttcagtggtaaggtgt gagagaatta agatcttatc cagtgaaaga ccttgagaat 121680 gggaaagaatggaatgattg ttgagccata aagcacatgg gtgtgcacca ctcatacaca 121740 tcttctcatatcagcttcct tccaaggtat tctcagagag tacactccca acccagccca 121800 ggacagacactactacgacc cctacaagat gcacagccat tctccctgcc tgcgccagaa 121860 actactagtgctccacaaca cacaccaaca tttgtgtgtc tctttctggg cacagtacct 121920 cccaaatttgaactacactt cccagcttcc ttgcagtcaa acggatgcca tgggatcagg 121980 ttctgaacaatggaatgaag gcagaagcaa tgtgcgccat ttctaggctg ggctcattta 122040 aaaatcttccatacaacctg cattccctct tcccattctg tgacaatttt agaggccata 122100 tgtaccacataatggaaaga acctaggctt gaatgaatgg atggagcaga gctacccctg 122160 tcccctagaccctcactgga ctatag 122186

What is claimed is:
 1. An antisense oligonucleotide that inhibits theexpression of a histone deacetylase.
 2. The antisense oligonucleotide ofclaim 1, wherein the histone deacetylase is selected from the groupconsisting of HDAC-1, HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D,and HDAC-E.
 3. The antisense oligonucleotide of claim 1, wherein theoligonucleotide inhibits more than one histone deacetylase.
 4. Theantisense oligonucleotide of claim 3, wherein the oligonucleotideinhibits all histone deacetylases.
 5. The antisense oligonucleotide ofclaim 1, wherein the oligonucleotide inhibits transcription of a nucleicacid molecule encoding the histone deacetylase.
 6. The oligonucleotideof claim 5, wherein the nucleic acid molecule is selected from the groupconsisting of genomic DNA, cDNA, and RNA.
 7. The antisenseoligonucleotide of claim 1, wherein the oligonucleotide inhibitstranslation of the histone deacetylase.
 8. The antisense oligonucleotideof claim 1, wherein the oligonucleotide has at least one internucleotidelinkage selected from the group consisting of phosphorothioate,phosphorodithioate, alkylphosphonate, alkylphosphonothioate,phosphotriester, phosphoramidate, siloxane, carbonate,carboxymethylester, acetamidate, carbamate, thioether, bridgedphosphoramidate, bridged methylene phosphonate, bridgedphosphorothioate, and sulfone internucleotide linkages.
 9. The antisenseoligonucleotide of claim 1, wherein the oligonucleotide is a chimericoligonucleotide or a hybrid oligonucleotide.
 10. The antisenseoligonucleotide of claim 1, wherein the oligonucleotide comprises aribonucleotide or 2′-O-substituted ribonucleotide region and adeoxyribonucleotide region.
 11. A method for inhibiting a histonedeacetylase in a cell comprising contacting the cell with the antisenseoligonucleotide of claim
 1. 12. The method of claim 11, wherein cellproliferation is inhibited in the contacted cell.
 13. The method ofclaim 11, wherein the cell is a neoplastic cell.
 14. The method of claim13, wherein neoplastic cell is in an animal.
 15. The method of claim 14,wherein the neoplastic cell is in a neoplastic growth.
 16. The method ofclaim 11 further comprising contacting the cell with a histonedeacetylase protein inhibitor that interacts with and reduces theenzymatic activity of the histone deacetylase.
 17. The method of claim16, wherein the histone deacetylase protein inhibitor is operablyassociated with the antisense oligonucleotide.
 18. A method forinhibiting neoplastic growth in an animal comprising administering to ananimal having at least one neoplastic cell present in its body atherapeutically effective amount of the antisense oligonucleotide ofclaim 1 with a pharmaceutically acceptable carrier for therapeuticallyeffective period of time.
 19. The method of claim 18, wherein the animalis a mammal.
 20. The method of claim 19, wherein the mammal is a human.21. The method of claim 18 further comprising administering to theanimal a therapeutically effective amount of a histone deacetylaseprotein inhibitor that interacts with and reduces the enzymatic activityof the histone deacetylase with a pharmaceutically acceptable carrierfor a therapeutically effective period of time.
 22. The method of claim21, wherein the histone deacetylase protein inhibitor is operablyassociated with the antisense oligonucleotide.
 23. A method foridentifying a histone deacetylase that is involved in the induction ofcell proliferation comprising contacting a cell with an antisenseoligonucleotide that inhibits the expression of a histone deacetylase,wherein inhibition of cell proliferation in the contacted cellidentifies the histone deacetylase as a histone deacetylase that isinvolved in the induction of cell proliferation.
 24. The method of claim23, wherein the cell is a neoplastic cell and the induction of cellproliferation is tumorigenesis.
 25. The method of claim 23, wherein thehistone deacetylase is selected from the group consisting of HDAC-1,HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D, and HDAC-E.
 26. A methodfor identifying a histone deacetylase protein inhibitor that inhibits ahistone deacetylase that is involved in the induction of cellproliferation comprising contacting a histone deacetylase identified bythe method of claim 23 with a candidate compound and measuring theenzymatic activity of the contacted histone deacetylase, wherein areduction in the enzymatic activity of the contacted histone deacetylaseidentifies the candidate compound as a histone deacetylase proteininhibitor that inhibits a histone deacetylase that is involved in theinduction of cell proliferation.
 27. The method of claim 26, wherein thehistone deacetylase protein inhibitor interacts with and reduces theenzymatic activity of fewer than all histone deacetylases.
 28. A methodfor identifying a histone deacetylase that is involved in the inductionof cell differentiation comprising contacting a cell with an antisenseoligonucleotide that inhibits the expression of a histone deacetylase,wherein induction of differentiation in the contacted cell identifiesthe histone deacetylase as a histone deacetylase that is involved in theinduction of cell differentiation.
 29. The method of claim 28, whereinthe cell is a neoplastic cell.
 30. The method of claim 28, wherein thehistone deacetylase is selected from the group consisting of HDAC-1,HDAC-2, HDAC-3, HDAC-4, HDAC-5, HDAC-C, HDAC-D, and HDAC-E.
 31. A methodfor identifying a histone deacetylase protein inhibitor that inhibits ahistone deacetylase that is involved in the induction of celldifferentiation comprising contacting a histone deacetylase identifiedby the method of claim 28 with a candidate compound and measuring theenzymatic activity of the contacted histone deacetylase, wherein areduction in the enzymatic activity of the contacted histone deacetylaseidentifies the candidate compound as a histone deacetylase proteininhibitor that inhibits a histone deacetylase that is involved in theinduction of cell differentiation.
 32. The method of claim 31, whereinthe histone deacetylase protein inhibitor interacts with and reduces theenzymatic activity of fewer than all histone deacetylases.
 33. A histonedeacetylase protein inhibitor identified by the method of claim 26 or31.
 34. The histone deacetylase protein inhibitor is substantially pure.35. A method for inhibiting cell proliferation in a cell comprisingcontacting a cell with at least two of the reagents selected from thegroup consisting of an antisense oligonucleotide that inhibits a histonedeacetylase, a histone deacetylase protein inhibitor, an antisenseoligonucleotide that inhibits a DNA methyltransferase, and a DNAmethyltransferase protein inhibitor.
 36. The method of claim 35, whereinthe inhibition of cell growth of the contacted cell is greater than theinhibition of cell growth of a cell contacted with only one of thereagents.
 37. The method of claim 35, wherein the each of the reagentsselected from the group is substantially pure.
 38. The method of claim35, wherein the cell is a neoplastic cell.
 39. The method of claim 35,wherein the reagents selected from the group are operably associated.